Research Topics
Genomes and Genes
| Xiao ShuSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Polymorphisms in inflammation pathway genes and endometrial cancer riskRyan J Delahanty
Corresponding Author Xiao Ou Shu, Vanderbilt Epidemiology Center, 2525 West End Avenue, Suite 600 IMPH, Nashville, TN 37203
Cancer Epidemiol Biomarkers Prev 22:216-23. 2013..Experimental and epidemiologic evidence have suggested that chronic inflammation may play a critical role in endometrial carcinogenesis...
Calcium intake and lung cancer risk among female nonsmokers: a report from the Shanghai Women's Health StudyYumie Takata
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Cancer Epidemiol Biomarkers Prev 22:50-7. 2013..Calcium has been implicated in carcinogenesis and linked to the risk of several cancers in epidemiologic studies; however, few studies have investigated the association of calcium intake with lung cancer risk, particularly among nonsmokers...- Genome-wide association study identifies a possible susceptibility locus for endometrial cancerJirong Long
Department of Medicine, Vanderbilt University Schoolof Medicine, Nashville, TN, USA
Cancer Epidemiol Biomarkers Prev 21:980-7. 2012..Genome-wide association studies (GWAS) have identified more than 100 genetic loci for various cancers. However, only one is for endometrial cancer... - Novel genetic markers of breast cancer survival identified by a genome-wide association studyXiao Ou Shu
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
Cancer Res 72:1182-9. 2012..39 × 10(-7)). Similar associations were observed for these two SNPs with breast cancer-specific mortality. This study provides strong evidence suggesting that the RAD51L1 gene and a chromosome 16 locus influence breast cancer prognosis... 
Duration of breast-feeding and the incidence of type 2 diabetes mellitus in the Shanghai Women's Health StudyR Villegas
Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 600, Nashville, TN 37232 1738, USA
Diabetologia 51:258-66. 2008..The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women...- IGFBP3 mRNA expression in benign and malignant breast tumorsZefang Ren
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, S 1121 MCN, 1161 21st Ave, S, Nashville, TN 37232 2587, USA
Breast Cancer Res 9:R2. 2007..Emerging evidence over the past few years suggests that IGFBP-3 may act directly on mammary epithelial cells... - Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer StudyAesun Shin
Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Breast Cancer Res 7:R506-12. 2005.... - Patterns and correlates of physical activity: a cross-sectional study in urban Chinese womenAdriana L Jurj
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203, USA
BMC Public Health 7:213. 2007..The purpose of this study was to investigate the patterns and correlates of physical activity in middle-aged and elderly women from urban Shanghai... - Concordance of self-reported and medical chart information on cancer diagnosis and treatmentVinay Gupta
Department of Cancer Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan Road West, Shanghai 200336, China
BMC Med Res Methodol 11:72. 2011..Self-reported information is an important tool for collecting clinical information for epidemiologic studies and in clinical settings where electronic medical records are not employed and shared... - Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort studyYinghao Su
Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203 1738, USA
BMC Cancer 11:292. 2011..Molecular classification of breast cancer is an important prognostic factor. The distribution of molecular subtypes of breast cancer and their prognostic value has not been well documented in Asians... - Soy food intake and breast cancer survivalXiao Ou Shu
Department of Medicine, Vanderbilt Epidemiology Center, 2525 West End Ave, Ste 600, Nashville, TN 37203 1738, USA
JAMA 302:2437-43. 2009..However, the estrogen-like effect of isoflavones and the potential interaction between isoflavones and tamoxifen have led to concern about soy food consumption among breast cancer patients... 
