Research Topics
| Charles W StrattonSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
In vitro susceptibility testing versus in vivo effectivenessCharles W Stratton
Vanderbilt University School of Medicine, 21st and Edgehill Road, Nashville, TN 37232, USA
Med Clin North Am 90:1077-88. 2006..Finally, the clinical microbiology laboratory has advanced with improved methods as well as the adaptation of breakpoints that are more realistic...
Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniaeCharles W Stratton
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Trends Microbiol 14:474-9. 2006..MS might be an infectious syndrome in which C. pneumoniae has a role in a subset of patients. Mechanisms by which such a cryptic infection could engender relapsing-remitting and, ultimately, progressive disease patterns are discussed...
Comparative in vitro activity of telithromycin and beta-lactam antimicrobials against community-acquired bacterial respiratory tract pathogens in the United States: findings from the PROTEKT US study, 2000-2001Charles W Stratton
Clinical Microbiology Laboratory, Vanderbilt University School of Medicine, Vanderbilt University Hospital, Nashville, TN 37201, USA
Clin Ther 26:522-30. 2004....
Antimicrobial resistance in respiratory tract pathogensCharles W Stratton
Medicine and Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Expert Rev Anti Infect Ther 2:641-7. 2004..Recognition of these resistance mechanisms allows them to be targeted, such as with beta-lactamase inhibitors. Newly recognized resistance mechanisms such as efflux may also be targeted in the future...
StaphPlex system for rapid and simultaneous identification of antibiotic resistance determinants and Panton-Valentine leukocidin detection of staphylococci from positive blood culturesYi Wei Tang
Department of Medicine, Molecular Infectious Disease Laboratory, Vanderbilt University Hospital, 4605 TVC, Nashville, TN 37232 5310, USA
J Clin Microbiol 45:1867-73. 2007....
Characterization of three Staphylococcus aureus isolates from a 17-year-old female who died of tampon-related toxic shock syndromeYi Wei Tang
Department of Pathology, Vanderbilt University Medical Center, and Molecular Infectious Disease Laboratory, Vanderbilt University Hospital, 4605 TVC, Nashville, TN 37232 5310, USA
J Clin Microbiol 48:1974-7. 2010....
Qualitative and quantitative detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid from multiple sclerosis patients and controlsYi Wei Tang
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 4:e5200. 2009..pneumoniae DNA in CSF. The TaqMan system may not be sensitive enough for diagnostic purposes due to the low C. pneumoniae copies existing in the majority of CSF specimens from MS patients...
Staphylococcus pseudolugdunensis sp. nov., a pyrrolidonyl arylamidase/ornithine decarboxylase-positive bacterium isolated from blood culturesYi Wei Tang
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Diagn Microbiol Infect Dis 60:351-9. 2008..On the basis of the close biochemical reactions with S. lugdunensis and phylogenetic evidence, these isolates are proposed the designation Staphylococcus pseudolugdunensis sp. nov...
Clonal dissemination of Staphylococcus epidermidis in an oncology wardKenneth L Muldrew
Department of Pathology, Vanderbilt University, School of Medicine, Nashville, Tennessee, USA
J Clin Microbiol 46:3391-6. 2008..This study demonstrates the presence of a predominant clone among central line isolates from an OW that is not present in CoNS venipuncture isolates from an ER...
Comparative evaluation of Bruker Biotyper and BD Phoenix systems for identification of bacterial pathogens associated with urinary tract infectionsYingjun Yan
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Clin Microbiol 49:3936-9. 2011..9% and 99.5% to the genus level and 99.1% and 98.5% to the species level, respectively. Both systems provide reliable results, and the Biotyper system offers a rapid tool for urine bacterial isolate identification...
Identification and differentiation of clinically relevant mycobacterium species directly from acid-fast bacillus-positive culture brothHaijing Li
Departments of Pathology1 and Medicine, 2 Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Clin Microbiol 47:3814-20. 2009..intracellulare complex strains into M. avium and M. intracellulare may provide a tool to better understand the role of Mycobacterium avium-M. intracellulare complex isolates in human disease...
