Luc Van Kaer

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules
    Jingbo Yan
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Exp Med 203:647-59. 2006
  2. pmc In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ
    Luc Van Kaer
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 8:e67821. 2013
  3. pmc Invariant natural killer T cells as sensors and managers of inflammation
    Luc Van Kaer
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Trends Immunol 34:50-8. 2013
  4. ncbi request reprint alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Rev Immunol 5:31-42. 2005
  5. ncbi request reprint Regulation of immune responses by CD1d-restricted natural killer T cells
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Immunol Res 30:139-53. 2004
  6. pmc Invariant natural killer T cells: bridging innate and adaptive immunity
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Room A 5301, 1161 21st Ave South, Nashville, TN 37232 2363, USA
    Cell Tissue Res 343:43-55. 2011
  7. pmc Comeback kids: CD8(+) suppressor T cells are back in the game
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 120:3432-4. 2010
  8. ncbi request reprint Natural killer T cells as targets for immunotherapy of autoimmune diseases
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Immunol Cell Biol 82:315-22. 2004
  9. pmc Glatiramer acetate for treatment of MS: regulatory B cells join the cast of players
    Luc Van Kaer
    Department of Microbiology and Immunology, Room A 5301, Medical Center North, 1161 21st Ave S, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Exp Neurol 227:19-23. 2011
  10. doi request reprint Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Room A 5301, 1161 21st Avenue South, Nashville, TN 37232 32363, USA
    Immunotherapy 3:59-75. 2011

Detail Information

Publications91

  1. pmc In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules
    Jingbo Yan
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Exp Med 203:647-59. 2006
    ..These findings reveal an important in vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules...
  2. pmc In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ
    Luc Van Kaer
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 8:e67821. 2013
    ..This novel in vitro differentiation culture should provide a powerful and tractable tool for dissecting the differentiation and biological functions of CD4(+)CD8α(+) T cells. ..
  3. pmc Invariant natural killer T cells as sensors and managers of inflammation
    Luc Van Kaer
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Trends Immunol 34:50-8. 2013
    ..These new findings should be instrumental to promote the immunomodulatory properties of iNKT cells for treatment of inflammatory diseases...
  4. ncbi request reprint alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Rev Immunol 5:31-42. 2005
    ....
  5. ncbi request reprint Regulation of immune responses by CD1d-restricted natural killer T cells
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Immunol Res 30:139-53. 2004
    ..Our findings indicate that NKT cells play a regulatory role in the immune response and that specific activation of these cells may be exploited for therapeutic purposes...
  6. pmc Invariant natural killer T cells: bridging innate and adaptive immunity
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Room A 5301, 1161 21st Ave South, Nashville, TN 37232 2363, USA
    Cell Tissue Res 343:43-55. 2011
    ..Here, we review the innate-like properties and functions of iNKT cells and discuss their interactions with other cell types of the immune system...
  7. pmc Comeback kids: CD8(+) suppressor T cells are back in the game
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 120:3432-4. 2010
    ..These investigators further show that patients with type 1 diabetes have defects in their CD8(+) suppressor T cells, thus identifying these cells as potential therapeutic targets in human disease...
  8. ncbi request reprint Natural killer T cells as targets for immunotherapy of autoimmune diseases
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Immunol Cell Biol 82:315-22. 2004
    ....
  9. pmc Glatiramer acetate for treatment of MS: regulatory B cells join the cast of players
    Luc Van Kaer
    Department of Microbiology and Immunology, Room A 5301, Medical Center North, 1161 21st Ave S, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Exp Neurol 227:19-23. 2011
    ..This commentary discusses these new findings in the context of the pathogenesis of MS and EAE, the emerging immunoregulatory role of B cells in autoimmunity, and the relevance of B cells as targets for immunotherapy in MS...
  10. doi request reprint Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Room A 5301, 1161 21st Avenue South, Nashville, TN 37232 32363, USA
    Immunotherapy 3:59-75. 2011
    ..In this article, we review the immunodulatory activities of iNKT cells and the potential for developing iNKT cell-based prophylactic and curative therapies of human disease...
