JOHN PETER contact WIKSWO

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Scaling and systems biology for integrating multiple organs-on-a-chip
    John P Wikswo
    Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN 37235, USA
    Lab Chip 13:3496-511. 2013
  2. pmc Engineering challenges for instrumenting and controlling integrated organ-on-chip systems
    John P Wikswo
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235 1807, USA
    IEEE Trans Biomed Eng 60:682-90. 2013
  3. ncbi request reprint Engineering challenges of BioNEMS: the integration of microfluidics, micro- and nanodevices, models and external control for systems biology
    J P Wikswo
    Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, TN 37235, USA
    IEE Proc Nanobiotechnol 153:81-101. 2006
  4. ncbi request reprint Biomagnetic detection of gastric electrical activity in normal and vagotomized rabbits
    L A Bradshaw
    Living State Physics Group, Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    Neurogastroenterol Motil 15:475-82. 2003
  5. ncbi request reprint Experimental and theoretical analysis of phase singularity dynamics in cardiac tissue
    M A Bray
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA
    J Cardiovasc Electrophysiol 12:716-22. 2001
  6. ncbi request reprint Spatial filter approach for comparison of the forward and inverse problems of electroencephalography and magnetoencephalography
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    Ann Biomed Eng 29:214-26. 2001
  7. ncbi request reprint Spatial filter approach for evaluation of the surface Laplacian of the electroencephalogram and magnetoencephalogram
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    Ann Biomed Eng 29:202-13. 2001
  8. ncbi request reprint Vector projection of biomagnetic fields
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, USA
    Med Biol Eng Comput 43:85-93. 2005
  9. ncbi request reprint Volume conductor effects on the spatial resolution of magnetic fields and electric potentials from gastrointestinal electrical activity
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA
    Med Biol Eng Comput 39:35-43. 2001
  10. ncbi request reprint Three-dimensional surface reconstruction and fluorescent visualization of cardiac activation
    M A Bray
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 47:1382-91. 2000

