Research Topics
| Kurt SpindlerSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Current concepts review: revision anterior cruciate ligament reconstructionMichael S George
Vanderbilt Sports Medicine, Vanderbilt Orthopaedic Institute, 4200 Medical Center East, South Tower, Nashville, TN 37232-8774, USA
Am J Sports Med 34:2026-37. 2006..Published outcomes of revision ACL reconstruction have been worse than for primary ACL reconstruction. The preoperative evaluation, surgical techniques, and clinical outcomes of revision ACL reconstruction are reviewed...
Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studiesKurt P Spindler
Vanderbilt University Medical Center, 4200 Medical Center East, South Tower, 1215 21st Avenue South, Nashville, Tennessee 37232 8774, USA
J Orthop Res 31:2-9. 2013..This manuscript summarizes the Kappa Delta Ann Doner Vaughan Award paper and presentation at the 2012 ORS/AAOS Annual Meeting...
Return to high school- and college-level football after anterior cruciate ligament reconstruction: a Multicenter Orthopaedic Outcomes Network (MOON) cohort studyKirk A McCullough
Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Sports Med 40:2523-9. 2012....
The rationale for identifying clinical predictors modifiable by tissue engineering for translational modelsKurt P Spindler
Department of Orthopaedics, Vanderbilt University, Vanderbilt Sports Medicine, Nashville, Tennessee 37232 8774, USA
Tissue Eng Part B Rev 16:117-21. 2010..TE could promote repair of torn meniscus and/or replacement of meniscus loss because meniscus tear is a proven predictor of clinically relevant outcomes (such as osteoarthritis) in patients and is amenable to a potential TE solution...
Anterior cruciate ligament reconstruction autograft choice: bone-tendon-bone versus hamstring: does it really matter? A systematic reviewKurt P Spindler
Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Sports Med 32:1986-95. 2004..With numbers available, failure rates were not significantly different between groups. These findings suggest that graft type may not be the primary determinant for successful outcomes after anterior cruciate ligament surgery...
The prognosis and predictors of sports function and activity at minimum 6 years after anterior cruciate ligament reconstruction: a population cohort studyKurt P Spindler
Vanderbilt Sports Medicine, 4200 Medical Center East, South Tower, 1215 21st Ave South, Nashville, TN 37232 8774, USA
Am J Sports Med 39:348-59. 2011..The predictors of anterior cruciate ligament reconstruction (ACLR) outcome at 6 years as measured by validated patient-based outcome instruments are unknown...
The central ACL defect as a model for failure of intra-articular healingK P Spindler
Vanderbilt Orthopaedic Institute, Vanderbilt University Medical Center East, South Tower, Ste 4200, Nashville, Tennessee 37232 8774, USA
J Orthop Res 24:401-6. 2006....
Clinical outcome at a minimum of five years after reconstruction of the anterior cruciate ligamentKurt P Spindler
Department of Orthopaedics and Rehabilitation, Vanderbilt University, Nashville, Tennessee 37232-8774, USA
J Bone Joint Surg Am 87:1673-9. 2005..Suggestions regarding weight control and future education may improve intermediate-term outcomes...
DTI-based muscle fiber tracking of the quadriceps mechanism in lateral patellar dislocationJ Herman Kan
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232, USA
J Magn Reson Imaging 29:663-70. 2009..To determine the feasibility of using diffusion tensor MRI (DT-MRI) -based muscle fiber tracking to create biomechanical models of the quadriceps mechanism in healthy subjects and those with chronic lateral patellar dislocation (LPD)...
Ethics in sports medicineWarren R Dunn
Vanderbilt Sports Medicine Center, Nashville, Tennessee, USA
Am J Sports Med 35:840-4. 2007..Unfortunately, there is no widely accepted code of sports medicine ethics that adequately addresses these issues...
A systematic review of anterior cruciate ligament reconstruction with autograft compared with allograftJames L Carey
Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Bone Joint Surg Am 91:2242-50. 2009..This systematic review and meta-analysis investigated whether the short-term clinical outcomes of anterior cruciate reconstruction with allograft were significantly different from those with autograft...