Association of cyclin D1 genotype with breast cancer risk and survivalXiao Ou Shu
Department of Medicine, Vanderbilt University Center for Health Services Research, 6th Floor, Medical Center East, Nashville, TN 37232 8300, USA
Cancer Epidemiol Biomarkers Prev 14:91-7. 2005..This study suggests that CCND1 A870G polymorphism may modify the postmenopausal breast cancer risk associated with hormonal exposure and predict survival after breast cancer diagnosis...- Polymorphisms in ER-alpha gene interact with estrogen receptor status in breast cancer survivalSonia M Boyapati
Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
Clin Cancer Res 11:1093-8. 2005..Polymorphisms in the ER-alpha gene have been reported to be associated with breast cancer risk. However, to our knowledge, no study has been published on the relation between ER-alpha gene polymorphisms and breast cancer survival... - Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology GroupXiao Ou Shu
Vanderbilt Ingram Cancer Center and Vanderbilt Center for Health Services Research, Vanderbilt University, Nashville, Tennessee, USA
Cancer Epidemiol Biomarkers Prev 13:1230-5. 2004..8, 95% CI 1.0-1.3) were associated with N-ras mutations. This study suggests that parental exposure to specific chemicals may be associated with distinct ras mutations in children who develop ALL... - Exercise after diagnosis of breast cancer in association with survivalXiaoli Chen
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Cancer Prev Res (Phila) 4:1409-18. 2011..An interaction between disease stage and hormone receptor status and total mortality was noted. Our study suggests that exercise after breast cancer diagnosis may improve overall and disease-free survival... - Validity and reproducibility of the food frequency questionnaire used in the Shanghai Women's Health StudyX O Shu
Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt Center for Health Services Research, Vanderbilt University, Nashville, TN 37232 8300, USA
Eur J Clin Nutr 58:17-23. 2004..These data indicate that the SWHS FFQ can reliably and accurately measure usual intake of major nutrients and food groups among women in Shanghai... - Genetic polymorphisms in the TGF-beta 1 gene and breast cancer survival: a report from the Shanghai Breast Cancer StudyXiao Ou Shu
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
Cancer Res 64:836-9. 2004..4, 95% confidence interval, 1.0-1.9). Our study suggests that genetic polymorphisms in the TGF-beta1 gene may play a role in breast cancer progression... - Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer riskSang Ah Lee
Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA
Am J Clin Nutr 87:753-60. 2008..Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs)... - Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese womenZefang Ren
Department of Medicine, Vanderbilt University, Nashville, TN, USA
Cancer Epidemiol Biomarkers Prev 13:1290-5. 2004..05). These results indicated that IGFBP3 polymorphisms may be associated with the level of blood IGFBP-3 protein and an increased risk of breast cancer... - Polymorphisms in the CYP19A1 (aromatase) gene and endometrial cancer risk in Chinese womenMeng Hua Tao
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 16:943-9. 2007..In summary, our data show that polymorphisms in the CYP19A1 gene may contribute to endometrial carcinogenesis... - Association of mitochondrial DNA displacement loop (CA)n dinucleotide repeat polymorphism with breast cancer risk and survival among Chinese womenChuanzhong Ye
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, TN 37232 2400, USA
Cancer Epidemiol Biomarkers Prev 17:2117-22. 2008..62; 95% confidence interval, 1.16-2.26). These results suggest that the mtDNA D-loop (CA)(n) repeat polymorphism may be associated with breast cancer survival. Additional studies with a larger sample size are warranted... - Energy balance, insulin resistance biomarkers, and breast cancer riskAlecia Malin Fair
Meharry Medical College, School of Medicine, Department of Surgery, 1005 Dr D B Todd Jr Boulevard, Nashville, TN 37208 3599, USA
Cancer Detect Prev 31:214-9. 2007.... - Population-based case-control study of VEGF gene polymorphisms and breast cancer risk among Chinese womenNobuhiko Kataoka
Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
Cancer Epidemiol Biomarkers Prev 15:1148-52. 2006..67; 95% CI, 0.43-1.04), particularly in premenopausal women (OR, 0.47; 95% CI, 0.27-0.81). Our study suggests that the VEGF C936T polymorphism might be a susceptibility factor for breast cancer among Chinese women... - Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, ChinaJay H Fowke
Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
Cancer Epidemiol Biomarkers Prev 12:1536-9. 2003..In conclusion, a single urinary ITC measure, in conjunction with markers of Phase II enzyme activity, provides a complementary measure of habitual Brassica intake among Shanghai women... - Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin geneYong Cui
