David Wasserman

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Point-Counterpoint: Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle
    David H Wasserman
    Department of Molecular Physiology and Biophysics and Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Appl Physiol 101:1803-5. 2006
  2. ncbi request reprint Interaction of physiological mechanisms in control of muscle glucose uptake
    David H Wasserman
    Department of Molecular Physiological and Biophysics, Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Exp Pharmacol Physiol 32:319-23. 2005
  3. pmc Four grams of glucose
    David H Wasserman
    Department of Molecular Physiology, Vanderbilt Univ School of Medicine, Nashville, TN 37232, USA
    Am J Physiol Endocrinol Metab 296:E11-21. 2009
  4. pmc The physiological regulation of glucose flux into muscle in vivo
    David H Wasserman
    Department of Molecular Physiology and Biophysics and the Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Exp Biol 214:254-62. 2011
  5. ncbi request reprint Prior exercise and the response to insulin-induced hypoglycemia in the dog
    Yoshiharu Koyama
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 282:E1128-38. 2002
  6. ncbi request reprint Portal venous hyperinsulinemia does not stimulate gut glucose absorption in the conscious dog
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashille, TN 37232, USA
    Metabolism 53:1290-5. 2004
  7. ncbi request reprint Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II
    Patrick T Fueger
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 56:2476-84. 2007
  8. pmc Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse
    Patrick T Fueger
    Department of Molecular Physiology ans Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Physiol 566:533-41. 2005
  9. ncbi request reprint Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse
    Patrick T Fueger
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 279:50956-61. 2004
  10. ncbi request reprint Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liver
    R Richard Pencek
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 53:3041-7. 2004

Research Grants

  1. INTEGRATED CONTROL OF MUSCLE GLUCOSE UPTAKE IN VIVO
    David Wasserman; Fiscal Year: 2007
  2. EXERCISE AND FUEL METABOLISM
    David Wasserman; Fiscal Year: 2007
  3. Vanderbilt Mouse Metabolic Phenotyping Center
    David Wasserman; Fiscal Year: 2007
  4. EXERCISE AND FUEL METABOLISM
    David Wasserman; Fiscal Year: 2003
  5. INTEGRATED CONTROL OF MUSCLE GLUCOSE UPTAKE IN VIVO
    David Wasserman; Fiscal Year: 2003
  6. INTEGRATED CONTROL OF MUSCLE GLUCOSE UPTAKE IN VIVO
    David H Wasserman; Fiscal Year: 2010

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Point-Counterpoint: Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle
    David H Wasserman
    Department of Molecular Physiology and Biophysics and Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Appl Physiol 101:1803-5. 2006
  2. ncbi request reprint Interaction of physiological mechanisms in control of muscle glucose uptake
    David H Wasserman
    Department of Molecular Physiological and Biophysics, Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Exp Pharmacol Physiol 32:319-23. 2005
    ..4. There is a growing body of data that suggests that insulin resistance to muscle glucose uptake can be because of impairments in any one or more of the three steps that comprise the process...
  3. pmc Four grams of glucose
    David H Wasserman
    Department of Molecular Physiology, Vanderbilt Univ School of Medicine, Nashville, TN 37232, USA
    Am J Physiol Endocrinol Metab 296:E11-21. 2009
    ..With regard to the latter, studies are presented that show how regulation of muscle glucose uptake is regulated by glucose delivery to muscle, glucose transport into muscle, and glucose phosphorylation within muscle...
  4. pmc The physiological regulation of glucose flux into muscle in vivo
    David H Wasserman
    Department of Molecular Physiology and Biophysics and the Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Exp Biol 214:254-62. 2011
    ..More recent research definitively shows that the distributed control paradigm more accurately defines the regulation of muscle glucose uptake as each of the three steps that define this process are important sites of flux control...
  5. ncbi request reprint Prior exercise and the response to insulin-induced hypoglycemia in the dog
    Yoshiharu Koyama
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 282:E1128-38. 2002
    ..The primary site of this reduction is the liver...
  6. ncbi request reprint Portal venous hyperinsulinemia does not stimulate gut glucose absorption in the conscious dog
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashille, TN 37232, USA
    Metabolism 53:1290-5. 2004
    ..This study shows that under physiological conditions, a portal vein insulin infusion that results in circulating hyperinsulinemia does not increase either transporter-mediated or passive absorption of an intraduodenal glucose load...
  7. ncbi request reprint Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II
    Patrick T Fueger
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 56:2476-84. 2007
    ..The aim of this study was to determine the role of limitations in glucose phosphorylation in the control of MGU during either physiological insulin stimulation (4 mU x kg(-1) x min(-1)) or exercise with chow or high-fat feeding...
