M Kay Washington

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc 53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma
    Natalie L Ausborn
    Department of Radiation Oncology, The Ohio State University College of Medicine, Starling Loving, 300 W 10th Avenue, Columbus, OH, 43210, USA
    BMC Cancer 13:155. 2013
  2. pmc Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation
    Kevin Vo
    College of Pharmacy, The University of Tennessee, Memphis, TN, USA
    Mol Cancer 10:138. 2011
  3. pmc The deployment of a tissue request tracking system for the CHTN: a case study in managing change in informatics for biobanking operations
    Mary E Edgerton
    Section of Pathology Informatics, Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA
    BMC Med Inform Decis Mak 10:32. 2010
  4. doi request reprint Pathology of graft-versus-host disease in the gastrointestinal tract
    Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Pathol 40:909-17. 2009
  5. doi request reprint Colorectal carcinoma: selected issues in pathologic examination and staging and determination of prognostic factors
    Mary Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    Arch Pathol Lab Med 132:1600-7. 2008
  6. doi request reprint Protocol for the examination of specimens from patients with primary carcinomas of the colon and rectum
    Mary Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Arch Pathol Lab Med 132:1182-93. 2008
  7. ncbi request reprint Update on post-liver transplantation infections, malignancies, and surgical complications
    Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Adv Anat Pathol 12:221-6. 2005
  8. ncbi request reprint Autoimmune liver disease: overlap and outliers
    Mary K Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    Mod Pathol 20:S15-30. 2007
  9. pmc Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia
    Ahmed Katsha
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
    Gastroenterology 145:1312-22.e1-8. 2013
  10. pmc Deciphering the unique microRNA signature in human esophageal adenocarcinoma
    Rama Saad
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e64463. 2013

Research Grants

  1. Ariol SL-50 Workstation and Review Stations
    MARY WASHINGTON; Fiscal Year: 2005
  2. Tennessee Valley Cooperative Human Tissue Network
    MARY WASHINGTON; Fiscal Year: 2007

Detail Information

Publications89

  1. pmc 53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma
    Natalie L Ausborn
    Department of Radiation Oncology, The Ohio State University College of Medicine, Starling Loving, 300 W 10th Avenue, Columbus, OH, 43210, USA
    BMC Cancer 13:155. 2013
    ..The role of 53BP1 in pancreatic ductal adenocarcinoma (PDAC) has yet to be determined. We aimed to investigate whether 53BP1 levels interact with established prognostic factors in PDAC...
  2. pmc Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation
    Kevin Vo
    College of Pharmacy, The University of Tennessee, Memphis, TN, USA
    Mol Cancer 10:138. 2011
    ..The mounting evidence supporting a role for Notch in cancer promotion and survival suggests that targeting this pathway alone or in combination with other therapeutics represents a promising therapeutic strategy...
  3. pmc The deployment of a tissue request tracking system for the CHTN: a case study in managing change in informatics for biobanking operations
    Mary E Edgerton
    Section of Pathology Informatics, Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA
    BMC Med Inform Decis Mak 10:32. 2010
    ....
  4. doi request reprint Pathology of graft-versus-host disease in the gastrointestinal tract
    Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Pathol 40:909-17. 2009
    ..This review summarizes the histopathologic features of GVHD in the GI tract and outlines recent recommendations for reporting of GI biopsies with suspected GVHD...
  5. doi request reprint Colorectal carcinoma: selected issues in pathologic examination and staging and determination of prognostic factors
    Mary Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    Arch Pathol Lab Med 132:1600-7. 2008
    ..However, although the pathologist influences clinical care in colorectal cancer, certain aspects of staging and evaluation of prognostic factors remain challenging and confusing...
  6. doi request reprint Protocol for the examination of specimens from patients with primary carcinomas of the colon and rectum
    Mary Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Arch Pathol Lab Med 132:1182-93. 2008
  7. ncbi request reprint Update on post-liver transplantation infections, malignancies, and surgical complications
    Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Adv Anat Pathol 12:221-6. 2005
    ....