Vanderbilt University Center for Health Services Research, 6th Floor, Medical Center East, Nashville, TN 37232 8300, USA
Cancer Epidemiol Biomarkers Prev 14:1096-101. 2005..05). This study suggests that the Asn allele in the SHBG gene may be related to a reduced risk of breast cancer among postmenopausal women by increasing their blood SHBG levels... - Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin geneNobuhiko Kataoka
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
Cancer 109:1296-302. 2007.... - Dietary patterns and blood pressure among middle-aged and elderly Chinese men in ShanghaiSang Ah Lee
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2525 West End Avenue, Suite 600, IMPH, Nashville TN 37203 1738, USA
Br J Nutr 104:265-75. 2010..Results of the present study suggest an important role for diet in the prevention of hypertension... - Two-stage case-control study of common ATM gene variants in relation to breast cancer riskChuanzhong Ye
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2587, USA
Breast Cancer Res Treat 106:121-6. 2007.... - MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer StudyMartha J Shrubsole
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232 8300, USA
Cancer Epidemiol Biomarkers Prev 13:190-6. 2004..Results of this study suggest that the MTHFR C677T polymorphisms may modify the association between dietary folate intake and breast cancer risk... - Correlates of high serum C-reactive protein levels in a socioeconomically disadvantaged populationXianglan Zhang
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA
Dis Markers 24:351-9. 2008..Moreover, inflammatory response to obesity differed by race and sex, which may contribute to CVD disparities... - Evaluation of genetic susceptibility loci for obesity in Chinese womenJiajun Shi
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Epidemiol 172:244-54. 2010..Results from this study extend some previous GWA findings to Chinese women and show the need for additional studies to identify susceptibility loci in Chinese and other Asian populations... - Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancerOlufemi J Adegoke
Department of Surgery, School of Medicine, Meharry Medical College, Vanderbilt University, Nashville, TN 37208, USA
Breast Cancer Res Treat 85:239-45. 2004..No significant associations were observed with *28 allele and breast cancer risk by estrogen receptor/progesterone receptor status... - Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women's Health StudyRaquel Villegas
Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203 1738, USA
Am J Clin Nutr 87:162-7. 2008..It has been postulated that a diet high in legumes may be beneficial for the prevention of type 2 diabetes mellitus (type 2 DM). However, data linking type 2 DM risk and legume intake are limited... - Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the shanghai breast cancer study and a meta-analysisWanqing Wen
Department of Medicine, Vanderbilt Ingram Cancer Center, Center for Health Service Research, Vanderbilt University School of Medicine, Nashville, TN, USA
Cancer Epidemiol Biomarkers Prev 14:329-35. 2005..The results from this study were consistent with those from most previous studies, indicating no major associations of breast cancer risk with CYP1B1 and COMT polymorphisms... - Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese womenRaquel Villegas
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Ave, Ste 600, Nashville, TN 37203 1738, USA
Arch Intern Med 167:2310-6. 2007..Much uncertainty exists about the role of dietary glycemic index and glycemic load in the development of type 2 diabetes mellitus, especially in populations that traditionally subsist on a diet high in carbohydrates... - Genetic polymorphisms of the CYP19A1 gene and breast cancer survivalJi Rong Long
Department of Medicine, Center for Epidemiologic Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2587, USA
Cancer Epidemiol Biomarkers Prev 15:2115-22. 2006..2-4.1) for overall survival and 2.1 (95% CI, 1.1-3.9) for disease-free survival, compared with those carrying the Arg (C) allele. These results suggest that polymorphisms in the CYP19A1 gene may have effects on breast cancer prognosis... - Prevalence of obesity and correlations with lifestyle and dietary factors in Chinese menSang Ah Lee
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
Obesity (Silver Spring) 16:1440-7. 2008..To estimate the age-adjusted prevalence of general and centralized obesity among Chinese men living in urban Shanghai... - Dietary and lifestyle predictors of age at natural menopause and reproductive span in the Shanghai Women's Health StudyTsogzolmaa Dorjgochoo
Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Menopause 15:924-33. 2008..We evaluated the impact of dietary, lifestyle and reproductive factors on age at natural menopause and reproductive span in Chinese women... - UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer riskSandra L Deming