Pharmacologic agents in fracture healingMichael C Koester
Vanderbilt Sports Medicine, Medical Center East, Nashville, TN 37232, USA
Clin Sports Med 25:63-73, viii. 2006..Large randomized clinical trials are needed to further delineate the role of these and other drugs and their effects on fracture healing...
Which preoperative factors, including bone bruise, are associated with knee pain/symptoms at index anterior cruciate ligament reconstruction (ACLR)? A Multicenter Orthopaedic Outcomes Network (MOON) ACLR Cohort StudyWarren R Dunn
Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical School, Nashville, TN 37232 8300, USA
Am J Sports Med 38:1778-87. 2010..Increased knee pain at the time of anterior cruciate ligament reconstruction may potentially predict more difficult rehabilitation, prolonged recovery, and/or be predictive of increased knee pain at 2 years...
Interobserver agreement in the classification of rotator cuff tearsJohn E Kuhn
Division of Sports Medicine and Shoulder Surgery, Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Sports Med 35:437-41. 2007..Six classification systems have been proposed for describing rotator cuff tears designed to help understand their natural history and make treatment decisions...
The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligamentKurt P Spindler
Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 2601 Jess Neely Drive, Nashville, TN 37212, USA
J Orthop Res 21:245-9. 2003..This study suggests the mechanical stiffness, but not the load at failure, of ligament scar can be significantly altered by the administration of TGF-beta 2...
Endoscopic versus rear-entry ACL reconstruction: a systematic reviewMichael S George
Vanderbilt University Medical Center, Nashville, TN 37232 8774, USA
Clin Orthop Relat Res 455:158-61. 2007..Overall, these studies show similar outcomes comparing the all-endoscopic and rear-entry anterior cruciate ligament reconstruction techniques...
Intraarticular injuries associated with anterior cruciate ligament tear: findings at ligament reconstruction in high school and recreational athletes. An analysis of sex-based differencesDana P Piasecki
Vanderbilt Sports Medicine Center, Nashville, Tennessee 37212, USA
Am J Sports Med 31:601-5. 2003..If such intraarticular injuries prove to be a significant risk factor for poor long-term outcome, women may enjoy a better prognosis after reconstruction...
Comparison of fresh osteochondral autografts and allografts: a canine modelR Edward Glenn
Department of Orthopaedics and Rehabilitation, Vanderbilt Sports Medicine Center, Nashville, TN 37232, USA
Am J Sports Med 34:1084-93. 2006..CLINICAL RELEVANCE: The use of fresh allograft tissue to treat osteochondral defects eliminates morbidity associated with harvesting autograft tissue without compromising the results of the surgical procedure...
Cross-cultural comparison of patients undergoing ACL reconstruction in the United States and NorwayRobert A Magnussen
Vanderbilt University Medical Center, Nashville, TN 37232 8774, USA
Knee Surg Sports Traumatol Arthrosc 18:98-105. 2010..Surgeons should investigate and consider the characteristics of these cohorts when applying knowledge gleaned from these groups to their own patient populations...
The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction modelKurt P Spindler
Vanderbilt Sports Medicine, Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Orthop Res 27:631-8. 2009..These findings emphasize the importance of further research on delineating the effect of platelets in treating of ACL injuries...
Treatment of focal articular cartilage defects in the knee: a systematic reviewRobert A Magnussen
Vanderbilt Orthopaedic Institute, 4200 Medical Center East, 1215 21st Avenue South, Suite 4200, Nashville, TN, 37232 8774, USA
Clin Orthop Relat Res 466:952-62. 2008..LEVEL OF EVIDENCE: Level II, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence...
Meniscal tears in athletesCharles L Cox
Vanderbilt Sports Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8774, USA
J Surg Orthop Adv 18:2-8. 2009..Meniscus tears in athletes display a variety of clinical presentations. Three different case scenarios are presented along with diagnoses and treatment options, and the best available evidence, at present, is reviewed...
