L B Ware

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Design, conduct, and analysis of a multicenter, pharmacogenomic, biomarker study in matched patients with severe sepsis treated with or without drotrecogin Alfa (activated)
    Djillali Annane
    Service de Reanimation Medicale, CIC IT805 INSERM, Hôpital R, Poincare AP HP, 104 Bd Raymond Poincaré, 92380, Garches, France
    Ann Intensive Care 2:15. 2012
  2. pmc Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Transplant 26:665-71. 2012
  3. pmc The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury
    Yosaf F Zeyed
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Lung Cell Mol Physiol 303:L550-5. 2012
  4. pmc Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome
    Sara C Sebag
    Department of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st Avenue S Nashville, TN 37232 2650, USA
    Curr Pharm Biotechnol 12:1481-96. 2011
  5. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
  6. pmc Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury
    Dana McClintock
    Cardiovascular Research Institute, 505 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA
    Crit Care 12:R41. 2008
  7. pmc Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 35:1821-8. 2007
  8. ncbi request reprint Pathophysiology of acute lung injury and the acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Respir Crit Care Med 27:337-49. 2006
  9. ncbi request reprint Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury
    Lorraine B Ware
    Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Lung Cell Mol Physiol 291:L307-11. 2006
  10. ncbi request reprint Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Keio J Med 54:142-9. 2005

Research Grants

  1. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
  2. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2007
  3. Treatment of Pulmonary Edema in Organ Donors
    Lorraine B Ware; Fiscal Year: 2010

Detail Information

Publications91

  1. pmc Design, conduct, and analysis of a multicenter, pharmacogenomic, biomarker study in matched patients with severe sepsis treated with or without drotrecogin Alfa (activated)
    Djillali Annane
    Service de Reanimation Medicale, CIC IT805 INSERM, Hôpital R, Poincare AP HP, 104 Bd Raymond Poincaré, 92380, Garches, France
    Ann Intensive Care 2:15. 2012
    ..abstract:..
  2. pmc Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Transplant 26:665-71. 2012
    ..80. This chest radiographic scoring system may potentially be used to assess the clinical severity of pulmonary edema and may be useful as part of the evaluation of donors for suitability for lung transplantation...
  3. pmc The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury
    Yosaf F Zeyed
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Lung Cell Mol Physiol 303:L550-5. 2012
    ....
  4. pmc Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome
    Sara C Sebag
    Department of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st Avenue S Nashville, TN 37232 2650, USA
    Curr Pharm Biotechnol 12:1481-96. 2011
    ..Modulation of coagulation and fibrinolysis has complex effects on both hemostasis and inflammatory pathways and further studies are needed to develop new treatment strategies for patients with ALI/ARDS...
  5. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
    ..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status...
  6. pmc Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury
    Dana McClintock
    Cardiovascular Research Institute, 505 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA
    Crit Care 12:R41. 2008
    ..We measured plasma markers of inflammation, coagulation and fibrinolysis simultaneously to assess whether these markers remain predictive in the era of lung-protective ventilation...
  7. pmc Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 35:1821-8. 2007
    ..However, direct evidence for the contribution of abnormalities in coagulation and fibrinolysis proteins to outcomes in patients with acute lung injury/acute respiratory distress syndrome is lacking...
  8. ncbi request reprint Pathophysiology of acute lung injury and the acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Respir Crit Care Med 27:337-49. 2006
    ..Future therapies aimed at restoring the overall balance of cytokines, oxidants, coagulants, and proteases may ultimately be successful where therapies that target individual cytokines or other mediators have not...
  9. ncbi request reprint Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury
    Lorraine B Ware
    Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Lung Cell Mol Physiol 291:L307-11. 2006
    ....
  10. ncbi request reprint Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Keio J Med 54:142-9. 2005
    ..Modulation of fibrin deposition in the lung through targeting activation and modulation of coagulation as well as fibrinolysis may be an important therapeutic target in clinical ALI/ARDS that deserves further exploration...
  11. ncbi request reprint Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, T1217 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 170:766-72. 2004
    ..To improve outcomes further, new treatment strategies targeted at the endothelium should be investigated...
