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Genomes and Genes | L B WareSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donorsLorraine B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Clin Transplant 26:665-71. 2012..80. This chest radiographic scoring system may potentially be used to assess the clinical severity of pulmonary edema and may be useful as part of the evaluation of donors for suitability for lung transplantation...- The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injuryYosaf F Zeyed
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Physiol Lung Cell Mol Physiol 303:L550-5. 2012.... 
Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndromeSara C Sebag
Department of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st Avenue S Nashville, TN 37232 2650, USA
Curr Pharm Biotechnol 12:1481-96. 2011..Modulation of coagulation and fibrinolysis has complex effects on both hemostasis and inflammatory pathways and further studies are needed to develop new treatment strategies for patients with ALI/ARDS...- Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid statusTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
Crit Care 15:R86. 2011..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status... - Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injuryDana McClintock
Cardiovascular Research Institute, 505 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA
Crit Care 12:R41. 2008..We measured plasma markers of inflammation, coagulation and fibrinolysis simultaneously to assess whether these markers remain predictive in the era of lung-protective ventilation... - VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedemaL B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, Dept of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Eur Respir J 26:101-5. 2005..The decrease in air space concentrations of vascular endothelial growth factor in acute lung injury may not be a function of the degree of lung injury, but rather may result from alveolar flooding... - Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injuryLorraine B Ware
DivisionAllergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Chest 137:288-96. 2010..We hypothesized that a combination of biologic and clinical markers would be superior to either biomarkers or clinical factors alone in predicting ALI/ARDS mortality and would provide insight into the pathogenesis of clinical ALI/ARDS... - High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantationLorraine B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
J Heart Lung Transplant 24:1650-6. 2005..The secondary objective was to better define the spectrum of histologic abnormalities in the same group of lungs... - Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?Lorraine B Ware
Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Keio J Med 54:142-9. 2005..Modulation of fibrin deposition in the lung through targeting activation and modulation of coagulation as well as fibrinolysis may be an important therapeutic target in clinical ALI/ARDS that deserves further exploration... - Protein C and thrombomodulin in human acute lung injuryLorraine B Ware
Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 285:L514-21. 2003..In summary, the protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes. The protein C system may be a potential therapeutic target in patients with ALI/ARDS... - Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratioL B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, Dept of Medicine, Vanderbilt University School of Medicine, T1218 MCN, 1161 21st Avenue S, Nashville, TN 37232 2650, USA
Eur Respir J 35:331-7. 2010..Noninvasive measurement of the EF/PL ratio is a safe and reliable bedside method for rapidly determining the aetiology of acute pulmonary oedema that can be used at the bedside in both developed and developing countries... - Plasma biomarkers of oxidant stress and development of organ failure in severe sepsisLorraine B Ware
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 2650, USA
Shock 36:12-7. 2011..Plasma isoprostanes and isofurans may be useful for monitoring oxidative stress in treatment trials of antioxidant therapies in severe sepsis... - Significance of von Willebrand factor in septic and nonseptic patients with acute lung injuryLorraine B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, T1217 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Am J Respir Crit Care Med 170:766-72. 2004..To improve outcomes further, new treatment strategies targeted at the endothelium should be investigated... - Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lungLorraine B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
J Appl Physiol 93:1869-74. 2002..Aerosolized beta(2)-adrenergic agonists may have therapeutic value for hastening the resolution of alveolar edema during the management of donors before resection of lungs for transplantation or in the posttransplant setting... - Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndromeLorraine B Ware
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 35:1821-8. 2007..However, direct evidence for the contribution of abnormalities in coagulation and fibrinolysis proteins to outcomes in patients with acute lung injury/acute respiratory distress syndrome is lacking... - Assessment of lungs rejected for transplantation and implications for donor selectionLorraine B Ware
Division of Allergy, Pulmonary, and Critical Care, Department of Medicine, Vanderbilt University School of Medicine, T1217 MCN, Nashville, TN 37232 2650, USA
Lancet 360:619-20. 2002..Our findings emphasise the urgent need for prospective scientific assessment of selection of donors for lung transplantation... - Pathophysiology of acute lung injury and the acute respiratory distress syndromeLorraine B Ware