  8. ncbi request reprint Autoimmune liver disease: overlap and outliers
    Mary K Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    Mod Pathol 20:S15-30. 2007
    ..Sequential syndromes with transition from one form of autoimmune liver disease to another are rare...
  9. pmc Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia
    Ahmed Katsha
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
    Gastroenterology 145:1312-22.e1-8. 2013
    ..The aurora kinase A (AURKA) gene is frequently amplified and overexpressed in gastrointestinal cancers. We investigated the roles of AURKA in inflammation and gastric tumorigenesis...
  10. pmc Deciphering the unique microRNA signature in human esophageal adenocarcinoma
    Rama Saad
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e64463. 2013
    ..Herein, we performed a comprehensive microarray profiling for the specific miRNA signature associated with EAC. We validated this signature by qRT-PCR...
  11. pmc The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells
    Vikas Sehdev
    Department of Surgery, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2215 Garland Avenue, Nashville, TN 37232, USA
    Mol Cancer Ther 11:763-74. 2012
    ..001). In conclusion, this study shows frequent overexpression of AURKA and suggests that MLN8237 could be an effective antitumor agent, which can be combined with cisplatin for a better therapeutic outcome in esophageal adenocarcinomas...
  12. pmc Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
    Fang Yan
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 0696, USA
    J Clin Invest 121:2242-53. 2011
    ..These data define what we believe to be a previously unrecognized mechanism of probiotic-derived soluble proteins in protecting the intestine from injury and inflammation...
  13. pmc Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response
    Kshipra Singh
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 305:G225-40. 2013
    ..Thus CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis, and impaired L-Arg availability may contribute to UC pathogenesis...
  14. pmc Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB
    Karen L Edelblum
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA
    Gastroenterology 135:539-51. 2008
    ..This study addresses the role of Raf in epithelial cell survival in response to dextran sulfate sodium (DSS)-induced injury and inflammation...
  15. pmc Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    Gastroenterology 136:1297-1307, e1-3. 2009
    ..Because EGFR signaling regulates cell survival, we investigated whether activation of EGFR following H pylori infection promotes gastric epithelial survival...
  16. pmc High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis
    Jennifer A Gaddy
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Infect Immun 81:2258-67. 2013
    ..Animals infected with the cagA mutant strain had low levels of gastric inflammation and did not develop hypochlorhydria. These results indicate that a high-salt diet potentiates the carcinogenic effects of cagA(+) H. pylori strains...
  17. pmc L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis
    Lori A Coburn
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33546. 2012
    ..These preclinical studies indicate that L-Arg supplementation could be a potential therapy for IBD, and that one mechanism of action may be functional enhancement of iNOS activity...
  18. pmc Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice
    Fang Yan
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 302:G504-14. 2012
    ..Thus berberine may represent a new therapeutic approach for treating gastrointestinal inflammatory disorders...
  19. pmc BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma
    Christopher S Williams
    Department of Medicine GI, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 121:4056-69. 2011
    ..Therefore, BVES prevents EMT, and its epigenetic silencing may be an important step in promoting EMT programs during colon carcinogenesis...
  20. pmc Loss of TFF1 is associated with activation of NF-κB-mediated inflammation and gastric neoplasia in mice and humans
    Mohammed Soutto
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 121:1753-67. 2011
    ....
  21. pmc Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction
    Chanjuan Shi
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
    Lab Invest 94:409-21. 2014
    ..In summary, fibrosis in pancreatic cancer involves a complex interplay of cells and matrices that regulate not only the tumor epithelium but the composition of the microenvironment itself. ..
  22. pmc Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer
    J Joshua Smith
    Department of Surgery, Vanderbilt Medical Center, Nashville, TN, USA
    Gastroenterology 138:958-68. 2010
    ..We used a gene expression profile derived from invasive, murine colon cancer cells that were highly metastatic in an immunocompetent mouse model to identify patients with colon cancer at risk of recurrence...
