Research Topics
| Arthur WheelerSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Recent developments in the diagnosis and management of severe sepsisArthur P Wheeler
Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University, T 1217 MCN Vanderbilt Medical Center, Nashville, TN 37232 250, USA
Chest 132:1967-76. 2007..Although there is still much to learn, numerous studies now indicate that improvements in outcomes are possible when treatment protocols that incorporate all known beneficial therapies are applied in a timely fashion...
Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid statusTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
Crit Care 15:R86. 2011..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status...- Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsisJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
Crit Care 10:R74. 2006.... - Pulmonary-artery versus central venous catheter to guide treatment of acute lung injuryArthur P Wheeler
Vanderbilt University, Nashville, USA
N Engl J Med 354:2213-24. 2006..The balance between the benefits and the risks of pulmonary-artery catheters (PACs) has not been established... - A retrospective observational study of drotrecogin alfa (activated) in adults with severe sepsis: comparison with a controlled clinical trialArthur Wheeler
Vanderbilt Medical Center, Nashville, TN, USA
Crit Care Med 36:14-23. 2008..To compare characteristics and outcomes of patients treated with drotrecogin alfa (activated) (DrotAA) in clinical practice to those treated in a phase III randomized controlled trial (PROWESS)... 
Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testingArthur P Wheeler
Medical Intensive Care Unit, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1210 MCN Vanderbilt Medical Center, Nashville, TN 37232 2650, USA
Chest 137:185-94. 2010..Limitations and pitfalls of diagnostic testing are highlighted...- Comparison of two fluid-management strategies in acute lung injuryHerbert P Wiedemann
Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
N Engl J Med 354:2564-75. 2006..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion... - Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case studyJames C Jackson
Center for Health Services Research, Vanderbilt University, 6100 Medical Center East, Nashville, TN 37232 8300, USA
South Med J 102:1150-7. 2009.... - Approaching and analyzing a large literature on vancomycin monitoring and pharmacokineticsPatricia Lee
Eskind Biomedical Library, Vanderbilt University Medical Center, Nashville, TN, USA
J Med Libr Assoc 95:374-80. 2007 - A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsisTodd W Rice
Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 38:1685-94. 2010..To evaluate whether TAK-242, a small-molecule inhibitor of Toll-like receptor-4-mediated signaling, suppresses cytokine levels and improves 28-day all-cause mortality rates in patients with severe sepsis... - Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDSTodd W Rice
MSc, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
Chest 132:410-7. 2007..We hypothesized that the pulse oximetric saturation (Spo(2))/Fio(2) (S/F) ratio can be substituted for the P/F ratio in assessing the oxygenation criterion of ALI... - Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndromeE Wesley Ely
Division of Allergy, Center for Health Services Research, 6th Floor, 6109 Medical Center East, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA
Ann Intern Med 136:25-36. 2002.... - Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsisTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 34:2271-81. 2006..CONCLUSIONS: CytoFab is well tolerated in patients with severe sepsis, effectively reducing serum and BAL TNF-alpha and serum IL-6 concentrations and increasing the number of ventilator-free and ICU-free days at day 28... - Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS)E Wesley Ely
Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research Education and Clinical Center, Nashville 37232, USA
JAMA 289:2983-91. 2003.... - Variation in enteral nutrition delivery in mechanically ventilated patientsTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Nutrition 21:786-92. 2005..We determined the variability in enteral feeding practices in mechanically ventilated patients in four adult intensive care units of a tertiary-care, referral hospital... - Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsisGordon R Bernard
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Chest 125:2206-16. 2004..To gather additional 28-day all-cause mortality and safety data among adult patients with severe sepsis who were treated with drotrecogin alfa (activated)... - Coagulopathy in critically ill patients: part 1: platelet disordersTodd W Rice
Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN, USA
Chest 136:1622-30. 2009..Guidelines for treating thrombocytopenia and platelet dysfunction are also provided... - Acute lung injury and the acute respiratory distress syndrome: a clinical reviewArthur P Wheeler
Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
Lancet 369:1553-64. 2007..Refinements in ventilator and fluid management supported by data from prospective randomised trials have increased the methods available to effectively manage this disorder... - Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injuryPolly E Parsons
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, USA
Crit Care Med 33:1-6; discussion 230-2. 2005..Low tidal volume ventilation is associated with a more rapid attenuation of the inflammatory response... - Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disordersCarolyn S Calfee
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Crit Care Med 35:2243-50. 2007.... - Albumin and furosemide therapy in hypoproteinemic patients with acute lung injuryGreg S Martin
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Crit Care Med 30:2175-82. 2002..Determining the effect of this simple therapy on cost, outcomes, and other patient populations requires further study... - A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injuryGreg S Martin
Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Crit Care Med 33:1681-7. 2005..Additional randomized clinical trials are necessary to examine mechanisms and determine the effect on important clinical outcomes, such as the duration of mechanical ventilation... - Reasons for nonenrollment in a clinical trial of acute lung injuryAndrea E Glassberg
The Permanente Medical Group, 39400 Paseo Padre Parkway, Fremont, CA 94538, USA
Chest 134:719-23. 2008..We examined the reasons for nonenrollment and the impact of the availability of a surrogate decision maker on critical care clinical trials enrollment...