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Semin Respir Crit Care Med 27:337-49. 2006..Future therapies aimed at restoring the overall balance of cytokines, oxidants, coagulants, and proteases may ultimately be successful where therapies that target individual cytokines or other mediators have not... - Bench to bedside: targeting coagulation and fibrinolysis in acute lung injuryLorraine B Ware
Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Physiol Lung Cell Mol Physiol 291:L307-11. 2006.... - von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injuryL B Ware
Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Crit Care Med 29:2325-31. 2001..CONCLUSIONS: These findings suggest that the degree of systemic endothelial activation and injury at the onset of acute lung injury is an important determinant of the outcome from acute lung injury... - Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injuryPolly E Parsons
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, Burlington, Vermont 05401, USA
Am J Physiol Lung Cell Mol Physiol 288:L426-31. 2005..Furthermore, LTVV is associated with a specific decrease in sTNFRI levels. This suggests that one beneficial effect of LTVV may be to attenuate alveolar epithelial injury... - Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosisJ M Diamond
Pulmonary, Allergy, and Critical Care Division, Department of Anesthesia and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Transplant 11:2517-22. 2011..4, p = 0.008 at 24 h). Elevated PTX3 levels were associated with the development of PGD after lung transplantation in IPF patients. Future studies evaluating the role of innate immune activation in IPF and PGD are warranted... - Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesisRichard D Fremont
Division of Allergy, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
J Trauma 68:1121-7. 2010..The aims of this study were to develop a panel of plasma biomarkers to facilitate diagnosis of trauma-induced ALI and to enhance our understanding of the pathogenesis of human ALI... - Novel role of the human alveolar epithelium in regulating intra-alveolar coagulationLing Wang
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Respir Cell Mol Biol 36:497-503. 2007..Local fibrin deposition may be a fundamental mechanism for the lung to localize and confine injury, thus limiting the risk of dissemination of injury or infection to the systemic circulation... - Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injuryJonathan A Kropski
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
Chest 135:1440-7. 2009..We tested the diagnostic and prognostic utility of CC16 in patients with non-trauma-related ALI/ARDS compared to a control group of patients with acute cardiogenic pulmonary edema (CPE)... - Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunctionJ M Diamond
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Transplant 11:561-7. 2011..02. Elevated CC16 levels were associated with increased odds of PGD after lung transplantation. Damage to airway epithelium or altered alveolar permeability as a result of lung ischemia and reperfusion may explain this association... - The coagulation cascade in sepsisLing Wang
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Curr Pharm Des 14:1860-9. 2008..This review summarizes recent basic and clinical findings with regard to the role of the coagulation cascade in sepsis and explores potential therapeutic targets in the coagulation and fibrinolytic pathways in the management of sepsis... - Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injuryC S Calfee
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0130, USA
Thorax 63:1083-9. 2008.... - Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantationS A Hoffman
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Transplant 9:389-96. 2009..Profound injury in clinical PGD is distinguished by the upregulation of selected chemokine pathways, which may useful for the prediction or early detection of PGD if confirmed in future studies... - Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunctionJason D Christie
Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Respir Crit Care Med 175:69-74. 2007..Design: Prospective, multicenter cohort study... - Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1Mitchell A Olman
Department of Medicine, Division of Pulmonary and Critical Care Medicine, The University of Alabama, Birmingham, AL 35294, USA
Chest 121:69S-70S. 2002 - Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failureKamran Atabai
Department of Medicine, University of California San Francisco, San Francisco, CA 94143-0130, USA
Intensive Care Med 28:705-11. 2002.... - The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndromeJulie A Bastarache
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Semin Respir Crit Care Med 27:365-76. 2006.... - Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDSTodd W Rice
MSc, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
Chest 132:410-7. 2007..We hypothesized that the pulse oximetric saturation (Spo(2))/Fio(2) (S/F) ratio can be substituted for the P/F ratio in assessing the oxygenation criterion of ALI... - Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activityJulie A Bastarache
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Univ School of Medicine, T 1218 Medical Center North, Nashville, TN 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 294:L874-81. 2008..Levels of intra-alveolar TFPI in ARDS are not sufficient to block intra-alveolar TF procoagulant activity due to truncation and inactivation of intra-alveolar TFPI... - The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factorJulie A Bastarache
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T1218 Medical Center North, Nashville, Tennessee 37232 2650, USA
Thorax 62:608-16. 2007..A study was undertaken to test the hypothesis that the alveolar epithelium can initiate intra-alveolar coagulation by expressing active tissue factor (TF)... 
Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infectionWilliam E Lawson
Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 294:L1119-26. 2008..Activation of these pathways may result from altered surfactant protein processing or chronic herpesvirus infection...- Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndromeJulie A Bastarache
Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 297:L1035-41. 2009..These findings suggest that alveolar epithelial-derived MPs are one potential source of TF procoagulant activity in the air space in ARDS and that epithelial MP formation and release may represent a unique therapeutic target in ARDS... - Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment scorePratik P Pandharipande
Department of Anesthesiology, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 37:1317-21. 2009.... - Postobstructive pulmonary edema: a case for hydrostatic mechanismsRichard D Fremont
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, T1218 MCN, 1161 Twenty First Ave S, Nashville, TN 37232 2650, USA
Chest 131:1742-6. 2007..The goal of the current study was to investigate the mechanisms of pulmonary edema formation in patients with postobstructive pulmonary edema by serial sampling of undiluted pulmonary edema fluid... - Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophagesHye Jeong Lee
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 285:39655-62. 2010..In vitro citrullination assay showed that incubation of purified PAD2 and IKKγ proteins in the presence of Ca(2+) citrullinated IKKγ. These results demonstrate that PAD2 interacts with IKKγ and suppresses NF-κB activity... - Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantationM Covarrubias
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA
Am J Transplant 7:2573-8. 2007..There was no association between plasma vWF levels and PGD. We conclude that higher levels of plasma ICAM-1 are associated with PGD following lung transplantation... - Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injuryCarolyn S Calfee
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143 0111, USA
Intensive Care Med 35:248-57. 2009.... - Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomesEdward D Siew
Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Clin J Am Soc Nephrol 5:1497-505. 2010..Its ability to predict AKI and provide prognostic information in broadly selected, critically ill adults remains unknown... - Soluble p-selectin and the risk of primary graft dysfunction after lung transplantationSteven M Kawut
Department of Medicine, Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Chest 136:237-44. 2009..We hypothesized that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction (PGD) after lung transplantation... - Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shockCarolyn S Calfee
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA
Crit Care Med 38:1436-41. 2010..Whether plasma interleukin-8 would have similar utility in adults with septic shock is unknown... - Pulmonary edema fluid antioxidants are depressed in acute lung injuryRussell P Bowler
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Crit Care Med 31:2309-15. 2003..In acute lung injury, the distal airspace antioxidants ascorbate, urate, and glutathione may play a role in attenuating lung injury... - Early plasma soluble receptor for advanced glycation end-product levels are associated with bronchiolitis obliterans syndromeR J Shah
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA
Am J Transplant 13:754-9. 2013..Elevated plasma sRAGE levels measured in the immediate postoperative period are associated with the development of BOS. Early epithelial injury after transplantation may contribute to the development of fibrosis in BOS... - Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adultsEdward D Siew
Vanderbilt University Medical Center, Department of Medicine, Division of Nephrology, Nashville, TN 37232, USA
J Am Soc Nephrol 20:1823-32. 2009.... - Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunctionJason D Christie
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Respir Crit Care Med 180:1010-5. 2009..We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD... - Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disordersCarolyn S Calfee
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Crit Care Med 35:2243-50. 2007.... - Clinical practice. Acute pulmonary edemaLorraine B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2650, USA
N Engl J Med 353:2788-96. 2005 - Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repairLorraine B Ware
Division of Pulmonary and Critical Care, Department of Medicine, University of California, Los Angeles 90024, USA
Am J Physiol Lung Cell Mol Physiol 282:L924-40. 2002.... - Prognostic determinants of acute respiratory distress syndrome in adults: impact on clinical trial designLorraine B Ware
Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA
Crit Care Med 33:S217-22. 2005..Whether enriching study populations with these sicker patients will increase or decrease the likelihood of a treatment effect for a given therapy is unknown... - Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expressionMitchell A Olman