  11. ncbi request reprint Innate immunity: NKT cells in the spotlight
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Curr Biol 15:R429-31. 2005
    ..Recent studies have revealed how one intriguing member of the innate immune system, the natural killer T cell, is activated during bacterial infections...
  12. ncbi request reprint Role of invariant natural killer T cells in immune regulation and as potential therapeutic targets in autoimmune disease
    Luc Van Kaer
    Professor of Microbiology and Immunology, Vanderbilt University, Department of Microbiology and Immunology, School of Medicine, Room A 5301, Medical Center North, Nashville, TN 37232, USA
    Expert Rev Clin Immunol 2:745-57. 2006
    ....
  13. ncbi request reprint Pillars article: antigen presentation: discovery of the peptide TAP
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 180:2723-4. 2008
  14. ncbi request reprint Role of NKT cells in the digestive system. II. NKT cells and diabetes
    Lan Wu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Nashville, TN 37232, USA
    Am J Physiol Gastrointest Liver Physiol 293:G919-22. 2007
    ..In addition, glycolipid agonists of NKT cells have been successful in preventing diabetes in mice, raising enthusiasm for the development of NKT cell-based therapies for T1D...
  15. ncbi request reprint NKT cells: T lymphocytes with innate effector functions
    Luc Van Kaer
    Department of Microbiology, Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Curr Opin Immunol 19:354-64. 2007
    ..Finally, there is continued enthusiasm for the development of NKT cell-based therapies of human diseases...
  16. ncbi request reprint Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs
    Liqi Li
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 173:3707-15. 2004
    ....
  17. ncbi request reprint Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 173:3693-706. 2004
    ..These findings indicate that NKT cells can fine-tune their immune responses to distinct glycolipid Ags in vivo, a property that may be exploited for the development of effective and safe NKT cell-based immunotherapies...
  18. ncbi request reprint Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo
    Jelena S Bezbradica
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 174:4696-705. 2005
    ..Thus, the differential immune outcome based on the type of APC that displays glycolipid Ags in vivo has implications for the design of therapies that harness the immunoregulatory functions of iNKT cells...
  19. ncbi request reprint Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B
    Aleksandar K Stanic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 172:4667-71. 2004
    ..Thus, we conclude that NF-kappa B signaling plays a crucial role at distinct levels of iNKT cell biology...
  20. pmc Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia
    Nicole A Braun
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Arterioscler Thromb Vasc Biol 30:1758-65. 2010
    ..In this study, we investigated whether dyslipidemia-associated perturbed invariant natural killer T (iNKT) cell function is due to intrinsic changes in iNKT cells or defects in the ability of antigen-presenting cells to activate iNKT cells...
  21. ncbi request reprint Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny
    Jelena S Bezbradica
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Immunity 25:487-97. 2006
    ..Thus, we ascribe a unique function to Csf-2, which regulates iNKT cell effector differentiation during development by a mechanism that renders them competent for cytokine secretion...
  22. pmc Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny
    Jelena S Bezbradica
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:5114-9. 2005
    ....
  23. pmc Glycolipid antigen induces long-term natural killer T cell anergy in mice
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 115:2572-83. 2005
    ..Our findings have important implications for the development of NKT cell-based vaccines and immunotherapies...
  24. ncbi request reprint NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes
    Aleksandar K Stanic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 172:2265-73. 2004
    ..Thus, antiapoptotic signals relayed by NF-kappaB critically control cell fate specification and molecular differentiation of iNKT cells and, hence, reveal a novel role for such signals within the immune system...
  25. pmc Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells
    Vrajesh V Parekh
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1948-60. 2013
    ....
  26. ncbi request reprint A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation
    Feng Zhang
    Division of Rheumatology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 171:4613-20. 2003
    ..Taken together, these data indicate that genes within chromosome 18 control strain-dependent development of Va14Ja18 NKT cells...