  12. ncbi request reprint High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Heart Lung Transplant 24:1650-6. 2005
    ..The secondary objective was to better define the spectrum of histologic abnormalities in the same group of lungs...
  13. pmc VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema
    L B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Dept of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Eur Respir J 26:101-5. 2005
    ..The decrease in air space concentrations of vascular endothelial growth factor in acute lung injury may not be a function of the degree of lung injury, but rather may result from alveolar flooding...
  14. ncbi request reprint Protein C and thrombomodulin in human acute lung injury
    Lorraine B Ware
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 285:L514-21. 2003
    ..In summary, the protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes. The protein C system may be a potential therapeutic target in patients with ALI/ARDS...
  15. pmc Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis
    Lorraine B Ware
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 2650, USA
    Shock 36:12-7. 2011
    ..Plasma isoprostanes and isofurans may be useful for monitoring oxidative stress in treatment trials of antioxidant therapies in severe sepsis...
  16. pmc Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio
    L B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Dept of Medicine, Vanderbilt University School of Medicine, T1218 MCN, 1161 21st Avenue S, Nashville, TN 37232 2650, USA
    Eur Respir J 35:331-7. 2010
    ..Noninvasive measurement of the EF/PL ratio is a safe and reliable bedside method for rapidly determining the aetiology of acute pulmonary oedema that can be used at the bedside in both developed and developing countries...
  17. pmc Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury
    Lorraine B Ware
    DivisionAllergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Chest 137:288-96. 2010
    ..We hypothesized that a combination of biologic and clinical markers would be superior to either biomarkers or clinical factors alone in predicting ALI/ARDS mortality and would provide insight into the pathogenesis of clinical ALI/ARDS...
  18. ncbi request reprint Assessment of lungs rejected for transplantation and implications for donor selection
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care, Department of Medicine, Vanderbilt University School of Medicine, T1217 MCN, Nashville, TN 37232 2650, USA
    Lancet 360:619-20. 2002
    ..Our findings emphasise the urgent need for prospective scientific assessment of selection of donors for lung transplantation...
  19. ncbi request reprint Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Appl Physiol (1985) 93:1869-74. 2002
    ..Aerosolized beta(2)-adrenergic agonists may have therapeutic value for hastening the resolution of alveolar edema during the management of donors before resection of lungs for transplantation or in the posttransplant setting...
  20. ncbi request reprint von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury
    L B Ware
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Crit Care Med 29:2325-31. 2001
    ..CONCLUSIONS: These findings suggest that the degree of systemic endothelial activation and injury at the onset of acute lung injury is an important determinant of the outcome from acute lung injury...
  21. ncbi request reprint Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury
    Polly E Parsons
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, Burlington, Vermont 05401, USA
    Am J Physiol Lung Cell Mol Physiol 288:L426-31. 2005
    ..Furthermore, LTVV is associated with a specific decrease in sTNFRI levels. This suggests that one beneficial effect of LTVV may be to attenuate alveolar epithelial injury...
  22. doi request reprint Preoperative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation
    R J Shah
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    Am J Transplant 14:446-52. 2014
    ..26, 7.30, p=0.013) in non-IPF subjects. Our study suggests the importance of preexisting airway epithelial injury in PGD. Markers of airway epithelial injury may be helpful in pretransplant risk stratification in specific recipients...
  23. pmc Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis
    J M Diamond
    Pulmonary, Allergy, and Critical Care Division, Department of Anesthesia and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 11:2517-22. 2011
    ..4, p = 0.008 at 24 h). Elevated PTX3 levels were associated with the development of PGD after lung transplantation in IPF patients. Future studies evaluating the role of innate immune activation in IPF and PGD are warranted...
  24. pmc Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis
    Richard D Fremont
    Division of Allergy, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Trauma 68:1121-7. 2010
    ..The aims of this study were to develop a panel of plasma biomarkers to facilitate diagnosis of trauma-induced ALI and to enhance our understanding of the pathogenesis of human ALI...