Department of Medicine, University of Alabama, Birmingham AL 35294, USA
J Immunol 172:2668-77. 2004.... - Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptorsKimberly E White
Department of Medicine, University of Alabama at Birmingham 35294, USA
J Immunol 180:637-46. 2008..Such mechanisms may drive the fibroproliferative response to ALI... - Measuring microvascular blood flow in sepsis--a continuing challengeLorraine B Ware
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Lancet 360:1187-8. 2002 - Clinical Year in Review III: asthma, lung transplantation, cystic fibrosis, acute respiratory distress syndromeLorraine B Ware
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA
Proc Am Thorac Soc 4:489-93. 2007 - Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanismsKamran Atabai
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143-0130, USA
Am J Physiol Lung Cell Mol Physiol 283:L163-9. 2002..In conclusion, in vivo administration of KGF augments the epithelial repair rate of alveolar epithelial cells by altering cell adherence, spreading, and migration and through stimulation of the EGF receptor... - Ventilator-induced lung injury: in vivo and in vitro mechanismsMichael A Matthay
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 283:L678-82. 2002.... - Case of fulminant hepatic failure due to unrecognized peripartum cardiomyopathyKevin M Fussell
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 33:891-3. 2005..CONCLUSIONS: Congestive heart failure is one of the few treatable causes of fulminant hepatic failure. Congestive heart failure must always be included in the differential diagnosis of fulminant hepatic failure of unknown pathogenesis... - The association between BMI and plasma cytokine levels in patients with acute lung injuryRenee D Stapleton
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, HSRF 222, Burlington, VT 05405, USA
Chest 138:568-77. 2010..We hypothesized that cytokine response might be attenuated in patients who are obese and critically ill or that obesity might modify the relationship between plasma cytokines and clinical outcomes in ALI... - Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogsLing Wang
Research Institute of Respiratory Diseases and Department of Surgical Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, China
Exp Lung Res 30:31-42. 2004..Thus, dual-ET receptor antagonists such as Tezosentan may be useful in the management of acute pulmonary arterial hypertension, complicating the course of OA-induced lung injury... - Prognostic value of surfactant proteins A and D in patients with acute lung injuryIvan W Cheng
Cardiovascular Research Institute and Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, USA
Crit Care Med 31:20-7. 2003.... - Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndromeKurt H Albertine
Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City 84132, USA
Am J Pathol 161:1783-96. 2002.... - Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injuryRussell P Bowler
National Jewish Medical and Research Center, K736a, 1400 Jackson St, Denver, CO 80206, USA
Am J Physiol Lung Cell Mol Physiol 286:L1095-104. 2004..Nearly all ALI patients also had protein spots that indicate truncation or other posttranslational modifications. Several of these novel changes could serve as new biomarkers of lung injury... - Modulation of alveolar fluid clearance by acute inflammation: the plot thickensLorraine B Ware
Am J Respir Crit Care Med 169:332-3. 2004 - Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivoIsabelle Pham
Department of Physiology, faculté de médecine Leonard de Vinci, Bobigny, Universite Paris 13, and Institut National de la Santé et de la Recherche Médicale U 426, Faculte Xavier Bichat, Paris, France
Am J Physiol Lung Cell Mol Physiol 283:L1133-42. 2002..These findings suggest that release of VEGF synthesized by AEC may target not only endothelial cells but also other alveolar cells, including macrophages and epithelial cells... - Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilationHeidi R Flori
Department of Pediatric Critical Care, Children s Hospital and Research Center, Oakland, Oakland, CA 94609, USA
Pediatr Crit Care Med 4:315-21. 2003.... - Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injuryPriya Prabhakaran
Department of Pediatrics, University of Alabama, Birmingham, Alabama 35294, USA
Am J Physiol Lung Cell Mol Physiol 285:L20-8. 2003..The data indicate that fibrin turnover in early ALI is a consequence of a rapid fibrinogen influx and fractional fibrinolytic inhibition... - Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edemaRichard D Sue
Division of Pulmonary and Critical Care Medicine, University of California, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90024-1999, USA
Intensive Care Med 30:1921-6. 2004..8+/-8.0%/h) was intact in the subset of three patients in whom it was measured. CONCLUSIONS: This study provides the first direct evidence that hydrostatic forces may contribute to the development of re-expansion pulmonary edema... - Management of the critically ill patient with severe acute pancreatitisAvery B Nathens