  27. pmc Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors
    Eric Adeeku
    Department of Microbiology, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:9307-12. 2008
    ....
  28. pmc Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease
    Danyvid Olivares-Villagómez
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:17931-6. 2008
    ..Also, TL deficiency accelerated colitis in a genetic model of inflammatory bowel disease. These findings reveal an important regulatory role of TL in controlling IEL function and intestinal inflammation...
  29. pmc IL-15 regulates homeostasis and terminal maturation of NKT cells
    Laura E Gordy
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 187:6335-45. 2011
    ..Taken together, our findings reveal a critical role for IL-15 in NKT cell survival, which is mediated by Bcl-x(L), and effector differentiation, which is consistent with a role of T-bet in regulating terminal maturation...
  30. ncbi request reprint Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice
    Naoto Matsuki
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 170:5429-37. 2003
    ..The most notable of these map to the Idd4, Idd5, Idd9.1, and Idd13 regions of the mouse genome. Together these findings provide a clue to the genetic mechanism(s) underlying iNKT cell deficiency in NOD mice...
  31. pmc Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens
    Srdjan M Dragovic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    J Immunol 186:6683-92. 2011
    ..From these findings, a novel model emerged in which the cytosolic Ag-processing machinery regulates the quantity of cytoplasmic peptides available for presentation by class II molecules and, hence, modulates Th cell responses...
  32. pmc Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice
    Sungjune Kim
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 118:2301-15. 2008
    ..These findings may have important implications for the development of iNKT cell-based therapies...
  33. pmc Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
    Lan Wu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 109:E1143-52. 2012
    ..These findings place iNKT cells into the complex network linking lipid excess to inflammation in obesity and suggest new therapeutic avenues for obesity-associated metabolic disorders...
  34. pmc Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen
    Danyvid Olivares-Villagómez
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 187:4051-60. 2011
    ..Overall, our results provide evidence for an important interaction between IEC and CD4(+) T cells via TL, which modulates mucosal immune responses...
  35. ncbi request reprint iNKT-cell responses to glycolipids
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Crit Rev Immunol 25:183-213. 2005
    ..These studies have raised significant enthusiasm for the development of effective and safe iNKT-cell-based immunotherapies for a variety of human diseases...
  36. pmc Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses
    Charles T Spencer
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Eur J Immunol 43:1162-72. 2013
    ..Together with our previous findings, these data suggest multiple CAP machinery components sequester or degrade MHC class II-restricted epitopes that would otherwise be capable of eliciting functional Th-cell responses...
  37. ncbi request reprint CD1d1-dependent control of the magnitude of an acute antiviral immune response
    Tonya J Roberts
    Department of Microbiology and Immunology, Indiana University School of Medicine, and the Walther Oncology Center, Indianapolis, IN 46202, USA
    J Immunol 172:3454-61. 2004
    ..Collectively, these data provide clear evidence that the expression of CD1d1 molecules controls the magnitude of the cell-mediated immune response to an acute viral infection...
  38. ncbi request reprint Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice
    Amy S Major
    Department of Medicine, Division of Cardiovascular Medicine, 2220 Pierce Avenue, Room 383 PRB, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Arterioscler Thromb Vasc Biol 24:2351-7. 2004
    ..The capacity of NKT cells to respond to lipid antigens and modulate innate and acquired immunity suggests that they may play a role in atherogenesis...
  39. ncbi request reprint Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo
    Gourapura J Renukaradhya
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, I46202, USA
    Int J Cancer 118:3045-53. 2006
    ..However, iNKT cell numbers were elevated in tumor-bearing mice. Thus, iNKT cells may be playing a negative role in the host's antitumor immune response against T-cell lymphomas in a CD1d-dependent manner...
  40. ncbi request reprint Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH
    Peter J Chefalo
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 170:5825-33. 2003
    ..These results are consistent with alternate MHC-I Ag processing mechanisms that involve binding of peptides to MHC-I within acidic vacuolar compartments...