  25. pmc Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation
    Ling Wang
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Cell Mol Biol 36:497-503. 2007
    ..Local fibrin deposition may be a fundamental mechanism for the lung to localize and confine injury, thus limiting the risk of dissemination of injury or infection to the systemic circulation...
  26. pmc Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury
    Jonathan A Kropski
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Chest 135:1440-7. 2009
    ..We tested the diagnostic and prognostic utility of CC16 in patients with non-trauma-related ALI/ARDS compared to a control group of patients with acute cardiogenic pulmonary edema (CPE)...
  27. pmc Early plasma soluble receptor for advanced glycation end-product levels are associated with bronchiolitis obliterans syndrome
    R J Shah
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 13:754-9. 2013
    ..Elevated plasma sRAGE levels measured in the immediate postoperative period are associated with the development of BOS. Early epithelial injury after transplantation may contribute to the development of fibrosis in BOS...
  28. pmc Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction
    J M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 11:561-7. 2011
    ..02. Elevated CC16 levels were associated with increased odds of PGD after lung transplantation. Damage to airway epithelium or altered alveolar permeability as a result of lung ischemia and reperfusion may explain this association...
  29. ncbi request reprint The coagulation cascade in sepsis
    Ling Wang
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Curr Pharm Des 14:1860-9. 2008
    ..This review summarizes recent basic and clinical findings with regard to the role of the coagulation cascade in sepsis and explores potential therapeutic targets in the coagulation and fibrinolytic pathways in the management of sepsis...
  30. pmc Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation
    S A Hoffman
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 9:389-96. 2009
    ..Profound injury in clinical PGD is distinguished by the upregulation of selected chemokine pathways, which may useful for the prediction or early detection of PGD if confirmed in future studies...
  31. pmc Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury
    C S Calfee
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Thorax 63:1083-9. 2008
    ....
  32. ncbi request reprint Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure
    Kamran Atabai
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Intensive Care Med 28:705-11. 2002
    ..However, no studies have determined whether aerosolized beta-adrenergic agonists are delivered to the distal air spaces of the lung in therapeutic concentrations in patients with pulmonary edema...
  33. pmc Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 175:69-74. 2007
    ..Design: Prospective, multicenter cohort study...
  34. ncbi request reprint Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1
    Mitchell A Olman
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The University of Alabama, Birmingham, AL 35294, USA
    Chest 121:69S-70S. 2002
  35. pmc Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score
    Pratik P Pandharipande
    Department of Anesthesiology, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:1317-21. 2009
    ....
  36. ncbi request reprint The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Respir Crit Care Med 27:365-76. 2006
    ....
  37. pmc The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T1218 Medical Center North, Nashville, Tennessee 37232 2650, USA
    Thorax 62:608-16. 2007
    ..A study was undertaken to test the hypothesis that the alveolar epithelium can initiate intra-alveolar coagulation by expressing active tissue factor (TF)...
  38. pmc Postobstructive pulmonary edema: a case for hydrostatic mechanisms
    Richard D Fremont
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, T1218 MCN, 1161 Twenty First Ave S, Nashville, TN 37232 2650, USA
    Chest 131:1742-6. 2007
    ..The goal of the current study was to investigate the mechanisms of pulmonary edema formation in patients with postobstructive pulmonary edema by serial sampling of undiluted pulmonary edema fluid...
  39. pmc Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome
    Julie A Bastarache
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1035-41. 2009
    ..These findings suggest that alveolar epithelial-derived MPs are one potential source of TF procoagulant activity in the air space in ARDS and that epithelial MP formation and release may represent a unique therapeutic target in ARDS...
  40. doi request reprint Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection
    William E Lawson
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1119-26. 2008
    ..Activation of these pathways may result from altered surfactant protein processing or chronic herpesvirus infection...
  41. ncbi request reprint Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS
    Todd W Rice
    MSc, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Chest 132:410-7. 2007
    ..We hypothesized that the pulse oximetric saturation (Spo(2))/Fio(2) (S/F) ratio can be substituted for the P/F ratio in assessing the oxygenation criterion of ALI...