  23. pmc STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines
    Michael J Rosen
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1849-58. 2013
    ..These data implicate STAT6 in the pathogenesis of colitis in vivo with important roles in altering epithelial barrier function and regulating Th2-inducing cytokine production...
  24. pmc Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice
    Seth R Ogden
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 2279, USA
    Cancer Res 70:30-5. 2010
    ..Collectively, these studies indicate that H. pylori-mediated induction of MMP-7 may serve to protect the gastric mucosa from pathophysiologic processes that promote carcinogenesis...
  25. ncbi request reprint Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation
    Nina M Munoz
    Department of Cancer Biology, Vanderbilt University Medical School, Nashville, Tennessee, USA
    Cancer Res 66:9837-44. 2006
    ....
  26. ncbi request reprint Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells
    Sheng Ru Shiou
    Surgical Oncology Research Laboratories, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Res 67:1571-9. 2007
    ..Taken together, these findings suggest a novel mechanism underlying Smad4 tumor-suppressive function through regulation of a potential metastatic modulator, claudin-1, in a TGF-beta-independent manner...
  27. pmc 3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer
    Eliot T McKinley
    Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    J Nucl Med 54:424-30. 2013
    ....
  28. pmc Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin
    Tanner J Freeman
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2730, USA
    Gastroenterology 142:562-571.e2. 2012
    ..However, the interactions between these pathways are not clear. We investigated the effects of loss of the transcription factor Smad4 on levels of β-catenin messenger RNA (mRNA) and Wnt signaling...
  29. ncbi request reprint In vivo assessment of thermal damage in the liver using optical spectroscopy
    Clay R Buttemere
    Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee 37235, USA
    J Biomed Opt 9:1018-27. 2004
    ..The results of this study suggest that fluorescence and diffuse reflectance spectroscopy show strong potential as tools to monitor liver tissue thermal damage intraoperatively...
  30. pmc Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions
    Altaf A Dar
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer 112:1688-98. 2008
    ..In this study, the authors investigated the prevalence and biological significance of Aurora Kinase A (AURKA) overexpression in upper gastrointestinal adenocarcinomas...
  31. pmc Gastric adenocarcinoma has a unique microRNA signature not present in esophageal adenocarcinoma
    Zheng Chen
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer 119:1985-93. 2013
    ..For the current study, the authors investigated the miRNA expression profile of gastric adenocarcinomas and compared it with esophageal adenocarcinomas to better identify a unique miRNA signature of gastric adenocarcinoma...
  32. pmc Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity
    Tiffany E Farmer
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Biochem 104:2228-40. 2008
    ..Surprisingly, inactivation of p19(ARF) restored the loss of the secretory lineage in mice deficient in Mtgr1, suggesting an additional role for p19(ARF) in the small intestinal epithelium...
  33. pmc Pattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma
    Tong Wang
    Department of Radiation Oncology, School of Medicine, Vanderbilt University, Nashville, TN, USA
    Pancreas 42:977-82. 2013
    ..We hypothesized that BRCA1 expression pattern could be used as a prognostic biomarker...
  34. pmc Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas
    Ryan L O'Neal
    Nashville VA Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hum Pathol 44:734-42. 2013
    ..8% of pancreatic adenocarcinomas expressed HE4. Still, we did not observe any influence of HE4 expression on survival. The results suggest that HE4 is up-regulated during gastric and pancreatic carcinogenesis...
  35. pmc ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival
    Yongqin Zhang
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA
    Lab Invest 92:437-50. 2012
    ..These results suggest that ErbB2 and ErbB3 have important cytoprotective and reparative roles in the colonic epithelium following injury, by promoting colon epithelial cell survival...
  36. pmc Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS
    Baogang J Xu
    Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Proteomics 8:936-45. 2009
    ..In addition, the identified cancer protein biomarkers will aid in the exploration of colorectal tumorigenesis mechanisms as well as in the advancement of molecularly based diagnosis of colorectal cancer...