The Multicenter ACL Revision Study (MARS): a prospective longitudinal cohort to define outcomes and independent predictors of outcomes for revision anterior cruciate ligament reconstructionKurt P Spindler
Vanderbilt Sports Medicine, 4200 Medical Center East, South Tower, 1215 21st Ave South, Ste 4200, Nashville, TN 37232-8774, USA
J Knee Surg 20:303-7. 2007
NSAIDs and fracture healing: what's the evidence?Michael C Koester
Vanderbilt Sports Medicine, Suite 4200 Medical Center East, South Tower, 1215 21st Avenue South, Nashville, TN 37232 8774, USA
Curr Sports Med Rep 4:289-90. 2005
Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine modelBraden C Fleming
Department of Orthopaedics, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
Am J Sports Med 37:1554-63. 2009..The outcome of anterior cruciate ligament (ACL) reconstruction is variable, and many patients have increased joint laxity postoperatively...
Meniscus status at anterior cruciate ligament reconstruction associated with radiographic signs of osteoarthritis at 5- to 10-year follow-up: a systematic reviewRobert A Magnussen
Department of Orthopaedic Surgery, Division of Sports Medicine, Vanderbilt University Medical Center, Vanderbilt Sports Medicine Center, Nashville, Tenn, USA
J Knee Surg 22:347-57. 2009..Meniscal repair resulted in inconsistent findings. Virtually all patients who underwent complete meniscectomy at the time of ACL reconstruction had radiographic evidence of osteoarthritis at follow-up...
Height, weight, and BMI predict intra-articular injuries observed during ACL reconstruction: evaluation of 456 cases from a prospective ACL databaseAndrea L Bowers
Vanderbilt Sports Medicine Center, 2601 Jess Neely Drive, Nashville, TN 37212, USA
Clin J Sport Med 15:9-13. 2005..We hypothesize that athletes possibly could reduce risk of certain IA pathologies with maintenance of lower body weight and BMI and thus potentially improve long-term functional outcomes after ACL reconstruction...
Intra-articular knee temperature changes: ice versus cryotherapy deviceTodd A Warren
Vanderbilt Sports Medicine Center, Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Sports Med 32:441-5. 2004..However, ice was more effective yet resulted in higher pain scores. The authors hypothesize that IA temperatures below a threshold are associated with increased perceived pain...
Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo studyBraden C Fleming
Department of Orthopaedics, Warren Alpert Medical School of Brown University, CORO West, 1 Hoppin Street, Providence, Rhode Island 02903, USA
J Orthop Res 26:1500-5. 2008..Additional studies defining the changes in laxity with cyclic loading and in vivo healing are indicated...
CALAXO osteoconductive interference screw: the value of postmarket surveillanceCharles L Cox
Vanderbilt Sports Medicine Center, Nashville, TN 37232 8774, USA
J Surg Orthop Adv 19:121-4. 2010..The authors hypothesize that the inability to bury the longer screw length into the bone tunnel is associated with postoperative complications associated with the CALAXO screw...
Does operative fixation of an osteochondritis dissecans loose body result in healing and long-term maintenance of knee function?Robert A Magnussen
Vanderbilt Orthopaedic Institute, Nashville, TN 37232 8774, USA
Am J Sports Med 37:754-9. 2009..The decision to fix versus excise the loose body is controversial. Published operative fixation outcomes are small case series with short follow-up...
The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studiesC Tate Hepper
Department of Orthopaedics, Washington University School of Medicine, St Louis, MO, USA
J Am Acad Orthop Surg 17:638-46. 2009..We concluded that intra-articular corticosteroids reduce knee pain for at least 1 week and that intra-articular corticosteroid injection is a short-term treatment of a chronic problem...
Corticosteroid injections in the treatment of trigger finger: a level I and II systematic reviewSheryl B Fleisch
Vanderbilt University School of Medicine, Nashville, TN 37232 8828, USA
J Am Acad Orthop Surg 15:166-71. 2007..Combined analysis of these four studies shows that corticosteroid injections are effective in 57% of patients...