  42. pmc Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Univ School of Medicine, T 1218 Medical Center North, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 294:L874-81. 2008
    ..Levels of intra-alveolar TFPI in ARDS are not sufficient to block intra-alveolar TF procoagulant activity due to truncation and inactivation of intra-alveolar TFPI...
  43. pmc Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages
    Hye Jeong Lee
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:39655-62. 2010
    ..In vitro citrullination assay showed that incubation of purified PAD2 and IKKγ proteins in the presence of Ca(2+) citrullinated IKKγ. These results demonstrate that PAD2 interacts with IKKγ and suppresses NF-κB activity...
  44. ncbi request reprint Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation
    M Covarrubias
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Am J Transplant 7:2573-8. 2007
    ..There was no association between plasma vWF levels and PGD. We conclude that higher levels of plasma ICAM-1 are associated with PGD following lung transplantation...
  45. ncbi request reprint Pulmonary edema fluid antioxidants are depressed in acute lung injury
    Russell P Bowler
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Crit Care Med 31:2309-15. 2003
    ..To test the hypothesis that low concentrations of distal airspace water-soluble antioxidants are associated with acute lung injury...
  46. pmc Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury
    Carolyn S Calfee
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143 0111, USA
    Intensive Care Med 35:248-57. 2009
    ....
  47. pmc Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation
    Steven M Kawut
    Department of Medicine, Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:237-44. 2009
    ..We hypothesized that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction (PGD) after lung transplantation...
  48. pmc Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes
    Edward D Siew
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Clin J Am Soc Nephrol 5:1497-505. 2010
    ..Its ability to predict AKI and provide prognostic information in broadly selected, critically ill adults remains unknown...
  49. pmc Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock
    Carolyn S Calfee
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA
    Crit Care Med 38:1436-41. 2010
    ..Whether plasma interleukin-8 would have similar utility in adults with septic shock is unknown...
  50. pmc Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults
    Edward D Siew
    Vanderbilt University Medical Center, Department of Medicine, Division of Nephrology, Nashville, TN 37232, USA
    J Am Soc Nephrol 20:1823-32. 2009
    ....
  51. pmc Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction
    Jason D Christie
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 180:1010-5. 2009
    ..We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD...
  52. ncbi request reprint Clinical practice. Acute pulmonary edema
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    N Engl J Med 353:2788-96. 2005
  53. pmc Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders
    Carolyn S Calfee
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Crit Care Med 35:2243-50. 2007
    ....
  54. pmc Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors
    Kimberly E White
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    J Immunol 180:637-46. 2008
    ..Such mechanisms may drive the fibroproliferative response to ALI...
  55. ncbi request reprint Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair
    Lorraine B Ware
    Division of Pulmonary and Critical Care, Department of Medicine, University of California, Los Angeles 90024, USA
    Am J Physiol Lung Cell Mol Physiol 282:L924-40. 2002
    ....
  56. ncbi request reprint Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms
    Kamran Atabai
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 283:L163-9. 2002
    ..In conclusion, in vivo administration of KGF augments the epithelial repair rate of alveolar epithelial cells by altering cell adherence, spreading, and migration and through stimulation of the EGF receptor...
  57. ncbi request reprint Ventilator-induced lung injury: in vivo and in vitro mechanisms
    Michael A Matthay
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 283:L678-82. 2002
    ....
  58. ncbi request reprint Measuring microvascular blood flow in sepsis--a continuing challenge
    Lorraine B Ware
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Lancet 360:1187-8. 2002
  59. ncbi request reprint Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression
    Mitchell A Olman
    Department of Medicine, University of Alabama, Birmingham AL 35294, USA
    J Immunol 172:2668-77. 2004
    ....
  60. ncbi request reprint Clinical Year in Review III: asthma, lung transplantation, cystic fibrosis, acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Proc Am Thorac Soc 4:489-93. 2007
  61. ncbi request reprint Prognostic determinants of acute respiratory distress syndrome in adults: impact on clinical trial design
    Lorraine B Ware
    Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Crit Care Med 33:S217-22. 2005
    ....
