Luc Van Kaer

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. Van Kaer L, Wu L, Joyce S. Mechanisms and Consequences of Antigen Presentation by CD1. Trends Immunol. 2016;37:738-754 pubmed publisher
    ....
  2. Van Kaer L, Algood H, Singh K, Parekh V, Greer M, Piazuelo M, et al. CD8??? innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Immunity. 2014;41:451-464 pubmed publisher
    ..These findings suggest a critical role of iCD8? cells in immune responses associated with the intestinal epithelium. ..
  3. Van Kaer L, Parekh V, Postoak J, Wu L. Role of autophagy in MHC class I-restricted antigen presentation. Mol Immunol. 2017;: pubmed publisher
    ..A mechanistic understanding of the role of autophagy-related proteins in MHC class I restricted antigen presentation may guide future efforts in manipulating autophagy to prevent or treat human disease. ..
  4. Van Kaer L, Parekh V, Wu L. Invariant natural killer T cells as sensors and managers of inflammation. Trends Immunol. 2013;34:50-8 pubmed publisher
    ..These new findings should be instrumental to promote the immunomodulatory properties of iNKT cells for treatment of inflammatory diseases. ..
  5. Parekh V, Pabbisetty S, Wu L, Sebzda E, Martinez J, Zhang J, et al. Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8?+ dendritic cells. Proc Natl Acad Sci U S A. 2017;114:E6371-E6380 pubmed publisher
    ..Our findings also have important implications for the development of small-molecule inhibitors of Vps34 for therapeutic purposes. ..
  6. Olivares Villagómez D, Van Kaer L. Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier. Trends Immunol. 2017;: pubmed publisher
    ..We review here sentinel functions of IELs in the maintenance of the mucosal barrier integrity, as well as how dysregulated IEL responses can contribute to pathology...

Detail Information

Publications6

  1. Van Kaer L, Wu L, Joyce S. Mechanisms and Consequences of Antigen Presentation by CD1. Trends Immunol. 2016;37:738-754 pubmed publisher
    ....
  2. Van Kaer L, Algood H, Singh K, Parekh V, Greer M, Piazuelo M, et al. CD8??? innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Immunity. 2014;41:451-464 pubmed publisher
    ..These findings suggest a critical role of iCD8? cells in immune responses associated with the intestinal epithelium. ..
  3. Van Kaer L, Parekh V, Postoak J, Wu L. Role of autophagy in MHC class I-restricted antigen presentation. Mol Immunol. 2017;: pubmed publisher
    ..A mechanistic understanding of the role of autophagy-related proteins in MHC class I restricted antigen presentation may guide future efforts in manipulating autophagy to prevent or treat human disease. ..
  4. Van Kaer L, Parekh V, Wu L. Invariant natural killer T cells as sensors and managers of inflammation. Trends Immunol. 2013;34:50-8 pubmed publisher
    ..These new findings should be instrumental to promote the immunomodulatory properties of iNKT cells for treatment of inflammatory diseases. ..
  5. Parekh V, Pabbisetty S, Wu L, Sebzda E, Martinez J, Zhang J, et al. Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8?+ dendritic cells. Proc Natl Acad Sci U S A. 2017;114:E6371-E6380 pubmed publisher
    ..Our findings also have important implications for the development of small-molecule inhibitors of Vps34 for therapeutic purposes. ..
  6. Olivares Villagómez D, Van Kaer L. Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier. Trends Immunol. 2017;: pubmed publisher
    ..We review here sentinel functions of IELs in the maintenance of the mucosal barrier integrity, as well as how dysregulated IEL responses can contribute to pathology...