  37. ncbi request reprint Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation
    Natasha G Deane
    Department of Surgery and Division of Surgical Oncology, Vanderbilt University, Nashville, TN 37235, USA
    Mol Cancer Res 5:341-9. 2007
    ..Taken together, these results indicate that NIR-conPK11195 is a promising optical molecular imaging tool to rapidly screen for colonic tumors in mice and to discriminate inflammation from cancer...
  38. pmc STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction
    Michael J Rosen
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA
    Inflamm Bowel Dis 17:2224-34. 2011
    ..The study aims were to determine if mucosal STAT6 phosphorylation is increased in patients with UC, and if STAT6 inhibition attenuates IL-13-induced colon epithelial cell dysfunction...
  39. pmc Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth
    Nagathihalli S Nagaraj
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Cancer Res 17:483-93. 2011
    ..The purpose of this study was to translate the current understanding of complementary activated tyrosine kinase signaling pathways by targeting Src kinase and epidermal growth factor receptor (EGFR)...
  40. pmc KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production
    Jeremy A Goettel
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee, USA
    Gastroenterology 140:265-74. 2011
    ..In this study, we tested the hypothesis that KSR1 is protective against spontaneous experimental colitis...
  41. pmc Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis
    Nagathihalli S Nagaraj
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA
    Mol Cancer Ther 9:2322-32. 2010
    ..These results establish a mechanistic rationale for Src inhibition with dasatinib as a therapeutic target in the treatment of pancreatic cancer and identify potential biomarkers of resistance to Src inhibition...
  42. pmc Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Gastroenterology 132:562-75. 2007
    ..Here, we purify and characterize 2 secreted LGG proteins that regulate intestinal epithelial cell antiapoptotic and proliferation responses...
  43. ncbi request reprint Alterations in Barrett's-related adenocarcinomas: a proteomic approach
    Dunfa Peng
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Int J Cancer 122:1303-10. 2008
    ..In conclusion, we have identified and validated several novel proteins that are involved in Barrett's carcinogenesis...
  44. pmc The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis
    Kshipra Singh
    Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 286:3839-50. 2011
    ..Isolated colonic epithelial cells exhibited marked attenuation of expression of iNOS and the CXC chemokines KC and MIP-2. These studies indicate that apoE-mimetic peptides such as COG112 are novel potential therapies for IBD...
  45. pmc Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas
    Kevin C Ray
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 137:1785-94. 2009
    ..HB-EGF, often overexpressed in damaged or diseased epithelium, is normally expressed in pancreatic islets, but its function is not understood...
  46. pmc Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels
    Kaidi Mikhitarian
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
    Mod Pathol 27:665-74. 2014
    ..Mutational analysis of the EGFR pathway genes may provide important insights into personalized treatment for patients with ampullary carcinoma. ..
  47. ncbi request reprint Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia
    J Chad Johnson
    Department of Surgery, Vanderbilt University, Nashville, Tennessee, USA
    Clin Gastroenterol Hepatol 4:1358-65. 2006
    ..The purpose of this pre-validation study was to determine if urinary PGE-M levels can be used as a biomarker to discriminate between healthy patients and those with colorectal disease...
  48. pmc Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer
    H Charles Manning
    Vanderbilt Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Cancer Res 14:7413-22. 2008
    ..The correlation between molecular imaging and immunohistochemical analysis to quantify epidermal growth factor (EGF) binding, apoptosis, and proliferation was evaluated in treated and untreated tumor-bearing cohorts...
  49. pmc Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model
    Kevin C Ray
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16786. 2011
    ....
  50. pmc Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation
    Fang Yan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    J Clin Invest 114:1272-80. 2004
    ..These effects are reversed by WT, but not kinase-inactive, KSR1. We conclude that KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways...
  51. pmc Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation
    Hongjie Zhang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 0475, USA
    Mech Dev 126:958-73. 2009
    ..These data confirm that HNF6 has both early and late functions in the developing pancreas and is essential for maintenance of Ngn3 expression and proper pancreatic duct morphology...
  52. ncbi request reprint Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation?