  8. pmc Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse
    Patrick T Fueger
    Department of Molecular Physiology ans Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Physiol 566:533-41. 2005
    ..In conclusion, adaptations that increase HK protein content and/or functional activity such as regular exercise contribute to increased muscular endurance...
  9. ncbi request reprint Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse
    Patrick T Fueger
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 279:50956-61. 2004
    ..However, when glucose phosphorylation capacity is increased by HK II overexpression, GLUT4 availability becomes a marked limitation to exercise-stimulated MGU...
  10. ncbi request reprint Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liver
    R Richard Pencek
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 53:3041-7. 2004
    ....
  11. ncbi request reprint Prevention of overt hypoglycemia during exercise: stimulation of endogenous glucose production independent of hepatic catecholamine action and changes in pancreatic hormone concentration
    Robert H Coker
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 51:1310-8. 2002
    ..In conclusion, stimulation of R(a) by a mechanism independent of pancreatic hormones and hepatic adrenergic stimulation is a primary defense against overt hypoglycemia...
  12. ncbi request reprint 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin
    Raul C Camacho
    Dept of Molecular Physiology and Biophysics, Duiabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Physiol Endocrinol Metab 289:E1039-43. 2005
    ..The effectiveness of AICAR in countering the suppressive effect of pharmacological insulin on NHGO occurs even though AICAR-stimulated ACC phosphorylation is completely blocked...
  13. doi request reprint Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscle
    Jane Shearer
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Biochim Biophys Acta 1782:586-92. 2008
    ..In conclusion, cardiac insulin resistance and glucose uptake is largely corrected by a reduction in FABP3 in vivo without contemporaneous deleterious effects on cardiac function...
  14. pmc Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo
    Eric D Berglund
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Endocrinol Metab 299:E607-14. 2010
    ....
  15. ncbi request reprint AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo
    Jane Shearer
    Dept of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 287:E871-7. 2004
    ..These results demonstrate that, in vivo, AMPK stimulation increases LCFA but not glucose clearance by a NOS-independent mechanism...
  16. ncbi request reprint Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes
    Pietro Galassetti
    Departments of Medicine and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine and Nashville Veteran Affairs Medical Center, Nashville, Tennessee 37232 6303, USA
    Diabetes 52:1761-9. 2003
    ..These data indicate that counterregulatory failure may be a significant in vivo mechanism responsible for exercise-associated hypoglycemia in type 1 diabetes...
  17. pmc Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter
    Patrick T Fueger
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Physiol 582:801-12. 2007
    ..Finally, studies in GLUT4(-/-)HK(Tg) show that HK II improves exercise tolerance, independent of its effects on MGU...
  18. pmc Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
    Julio E Ayala
    Vanderbilt NIH Mouse Metabolic Phenotyping Center, Nashville, TN 37232, USA
    Dis Model Mech 3:525-34. 2010
    ..We also propose guidelines for the description of methods, presentation of data and interpretation of results. The recommendations presented in this article are based on the experience of the MMPC Consortium and other investigators...
  19. ncbi request reprint Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia in type 1 diabetes
    Pietro Galassetti
    715 PRB, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt Univ School of Medicine, Nashville, TN 37232 6303, USA
    Am J Physiol Endocrinol Metab 287:E16-24. 2004
    ..Preserved counterregulatory responses during exercise in T1DM women may confer greater protection against hypoglycemia than in men with T1DM...
  20. ncbi request reprint 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo
    R Richard Pencek
    Department of Molecular Physiology and Biophysics, Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Diabetes 54:355-60. 2005
    ..These findings have important implications for the targeting of AMP kinase for the treatment of insulin resistance, using AMP analogs...
  21. pmc Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance
    Julio E Ayala
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 151:4678-87. 2010
    ..These results show that mice lacking the Glp1r are protected from HF diet-induced muscle and hepatic insulin resistance independent of effects on total fat mass...
  22. ncbi request reprint Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exercise
    Jane Shearer
    Dept of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 288:E292-7. 2005
    ..These results show that, in vivo, H-FABP has reciprocal effects on glucose and LCFA utilization and whole body fuel homeostasis when metabolic demands are elevated by exercise...
  23. ncbi request reprint Fiber type-specific determinants of Vmax for insulin-stimulated muscle glucose uptake in vivo
    Hilary Ann Petersen
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 284:E541-8. 2003
    ....