Collaborators

Detail Information

Publications42

  1. pmc Scaling and systems biology for integrating multiple organs-on-a-chip
    John P Wikswo
    Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN 37235, USA
    Lab Chip 13:3496-511. 2013
    ..This review presents several examples of scaling arguments and discusses steps that should ensure the success of this endeavour...
  2. pmc Engineering challenges for instrumenting and controlling integrated organ-on-chip systems
    John P Wikswo
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235 1807, USA
    IEEE Trans Biomed Eng 60:682-90. 2013
    ..Toward this goal, we are building functional prototype components and are working toward top-down system integration...
  3. ncbi request reprint Engineering challenges of BioNEMS: the integration of microfluidics, micro- and nanodevices, models and external control for systems biology
    J P Wikswo
    Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, TN 37235, USA
    IEE Proc Nanobiotechnol 153:81-101. 2006
    ..Externally controlled nano-actuators, needed to effect changes in the biochemical, mechanical and electrical environment both outside and inside the cell, will provide a major impetus for nanoscience...
  4. ncbi request reprint Biomagnetic detection of gastric electrical activity in normal and vagotomized rabbits
    L A Bradshaw
    Living State Physics Group, Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    Neurogastroenterol Motil 15:475-82. 2003
    ..We conclude that non-invasive recordings of the vector magnetogastrogram reflect underlying serosal potentials as well as pathophysiological changes following vagotomy...
  5. ncbi request reprint Experimental and theoretical analysis of phase singularity dynamics in cardiac tissue
    M A Bray
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA
    J Cardiovasc Electrophysiol 12:716-22. 2001
    ....
  6. ncbi request reprint Spatial filter approach for comparison of the forward and inverse problems of electroencephalography and magnetoencephalography
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    Ann Biomed Eng 29:214-26. 2001
    ..The tangential component of the magnetic field provides even higher spatial resolution than can be obtained using the radial component. An accompanying article examines the surface Laplacian for both the EEG and the MEG...
  7. ncbi request reprint Spatial filter approach for evaluation of the surface Laplacian of the electroencephalogram and magnetoencephalogram
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    Ann Biomed Eng 29:202-13. 2001
    ..Substantial improvements in spatial resolution may be obtained using the surface Laplacian techniques as long as correlated noise levels are small and raw signals have relatively high signal-to-noise ratios...
  8. ncbi request reprint Vector projection of biomagnetic fields
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, USA
    Med Biol Eng Comput 43:85-93. 2005
    ..In each case, it was found that the information obtained by examination of the projected magnetic field vectors gave superior clinical insight to that obtained by analysis of any single magnetic field component...
  9. ncbi request reprint Volume conductor effects on the spatial resolution of magnetic fields and electric potentials from gastrointestinal electrical activity
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA
    Med Biol Eng Comput 39:35-43. 2001
    ..Thus, sources are more accurately localized and imaged using magnetic measurements than using measurements of electric potential...
  10. ncbi request reprint Three-dimensional surface reconstruction and fluorescent visualization of cardiac activation
    M A Bray
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 47:1382-91. 2000
    ..Both sets of images produced mean registration image errors on the order of 2 pixels, corresponding to roughly 3 mm on the geometry. We demonstrate the algorithm by visualizing epicardial wavefronts on an isolated, perfused rabbit heart...
  11. ncbi request reprint Quatrefoil reentry in myocardium: an optical imaging study of the induction mechanism
    S F Lin
    Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA
    J Cardiovasc Electrophysiol 10:574-86. 1999
    ..An optical imaging technique was used to explore its existence and to study the induction mechanism of this peculiar reentry pattern...
  12. ncbi request reprint The human vector magnetogastrogram and magnetoenterogram
    L A Bradshaw
    Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 46:959-70. 1999
    ....
  13. ncbi request reprint A simple nonlinear model of electrical activity in the intestine
    R R Aliev
    Department of Physics and Astronomy, Vanderbilt University, Station B, Nashville, TN 37235, USA
    J Theor Biol 204:21-8. 2000
    ..We have observed the occurrence of phase interruptions or breaks, which are responsible for the limited values of propagation distance and time...
  14. ncbi request reprint Delayed activation and retrograde propagation in cardiac muscle: implication of virtual electrode effects
    J Wu
    Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA
    Ann Biomed Eng 28:1318-25. 2000
    ..We conclude that point cathodal stimulation induce delayed activation along the fiber axis and retrograde propagation both along and transverse to the axis...
  15. pmc Effects of bath resistance on action potentials in the squid giant axon: myocardial implications
    J Wu
    The Living State Physics Group, Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biophys J 73:2347-58. 1997
    ..Therefore, this study not only develops a quasi-one-dimensional theory for a squid axon, but also provides one possible factor contributing to the anisotropic propagation of action potentials in cardiac muscle...
  16. ncbi request reprint The effects of tubulin-binding agents on stretch-induced ventricular arrhythmias
    K K Parker
    Living State Physics Group, Department of Physics and Astronomy, Vanderbilt University, Box 1807 Station B, Nashville, TN 37235, USA
    Eur J Pharmacol 417:131-40. 2001
    ..The data would indicate that the cytoskeleton represents a possible target for antiarrhythmic therapies...
  17. pmc 3'-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis
    J S Gruver
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Biophys J 95:4057-67. 2008
    ..Our evidence suggests that receptor-driven 3'-PI signaling regulates the ability of a cell to capitalize on stronger directional inputs and minimize the effects of inaccurate turns to increase chemotactic efficiency...
  18. pmc Mirrored pyramidal wells for simultaneous multiple vantage point microscopy
    K T Seale
    Department of Biological Sciences, Vanderbilt University, VU Station B 351807, Nashville, TN 37235 1807, USA
    J Microsc 232:1-6. 2008
    ....
  19. doi request reprint Gastrointestinal arrhythmias are associated with statistically significant fluctuations in systemic information dimension
    Andrei Irimia
    Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    Physiol Meas 29:N33-40. 2008
    ..In conclusion, dimensionality may be an important diagnostic factor for the characterization of arrhythmias in the context of GI pathophysiology...
  20. doi request reprint Model-controlled hydrodynamic focusing to generate multiple overlapping gradients of surface-immobilized proteins in microfluidic devices
    Walter Georgescu
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
    Lab Chip 8:238-44. 2008
    ..Simple and non-monotonic single and multi-protein gradient profiles were designed and deposited using the same device...
  21. ncbi request reprint Experimental evidence of improved transthoracic defibrillation with electroporation-enhancing pulses
    Robert A Malkin
    Department of Biomedical Engineering, Hudson 136, P O Box 90281, Durham, NC 27708, USA
    IEEE Trans Biomed Eng 53:1901-10. 2006
    ..There is considerable work on defibrillation wave form optimization. This paper determines the impedance changes during defibrillation, then uses that information to derive the optimum defibrillation wave form...