Vanderbilt Epidemiology Center, Department of Medicine and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 17:563-70. 2008.... - Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health StudySang Ah Lee
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
Am J Clin Nutr 89:1920-6. 2009..Soy food is a rich source of isoflavones--a class of phytoestrogens that has both antiestrogenic and anticarcinogenic properties... - Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survivalJi Rong Long
Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 1121 Medical Center North, Nashville, TN 37232, USA
Pharmacogenet Genomics 17:331-8. 2007..The objective of the study is to investigate associations of breast cancer survival with genetic polymorphisms in several genes involved in estrogen metabolism (CYP1A1, CYP1A2, CYP1B1, COMT, and AhR)... - Vegetable but not fruit consumption reduces the risk of type 2 diabetes in Chinese womenRaquel Villegas
Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Nashville, TN 37203 1738, USA
J Nutr 138:574-80. 2008..Fruit intake was not associated with the incidence of diabetes in this population. Our data suggest that vegetable consumption may protect against the development of T2D... - Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer riskBrian L Yaspan
Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, TN 37232 0275, USA
Cancer Res 67:5673-82. 2007..94 (95% CI, 1.22-7.12), test for trend, P = 5.0e-5. Among genes controlling endogenous estrogen metabolism, CYP11A1 harbors common variants that may influence expression to significantly modify risk of breast cancer... - Nutrient intake among Chinese women living in Shanghai, ChinaZhi Chen
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232-8300, USA
Br J Nutr 96:393-9. 2006.... - Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer riskJi Rong Long
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
Pharmacogenet Genomics 16:237-43. 2006.... - Genetic polymorphisms of the transforming growth factor-beta1 gene and breast cancer risk: a possible dual role at different cancer stagesAesun Shin
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Cancer Epidemiol Biomarkers Prev 14:1567-70. 2005.... - Mutations in the mitochondrial DNA D-loop region and breast cancer riskChuanzhong Ye
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, B 2104, Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2400, USA
Breast Cancer Res Treat 119:431-6. 2010..3%) than in BBD patients (15.3%) (P = 0.05) and more frequently in proliferative BBD (13.0%) than in non-proliferative BBD (7.1%). Our data suggest that somatic MnlI site mutations may play a role in the pathogenesis of breast cancer... - Association of passive smoking by husbands with prevalence of stroke among Chinese women nonsmokersXianglan Zhang
Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
Am J Epidemiol 161:213-8. 2005..The authors found that women nonsmokers who lived with husbands who smoked had an elevated prevalence of stroke, and prevalence increased with increasing intensity and duration of husbands' smoking... - Matrix metalloproteinase-2 polymorphisms and breast cancer susceptibilityAlicia Beeghly-Fadiel
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 18:1770-6. 2009..4; 95% CI, 0.9-2.4). Together, these findings support a role for MMP-2 genetic variation in breast cancer susceptibility... - Genetic polymorphisms in the MMP-7 gene and breast cancer survivalAlicia Beeghly-Fadiel
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
Int J Cancer 124:208-14. 2009..9) and TT (OS HR: 0.3, 95% CI: 0.1-0.8) fared better than patients with AA (p-value for trend: 0.001). Thus, common MMP-7 genetic polymorphisms were found to be significant determinants of survival among Chinese women with breast cancer... - Association of genetic polymorphisms in the VEGF gene with breast cancer survivalHua Lu
Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Cancer Res 65:5015-9. 2005..1; 95% CI, -0.9 to 4.7). The C+936T polymorphism alone was not related to overall or disease-free survival. This study suggests that VEGF polymorphisms may be a significant genetic marker for breast cancer prognosis... - Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese womenSonia M Boyapati
Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Cancer 103:2228-35. 2005..Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma... - Exercise, tea consumption, and depression among breast cancer survivorsXiaoli Chen
Vanderbilt Epidemiology Center, 2525 West End Ave, Suite 600, Nashville, TN 37203 1738, USA
J Clin Oncol 28:991-8. 2010..84). No associations were found for dietary intake or supplement use with depression. CONCLUSION Regular exercise participation and tea consumption may play an important role in the prevention of depression among breast cancer survivors... - Interaction of soy and 17beta-HSD1 gene polymorphisms in the risk of endometrial cancerQi Dai
Department of Medicine and Vanderbilt Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