    Derek C Welch
    Department of Pathology, Division of Gastroenterology, Vanderbilt Medical Center, Nashville, TN 37232 2561, USA
    Am J Surg Pathol 30:444-9. 2006
    ..A similar increase in apoptosis was not seen in fundic biopsies; biopsy of the gastric fundus rather than antrum may be preferable for the diagnosis of upper gastrointestinal GvHD...
  53. ncbi request reprint Immunohistochemical expressions of Ki-67, cyclin D1, beta-catenin, cyclooxygenase-2, and epidermal growth factor receptor in human colorectal adenoma: a validation study of tissue microarrays
    Yinghao Su
    Vanderbilt University Medical Center, S 1121A Medical Center North, Nashville, TN 37232 2587, USA
    Cancer Epidemiol Biomarkers Prev 15:1719-26. 2006
    ..Tissue microarray (TMA) holds promise as a high-throughput method for the analysis of biomarkers in tissue specimens. The validity and reliability of this method, however, may vary for different biomarkers in different tissue specimens...
  54. pmc Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    Gastroenterology 146:1739-51.e14. 2014
    ..A subpopulation of SMOX(high) cells are resistant to apoptosis, despite their high levels of DNA damage. Because epidermal growth factor receptor (EGFR) activation can regulate apoptosis, we determined its role in SMOX-mediated effects...
  55. pmc Do adverse histopathologic findings in colorectal cancer patients explain disparate outcomes?
    Keith D Gray
    Departments of Surgery, Meharry Medica College, Nashville, TN, USA
    J Natl Med Assoc 98:348-51. 2006
    ..Histopathologic findings did not explain the apparent disparity in survival. The differences in number of nodes harvested may suggest inadequate resection or insufficient recovery of nodes by the pathologist...
  56. ncbi request reprint Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging
    Natasha G Deane
    Department of Surgery, Division of Surgical Oncology, Vanderbilt University Medical Center, D2300 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2730, USA
    Cancer Res 64:1315-22. 2004
    ..These findings demonstrate that TGF-beta1 promotes stem cell activation and tumor progression in the context of cyclin D1 overexpression in the liver...
  57. pmc Hdac3 is essential for the maintenance of chromatin structure and genome stability
    Srividya Bhaskara
    Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Cell 18:436-47. 2010
    ..siRNA targeting of NCOR1 and SMRT (NCOR2) increased H4K5ac and caused DNA damage, indicating that the HDAC3/NCOR/SMRT axis is critical for maintaining chromatin structure and genomic stability...
  58. pmc Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
    Punita Dhawan
    Surgical Oncology Research Laboratories, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Clin Invest 115:1765-76. 2005
    ..We further provide data suggesting that the regulation of E-cadherin expression and beta-catenin/Tcf signaling is a possible mechanism underlying claudin-1-dependent changes...
  59. ncbi request reprint Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas
    Chuanzhong Ye
    Department of Medicine, Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Oncol Rep 16:429-35. 2006
    ..The methylation status of these genes in rectal mucosa biopsies detected by MSP assays may not distinguish between patients with and without adenomas in the colon...
  60. ncbi request reprint Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis
    Anne E Powell
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol Gastrointest Liver Physiol 307:G16-23. 2014
    ..This inducible stem cell-driven model recapitulates features of FAP and offers a tractable platform on which therapeutic interventions can be monitored over time by colonoscopy and noninvasive imaging. ..
  61. pmc Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis
    Elizabeth M Johnson
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Virol 83:9630-40. 2009
    ..Collectively, these data indicate that cathepsins B, L, and S influence reovirus pathogenesis and suggest that pharmacologic modulation of cathepsin activity diminishes reovirus disease severity...
  62. pmc p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice
    Whitney G Smalley-Freed
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Clin Invest 120:1824-35. 2010
    ..Thus, we conclude that p120 has an essential role in barrier function and epithelial homeostasis and survival in the intestine...
