Arthur Wheeler

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Recent developments in the diagnosis and management of severe sepsis
    Arthur P Wheeler
    Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University, T 1217 MCN Vanderbilt Medical Center, Nashville, TN 37232 250, USA
    Chest 132:1967-76. 2007
  2. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
  3. pmc Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 10:R74. 2006
  4. ncbi request reprint Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury
    Arthur P Wheeler
    Vanderbilt University, Nashville, USA
    N Engl J Med 354:2213-24. 2006
  5. ncbi request reprint A retrospective observational study of drotrecogin alfa (activated) in adults with severe sepsis: comparison with a controlled clinical trial
    Arthur Wheeler
    Vanderbilt Medical Center, Nashville, TN, USA
    Crit Care Med 36:14-23. 2008
  6. doi request reprint Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testing
    Arthur P Wheeler
    Medical Intensive Care Unit, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1210 MCN Vanderbilt Medical Center, Nashville, TN 37232 2650, USA
    Chest 137:185-94. 2010
  7. ncbi request reprint Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
  8. pmc Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study
    James C Jackson
    Center for Health Services Research, Vanderbilt University, 6100 Medical Center East, Nashville, TN 37232 8300, USA
    South Med J 102:1150-7. 2009
  9. pmc Approaching and analyzing a large literature on vancomycin monitoring and pharmacokinetics
    Patricia Lee
    Eskind Biomedical Library, Vanderbilt University Medical Center, Nashville, TN, USA
    J Med Libr Assoc 95:374-80. 2007
  10. doi request reprint A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
    Todd W Rice
    Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:1685-94. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Recent developments in the diagnosis and management of severe sepsis
    Arthur P Wheeler
    Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University, T 1217 MCN Vanderbilt Medical Center, Nashville, TN 37232 250, USA
    Chest 132:1967-76. 2007
    ..Although there is still much to learn, numerous studies now indicate that improvements in outcomes are possible when treatment protocols that incorporate all known beneficial therapies are applied in a timely fashion...
  2. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
    ..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status...
  3. pmc Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 10:R74. 2006
    ....
  4. ncbi request reprint Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury
    Arthur P Wheeler
    Vanderbilt University, Nashville, USA
    N Engl J Med 354:2213-24. 2006
    ..The balance between the benefits and the risks of pulmonary-artery catheters (PACs) has not been established...
  5. ncbi request reprint A retrospective observational study of drotrecogin alfa (activated) in adults with severe sepsis: comparison with a controlled clinical trial
    Arthur Wheeler
    Vanderbilt Medical Center, Nashville, TN, USA
    Crit Care Med 36:14-23. 2008
    ..To compare characteristics and outcomes of patients treated with drotrecogin alfa (activated) (DrotAA) in clinical practice to those treated in a phase III randomized controlled trial (PROWESS)...
  6. doi request reprint Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testing
    Arthur P Wheeler
    Medical Intensive Care Unit, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1210 MCN Vanderbilt Medical Center, Nashville, TN 37232 2650, USA
    Chest 137:185-94. 2010
    ..Limitations and pitfalls of diagnostic testing are highlighted...
  7. ncbi request reprint Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  8. pmc Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study
    James C Jackson
    Center for Health Services Research, Vanderbilt University, 6100 Medical Center East, Nashville, TN 37232 8300, USA
    South Med J 102:1150-7. 2009
    ....
  9. pmc Approaching and analyzing a large literature on vancomycin monitoring and pharmacokinetics
    Patricia Lee
    Eskind Biomedical Library, Vanderbilt University Medical Center, Nashville, TN, USA
    J Med Libr Assoc 95:374-80. 2007
  10. doi request reprint A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
    Todd W Rice
    Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:1685-94. 2010
    ..To evaluate whether TAK-242, a small-molecule inhibitor of Toll-like receptor-4-mediated signaling, suppresses cytokine levels and improves 28-day all-cause mortality rates in patients with severe sepsis...
  11. ncbi request reprint Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS
    Todd W Rice
    MSc, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Chest 132:410-7. 2007
    ..We hypothesized that the pulse oximetric saturation (Spo(2))/Fio(2) (S/F) ratio can be substituted for the P/F ratio in assessing the oxygenation criterion of ALI...
  12. ncbi request reprint Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, 6th Floor, 6109 Medical Center East, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Ann Intern Med 136:25-36. 2002
    ..The incidence of acute respiratory failure requiring mechanical ventilation increases 10-fold from the ages of 55 to 85 years, yet the rate of recovery and outcomes in older persons who develop acute lung injury are poorly defined...
  13. ncbi request reprint Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 34:2271-81. 2006
    ....
  14. ncbi request reprint Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS)
    E Wesley Ely
    Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research Education and Clinical Center, Nashville 37232, USA
    JAMA 289:2983-91. 2003
    ....
  15. ncbi request reprint Variation in enteral nutrition delivery in mechanically ventilated patients
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nutrition 21:786-92. 2005
    ..We determined the variability in enteral feeding practices in mechanically ventilated patients in four adult intensive care units of a tertiary-care, referral hospital...
  16. ncbi request reprint Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis
    Gordon R Bernard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Chest 125:2206-16. 2004
    ..To gather additional 28-day all-cause mortality and safety data among adult patients with severe sepsis who were treated with drotrecogin alfa (activated)...
  17. doi request reprint Coagulopathy in critically ill patients: part 1: platelet disorders
    Todd W Rice
    Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN, USA
    Chest 136:1622-30. 2009
    ..Guidelines for treating thrombocytopenia and platelet dysfunction are also provided...
  18. ncbi request reprint Acute lung injury and the acute respiratory distress syndrome: a clinical review
    Arthur P Wheeler
    Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Lancet 369:1553-64. 2007
    ..Refinements in ventilator and fluid management supported by data from prospective randomised trials have increased the methods available to effectively manage this disorder...
  19. ncbi request reprint Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury
    Polly E Parsons
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, USA
    Crit Care Med 33:1-6; discussion 230-2. 2005
    ....
  20. pmc Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders
    Carolyn S Calfee
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Crit Care Med 35:2243-50. 2007
    ....
  21. ncbi request reprint Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury
    Greg S Martin
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 30:2175-82. 2002
    ..We designed a clinical trial to determine whether diuresis and colloid replacement in hypoproteinemic patients with acute lung injury would improve pulmonary physiology...
  22. ncbi request reprint A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury
    Greg S Martin
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 33:1681-7. 2005
    ..Albumin with furosemide benefits lung physiology in hypoproteinemic patients with acute lung injury/acute respiratory distress syndrome, but the independent pharmacologic effects of these drugs are unknown...
  23. pmc Reasons for nonenrollment in a clinical trial of acute lung injury
    Andrea E Glassberg
    The Permanente Medical Group, 39400 Paseo Padre Parkway, Fremont, CA 94538, USA
    Chest 134:719-23. 2008
    ..We examined the reasons for nonenrollment and the impact of the availability of a surrogate decision maker on critical care clinical trials enrollment...