University of Washington, Seattle, WA, USA
Crit Care Med 32:2524-36. 2004..The goal of this consensus statement is to provide recommendations regarding the management of the critically ill patient with severe acute pancreatitis (SAP)... - Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injuryMichael T Ganter
Department of Anesthesia, University of California, San Francisco, 94110, USA
Am J Physiol Lung Cell Mol Physiol 291:L354-61. 2006..Thus SPR may protect the alveolar epithelium against oxidative stress associated with experimental ALI, and eHsp72 may serve as a marker of SPR activation in the distal air spaces of patients with ALI... - Modeling human lung disease in animalsLorraine B Ware
Am J Physiol Lung Cell Mol Physiol 294:L149-50. 2008 - Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injuryDana E McClintock
Cardiovascular Research Institute and Division of Occupational and Environmental Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA
Am J Respir Crit Care Med 175:256-62. 2007..Nitrogen oxide (NO) species are markers for oxidative stress that may be pathogenic in acute lung injury (ALI)... - Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrineTsutomu Sakuma
Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Crit Care Med 34:676-81. 2006.... - Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injuryTokujiro Uchida
Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Am J Respir Crit Care Med 173:1008-15. 2006..Receptor for advanced glycation end-products (RAGE) is one of the alveolar type I cell-associated proteins in the lung... - Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part V: predictors and outcomesSelim M Arcasoy
Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Heart Lung Transplant 24:1483-8. 2005 - Reasons for nonenrollment in a clinical trial of acute lung injuryAndrea E Glassberg
The Permanente Medical Group, 39400 Paseo Padre Parkway, Fremont, CA 94538, USA
Chest 134:719-23. 2008..We examined the reasons for nonenrollment and the impact of the availability of a surrogate decision maker on critical care clinical trials enrollment... - Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathwaysAnil Sapru
Pediatric Critical Care Medicine, University of California, 505 Parnassus Avenue, Moffitt 680 B, San Francisco, CA 94143 0106, USA
Intensive Care Med 32:1293-303. 2006.... - Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cellsJae W Lee
Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
J Biol Chem 282:24109-19. 2007.... - Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injuryIvan W Cheng
Cardiovascular Research Institute, University of California, San Francisco, USA
Crit Care Med 33:63-70; discussion 239-40. 2005..Therefore, concerns regarding potential adverse effects of this protocol should not preclude its use in patients with acute lung injury or the acute respiratory distress syndrome... - Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilationHeidi R Flori
Children s Hospital and Research Center Oakland, Division of Pediatric Critical Care, 747 52nd Street, Oakland, CA 94609, USA
Pediatr Crit Care Med 8:96-101. 2007.... - Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injuryKathleen D Liu
Division of Nephrology, University of California, San Francisco, CA, USA
Crit Care Med 35:2755-61. 2007..To identify biological and clinical predictors of acute kidney injury in subjects with acute lung injury... - Biomarkers of cardiac injury in acute respiratory distress syndrome: getting to the heart of the matterTimothy D Girard
Crit Care Med 35:2638-9. 2007 - Keratinocyte growth factor as an epithelial protective agent: where do we stand?Lorraine B Ware
Int J Radiat Oncol Biol Phys 60:1345-6. 2004 - Executive summary: management of the critically ill patient with severe acute pancreatitisAvery B Nathens
American Thoracic Society
Proc Am Thorac Soc 1:289-90. 2004 - Plasma protein C levels in patients with acute lung injury: prognostic significanceMichael A Matthay
Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA, USA
Crit Care Med 32:S229-32. 2004..In summary, the protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes. The protein C system may be a therapeutic target in patients with ALI/ARDS... - Can nicotine treat sepsis?Michael A Matthay
Nat Med 10:1161-2. 2004 - Genomics and proteomics of lung disease: conference summaryJ Usha Raj
Division of Neonatology, Harbor-UCLA Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
Am J Physiol Lung Cell Mol Physiol 293:L45-51. 2007
Research Grants
- Alveolar Epithelium in Acute Lung InjuryLorraine Ware; Fiscal Year: 2005..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
- Biomarker Profiles in the Diagnosis/Prognosis of ARDSLorraine Ware; Fiscal Year: 2007..This multidisciplinary team approach, combined with proven ongoing access to large clinical trial datasets will be used to target major areas of unmet need in both clinical practice and clinical research in ARDS. ..
- Treatment of Pulmonary Edema in Organ DonorsLorraine B Ware; Fiscal Year: 2010..The proposed studies will test a widely used, safe, inhaled therapy to determine whether donor lung function can be improved. ..