  24. ncbi request reprint Energy state of the liver during short-term and exhaustive exercise in C57BL/6J mice
    Raul C Camacho
    Department of Molecular Physiology and Biolphysics and Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Physiol Endocrinol Metab 290:E405-8. 2006
    ..In conclusion, AMP is sensitively regulated, consistent with it having an important role in hepatic metabolism...
  25. ncbi request reprint Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 53:336-46. 2004
    ..Inhibition of PAI-1 might provide a novel anti-obesity and anti-insulin resistance treatment...
  26. ncbi request reprint Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistance
    Jane Shearer
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 54:3133-9. 2005
    ..In conclusion, a partial reduction in H-FABP protein normalizes fasting glucose levels and improves whole-body insulin sensitivity in HFD-fed mice despite obesity...
  27. ncbi request reprint Mobilization of glucose from the liver during exercise and replenishment afterward
    R Richard Pencek
    Dept of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Can J Appl Physiol 30:292-303. 2005
    ..The fate of glucose taken up by the liver is critically dependent on hepatic glycogen stores, however, as glycogen deposition is greatly facilitated by prior glycogen depletion...
  28. pmc Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c
    Byoung Geun Han
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Endocrinol Metab 295:E981-6. 2008
    ..These results show that 6-h fasting glucose provides a superior index of glycemic control and correlates more closely with Hb A(1c) than overnight-fasted blood glucose in these strains of mice...
  29. ncbi request reprint Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice
    Julio E Ayala
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 2200 Pierce Ave, 702 Light Hall, Nashville, TN 37232, USA
    Diabetes 56:1025-33. 2007
    ..These results show that phosphodiesterase-5 is a potential target for therapies aimed at preventing diet-induced energy imbalance and insulin resistance...
  30. pmc Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo
    Robert S Lee-Young
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 284:23925-34. 2009
    ....
  31. pmc Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity
    Eric D Berglund
    Department of Molecular Physiology and Biophysics, National Institutes of Health Vanderbilt University Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 150:4084-93. 2009
    ..Thus, these studies define mechanisms underlying anti-hyperglycemic actions of FGF21 and support its therapeutic potential...
  32. pmc The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action
    Julio E Ayala
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 150:1155-64. 2009
    ..In conclusion, these results show that the endogenous Glp1r regulates hepatic and muscle glucose flux independent of its ability to enhance insulin secretion...
  33. pmc Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 60:416-26. 2011
    ....
  34. pmc NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse
    Owen P McGuinness
    Vanderbilt NIH Mouse Metabolic Phenotyping Center, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 297:E849-55. 2009
    ..To facilitate and maximize the exchange of scientific information, we suggest that guidelines be developed for methods used to assess glucose tolerance and insulin action in vivo...
  35. ncbi request reprint Insulin action in the double incretin receptor knockout mouse
    Julio E Ayala
    Vanderbilt University Medical Center, 2200 Pierce Ave, 702 Light Hall, Nashville, TN 37232, USA
    Diabetes 57:288-97. 2008
    ..We used the hyperinsulinemic-euglycemic clamp to determine sites where insulin action may be modulated in double incretin receptor knockout (DIRKO) mice, which lack endogenous incretin action...
  36. pmc Hepatic energy state is regulated by glucagon receptor signaling in mice
    Eric D Berglund
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 119:2412-22. 2009
    ..Taken together, these data demonstrate in vivo that the hepatic energy state is sensitive to glucagon receptor activation and requires PEPCK-C, thus providing new insights into liver metabolism...
  37. pmc Glucose metabolism in vivo in four commonly used inbred mouse strains
    Eric D Berglund
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 57:1790-9. 2008
    ..To characterize differences in whole-body glucose metabolism between commonly used inbred mouse strains...
  38. pmc Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo
    Robert S Lee-Young
    Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, 2200 Pierce Ave, Nashville, TN 37232, U S A
    Am J Physiol Regul Integr Comp Physiol 298:R1399-408. 2010
    ....
  39. doi request reprint Long chain fatty acid uptake in vivo: comparison of [125I]-BMIPP and [3H]-bromopalmitate
    Jane Shearer
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    Lipids 43:703-11. 2008
    ..Exercise preferentially exacerbates the breakdown of [3H]-BROMO, making [125I]-BMIPP the analogue of choice for prolonged (>30 min) experimental protocols with elevated metabolic demands...