  62. ncbi request reprint Case of fulminant hepatic failure due to unrecognized peripartum cardiomyopathy
    Kevin M Fussell
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 33:891-3. 2005
    ..To describe a postpartum patient who presented with fulminant hepatic failure and hepatic coma as a result of unrecognized peripartum cardiomyopathy...
  63. pmc The association between BMI and plasma cytokine levels in patients with acute lung injury
    Renee D Stapleton
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, HSRF 222, Burlington, VT 05405, USA
    Chest 138:568-77. 2010
    ..We hypothesized that cytokine response might be attenuated in patients who are obese and critically ill or that obesity might modify the relationship between plasma cytokines and clinical outcomes in ALI...
  64. pmc Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, CA, USA
    Crit Care Med 35:2755-61. 2007
    ..To identify biological and clinical predictors of acute kidney injury in subjects with acute lung injury...
  65. pmc Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury
    Tokujiro Uchida
    Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Respir Crit Care Med 173:1008-15. 2006
    ..Receptor for advanced glycation end-products (RAGE) is one of the alveolar type I cell-associated proteins in the lung...
  66. pmc Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome
    Kurt H Albertine
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City 84132, USA
    Am J Pathol 161:1783-96. 2002
    ....
  67. ncbi request reprint Prognostic value of surfactant proteins A and D in patients with acute lung injury
    Ivan W Cheng
    Cardiovascular Research Institute and Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, USA
    Crit Care Med 31:20-7. 2003
    ....
  68. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part V: predictors and outcomes
    Selim M Arcasoy
    Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Heart Lung Transplant 24:1483-8. 2005
  69. ncbi request reprint Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema
    Richard D Sue
    Division of Pulmonary and Critical Care Medicine, University of California, 900 Veteran Avenue, 14 154 Warren Hall, Los Angeles, CA 90024 1999, USA
    Intensive Care Med 30:1921-6. 2004
    ..A secondary objective was to determine if the alveolar epithelium was functionally intact in patients with re-expansion pulmonary edema by measuring net alveolar epithelial fluid transport in a subset of patients...
  70. ncbi request reprint Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo
    Isabelle Pham
    Department of Physiology, faculté de médecine Leonard de Vinci, Bobigny, Universite Paris 13, and Institut National de la Santé et de la Recherche Médicale U 426, Faculte Xavier Bichat, Paris, France
    Am J Physiol Lung Cell Mol Physiol 283:L1133-42. 2002
    ..These findings suggest that release of VEGF synthesized by AEC may target not only endothelial cells but also other alveolar cells, including macrophages and epithelial cells...
  71. ncbi request reprint Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury
    Ivan W Cheng
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Crit Care Med 33:63-70; discussion 239-40. 2005
    ....
  72. ncbi request reprint Management of the critically ill patient with severe acute pancreatitis
    Avery B Nathens
    University of Washington, Seattle, WA, USA
    Crit Care Med 32:2524-36. 2004
    ..The goal of this consensus statement is to provide recommendations regarding the management of the critically ill patient with severe acute pancreatitis (SAP)...
  73. pmc Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine
    Tsutomu Sakuma
    Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Crit Care Med 34:676-81. 2006
    ....
  74. ncbi request reprint Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs
    Ling Wang
    Research Institute of Respiratory Diseases and Department of Surgical Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, China
    Exp Lung Res 30:31-42. 2004
    ..Thus, dual-ET receptor antagonists such as Tezosentan may be useful in the management of acute pulmonary arterial hypertension, complicating the course of OA-induced lung injury...
  75. pmc Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury
    Michael T Ganter
    Department of Anesthesia, University of California, San Francisco, 94110, USA
    Am J Physiol Lung Cell Mol Physiol 291:L354-61. 2006
    ..Thus SPR may protect the alveolar epithelium against oxidative stress associated with experimental ALI, and eHsp72 may serve as a marker of SPR activation in the distal air spaces of patients with ALI...
  76. ncbi request reprint Modeling human lung disease in animals
    Lorraine B Ware
    Am J Physiol Lung Cell Mol Physiol 294:L149-50. 2008
  77. ncbi request reprint Modulation of alveolar fluid clearance by acute inflammation: the plot thickens
    Lorraine B Ware
    Am J Respir Crit Care Med 169:332-3. 2004
  78. pmc Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    J Biol Chem 282:24109-19. 2007
    ....
