Prakash C Viswanathan
Affiliation: Vanderbilt University
- Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmiasBarry London
Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
Circulation 116:2260-8. 2007..We previously used positional cloning to identify a new locus on chromosome 3p24 in a large family with Brugada syndrome and excluded SCN5A as a candidate gene...
- Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2Carl Sims
University of Pittsburgh, School of Medicine, Department of Cell Biology and Physiology, Pittsburgh, PA 15261, USA
Circ Res 102:e86-100. 2008....
- Inherited sodium channelopathies: a continuum of channel dysfunctionPrakash C Viswanathan
Department of Anesthesiology, Room 560, Preston Research Building, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, TN 37232 6602, USA
Trends Cardiovasc Med 14:28-35. 2004..These new insights enhance understanding of the structure-function relationships of voltage-gated Na+ channels, and also highlight the complexities involved in linking single mutations, ion-channel behavior, and cardiac rhythm...
- New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutantKai Liu
Departments of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Circulation 112:3239-46. 2005..To address this discrepancy, we tested the hypothesis that this mutant channel is not processed normally...
- Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of CalmodulinFranck Potet
Departments of Anesthesiology, Pharmacology, Medicine, Biochemistry, and Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 284:8846-54. 2009..These findings have bearing upon Na(+) channel function in genetically altered channels and under pathophysiologic conditions where [Ca(2+)](i) impacts cardiac conduction...
- A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutationPrakash C Viswanathan
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Invest 111:341-6. 2003..The mutation and the polymorphism were both found in the same allele of a child with isolated conduction disease, suggesting a direct functional association between a polymorphism and a mutation in the same gene...
- Quantitation of protein kinase A-mediated trafficking of cardiac sodium channels in living cellsHaifa Hallaq
Department of Medicine, Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
Cardiovasc Res 72:250-61. 2006....
- HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase functionTadashi Nakajima
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
J Biol Chem 282:5506-13. 2007..Incorporation of in vitro data into a computational model indicated that KCR1 expression is protective against arrhythmias. These findings reveal a potential new avenue for targeted prevention of aLQTS...
- Genetics of acquired long QT syndromeDan M Roden
Department of Medicine, Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Invest 115:2025-32. 2005....
- Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channelsKoji Fukuda
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA
Circ Res 97:1262-9. 2005..These data suggest Na+ channel dysfunction evoked by lipid peroxidation is a candidate mechanism for ischemia-related conduction abnormalities and arrhythmias...
- Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointesPing Yang
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
Circulation 105:1943-8. 2002..We have previously identified functionally important DNA variants in genes encoding K+ channel ancillary subunits in 11% of an aLQTS cohort...
- Compound-specific Na+ channel pore conformational changes induced by local anaestheticsKoji Fukuda
Department of Anaesthesiology, Vanderbilt University, School of Medicine, Nashville, TN 37232 6602, USA
J Physiol 564:21-31. 2005..Our findings suggest that LA compounds may produce their kinetically distinct voltage-dependent behaviour by modulating slow inactivation gating to varying degrees...
- Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction blockDao W Wang
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn, and Department of Pediatrics, Medical University of South Carolina, Charleston, USA
Circulation 105:341-6. 2002..The mutations also reduce sodium current density and enhance slower inactivation components. Action potential simulations predict that this combination of biophysical abnormalities will significantly slow myocardial conduction velocity...
- A sodium channel pore mutation causing Brugada syndromeArnold E Pfahnl
Division of Cardiology, Atlanta Veterans Affairs Medical Center and Emory University, Atlanta, Georgia 30033, USA
Heart Rhythm 4:46-53. 2007..Both male and female carriers are symptomatic at young ages, have typical Brugada-type electrocardiogram changes, and have relatively normal corrected QT intervals...