  41. ncbi request reprint Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]
    Aleksandar K Stanic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 171:4539-51. 2003
    ..Our findings demonstrate that iNKT cell functions are controlled by affinity thresholds for glycolipid Ags and reveal a novel property of their Ag receptor apparatus that may have an important role in iNKT cell activation...
  42. ncbi request reprint The Ig-like domain of tapasin influences intermolecular interactions
    Heth R Turnquist
    Eppley Institute for Research in Cancer and Allied Diseases, Department of Pathology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 172:2976-84. 2004
    ..Taken together, these results reveal a critical role for the tapasin Ig-like domain in tapasin function...
  43. pmc STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection
    Martin L Moore
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN37232, USA
    J Immunol 183:2016-26. 2009
    ..Basophils were the primary source of IL-4 in the lung in RSV infection, and STAT1 was a negative regulator of virus-induced basophil IL-4 expression...
  44. ncbi request reprint Lipid metabolism, atherogenesis and CD1-restricted antigen presentation
    Amy S Major
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Room 383, Preston Research Building, Nashville, TN 37232, USA
    Trends Mol Med 12:270-8. 2006
    ..Targeting this pathway of immune activation might have therapeutic potential for the treatment of chronic inflammatory diseases...
  45. pmc Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells
    Alison Motsinger
    Department of Microbiology and Immunology, Vanderbilt University Medical School, 21st Avenue South, Medical Center North, Nashville, TN 37232, USA
    J Virol 77:8153-8. 2003
    ..Identification of macaque NKT cells has major implications for delineating the role of these cells in nonhuman primate disease models of HIV as well as other pathological conditions, such as allograft rejection and autoimmunity...
  46. ncbi request reprint Natural killer T cells and autoimmune disease
    Lan Wu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Mol Med 9:4-14. 2009
    ..Recent efforts have focused on developing NKT cell agonists with superior treatment efficacy than alpha-GalCer. Collectively, these studies have identified NKT cells as attractive targets for treatment of human autoimmune diseases...
  47. pmc Follicular B cell trafficking within the spleen actively restricts humoral immune responses
    Kristen L Hoek
    Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232 2363, USA
    Immunity 33:254-65. 2010
    ..This work demonstrates that in wild-type animals, naive FO B cells are actively removed from the MZ, thus restricting their capacity to respond to blood-borne pathogens...
  48. pmc The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion
    Michael T Wilson
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:10913-8. 2003
    ..These findings alter current understanding of NKT cell biology and should aid in the rational design of NKT cell-based immunotherapies...
  49. pmc Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases
    Gobardhan Das
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Exp Med 203:2603-11. 2006
    ..These findings provide direct evidence that CD8+ ILLs are sufficient to initiate and mediate autoimmune diseases...
  50. ncbi request reprint The in vivo response of invariant natural killer T cells to glycolipid antigens
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Int Rev Immunol 26:31-48. 2007
    ..These studies provide new insight into the biology of iNKT cells and have important implications for designing safe and effective iNKT cell-based vaccines and therapies...
  51. pmc The role of invariant natural killer T cells in lupus and atherogenesis
    Amy S Major
    Department of Medicine Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Immunol Res 34:49-66. 2006
    ....
  52. ncbi request reprint Immunotherapy with ligands of natural killer T cells
    Michael T Wilson
    Dept of Microbiology and Immunology, Howard Hughes Medical Institute, Vanderbilt University School of Medicine, 811 Rudolph Light Hall, Nashville, TN 37232, USA
    Trends Mol Med 8:225-31. 2002
    ..These findings suggest that appropriate stimulation of NKT cells could be exploited for prevention or treatment of human diseases...
  53. pmc The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice
    Avneesh K Singh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Eur J Immunol 35:1143-54. 2005
    ..These findings demonstrate that NKT cell activation with alpha-GalCer suppresses or promotes pristane-induced lupus-like autoimmunity in mice, in a strain-dependent manner...