Assessment of Clostridium difficile infections by quantitative detection of tcdB toxin by use of a real-time cell analysis systemAlex B Ryder
Departments of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5310, USA
J Clin Microbiol 48:4129-34. 2010..89 ng/ml) were significantly lower than those prior to the treatment (15.68 ng/ml, Wilcoxon P = 0.01). The study demonstrates that the RTCA assay provides a functional tool for the potential assessment of C. difficile infections...
Mass spectrometry biotyper system identifies enteric bacterial pathogens directly from colonies grown on selective stool culture mediaYing He
Departments of Pathology and Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, 5310, USA
J Clin Microbiol 48:3888-92. 2010..The Biotyper system provides a rapid and simple screening tool for identifying many, but not all, suspicious colonies grown on selective media within 24 h after inoculation, which shortens test turnaround time by 2 to 3 days...
Management of immune dysfunction after adult cardiac surgeryJ Scott Rankin
Centennial Medical Center, Nashville, Tenn, USA
J Thorac Cardiovasc Surg 142:575-80. 2011..In this series, results of immune augmentation were assessed in patients experiencing pulmonary dysfunction/multiorgan failure syndrome after cardiac surgery...
C. Diff Quik Chek complete enzyme immunoassay provides a reliable first-line method for detection of Clostridium difficile in stool specimensCriziel D Quinn
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Microbiol 48:603-5. 2010..Specimens with discrepant results for GDH and toxins A/B, which comprised 13.2% of the specimens, need to be retested...
Dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistanceCharles W Stratton
Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Emerg Infect Dis 9:10-6. 2003..Moreover, the ketolides are associated with a low potential for inducing resistance, making them promising first-line agents for respiratory tract infections...
Antimicrobial susceptibility patterns and staphylococcal cassette chromosome mec types of, as well as Panton-Valentine leukocidin occurrence among, methicillin-resistant Staphylococcus aureus isolates from children and adults in middle TennesseeAbdullah Kilic
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-5310, USA
J Clin Microbiol 44:4436-40. 2006..These data indicate that SCCmec-IV MRSA isolates frequently infect children in middle Tennessee and are likely to harbor the PVL gene...
Improved identification of yeast species directly from positive blood culture media by combining Sepsityper specimen processing and Microflex analysis with the matrix-assisted laser desorption ionization Biotyper systemYingjun Yan
Department of Pathology and Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 5310, USA
J Clin Microbiol 49:2528-32. 2011..Our data indicated that the Sepsityper specimen processing and Microflex analysis by the MALDI Biotyper system provide a rapid and reliable tool for yeast species identification directly from positive blood culture media...
Peripheral blood eosinophilia as a clue to the diagnosis of an occult Coccidioides infectionChristopher M Simons
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Hum Pathol 42:449-53. 2011....
Urine polymerase chain reaction is not as sensitive as urine antigen for the diagnosis of disseminated histoplasmosisYi Wei Tang
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Diagn Microbiol Infect Dis 54:283-7. 2006..Thus, positive PCR results in urine specimens correlate with positive culture results, but not with antigenuria. The low sensitivity of this PCR assay in urine limits its use in the diagnosis of disseminated histoplasmosis...
Staphylococcus aureus: An old pathogen with new weaponsYi Wei Tang
Department of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Clin Lab Med 30:179-208. 2010..This article addresses the emerging aspects of infections caused by S aureus, including microbiology, epidemiology, clinical presentation, pathogenesis, diagnosis, treatment and prognosis, and immunity...
The risk of valve surgery for endocarditis in patients with dialysis-dependent renal failureJ Scott Rankin
Centennial Medical Center, Nashville, TN, USA
J Heart Valve Dis 16:617-22; discussion 622. 2007..The study aim was to develop a simple risk scoring system to identify high-risk dialysis patients undergoing valve surgery for endocarditis...
Association of Chlamydia pneumoniae with central nervous system diseaseCharles W Stratton
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
Microbes Infect 5:1249-53. 2003..This review addresses the potential and the underlying mechanisms by which C. pneumoniae infections can play a role in such diverse neurological diseases as multiple sclerosis and Alzheimer's disease...