Pharmacogenet Genomics 17:161-7. 2007..In-vitro studies have found that soy isoflavones can inhibit the activity of 17beta-hydroxysteroid dehydrogenase type I, a key enzyme in catalyzing estrone (E1), to the biologically more active estradiol (E2)... - Obesity and weight change in relation to breast cancer survivalXiaoli Chen
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 600, Nashville, TN 37203 1738, USA
Breast Cancer Res Treat 122:823-33. 2010..Our study suggests that obesity and weight change after diagnosis are inversely associated with breast cancer prognosis. Weight control is important among women with breast cancer... - Animal origin foods and colorectal cancer risk: a report from the Shanghai Women's Health StudySang Ah Lee
Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Nashville, TN 37203 1738, USA
Nutr Cancer 61:194-205. 2009..The latter was positively associated with colon cancer (RR = 1.4 for ever vs. never, 95% CI = 1.1-1.9). A possible role of cholesterol and environmental pollution in the etiology of CRC was suggested... - Validity and reproducibility of the food-frequency questionnaire used in the Shanghai men's health studyRaquel Villegas
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Medical Center East, Suite 6000, 1215 21st Avenue South, Nashville, TN 37232 8300, USA
Br J Nutr 97:993-1000. 2007..8 and 49.2%, while misclassification to opposite quartiles was between 1.5 and 6.2%. These data indicate that the SMHS FFQ can reasonably categorise usual intake of nutrients and food groups among men living in urban Shanghai... - Genetic polymorphisms in the human growth hormone-1 gene (GH1) and the risk of breast carcinomaZefang Ren
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
Cancer 101:251-7. 2004..The authors investigated the association of breast carcinoma with genetic polymorphisms in the GH1 gene in the Shanghai Breast Cancer Study... - Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancerQi Dai
Vanderbilt Center for Health Services Research, 1215 21st Avenue South, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
Cancer Epidemiol Biomarkers Prev 13:2065-70. 2004.... - Soy food consumption is associated with lower risk of coronary heart disease in Chinese womenXianglan Zhang
Department of Medicine, Center for Health Services Research, Vanderbilt University, Nashville, TN 37232, USA
J Nutr 133:2874-8. 2003..14; 95% CI, 0.04-0.48 for the highest vs. the lowest quartile of intake; P for trend = 0.001). This study provides, for the first time, direct evidence that soy food consumption may reduce the risk of CHD in women... - Polymorphisms in tissue inhibitors of metalloproteinases-2 and -3 and breast cancer susceptibility and survivalNeeraja B Peterson
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Int J Cancer 125:844-50. 2009..Genetic variation in the TIMP-2 and TIMP-3 genes may contribute to individual differences in breast cancer susceptibility and survival... - Energy balance and breast cancer riskAlecia Malin
Department of Surgery, Meharry Medical College, 1005 Dr D B Todd Boulevard, Nashville, Tennessee 37208, USA
Cancer Epidemiol Biomarkers Prev 14:1496-501. 2005..74; 95% confidence interval, 2.05-12.20). Our study suggests that promotion of behavior patterns that optimize energy balance (weight control and increasing physical activity) may be a viable option for breast cancer prevention... - Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer StudySandra L Deming
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Breast Cancer Res Treat 104:309-19. 2007..9) for the N/A-A/A genotypes (rs6413441). Taken together, these data suggest that polymorphisms in the IGF-1R and IGFBP3 genes may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status... - Functional plasminogen activator inhibitor-1 gene variants and breast cancer survivalXianglan Zhang
Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Clin Cancer Res 12:6037-42. 2006..We evaluated the association between PAI-1 4G/5G polymorphism and breast cancer survival in a population-based cohort of breast cancer patients... - Expression patterns of insulin-like growth factor 1 (IGF-I) and its receptor in mammary tissues and their associations with breast cancer survivalAesun Shin
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, S1121 Medical Center North, 1161 21st Avenue S, Nashville, TN, 37232 2587, USA
Breast Cancer Res Treat 105:55-61. 2007..Our findings suggest that the expression of IGF-I and IGFIR genes may undergo substantial change over the course of breast tumorigenesis, and the pattern of changes may be associated with breast cancer prognosis... - Menopausal symptoms among breast cancer patients 6 months after diagnosis: a report from the Shanghai Breast Cancer Survival StudyTsogzolmaa Dorjgochoo
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
Menopause 16:1205-12. 2009..The aim of this study was to estimate the prevalence of menopausal symptoms in relation to treatment modalities in Asian women treated for breast cancer... - Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and endometrial cancer risk in Chinese womenMeng Hua Tao
