Genomes and Genes
Affiliation: Vanderbilt University
- Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesisAnna Spagnoli
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2579, USA
J Biol Chem 277:18860-7. 2002..We have demonstrated that STAT-1 is a major intracellular signaling and transcriptional target of the IGF-independent apoptotic effect of IGFBP-3 in chondrogenesis...
- Subcellular localization of IRS-1 in IGF-I-mediated chondrogenic proliferation, differentiation and hypertrophy of bone marrow mesenchymal stem cellsLara Longobardi
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
Growth Factors 27:309-20. 2009....
- Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effectsFroilan Granero-Molto
Department of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Stem Cells 29:1537-48. 2011..A callus that was basically absent in Irs1(-/-) left untransplanted or transplanted with MSCs. We provided evidence of effects and mechanisms for transplanted MSC(IGF) in fracture repair and potentially to treat nonunions...
- Mesenchymal stem cells at the intersection of cell and gene therapyTimothy J Myers
University of North Carolina at Chapel Hill, Department of Pediatrics, Chapel Hill, NC 27599 7239, USA
Expert Opin Biol Ther 10:1663-79. 2010..These properties can be enhanced through genetic-modification that would combine the best of both cell and gene therapy fields to treat monogenic and multigenic diseases...
- Systemically delivered insulin-like growth factor-I enhances mesenchymal stem cell-dependent fracture healingTimothy J Myers
Department of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
Growth Factors 30:230-41. 2012..In conclusion, MSC transplant concurrent with systemic delivery of IGF-I improves fracture repair suggesting that IGF-I+MSC could be a novel therapeutic approach in patients who have inadequate fracture repair...
- Comparison of microCT and an inverse finite element approach for biomechanical analysis: results in a mesenchymal stem cell therapeutic system for fracture healingJared A Weis
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37232, USA
J Biomech 45:2164-70. 2012..Additionally, our inverse FEA approach is shown to be very sensitive and may provide a first-step towards normalizing the often challenging process of assessing mechanical integrity of healing fractures...
- TGF-β type II receptor/MCP-5 axis: at the crossroad between joint and growth plate developmentLara Longobardi
Department of Pediatrics, University of North Carolina at Chapel Hill, NC 27599, USA
Dev Cell 23:71-81. 2012..Our study characterized the TβRII/MCP-5 axis as an essential crossroad for joint development and endochondral growth...
- Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signalingLara Longobardi
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2579, USA
J Bone Miner Res 21:626-36. 2006..We found that IGF-I had potent chondroinductive actions on MSCs. IGF-I effects were independent from and additive to TGF-beta...
- A novel insulin-like growth factor (IGF)-independent role for IGF binding protein-3 in mesenchymal chondroprogenitor cell apoptosisLara Longobardi
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2579, USA
Endocrinology 144:1695-702. 2003..In summary, we have identified a novel IGF-independent role for IGFBP-3 in the modulation of chondrocyte differentiation...
- TGF-beta signaling is essential for joint morphogenesisAnna Spagnoli
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Cell Biol 177:1105-17. 2007..We propose a model for joint development in which TGF-beta signaling represents a means of entry to initiate the process...
- Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repairFroilan Granero-Molto
University of North Carolina at Chapel Hill, Division of Endocrinology, Department of Pediatrics, 3341 Medical Biomolecular Research Building, 103 Mason Farm Road Campus Box 7039, Chapel Hill North Carolina 27599 7239, USA
Expert Opin Biol Ther 8:255-68. 2008..Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes...
- Cartilage disorders: potential therapeutic use of mesenchymal stem cellsAnna Spagnoli
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2579, USA
Endocr Dev 9:17-30. 2005..Understanding IGF-I chondroinductive and IGFBP-3 chondroinhibitory effects would provide critical information to optimize the therapeutic use of MSC in cartilage disorders...
- Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish developmentFroilan Granero-Molto
Center for Matrix Biology, Department of Medicine, Biochemistry, and Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Biol Chem 283:20495-504. 2008..Moreover, this phenotype is mediated by Gpbp but not GpbpDelta26/CERT, suggesting that Gpbp is an important factor for normal skeletal muscle and brain development...
- Metabolic control and bone health in adolescents with type 1 diabetesJill H Simmons
Department of Pediatrics, Division of Endocrinology and Diabetes, Vanderbilt Children s Hospital, Nashville, TN, USA
Int J Pediatr Endocrinol 2011:13. 2011..abstract:..
- Use of glycol chitosan modified by 5beta-cholanic acid nanoparticles for the sustained release of proteins during murine embryonic limb skeletogenesisTieshi Li
Department of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina at Chapel Hill, Mason Farm Road, Campus Box 7039, Chapel Hill, NC 27599 7039, USA
J Control Release 144:101-8. 2010..Results reveal that HGC is a valuable protein-delivery system in developmental biology...
- RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cellsAlfonso Torquati
Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Surgery 136:310-6. 2004..RUNX3 is essential for the antiproliferative and apoptotic effects of TGF-beta in SEG-1 cells and for the Smad-mediated transcriptional activity of TGF-beta...
- Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitusBradley J Van Sickle
Division of Pediatric Endocrinology, Vanderbilt University, 11136 Doctors Office Tower, 2200 Children s Way, Nashville, TN 37232 9170, USA
Cytokine 48:290-4. 2009..Poor control (PC) was defined as >or=3, consistent HbA1C>9% during the previous 2 years, while favorable control (FC) was consistent levels of HbA1C<9%...