  40. ncbi request reprint Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse
    Julio E Ayala
    Vanderbilt NIDDK National Institutes of Diabetes and Digestive and Kidney Diseases Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Diabetes 55:390-7. 2006
    ..kg(-1) . min(-1)), but endoR(a) was fully suppressed with doses higher than 0.8 mU . kg(-1) . min(-1). Thus, common variations in experimental factors yield different results and should be considered in designing and interpreting clamps...
  41. ncbi request reprint Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice
    Jeffrey N Rottman
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 283:E116-23. 2002
    ....
  42. ncbi request reprint Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, and Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 287:E269-74. 2004
    ..However, the liver of the resting dog is more sensitive to a small increment, rather than decrement, in arterial glucose...
  43. ncbi request reprint Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice
    Patrick T Fueger
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 53:306-14. 2004
    ..In conclusion, high-fat feeding impairs both insulin- and exercise-stimulated MGU, but only exercise-stimulated MGU was corrected by HK II overexpression...
  44. ncbi request reprint Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 53:285-93. 2004
    ....
  45. ncbi request reprint Quinides of roasted coffee enhance insulin action in conscious rats
    Jane Shearer
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    J Nutr 133:3529-32. 2003
    ..These results demonstrate that DIFEQ increases whole-body glucose disposal independently of skeletal muscle Rg...
  46. ncbi request reprint Distributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylation
    Patrick T Fueger
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 286:E77-84. 2004
    ..Glucose transport is not normally a significant barrier during exercise. However, when the phosphorylation barrier is lowered by HK II overexpression, glucose transport becomes a key site of control for regulating MGU during exercise...
  47. ncbi request reprint Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice
    Patrick T Fueger
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 285:E958-63. 2003
    ..This impairment is critically dependent on the tissue's glucose metabolic rate and correlates with tissue oxidative capacity...
  48. ncbi request reprint Prior exercise enhances passive absorption of intraduodenal glucose
    R Richard Pencek
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    J Appl Physiol (1985) 95:1132-8. 2003
    ..that prior exercise enhances passive absorption of intraduodenal glucose into the portal vein and 2). that basal and the added passive gut glucose absorption after exercise is dependent on initial transport of glucose via SGLT-1...
  49. ncbi request reprint Transporter-mediated absorption is the primary route of entry and is required for passive absorption of intestinal glucose into the blood of conscious dogs
    R Richard Pencek
    Department of Molecular Physiology and Biophysics, Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    J Nutr 132:1929-34. 2002
    ..The method described here is applicable to investigation of the mechanisms of gut glucose absorption under a variety of nutritional, physiologic and pathophysiologic conditions...
  50. ncbi request reprint AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide
    Jane Shearer
    Department of Molecular Physiology and Biophysics, 702 Light Hall, Vanderbilt University, Nashville, TN, 37232 0615, USA
    Diabetes 53:1429-35. 2004
    ..In addition, AICAR-induced increases in K(g) but not K(f) were abolished by l-NAME in the majority of muscles examined. This shows that the mechanisms by which AMPK stimulates glucose and LCFA uptake are distinct...
  51. ncbi request reprint Portal vein caffeine infusion enhances net hepatic glucose uptake during a glucose load in conscious dogs
    R Richard Pencek
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    J Nutr 134:3042-6. 2004
    ..5 +/- 3.8 vs. 5.5 +/- 1.5 micromol/(kg . min)]. These findings indicate that physiologic circulating levels of caffeine can enhance NHGU during a glucose load, and the added glucose consumed by the liver is in part converted to lactate...
  52. ncbi request reprint Interaction of insulin and prior exercise in control of hepatic metabolism of a glucose load
    R Richard Pencek
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 52:1897-903. 2003
    ..Although the increase in glucose extraction after exercise could be ascribed to increased insulin action, the increase in hepatic glycogen synthesis was independent of it...
  53. ncbi request reprint Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Diabetes 54:373-82. 2005
    ..This stimulation of glucose output by AICAR was equally marked in the presence of both euglycemia and hypoglycemia. However, hypoglycemia amplified the net hepatic glycogenolytic response to AICAR by approximately fourfold...
  54. ncbi request reprint Plasminogen activator inhibitor-1 modulates adipocyte differentiation
    Xiubin Liang
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232 2561, USA
    Am J Physiol Endocrinol Metab 290:E103-E113. 2006
    ..We postulate that these PAI-1 effects on adipocytes may, at least in part, be mediated via modulation of plasmin activity and extracellular matrix components...
  55. ncbi request reprint Regulation of hepatic and peripheral glucose disposal
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 702 Light Hall, Nashville, TN 37232 0615, USA
    Best Pract Res Clin Endocrinol Metab 17:343-64. 2003
    ..Exercise stimulates insulin-dependent and -independent muscle glucose uptake, as well as the liver's ability to take up glucose...