  22. ncbi request reprint Biomagnetic detection of injury currents in rabbit ischemic intestine
    L Alan Bradshaw
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37235, USA
    Dig Dis Sci 50:1561-8. 2005
    ..This study is the first report of DC injury currents in ischemic smooth muscle of the alimentary tract...
  23. pmc High-resolution high-speed panoramic cardiac imaging system
    Dale W Evertson
    Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 55:1241-3. 2008
    ..The geometric reconstruction algorithms were adapted from a previous cardiac imaging system. We demonstrate the system by imaging a polymorphic cardiac tachycardia...
  24. pmc Examination of optical depth effects on fluorescence imaging of cardiac propagation
    Mark Anthony Bray
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biophys J 85:4134-45. 2003
    ..Our results indicate that the depth-dependent optical signal has significant consequences on the interpretation of epicardial activation dynamics...
  25. ncbi request reprint Interaction dynamics of a pair of vortex filament rings
    Mark Anthony Bray
    Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37235, USA
    Phys Rev Lett 90:238303. 2003
    ..We conclude that ring interactions present unexpected behaviors associated with competing interaction and decay mechanisms...
  26. ncbi request reprint Spatiotemporal dynamics of damped propagation in excitable cardiac tissue
    Veniamin Y Sidorov
    Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA
    Phys Rev Lett 91:208104. 2003
    ..The cardiac DW-SPW transition is a key link in understanding defibrillation and stimulation close to the refractory period, and is ideal for a general study of DW dynamics...
  27. ncbi request reprint A spatio-temporal dipole simulation of gastrointestinal magnetic fields
    L Alan Bradshaw
    Department of Surgery, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 50:836-47. 2003
    ..Intestinal ischemia, which has been experimentally characterized by lower-than-normal ECA frequencies, also produces external magnetic fields with lower ECA frequencies...
  28. pmc Effects of elevated extracellular potassium on the stimulation mechanism of diastolic cardiac tissue
    Veniamin Y Sidorov
    Department of Physics and Astronomy, Vanderbilt Institute for Integrative Biosystems, Research and Education, Nashville, TN 37235 1807, USA
    Biophys J 84:3470-9. 2003
    ..We conclude that elevated potassium, as might occur in myocardial ischemia, alters not only stimulation threshold but also the excitation mechanism for anodal stimulation...
  29. pmc High resolution magnetic images of planar wave fronts reveal bidomain properties of cardiac tissue
    Jenny R Holzer
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37325, USA
    Biophys J 87:4326-32. 2004
    ..Our measurements reveal the anisotropic bidomain nature of cardiac tissue during plane wave propagation. These bidomain effects play an important role in the generation of the whole-heart magnetocardiogram and cannot be ignored...
  30. ncbi request reprint Use of topological charge to determine filament location and dynamics in a numerical model of scroll wave activity
    Mark Anthony Bray
    IEEE Trans Biomed Eng 49:1086-93. 2002
    ..We conclude that the use of state-space analysis, along with the unique properties of topological charge, allows for a novel means of filament localization...
  31. ncbi request reprint Considerations in phase plane analysis for nonstationary reentrant cardiac behavior
    Mark Anthony Bray
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 65:051902. 2002
    ..We find that phase singularities could be localized closer to the point of initial formation than was possible previously, which is important for the purposes of singularity tracking and investigating electrodynamic interactions...
  32. ncbi request reprint Virtual electrode effects around an artificial heterogeneity during field stimulation of cardiac tissue
    Marcella C Woods
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA
    Heart Rhythm 3:751-2. 2006
  33. doi request reprint A microfabricated nanocalorimeter: design, characterization, and chemical calibration
    Junkai Xu
    Department of Physics and Astronomy, VU Station B 351807, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, Tennessee 37232, USA
    Anal Chem 80:2728-33. 2008
    ..For a 50 nL sample and 0.8-1.5 nL titrant injection volumes, the heat uncertainty of 44 nJ corresponds to a 3sigma detection limit of 132 nJ, or the binding energy associated with 2.9 pM of IgG-protein A complex...
  34. pmc Mobility of protozoa through narrow channels
    Wei Wang
    Department of Civil and Environmental Engineering, Vanderbilt University, Box 1831 Station B, Nashville, TN 37235, USA
    Appl Environ Microbiol 71:4628-37. 2005
    ..The empirical results and qualitative observations resulting from this research help define the physical limitations on protozoan grazing, a critical process affecting microbes in the environment...
  35. pmc A phased-array stimulator system for studying planar and curved cardiac activation wavefronts
    Rashida A Abbas
    Department of Physics and Astronomy, Vanderbilt University, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 55:222-9. 2008
    ..This approach has potential applications in investigating curvature effects, testing numerical models of cardiac tissue, and creating complex wavefronts using one-, two-, or three-dimensional electrode arrays...
  36. pmc Microfluidic switching system for analyzing chemotaxis responses of wortmannin-inhibited HL-60 cells
    Yuxin Liu
    Vanderbilt Institute for Integrative Biosystems Research and Education VIIBRE, Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA
    Biomed Microdevices 10:499-507. 2008
    ..We observed that the role of PI3K in directing cellular response to gradient reversal was important in cell polarization and directional sensing associated with gradient switching...
  37. ncbi request reprint A high-voltage cardiac stimulator for field shocks of a whole heart in a bath
    David N Mashburn
    Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA
    Rev Sci Instrum 78:104302. 2007
    ..This device has been tested and used successfully in field shock experiments on rabbit hearts as well as other protocols requiring high voltage...
  38. ncbi request reprint Quantum dot probes for monitoring dynamic cellular response: reporters of T cell activation
    Michael R Warnement
    Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Nanobioscience 5:268-72. 2006
    ..Ultimately, incorporation with a microfluidic platform capable of simultaneously monitoring several cell signaling pathways will aid in toxin detection and discrimination...
  39. ncbi request reprint A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings
    Andreas A Werdich
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
    Lab Chip 4:357-62. 2004
    ..Our device architecture permits the integration of electrochemical and optical sensors for multiparameter recordings...
  40. ncbi request reprint Rapid stimulation causes electrical remodeling in cultured atrial myocytes
    Zhenjiang Yang
    Department of Medicine, Vanderbilt University School of Medicine, Room 559 Preston Research Building, 23rd Avenue South at Pierce Avenue, Nashville, TN 37232 6602, USA
    J Mol Cell Cardiol 38:299-308. 2005
    ....
  41. ncbi request reprint Voltage-calcium state-space dynamics during initiation of reentry
    Richard A Gray
    Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Heart Rhythm 3:247-8. 2006
  42. pmc Protozoan migration in bent microfluidic channels
    Wei Wang
    Department of Civil and Environmental Engineering, Vanderbilt University, Box 1831 Station B, Nashville, TN 37235, USA
    Appl Environ Microbiol 74:1945-9. 2008
    ..The dispersal rate and swimming speed increased with channel width, decreased with protozoan size, and was significantly impacted by the channel turning angle...