Vanderbilt Epidemiology Center, Vanderbilt University, 6009 Medical Center East, 1215 21st Avenue South, Nashville, TN 37232-8300, USA
Cancer Epidemiol Biomarkers Prev 15:2570-3. 2006 - E-cadherin polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer StudyAlicia Beeghly-Fadiel
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Institute of Medicine and Public Health, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 8th Floor, Nashville, TN 37203 1738, USA
Breast Cancer Res Treat 121:445-52. 2010.... - Correlation of blood sex steroid hormones with body size, body fat distribution, and other known risk factors for breast cancer in post-menopausal Chinese womenSonia M Boyapati
Division of General Internal Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232-8300, USA
Cancer Causes Control 15:305-11. 2004..CONCLUSIONS: These data suggest that breast cancer risk associated with measures of body size may be mediated, at least partially, by levels of endogenous sex hormones... - The use of complementary and alternative medicine among Chinese women with breast cancerZhi Chen
Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
J Altern Complement Med 14:1049-55. 2008.... - Birthweight, childhood growth and hypertension in adulthoodMingfang Zhao
Center for Health Services Research, Vanderbilt University, Nashville, TN 37232-8300, USA
Int J Epidemiol 31:1043-51. 2002..04). CONCLUSION: Our study suggests that low BW, particularly if accompanied by accelerated childhood growth, may increase the risk of early onset hypertension in adulthood... - Parental medication use and risk of childhood acute lymphoblastic leukemiaWanqing Wen
Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
Cancer 95:1786-94. 2002..CONCLUSIONS: The findings of this study suggest that certain parental medication use immediately before and during the index pregnancy may influence risk of ALL in offspring... - Impact of season of food frequency questionnaire administration on dietary reportingJay H Fowke
Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
Ann Epidemiol 14:778-85. 2004..This study investigates the effect of season of FFQ administration, a proxy for the recent diet, on FFQ responses... - Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health StudyRaquel Villegas
Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Am J Clin Nutr 89:1059-67. 2009..Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns differ from Western populations... - Evaluation of breast cancer susceptibility loci in Chinese womenJirong Long
Division of Epidemiology, Department ofMedicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 19:2357-65. 2010..Recent genome-wide association studies (GWAS), mostly conducted among women of European ancestry, have identified 16 single-nucleotide polymorphisms (SNP) associated with breast cancer... - Fruit and vegetable consumption and risk of distal gastric cancer in the Shanghai Women's and Men's Health studiesMeira Epplein
Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Sixth Floor, Nashville, TN 37203, USA
Am J Epidemiol 172:397-406. 2010..67). No associations between dietary intakes of select antioxidant micronutrients were seen for men or women. Fruit intake is inversely associated with distal gastric cancer risk among men in Shanghai, China... - A prospective study of dietary polyunsaturated fatty acids and colorectal cancer risk in Chinese womenHarvey J Murff
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 18:2283-91. 2009..03). These results suggest that dietary PUFA and the ratio of n-6 to n-3 PUFA intake may be positively associated with colorectal cancer risk, and this association may be mediated in part through PGE(2) production... - Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese womenHui Cai
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Pharmacogenet Genomics 18:657-64. 2008..We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women... - Genetic polymorphisms of metastasis suppressor gene NME1 and breast cancer survivalShimian Qu
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Clin Cancer Res 14:4787-93. 2008.... - Prevalence and determinants of metabolic syndrome according to three definitions in middle-aged Chinese menRaquel Villegas
Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
Metab Syndr Relat Disord 7:37-45. 2009..We estimated the prevalence and lifestyle risk factors of metabolic syndrome according to three definitions of metabolic syndrome in urban Chinese men participating in the Shanghai Men's Health Study (SMHS)... - Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer CancersWei Zheng
Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
Am J Epidemiol 172:70-80. 2010..01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women... - Dietary iron intake and risk of endometrial cancer: a population-based case-control study in Shanghai, ChinaAsha R Kallianpur