  54. pmc Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34
    Vrajesh V Parekh
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:5086-101. 2013
    ..Collectively, our study reveals a critical role for Vps34 in autophagy and for the peripheral homeostasis and function of T lymphocytes...
  55. pmc Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo
    Chang Yuan Ni
    Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 180:7107-11. 2008
    ..Thus, one function of NEMO ubiquitination is to fine tune innate immune responses under TLR control...
  56. pmc KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production
    Jeremy A Goettel
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee, USA
    Gastroenterology 140:265-74. 2011
    ..In this study, we tested the hypothesis that KSR1 is protective against spontaneous experimental colitis...
  57. pmc NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus
    Teresa R Johnson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Virol 76:4294-303. 2002
    ..These findings indicate that CD1d-dependent NK T cells play a role in expansion of CD8(+) T cells and amplification of antiviral responses to RSV...
  58. pmc Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants
    Sungjune Kim
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Nashville, TN 37232, USA
    Expert Rev Vaccines 7:1519-32. 2008
    ..This review aims to summarize the immunomodulatory activities of iNKT cell ligands and to discuss prospects for developing iNKT cell-based vaccine adjuvants...
  59. pmc TL and CD8αα: Enigmatic partners in mucosal immunity
    Danyvid Olivares-Villagómez
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232, USA
    Immunol Lett 134:1-6. 2010
    ..In this review we discuss the significance of the interaction between TL and CD8αα in mucosal immunity during health and disease...
  60. pmc Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency
    Aleksandar K Stanic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:1849-54. 2003
    ..These findings suggest that beta-D-GlcCer may play an important role in generating and/or loading a natural Va14Ja18 NKT antigen...
  61. pmc STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines
    Michael J Rosen
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1849-58. 2013
    ..These data implicate STAT6 in the pathogenesis of colitis in vivo with important roles in altering epithelial barrier function and regulating Th2-inducing cytokine production...
  62. pmc Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice
    James K Oeser
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 60:2922-7. 2011
    ..This study aimed to determine whether suppression of G6p2 gene expression might therefore prevent or delay disease progression...
  63. pmc Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG
    Shanmugalakshmi Sadagopal
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 4:e5531. 2009
    ..During decades of in vitro cultivation BCG not only lost some genes due to deletions of regions of the chromosome but also underwent gene duplication and other mutations resulting in increased antioxidant production...
  64. doi request reprint Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile
    Sebastian Joyce
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Host Microbe 3:275-7. 2008
    ..These findings provide a mechanistic understanding of the role of innate immunity toward a microbe in the development of autoimmunity...
  65. pmc Natural killer T cells in health and disease
    Lan Wu
    Department of Microbiology and Immunology, Room A 5301, Medical Center North, 1161 21st Avenue South, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2363, USA
    Front Biosci (Schol Ed) 3:236-51. 2011
    ..These properties of NKT cells are being exploited for therapeutic intervention to prevent or treat cancer, infections, and autoimmune and inflammatory diseases...
  66. ncbi request reprint CD1-restricted antigen presentation: an oily matter
    Sebastian Joyce
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Immunol 15:95-104. 2003
  67. pmc CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection
    Alison Motsinger
    Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Exp Med 195:869-79. 2002
    ..Taken together, our findings indicate that CD4(+) NKT cells are directly targeted by HIV-1 and may have a potential role during viral transmission and spread in vivo...
  68. ncbi request reprint Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice
    Christelle Faveeuw
    Institut National de la Sante et de la Recherche Medicale, Unite 547, Institut Pasteur de Lille, Lille, France
    J Immunol 169:906-12. 2002
    ....
  69. ncbi request reprint Rejection of grafts with no H-2 disparity in TAP1 mutant mice: CD4 T cells are important effector cells and self H-2b class I molecules are target
    Idania Marrero Suárez
    Heart Institute InCor, Sao Paulo University Medical School, SP, Brazil
    Transpl Immunol 9:101-10. 2002
    ..The low expression of MHC-I molecules on TAP1-/- mice may be determinant in the selection of a T cell repertoire strongly reactive to self MHC class I molecules which probably escapes the control of peripheral regulatory mechanisms...