A simple, accurate method to confirm placement of intra-articular knee injectionRudolph C Glattes
Department of Orthopaedics and Rehabilitation, Vanderbilt Sports Medicine Center, 2601 Jess Neely Drive, Nashville, TN 37212, USA
Am J Sports Med 32:1029-31. 2004..CLINICAL RELEVANCE: This simple method is easily reproduced, can confirm accurate placement, and can eliminate extra-articular injection as the reason for clinical response failure...
Evidence-based medicine for orthopedic surgeonsJohn E Kuhn
Vanderbilt Sports Medicine Center, Nashville, Tenn 37212, USA
J Knee Surg 18:57-63. 2005..Its basis is the scientific method. The practicing clinician need understand only a few simple concepts to use this approach, and in doing so will provide the best available care to the patients...
Radiographic measurements of the intercondylar notch: are they accurate?Allen F Anderson
Saint Thomas Hospital Tennessee Orthopaedic Alliance, Nashville, Tennessee 37205, USA
Arthroscopy 23:261-8, 268.e1-2. 2007..The purpose of this study was to evaluate the accuracy of radiographic measurements of the intercondylar notch...
The efficacy of subacromial corticosteroid injection in the treatment of rotator cuff disease: A systematic reviewMichael C Koester
Orthopaedic Healthcare Northwest, Eugene, OR, USA
J Am Acad Orthop Surg 15:3-11. 2007..This systematic review of the available literature indicates that there is little reproducible evidence to support the efficacy of subacromial corticosteroid injection in managing rotator cuff disease...
Management and return to play of stress fracturesChristopher C Kaeding
Ohio State University Sports Medicine Center, Columbus, OH, USA
Clin J Sport Med 15:442-7. 2005..The purpose of this article is to provide the clinician an evidence/experience-based algorithm for the management of stress fractures...
Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACLMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Orthop Res 24:820-30. 2006..02). Placement of a collagen-PRP bridging scaffold in a central ACL defect can stimulate healing of the ACL histologically and biomechanically...
Multirater agreement of arthroscopic grading of knee articular cartilageRobert G Marx
Sports Medicine and Shoulder Service and Foster Center for Clinical Outcome Research, Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
Am J Sports Med 33:1654-7. 2005..The validity of the classification of such injuries is critical for prospective multicenter studies. The agreement among multiple surgeons at different institutions for articular cartilage lesions has not been established...
Interspecies variation in the fibroblast distribution of the anterior cruciate ligamentMartha Meaney Murray
Department of Orthopedic Surgery, Children s Hospital of Boston, Harvard Medical School, Boston, Massachusetts, USA
Am J Sports Med 32:1484-91. 2004..Thus, when selecting an animal model for testing of these new treatment methods, it is important to select a model that has similar cellular distributions to that of the normal human anterior cruciate ligament...
Interobserver agreement in the classification of rotator cuff tears using magnetic resonance imagingEdwin E Spencer
Shoulder and Elbow Institute, Knoxville Orthopaedic Clinic, Knoxville, TN 37922, USA
Am J Sports Med 36:99-103. 2008....
Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffoldMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115, USA
J Orthop Res 25:1007-17. 2007..This study supports the hypothesis that premature scaffold failure may play a key role in the normally expected failure of the ACL to heal after injury...
Jumping versus nonjumping anterior cruciate ligament injuries: a comparison of pathologyJonathan J Paul
Section of Sports Medicine, Cleveland Clinic Foundation, Ohio, USA
Clin J Sport Med 13:1-5. 2003....
Risk of tearing the intact anterior cruciate ligament in the contralateral knee and rupturing the anterior cruciate ligament graft during the first 2 years after anterior cruciate ligament reconstruction: a prospective MOON cohort studyRick W Wright
Department of Orthopaedic Surgery, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
Am J Sports Med 35:1131-4. 2007..Clinicians have hypothesized that the opposite normal knee is at equal or increased risk compared with the risk of anterior cruciate ligament graft rupture in the operated knee...
