Subramaniam Sriram

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis
    Fanglin Zhang
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16795. 2011
  2. doi request reprint Role of glial cells in innate immunity and their role in CNS demyelination
    Subramaniam Sriram
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neuroimmunol 239:13-20. 2011
  3. ncbi request reprint Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis
    Subramaniam Sriram
    Department of Neurology, Vanderbilt Medical Center, Nashville, TN 37212, USA
    Ann Neurol 58:939-45. 2005
  4. ncbi request reprint Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis
    Subramaniam Sriram
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Infect Dis 192:1219-28. 2005
  5. ncbi request reprint Pilot study to examine the effect of antibiotic therapy on MRI outcomes in RRMS
    S Sriram
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Neurol Sci 234:87-91. 2005
  6. doi request reprint Activation of NOD2/RIPK2 pathway induces mitochondrial injury to oligodendrocyte precursor cells in vitro and CNS demyelination in vivo
    Chandramohan Natarajan
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Neuroimmunol 265:51-60. 2013
  7. pmc Qualitative and quantitative detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid from multiple sclerosis patients and controls
    Yi Wei Tang
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 4:e5200. 2009
  8. doi request reprint Astrogliopathy and oligodendrogliopathy are early events in CNS demyelination
    Fanglin Zhang
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Glia 61:1261-73. 2013
  9. ncbi request reprint Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamine
    Song yi Yao
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neuroimmunol 200:17-26. 2008
  10. pmc Chlamydia pneumoniae infection of the central nervous system worsens experimental allergic encephalitis
    Caigan Du
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Exp Med 196:1639-44. 2002

Research Grants

  1. ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MS
    Subramaniam Sriram; Fiscal Year: 2000
  2. ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MS
    Subramaniam Sriram; Fiscal Year: 2001
  3. ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MS
    Subramaniam Sriram; Fiscal Year: 2002
  4. Novel oral therapeutics for multiple sclerosis
    Subramaniam Sriram; Fiscal Year: 2006