Coccidioides, cryptococcus, or blastomyces? A diagnostic dilemma encountered during frozen section evaluationColt M McClain
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
Pediatr Dev Pathol 15:71-5. 2012..A brief overview of Blastomyces , including histopathologic features and key microscopic differences from Coccidioides and Cryptococcus , is discussed...
Immunotherapy for refractory pulmonary infection after adult cardiac surgery: immune dysregulation syndromeJ Scott Rankin
Department of Cardiac Surgery, Vanderbilt University, 2400 Patterson Street, Suite 103, Nashville, TN 37203, USA
J Heart Valve Dis 14:783-91. 2005..Moreover, the incidence of PD/MF may be increasing due to the emergence of antibiotic-resistant pathogens...
Sensitive, qualitative detection of human herpesvirus-6 and simultaneous differentiation of variants A and BHaijing Li
Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States
J Clin Virol 46:20-3. 2009..The current limitations of laboratory testing for the detection of human herpesvirus virus 6 (HHV-6) in clinical specimens with low HHV-6 viral loads make this area a priority for further research and development...
Complex febrile seizures followed by complete recovery in an infant with high-titer 2009 pandemic influenza A (H1N1) virus infectionMandy F O'Leary
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Microbiol 48:3803-5. 2010..Febrile seizures may be a complication in young children experiencing infection with high viral loads of 2009 H1N1 influenza virus...
PCR detection of Histoplasma capsulatum var. capsulatum in whole blood of a renal transplant patient with disseminated histoplasmosisJulianne Qualtieri
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Ann Clin Lab Sci 39:409-12. 2009..Blood fungal cultures in this case remained negative, suggesting that molecular assays may facilitate the laboratory diagnosis of disseminated histoplasmosis...
Outbreak of joint and soft-tissue infections associated with injections from a multiple-dose medication vialDavid L Kirschke
Epidemiology Program Office, Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA and Tennessee Department of Health, Nashville, TN, USA
Clin Infect Dis 36:1369-73. 2003..aureus in MDVs of lidocaine revealed prolonged survival at refrigerator temperatures. This outbreak highlights the importance of strict attention to aseptic procedures and carefully following manufacturers' instructions when using MDVs...
Culture and immunohistochemical evidence of Chlamydia pneumoniae infection in ulcerative pyoderma gangrenosumHunter H Sams
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennesses, USA
J Am Acad Dermatol 48:966-9. 2003....
Molecular diagnosis of necrotizing fasciitis by 16S rRNA gene sequencing and superantigen gene detectionKenneth L Muldrew
Molecular Infectious Disease Laboratory, Vanderbilt University Hospital, 4605 TVC, Nashville, TN 37232-5310, USA
J Mol Diagn 7:641-5. 2005..This confirmed the etiology of the patient's rapid deterioration with multisystem organ failure...
Acinetobacter septicus sp. nov. association with a nosocomial outbreak of bacteremia in a neonatal intensive care unitAbdullah Kilic
Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy and School of Medicine, 06018 Ankara, Turkey
J Clin Microbiol 46:902-8. 2008..We propose the designation of Acinetobacter septicus sp. nov. for these isolates, with isolate AK001 as the type strain...
Chlamydia pneumoniae and acute coronary syndromeWilliam M Mitchell
N Engl J Med 353:525-8; author reply 525-8. 2005
Pseudomonas putida septicemia in a special care nursery due to contaminated flush solutions prepared in a hospital pharmacyJoseph F Perz
Centers for Disease Control and Prevention, Office of Workforce and Career Development, Epidemic Intelligence Service, Atlanta, Georgia 30333, USA
J Clin Microbiol 43:5316-8. 2005..These findings highlight the need for compliance with current standards of aseptic technique and quality assurance during the preparation of compounded sterile products...
Clonal spread of serogroup W135 meningococcal disease in TurkeyAbdullah Kilic
Gulhane Military Medical Academy, Ankara, Turkey
J Clin Microbiol 44:222-4. 2006..These data demonstrate that serogroup W135 meningococci with different genotypes, including the Hajj epidemic strain, are endemic in Turkey...
PCR Enhances acid-fast bacillus stain-based rapid detection of Mycobacterium tuberculosisYi-Wei Tang
J Clin Microbiol 42:1849-50. 2004