Research Grants15

  1. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    John Wikswo; Fiscal Year: 2009
    ..This work will be a key step towards developing improved metabolic therapies. ..
  2. Metabolic Discrimination of Unknown Bacterial Pathogens
    John Wikswo; Fiscal Year: 2007
    ....
  3. ELECTROPHYSIOLOGICAL IMPLICATIONS OF CARDIAC BIDOMAIN
    John Wikswo; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
  4. ELECTROPHYSIOLOGICAL IMPLICATIONS OF CARDIAC BIDOMAIN
    John Wikswo; Fiscal Year: 2006
    ..This research may lead to more efficient cardiac pacemakers and defibrillators and improved magnetocardiographic diagnosis of coronary heart disease. ..
  5. ELECTROPHYSIOLOGICAL IMPLICATIONS OF CARDIAC BIDOMAIN
    John Wikswo; Fiscal Year: 2003
    ..This research may lead to more efficient cardiac pacemakers and defibrillators and improved magnetocardiographic diagnosis of coronary heart disease. ..
  6. ELECTROPHYSIOLOGICAL IMPLICATIONS OF CARDIAC BIDOMAIN
    John Wikswo; Fiscal Year: 2001
    ..This research could clarify the role of electrical anisotropy during propagation and repolarization, and during stimulation and defibrillation of the heart. ..
  7. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..This work will be a key step towards developing improved metabolic therapies. ..