Anterior cruciate ligament revision reconstruction: two-year results from the MOON cohortRick W Wright
Department of Orthopedic Surgery, Washington University School of Medicine and Barnes-Jewish Hospital, St Louis, MO 63110, USA
J Knee Surg 20:308-11. 2007
AOA Symposium. Orthopaedists partnering with other physicians to provide musculoskeletal careAlan S Hilibrand
The Rothman Institute, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
J Bone Joint Surg Am 89:2810-8. 2007
Intra-articular findings in the reconstructed multiligament-injured kneeChristopher C Kaeding
The Ohio State University, Columbus, Ohio, USA
Arthroscopy 21:424-30. 2005..ACL/LCL injuries had fewer meniscal injuries. Multiligament-injured knees showed increased risk of a torn medial meniscus as chronicity increased. LEVEL OF EVIDENCE: Level IV...
How to write a systematic reviewRick W Wright
Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
Clin Orthop Relat Res 455:23-9. 2007..Systematic reviews conducted in this fashion can be used as a higher form of current concepts or as review articles and replace the traditional expert opinion narrative review...
Multirater agreement of arthroscopic meniscal lesionsWarren R Dunn
Hospital for Special Surgery, New York, New York, USA
Am J Sports Med 32:1937-40. 2004..There are no studies investigating the reproducibility of arthroscopic classification of meniscal pathology among multiple surgeons at different institutions...
The effect of the menstrual cycle on anterior cruciate ligament injuries in women as determined by hormone levelsEdward M Wojtys
MedSport, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan 48106, USA
Am J Sports Med 30:182-8. 2002..Oral contraceptive use diminished the significant association between anterior cruciate ligament tear distribution and the ovulatory phase...
Twelve-year follow-up on anterior cruciate ligament reconstruction: long-term outcomes of prospectively studied osseous and articular injuriesBryan T Hanypsiak
Orthopaedic Associates of Long Island, E Setauket, New York, USA
Am J Sports Med 36:671-7. 2008..Although successful at restoring near normal laxity to the knee in the short term, anterior cruciate ligament reconstructions have not been shown to prevent the development of posttraumatic arthritis...
Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligamentMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
J Orthop Res 25:81-91. 2007..Further studies to determine the long-term effect of primary repair enhancement are needed...
A systematic review of anterior cruciate ligament reconstruction rehabilitation: part I: continuous passive motion, early weight bearing, postoperative bracing, and home-based rehabilitationRick W Wright
Department of Orthopedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO, USA
J Knee Surg 21:217-24. 2008..Topics discussed in this part of the article include continuous passive motion, early weight bearing in motion, postoperative bracing, and home-based rehabilitation...
A systematic review of anterior cruciate ligament reconstruction rehabilitation: part II: open versus closed kinetic chain exercises, neuromuscular electrical stimulation, accelerated rehabilitation, and miscellaneous topicsRick W Wright
Department of Orthopedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO, USA
J Knee Surg 21:225-34. 2008..This part of the article discusses open versus closed kinetic chain exercises, neuromuscular electrical stimulation, accelerated rehabilitation, and miscellaneous topics...
The drop-jump screening test: difference in lower limb control by gender and effect of neuromuscular training in female athletesTimothy Hewett
Am J Sports Med 35:145; author reply 146-7. 2007
Research Grants
- Prognosis and Predictors of ACL Reconstruction: A Multicenter Cohort StudyKurt Spindler; Fiscal Year: 2007....
- Prognosis and Predictors of ACL Reconstruction: A Multicenter Cohort StudyKurt Spindler; Fiscal Year: 2009....
- Prognosis and Predictors of ACL Reconstruction: A Multicenter Cohort StudyKurt P Spindler; Fiscal Year: 2010..Once the predictors for good and poor outcomes are identified, surgeons and patients can be educated to the potential modifiable variables that improve patient's outcomes. ..