  63. ncbi request reprint Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report
    Howard M Shulman
    Department of Pathology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, University of Washington School of Medicine, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 12:31-47. 2006
    ..Consensus recommendations and suggested data-capture forms should be validated in prospective clinicopathologic studies...
  64. ncbi request reprint Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis
    J Andres Martinez
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Gastroenterology 131:579-88. 2006
    ..To uncover colonic phenotypes in Mtgr1(-/-) mice, we stressed the colonic epithelium with low-molecular-weight dextran sodium sulfate (DSS), which is a well-studied model of murine ulcerative colitis...
  65. pmc Delineation of a carcinogenic Helicobacter pylori proteome
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    Mol Cell Proteomics 8:1947-58. 2009
    ..pylori proteins to use in vaccine development and for screening persons infected with strains most likely to induce severe disease...
  66. ncbi request reprint Transcriptional oncogenomic hot spots in Barrett's adenocarcinomas: serial analysis of gene expression
    Mohammad H Razvi
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Genes Chromosomes Cancer 46:914-28. 2007
    ..ANPEP is a secreted protein that may have diagnostic and/or prognostic significance for Barrett's progression. The use of genomic approaches in this study provided useful information about the molecular pathobiology of BAs...
  67. ncbi request reprint Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase
    Carl R Schmidt
    Department of Surgery, Vanderbilt University Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA
    Am J Surg 186:426-30. 2003
    ..Mutations in oncogenic Ras contribute to colorectal tumorigenesis. Loss of the cell adhesion protein E-cadherin is associated with tumor invasion and metastasis...
  68. ncbi request reprint Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps
    Zsolt Petko
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Clin Cancer Res 11:1203-9. 2005
    ..Notably, improvements in the specificity and sensitivity of the fecal DNA-based assays will be needed to make them clinically useful diagnostic tests for polyps...
  69. ncbi request reprint TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Science 303:848-51. 2004
    ..Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues...
  70. ncbi request reprint Cytomegalovirus enteritis in common variable immunodeficiency
    Elizabeth Stack
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 5280, USA
    South Med J 97:96-101. 2004
    ....
  71. ncbi request reprint CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:390-9. 2005
    ..These findings suggest a role for CDC2/CDK1 in esophageal adenocarcinogenesis, both as a potential histopathologic marker of dysplasia and a putative treatment target...
  72. ncbi request reprint Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis
    Keith D Gray
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37208 3599, USA
    J Surg Res 110:310-4. 2003
    ..Acute pancreatitis can result in remote tissue injury, but the involved mechanisms are unknown. This study evaluates the role of systemic NF-kappaB activation in the pathogenesis of lung inflammation in a transgenic pancreatitis model...
  73. pmc Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice
    Erin E Sparks
    Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Hepatology 51:1391-400. 2010
    ..Conclusion: There is a threshold requirement for Notch signaling at multiple steps, including IHBD tubulogenesis and maintenance, during hepatic development that determines the density of three-dimensional peripheral IHBD architecture...
  74. ncbi request reprint Real-time spectroscopic assessment of thermal damage: implications for radiofrequency ablation
    Christopher D Anderson
    Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4753, USA
    J Gastrointest Surg 8:660-9. 2004
    ..These results suggest that F and Rd spectroscopy can be used to create a real-time feedback system to accurately define RFA margins...
  75. ncbi request reprint Variability of in situ proteomic profiling and implications for study design in colorectal tumors
    Jia Qing Li
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 6848, USA
    Int J Oncol 31:103-11. 2007
    ..g. >70%). In summary, this study characterizes intra- and inter-case variability of high-throughput protein expression in colorectal tumors, and provides guidance for the sample numbers required for in situ proteomic studies...
  76. pmc Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis
    Layton H Smith
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232, USA
    Blood 107:132-4. 2006
    ..Taken together, these data indicate that NO and PAI-1 play pivotal and antagonistic roles in hepatic vein thrombosis and that PAI-1 is a potential target in the prevention and treatment of VOD in humans...
  77. ncbi request reprint Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer
    Swati Biswas
    Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Cancer Res 64:4687-92. 2004
    ....