  56. ncbi request reprint Glucoregulation during and after exercise in health and insulin-dependent diabetes
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Exerc Sport Sci Rev 33:17-23. 2005
    ..These mechanisms of glucoregulatory failure may cause hypoglycemia in insulin-dependent diabetics during and after exercise...
  57. pmc Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2
    Shuqun Shi
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Curr Biol 20:316-21. 2010
    ..Therefore, the role(s) of Bmal2 may be more important than has been appreciated heretofore...
  58. ncbi request reprint Zonation of labeling of lipogenic acetyl-CoA across the liver: implications for studies of lipogenesis by mass isotopomer analysis
    Ilya R Bederman
    Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:43207-16. 2004
    ..R., Kasumov, T., Reszko, A. E., David, F., Brunengraber, H., and Kelleher, J. K. (2004) J. Biol. Chem. 279, 43217-43226)...
  59. pmc Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice
    Patrick T Fueger
    Duke University Medical Center, Department of Pharmacology and Cancer Biology, 4321 Medical Park Drive, Suite 200, Durham, NC 27704, USA
    J Physiol 562:925-35. 2005
    ..The control of MGU is distributed rather than confined to a single rate-limiting step such as glucose transport as glucose transport and phosphorylation can both become barriers to skeletal muscle glucose influx...
  60. ncbi request reprint Physical activity/exercise and type 2 diabetes
    Ronald J Sigal
    Department of Medicine, University of Ottawa, Canada
    Diabetes Care 27:2518-39. 2004
  61. ncbi request reprint Regulation of insulin-stimulated muscle glucose uptake in the conscious mouse: role of glucose transport is dependent on glucose phosphorylation capacity
    Patrick T Fueger
    Duke University Medical Center, Department of Pharmacology and Cancer Biology, 4321 Medical Park Drive, Suite 200, Durham, North Carolina 27704, USA
    Endocrinology 145:4912-6. 2004
    ..However, when the glucose phosphorylation barrier is lowered by HK overexpression, GLUT4 availability becomes a limitation to insulin-stimulated MGU...
  62. ncbi request reprint Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association
    Ronald J Sigal
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Diabetes Care 29:1433-8. 2006
  63. ncbi request reprint Insulin secretion in the conscious mouse is biphasic and pulsatile
    Craig S Nunemaker
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Endocrinol Metab 290:E523-9. 2006
    ..The robust second phase observed in vivo suggests that the processes needed to generate second-phase insulin secretion may be abrogated by islet isolation...
  64. ncbi request reprint Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?
    Craig S Nunemaker
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980524, Richmond, Virginia 23298, USA
    Diabetes 54:3517-22. 2005
    ..We propose that individual mice have characteristic oscillatory [Ca2+]i patterns, which are imprinted in vivo through an unknown mechanism...

Research Grants34

  1. INTEGRATED CONTROL OF MUSCLE GLUCOSE UPTAKE IN VIVO
    David Wasserman; Fiscal Year: 2007
    ..The results from these studies will lead to a greater understanding of the dysregulation of MGU that occurs with insulin resistance and identification of potential treatment strategies. ..
  2. EXERCISE AND FUEL METABOLISM
    David Wasserman; Fiscal Year: 2007
    ..abstract_text> ..
  3. Vanderbilt Mouse Metabolic Phenotyping Center
    David Wasserman; Fiscal Year: 2007
    ..It requires a staff that is so skilled and committed that scientists are willing to entrust their mice, their research lifelines, with them. ..
  4. EXERCISE AND FUEL METABOLISM
    David Wasserman; Fiscal Year: 2003
    ..Accomplishing the objectives of the proposed experiments will add considerable insight into knowledge of glucoregulation during and after exercise in health and diabetes. ..
  5. INTEGRATED CONTROL OF MUSCLE GLUCOSE UPTAKE IN VIVO
    David Wasserman; Fiscal Year: 2003
    ..The hope is that, by identifying sites of regulation and dysfunction, these studies will allow optimal sites of therapy to be identified and targeted so that people with insulin resistance can be treated most effectively. ..
  6. INTEGRATED CONTROL OF MUSCLE GLUCOSE UPTAKE IN VIVO
    David H Wasserman; Fiscal Year: 2010
    ..Results from these studies will lead to a greater understanding of the sites involved in the dysregulation of muscle glucose uptake associated with insulin resistance and will identify potential treatment strategies. ..