  79. pmc Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation
    Heidi R Flori
    Children s Hospital and Research Center Oakland, Division of Pediatric Critical Care, 747 52nd Street, Oakland, CA 94609, USA
    Pediatr Crit Care Med 8:96-101. 2007
    ....
  80. pmc Reasons for nonenrollment in a clinical trial of acute lung injury
    Andrea E Glassberg
    The Permanente Medical Group, 39400 Paseo Padre Parkway, Fremont, CA 94538, USA
    Chest 134:719-23. 2008
    ..We examined the reasons for nonenrollment and the impact of the availability of a surrogate decision maker on critical care clinical trials enrollment...
  81. ncbi request reprint Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury
    Priya Prabhakaran
    Department of Pediatrics, University of Alabama, Birmingham, Alabama 35294, USA
    Am J Physiol Lung Cell Mol Physiol 285:L20-8. 2003
    ..The data indicate that fibrin turnover in early ALI is a consequence of a rapid fibrinogen influx and fractional fibrinolytic inhibition...
  82. ncbi request reprint Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury
    Russell P Bowler
    National Jewish Medical and Research Center, K736a, 1400 Jackson St, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1095-104. 2004
    ..Nearly all ALI patients also had protein spots that indicate truncation or other posttranslational modifications. Several of these novel changes could serve as new biomarkers of lung injury...
  83. ncbi request reprint Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation
    Heidi R Flori
    Department of Pediatric Critical Care, Children s Hospital and Research Center, Oakland, Oakland, CA 94609, USA
    Pediatr Crit Care Med 4:315-21. 2003
    ....
  84. ncbi request reprint Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways
    Anil Sapru
    Pediatric Critical Care Medicine, University of California, 505 Parnassus Avenue, Moffitt 680 B, San Francisco, CA 94143 0106, USA
    Intensive Care Med 32:1293-303. 2006
    ....
  85. pmc Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury
    Dana E McClintock
    Cardiovascular Research Institute and Division of Occupational and Environmental Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 175:256-62. 2007
    ..Nitrogen oxide (NO) species are markers for oxidative stress that may be pathogenic in acute lung injury (ALI)...
  86. ncbi request reprint Executive summary: management of the critically ill patient with severe acute pancreatitis
    Avery B Nathens
    American Thoracic Society
    Proc Am Thorac Soc 1:289-90. 2004
  87. ncbi request reprint Keratinocyte growth factor as an epithelial protective agent: where do we stand?
    Lorraine B Ware
    Int J Radiat Oncol Biol Phys 60:1345-6. 2004
  88. ncbi request reprint Plasma protein C levels in patients with acute lung injury: prognostic significance
    Michael A Matthay
    Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Crit Care Med 32:S229-32. 2004
    ..In summary, the protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes. The protein C system may be a therapeutic target in patients with ALI/ARDS...
  89. ncbi request reprint Genomics and proteomics of lung disease: conference summary
    J Usha Raj
    Division of Neonatology, Harbor UCLA Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
    Am J Physiol Lung Cell Mol Physiol 293:L45-51. 2007
  90. ncbi request reprint Can nicotine treat sepsis?
    Michael A Matthay
    Nat Med 10:1161-2. 2004
  91. ncbi request reprint Biomarkers of cardiac injury in acute respiratory distress syndrome: getting to the heart of the matter
    Timothy D Girard
    Crit Care Med 35:2638-9. 2007

Research Grants6

  1. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
    ..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
  2. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2007
    ..This multidisciplinary team approach, combined with proven ongoing access to large clinical trial datasets will be used to target major areas of unmet need in both clinical practice and clinical research in ARDS. ..
  3. Treatment of Pulmonary Edema in Organ Donors
    Lorraine B Ware; Fiscal Year: 2010
    ..The proposed studies will test a widely used, safe, inhaled therapy to determine whether donor lung function can be improved. ..