  70. ncbi request reprint Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice
    Dai Takagi
    Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Int J Mol Med 18:829-36. 2006
    ..The present findings demonstrate that overexpression of MIF exacerbates inflammation in this arthritis model and that NKT cells play an ameliorating role upon stimulation with alpha-GalCer in the inflammatory process in MIFTg mice...
  71. pmc Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Exp Med 197:997-1005. 2003
    ..These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells...
  72. ncbi request reprint Infiltration of the inflamed eye by NKT cells in a rat model of experimental autoimmune uveitis
    Hui Shao
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    J Autoimmun 21:37-45. 2003
    ..e. autoreactive) T cells and the development of intraocular inflammation, and the increased infiltration of the inflamed eye by suppressive NK/NKT cells favors rapid recovery from disease...
  73. ncbi request reprint Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells
    Daigo Hashimoto
    Biopathological Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Immunol 174:551-6. 2005
    ....
  74. ncbi request reprint De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis
    Stephen Mark Tompkins
    Department of Microbiology Immunology and Pathology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 168:4173-83. 2002
    ....
  75. ncbi request reprint Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis
    Jun Qi Yang
    Department of Internal Medicine, Autoimmunity and Tolerance Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 171:2142-53. 2003
    ..These findings suggest that CD1d may play an immunoregulatory role in the development of lupus in the pristane-induced model...
  76. ncbi request reprint Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation
    Jyoti Das
    Nat Med 12:1345-6; author reply 1347. 2006
  77. pmc Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model
    Jun Qi Yang
    University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Arthritis Rheum 56:1219-33. 2007
    ..The purpose of this study was to examine the role of these cells in the development of autoimmune disease in genetically lupus-prone (NZBxNZW)F1 (BWF1) mice...
  78. ncbi request reprint Viral evasion of antigen presentation: not just for peptides anymore
    Luc Van Kaer
    Nat Immunol 7:795-7. 2006
  79. ncbi request reprint Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi
    Monica M Medeiros
    Instituto de Microbiologia Prof Paulo de Goes, Universidade Federal do Rio de Janeiro, CCS Bloco I, 20 andar Sala I2 051, Avenida Carlos Chagas Filho, 373, Cidade Universitaria, Ilha do Fundao, CEP 21941 902, Rio de Janeiro, RJ, Brazil
    J Leukoc Biol 82:488-96. 2007
    ..Together, these results contribute to the understanding of the inflammatory properties of the GIPL molecule, pointing to its potential role as a parasite-derived modulator of the immune response during T. cruzi infection...
  80. doi request reprint Human invariant Valpha24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells
    Ayako Yamaura
    Department of Immunology, Graduate School of Medicine, Yokohama City University, 3 9 Fuku ura, Kanazawa Ku, Yokohama, Japan
    Blood 111:4254-63. 2008
    ..We conclude that the interaction of iNKT cells with tolDCs plays an important role in the immune regulatory network, which might be exploited for therapeutic purposes...
  81. ncbi request reprint Autoreactive T cells mediate NK cell degeneration in autoimmune disease
    Ruolan Liu
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    J Immunol 176:5247-54. 2006
    ..Thus, NK cell degeneration may serve as a means evolved by the immune system to control excessive autoimmunity...
  82. ncbi request reprint NK cells promote islet allograft tolerance via a perforin-dependent mechanism
    Joshua N Beilke
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 Ursula Street, Box B 140, Aurora, Colorado 80010, USA
    Nat Med 11:1059-65. 2005
    ..Together, these results show an obligatory role for NK cells, through perforin, for induction of tolerance to islet allografts...
  83. doi request reprint Lung NKT cell commotion takes your breath away
    Sebastian Joyce
    Nat Med 14:609-10. 2008
  84. ncbi request reprint Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway
    Ming Chen
    Center for Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Immunol 175:1047-55. 2005
    ..This type of response should promote rapid influx of newly generated peptides into the endoplasmic reticulum and preferential presentation of foreign/induced Ag by hepatic class I...