Collaborators

Detail Information

Publications30

  1. pmc Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis
    Fanglin Zhang
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16795. 2011
    ..While increased expression of HDAC3 is seen in neoplastic cells, the role of HDAC3 in T cells and their role in autoimmune disease is not known...
  2. doi request reprint Role of glial cells in innate immunity and their role in CNS demyelination
    Subramaniam Sriram
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neuroimmunol 239:13-20. 2011
    ..We propose that activation pathways of receptors of the innate immune system present on oligodendrocytes and astrocytes rather than microglia are central to the pathogenesis of demyelination seen in MS...
  3. ncbi request reprint Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis
    Subramaniam Sriram
    Department of Neurology, Vanderbilt Medical Center, Nashville, TN 37212, USA
    Ann Neurol 58:939-45. 2005
    ..We propose to reconsider the utilization of EAE, especially when this model is used to define therapy. This will also force us to examine MS without the restraints imposed by EAE, as to what it is, rather than what it looks like...
  4. ncbi request reprint Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis
    Subramaniam Sriram
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Infect Dis 192:1219-28. 2005
    ..Results of studies using these different approaches support our suspicion of the presence of chlamydial organisms in the CNS, in a subset of patients with MS...
  5. ncbi request reprint Pilot study to examine the effect of antibiotic therapy on MRI outcomes in RRMS
    S Sriram
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Neurol Sci 234:87-91. 2005
    ..The reduction in atrophy in patients receiving antibiotics must be viewed with caution, due to the small number of patients studied...
  6. doi request reprint Activation of NOD2/RIPK2 pathway induces mitochondrial injury to oligodendrocyte precursor cells in vitro and CNS demyelination in vivo
    Chandramohan Natarajan
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Neuroimmunol 265:51-60. 2013
    ..Taken together, these results suggest that PGN induced formation of NO, mitochondrial dysfunction and accumulation of N-tyrosinylated proteins in oligodendrocytes are likely mediators of central nervous system demyelination...
  7. pmc Qualitative and quantitative detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid from multiple sclerosis patients and controls
    Yi Wei Tang
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 4:e5200. 2009
    ..pneumoniae DNA in CSF. The TaqMan system may not be sensitive enough for diagnostic purposes due to the low C. pneumoniae copies existing in the majority of CSF specimens from MS patients...
  8. doi request reprint Astrogliopathy and oligodendrogliopathy are early events in CNS demyelination
    Fanglin Zhang
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Glia 61:1261-73. 2013
    ..We believe that the innate immune model of oligodendrocyte death will be useful in the development of neuroprotective agents capable of rescuing oligodendrocytes from apoptosis...
  9. ncbi request reprint Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamine
    Song yi Yao
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neuroimmunol 200:17-26. 2008
    ..The increase in HIF-1 alpha was due to increased protein stability that was mediated by activation of the ERK-MAP kinase pathway...
  10. pmc Chlamydia pneumoniae infection of the central nervous system worsens experimental allergic encephalitis
    Caigan Du
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Exp Med 196:1639-44. 2002
    ..pneumoniae results in localized infection in CNS tissues in animals with EAE. We propose that infection of the CNS by C. pneumoniae can amplify the autoreactive pool of lymphocytes and regulate the expression of an autoimmune disease...
  11. pmc Identification and characterization of the interferon-beta-mediated p53 signal pathway in human peripheral blood mononuclear cells
    Fanglin Zhang
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Immunology 128:e905-18. 2009
    ..These observations suggest that, in spite of the activation of a number of mutually overlapping pathways mediating cell death, cell cycle arrest was the most evident consequence of IFN-beta signalling in PBMC...
  12. ncbi request reprint Defective ATM-p53-mediated apoptotic pathway in multiple sclerosis
    Xinqing Deng
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
    Ann Neurol 58:577-84. 2005
    ..We predict that these fundamental defects likely alter the regulation of the immune population of cells in MS and may contribute to the development or progression of the disease...
  13. ncbi request reprint Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-alpha-mediated cell death
    Song yi Yao
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci Res 86:2403-13. 2008
    ..13 cells, when cultured with TNFalpha after a period of preconditioning by DFO or CoCl(2). These studies suggest that compoundsthat increase HIF-1alpha can function as neuroprotective agents in inflammatory disorders of the CNS...
  14. ncbi request reprint Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia
    Chandramohan Natarajan
    Department of Neurology and Pharmacology, Vanderbilt University Medical Center, 1222F VSRH, 2201 Capers Avenue, Nashville, TN 37212, USA
    Glia 45:188-96. 2004
    ..These findings highlight the fact that JAK2-STAT5 signaling pathway plays a critical role in mediating IL-3-induced activation of microglia...
  15. doi request reprint Diagnostic and therapeutic aspects of Hashimoto's encephalopathy
    Inan Olmez
    Vanderbilt University, Department of Neurology, Nashville, TN 37232, USA
    J Neurol Sci 331:67-71. 2013
    ..To share our experience on clinical presentation and management of patients diagnosed with Hashimoto's Encephalopathy (HE) at Vanderbilt Medical Center between 1999 and 2012...