  78. ncbi request reprint Histopathology of ulcerative colitis in initial rectal biopsy in children
    Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Surg Pathol 26:1441-9. 2002
    ..This difference may be related to a shorter duration of symptoms before biopsy...
  79. pmc Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach
    Robert J Coffey
    Department of Medicine, Vanderbilt University Medical Center and Nashville Veterans Affairs Medical Center, Nashville, Tennessee, USA
    J Clin Invest 117:70-80. 2007
    ....
  80. ncbi request reprint Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma
    Mace L Rothenberg
    Division of Hematology Oncology, Vanderbilt Ingram Cancer Center, Nashville, TN 37232 6307, USA
    J Clin Oncol 23:9265-74. 2005
    ..Serial serum samples were measured for amphiregulin and transforming growth factor-alpha (TGFalpha)...
  81. ncbi request reprint CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer
    Young Ho Kim
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genes Chromosomes Cancer 45:781-9. 2006
    ....
  82. ncbi request reprint Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma
    Charles M Leys
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232 2733, USA
    Hum Pathol 37:1162-8. 2006
    ..Given the pattern of normal Pdx-1 expression in the duodenum, goblet cell metaplasia in the stomach may reflect the adoption of a duodenal lineage paradigm...
  83. ncbi request reprint Protocol for the examination of specimens from pediatric patients with hepatoblastoma
    Milton J Finegold
    Department of Pathology, Texas Children s Cancer Center at Baylor College, Houston, USA
    Arch Pathol Lab Med 131:520-9. 2007
  84. ncbi request reprint The role of [18F]fluorodeoxyglucose positron emission tomography imaging in the evaluation of hepatocellular carcinoma
    L James Wudel
    Department of Surgery, Division of Hepatobiliary and Liver Transplant Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am Surg 69:117-24; discussion 124-6. 2003
    ..FDG-PET should be considered as part of the workup and management of selected patients with HCC...
  85. pmc Effect of Helicobacter pylori eradication on gastric carcinogenesis
    Judith Romero-Gallo
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Lab Invest 88:328-36. 2008
    ..The effectiveness of eradication is dependent upon the timing of intervention, providing insights into mechanisms that may regulate the development of malignancies arising within the context of inflammatory states...
  86. ncbi request reprint Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus
    Marie E Robert
    Department of Pathology, Yale University, New Haven, CT 06520, USA
    Am J Clin Pathol 124:519-27. 2005
    ..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed...
  87. pmc Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions
    Andrew T Thliveris
    McArdle Laboratory for Cancer Research, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:6960-5. 2005
    ..These statistical calculations indicate that the familial adenomas of the Apc(Min/+) mouse may commonly form through interactions between clones as close as 1-2 crypt diameters apart...
  88. ncbi request reprint A double-blind placebo-controlled study of emtricitabine in chronic hepatitis B
    Seng Gee Lim
    National University Hospital, Singapore
    Arch Intern Med 166:49-56. 2006
    ..Emtricitabine is a nucleoside analogue approved for treatment of human immunodeficiency virus 1 with clinical activity against hepatitis B virus (HBV)...
  89. pmc The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer
    Andres Rojas
    Department of Cancer Biology, Vanderbilt University Medical School, Nashville, TN, USA
    Int J Cancer 123:14-21. 2008
    ..Our results demonstrate that the aberrant methylation of TSP1 has biological consequences and provide evidence that the aberrant methylation of TSP1 is a novel epigenetic mechanism for suppressing TGF-beta signaling in colorectal cancer...

Research Grants3

  1. Ariol SL-50 Workstation and Review Stations
    MARY WASHINGTON; Fiscal Year: 2005
    ..An additional benefit is the ease of data sharing among groups, facilitating interactions among investigators and promoting inter-SPORE collaborations. ..
  2. Tennessee Valley Cooperative Human Tissue Network
    MARY WASHINGTON; Fiscal Year: 2007
    ..par \par } ..