  85. ncbi request reprint Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases
    Hongyan Diao
    Division of Molecular Immunology, Hokkaido University, Sapporo 060 0815, Japan
    Immunity 21:539-50. 2004
    ..These findings identify NKT cell-derived OPN as a novel target for the treatment of inflammatory liver diseases...
  86. ncbi request reprint Natural killer T cells accelerate atherogenesis in mice
    Yukihito Nakai
    Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Blood 104:2051-9. 2004
    ..Collectively, we conclude that NKT cells are proatherogenic in mice...
  87. ncbi request reprint Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice
    Keishi Adachi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 16:787-98. 2004
    ..berghei-induced liver injury. Our studies may have general implications for tissue injuries that are caused by 'bystander killing' or other poorly defined cell-mediated killing mechanisms...
  88. ncbi request reprint Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells
    Martin Mempel
    Unité de Biologie Moléculaire du Gène, Institut National de la Sante et de la Recherche Medicale, Unité 277, Departement d Immunologie, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    J Immunol 168:365-71. 2002
    ....
  89. ncbi request reprint NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice
    Katrin A Mühlen
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 172:3034-41. 2004
    ..Our results demonstrate that NK cells, activated and recruited independently of NKT cells, contribute to PEA-induced T cell-dependent liver injury in mice...
  90. ncbi request reprint Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice
    Jun Qi Yang
    Autoimmunity and Tolerance Laboratory, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 171:4439-46. 2003
    ..Our results indicate that NKT cell deficiency can be corrected by repeated alpha-GalCer treatment and that NKT cells may play a protective role in inflammatory dermatitis of lupus-prone mice...
  91. ncbi request reprint Reciprocal regulation between natural killer cells and autoreactive T cells
    Fu Dong Shi
    Barrow Neurological Institute, Saint Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Nat Rev Immunol 6:751-60. 2006
    ..Understanding the mechanisms and signals that control the reciprocal regulation of NK cells and autoreactive T cells could have important implications for treatment in the clinic...

Research Grants17

  1. Mechanisms and consequences of iNKT cell anergy
    Luc Van Kaer; Fiscal Year: 2010
    ..g., type 1 diabetes, multiple sclerosis and lupus), allergic and inflammatory (e.g., atherosclerosis) diseases. ..
  2. Glycolipid-Reactive NKT Cells, Obesity and Insulin Resistance
    Lan Wu; Fiscal Year: 2010
    ..Page 1 ..
  3. Modulation of chronic vascular inflammation by iNKT cells
    Luc Van Kaer; Fiscal Year: 2010
    ..The results from these proposed studies will be instrumental for the development of novel preventive measures and therapies for blood vessel diseases and their complications (e.g., heart disease and stroke). ..
  4. Mechanisms and consequences of iNKT cell anergy
    Luc Van Kaer; Fiscal Year: 2007
    ..g., type 1 diabetes, multiple sclerosis and lupus), allergic and inflammatory (e.g., atherosclerosis) diseases. ..
  5. Modulation of type I diabetes with NKT cells
    Luc Van Kaer; Fiscal Year: 2006
    ..These studies will provide a better understanding of the immunological mechanisms that result in autoimmunity, and may lead to the development of novel agents for treatment of type I diabetes and other autoimmune diseases. ..
  6. Modulation of EAE with ligand-activated NKT cells
    Luc Van Kaer; Fiscal Year: 2005
    ..These reagents will permit the selective activation of distinct adaptive immune responses in vivo, which could be exploited for therapeutic intervention in MS and other human autoimmune diseases. ..
  7. Modulation of chronic vascular inflammation by iNKT cells
    Luc Van Kaer; Fiscal Year: 2011
    ..The results from these proposed studies will be instrumental for the development of novel preventive measures and therapies for blood vessel diseases and their complications (e.g., heart disease and stroke). ..