  16. pmc Comparative study of the presence of Chlamydia pneumoniae in cerebrospinal fluid of Patients with clinically definite and monosymptomatic multiple sclerosis
    Subramaniam Sriram
    Department of Neurology Department of Pathology, Vanderbilt School of Medicine, Nashville, Tennessee, USA
    Clin Diagn Lab Immunol 9:1332-7. 2002
    ..pneumoniae in the CSF of MS patients. The presence of C. pneumoniae in patients with monosymptomatic MS would also suggest that infection with the organism occurs early in the course of the disease...
  17. ncbi request reprint Analysis of T2 intensity by magnetic resonance imaging of deep gray matter nuclei in multiple sclerosis patients: effect of immunomodulatory therapies
    Siddharama Pawate
    Multiple Sclerosis Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Neuroimaging 22:137-44. 2012
    ..To investigate differences in T2 intensity of deep gray matter (dGM) structures by magnetic resonance imaging (MRI) in multiple sclerosis (MS) patients undergoing various immunomodulatory therapies...
  18. ncbi request reprint Association of Chlamydia pneumoniae with central nervous system disease
    Charles W Stratton
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    Microbes Infect 5:1249-53. 2003
    ..This review addresses the potential and the underlying mechanisms by which C. pneumoniae infections can play a role in such diverse neurological diseases as multiple sclerosis and Alzheimer's disease...
  19. pmc Automated extraction of clinical traits of multiple sclerosis in electronic medical records
    Mary F Davis
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Am Med Inform Assoc 20:e334-40. 2013
    ..We evaluated natural language processing techniques applied to electronic medical records (EMR) to identify MS patients and the key clinical traits of their disease course...
  20. doi request reprint Adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia: report of five cases and a new mutation
    Kirk Kleinfeld
    Department of Neurology, Vanderbilt Multiple Sclerosis Center, Vanderbilt University Medical Center, 719 Thompson Lane 24100, Nashville, TN 37204, USA
    J Neurol 260:558-71. 2013
    ..Diagnosis may be made without histopathological evidence when a disease-causing mutation is demonstrated in the CSF1R gene...
  21. pmc Development of chemical exchange saturation transfer at 7 T
    Adrienne N Dula
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    Magn Reson Med 66:831-8. 2011
    ..These results indicate the potential utility of APT at high field as a noninvasive biomarker of white matter pathology, providing complementary information to other MRI methods in current clinical use...
  22. ncbi request reprint Role of microglia in multiple sclerosis
    Xinqing Deng
    Multiple Sclerosis Research Laboratory, 1222H Vanderbilt Stallworth Rehabilitation Hospital, Nashville, TN 37212, USA
    Curr Neurol Neurosci Rep 5:239-44. 2005
    ..This review examines the current controversies on the pathology of multiple sclerosis and the role played by microglia in the development of central nervous system demyelination...
  23. doi request reprint The spectrum of Susac's syndrome
    Siddharama Pawate
    Multiple Sclerosis Center, Department of Neurology, Vanderbilt University Medical Center, 2201 Childrens Way Room 1222, Nashville, TN 37211, USA
    Neurol Sci 30:59-64. 2009
    ..We also report the variable cerebrospinal fluid and brain magnetic resonance imaging findings, and treatment using a combination of steroids and intravenous immunoglobulin, followed by mycophenolate mofetil...
  24. pmc Identification of molecular biomarkers for multiple sclerosis
    Sallyanne C Fossey
    Department of Pathology, Vanderbilt University School of Medicine, Nashvill, Tennessee, USA
    J Mol Diagn 9:197-204. 2007
    ..This approach may have diagnostic utility not only for multiple sclerosis but also for other clinically complex autoimmune diseases...
  25. ncbi request reprint Gray matter involvement in multiple sclerosis
    Istvan Pirko
    Department of Neurology, University of Cincinnati, OH, USA
    Neurology 68:634-42. 2007
    ..However, continued studies of GM pathology as well as neuronal and axonal involvement in MS and related experimental models are necessary to better understand the etiology and pathogenesis of the degenerative components...
  26. ncbi request reprint TRAPS and MS: two diseases or an MS mimic?
    Subramaniam Sriram
    Neurology 70:1077-8. 2008
  27. ncbi request reprint In regard to Miller et al.: Multiple sclerosis, brain radiotherapy and risk of neurotoxicity: the Mayo Clinic experience (Int J Radiat Oncol Biol Phys 2006;66:1178-1186)
    Subramaniam Sriram
    Int J Radiat Oncol Biol Phys 68:960-1; author reply 961. 2007
  28. ncbi request reprint Infectious causes of multiple sclerosis
    Gavin Giovannoni
    Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Lancet Neurol 5:887-94. 2006
  29. ncbi request reprint CNS infection with C. pneumoniae complicated by multiple strokes
    Subramaniam Sriram
    J Neurol 250:1127; author reply 1128. 2003
  30. ncbi request reprint Increased severity of experimental allergic encephalomyelitis in lyn-/- mice in the absence of elevated proinflammatory cytokine response in the central nervous system
    Caigan Du
    Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Immunol 168:3105-12. 2002
    ..These observations underscore the potential role of lyn in regulation of Th1-mediated disease and the role of autoantibodies and complement in the development of EAE...

Research Grants5

  1. ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MS
    Subramaniam Sriram; Fiscal Year: 2000
    ..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
  2. ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MS
    Subramaniam Sriram; Fiscal Year: 2001
    ..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
  3. ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MS
    Subramaniam Sriram; Fiscal Year: 2002
    ..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
  4. Novel oral therapeutics for multiple sclerosis
    Subramaniam Sriram; Fiscal Year: 2006
    ....