Kylee L Spencer

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi C3 R102G polymorphism increases risk of age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Mol Genet 17:1821-4. 2008
  2. ncbi Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA
    Invest Ophthalmol Vis Sci 52:1748-54. 2011
  3. ncbi Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e17784. 2011
  4. ncbi Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
    Hum Mol Genet 16:1986-92. 2007
  5. ncbi Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 48:4277-83. 2007
  6. ncbi Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 17:971-7. 2008
  7. ncbi Complement factor H variant increases the risk of age-related macular degeneration
    Jonathan L Haines
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 308:419-21. 2005
  8. ncbi Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration
    William K Scott
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ophthalmology 114:1151-6. 2007

Detail Information

Publications8

  1. ncbi C3 R102G polymorphism increases risk of age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Mol Genet 17:1821-4. 2008
    ..17]. Therefore, while the strong LD between R102G and L314P makes it difficult to disentangle their individual effects on disease risk, the R102G polymorphism acting alone provides the best model for disease in our data...
  2. ncbi Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA
    Invest Ophthalmol Vis Sci 52:1748-54. 2011
    ..Multiple linkage studies have found evidence suggestive of another AMD locus on chromosome 16p12 but the gene responsible has yet to be identified...
  3. ncbi Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e17784. 2011
    ....
  4. ncbi Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
    Hum Mol Genet 16:1986-92. 2007
    ..21, 95% confidence interval 0.11-0.39; P < 10(-4)). Likelihood ratio testing and conditional analyses in the case-control data set suggest that a weaker, independent protective effect exists for CC2 E318D...
  5. ncbi Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 48:4277-83. 2007
    ..Besides the well-known risk imparted by carrying the Y402H variant in the complement factor H (CFH) gene on chromosome 1, recent evidence of the existence of protective haplotypes spanning CFH has been reported...
  6. ncbi Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 17:971-7. 2008
    ..The presence of protective haplotypes in CFH that do not carry the deletion, suggests that other protective variants in this region have yet to be discovered...
  7. ncbi Complement factor H variant increases the risk of age-related macular degeneration
    Jonathan L Haines
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 308:419-21. 2005
    ..45 and 5.57. This common variant likely explains approximately 43% of AMD in older adults...
  8. ncbi Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration
    William K Scott
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ophthalmology 114:1151-6. 2007
    ..To examine the potential gene-environment interaction between cigarette smoking and the complement factor H (CFH) T1277C polymorphism, 2 strong risk factors for age-related macular degeneration (AMD)...