Institute for Medicine and Public Health, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203 1738, USA
Nutr Cancer 62:40-50. 2010..Animal-derived iron intake is associated with increased risk of EC after menopause and among obese women. Avoidance of animal-derived (heme) iron may reduce the risk of EC in these women... - Is green tea drinking associated with a later onset of breast cancer?Qi Dai
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN 37203 1738, USA
Ann Epidemiol 20:74-81. 2010..Because of the substantial difference in levels of estrogens between premenopausal and postmenopausal women, the relationship between tea consumption and breast cancer risk may depend on menopausal status... - Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer riskGong Yang
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Am J Clin Nutr 91:704-11. 2010..Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates... - Oxidative stress, obesity, and breast cancer risk: results from the Shanghai Women's Health StudyQi Dai
Department of Medicine and Pharmacology, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Nashville, TN 37203 1738, USA
J Clin Oncol 27:2482-8. 2009..No prospective study has investigated whether levels of 15-F(2t)-isoprostane (15-F(2t)-IsoP) and its metabolite 2,3-dinor-5,6-dihydro-15-F(2t)-IsoP (15-F(2t)-IsoPM) are related to breast cancer risk... - Pregnancy, childrearing, and risk of stroke in Chinese womenXianglan Zhang
Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Sixth Floor, Suite 600, 2525 West End Avenue, Nashville, TN 37203 1738, USA
Stroke 40:2680-4. 2009..Although it has been suggested that high gravidity and parity increase the risk for coronary heart disease, their associations with stroke are unclear... - Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese menRaquel Villegas
Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
Metab Syndr Relat Disord 8:263-70. 2010..Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease. We estimated the prevalence and lifestyle risk factors of hyperuricemia in middle-aged, urban Chinese men... - Dietary patterns are associated with lower incidence of type 2 diabetes in middle-aged women: the Shanghai Women's Health StudyRaquel Villegas
Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
Int J Epidemiol 39:889-99. 2010..Data linking risk of type 2 diabetes (T2D) and dietary patterns in Chinese populations are scarce... - General and abdominal adiposity and risk of stroke in Chinese womenXianglan Zhang
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tenn 37203 1738, USA
Stroke 40:1098-104. 2009..Although both general and abdominal adiposity are well-established risk factors for coronary heart disease, their associations with stroke are less well characterized, particularly in generally lean Asian populations... - Prospective cohort study of soy food intake and colorectal cancer risk in womenGong Yang
Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
Am J Clin Nutr 89:577-83. 2009..Data from epidemiologic studies linking usual soy food intake with colorectal cancer are limited and inconsistent... - Dietary carbohydrates, fiber, and breast cancer risk in Chinese womenWanqing Wen
Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
Am J Clin Nutr 89:283-9. 2009..Few studies have investigated the association of dietary carbohydrate and fiber intake with breast cancer risk in women in China, where carbohydrate intake is traditionally high... - Resting heart rate and risk of type 2 diabetes in womenXianglan Zhang
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Int J Epidemiol 39:900-6. 2010..Resting heart rate has been shown to predict risk of cardiovascular disease; its association with diabetes remains unclear, particularly in non-Western populations... - Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese womenWei Zheng
Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
J Natl Cancer Inst 102:972-81. 2010..No risk assessment model that incorporates both genetic and clinical predictors is currently available to predict breast cancer risk in this population... - Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1Wei Zheng
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Nat Genet 41:324-8. 2009..01). These results strongly implicate 6q25.1 as a susceptibility locus for breast cancer... - Urinary isothiocyanate levels, brassica, and human breast cancerJay H Fowke
Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
Cancer Res 63:3980-6. 2003..In conclusion, greater Brassica vegetable consumption, as measured by the urinary ITC biomarker, was associated with significantly reduced breast cancer risk among Chinese women... - MTR and MTRR polymorphisms, dietary intake, and breast cancer riskMartha J Shrubsole
Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232-2587, USA
Cancer Epidemiol Biomarkers Prev 15:586-8. 2006 - The Shanghai Women's Health Study: rationale, study design, and baseline characteristicsWei Zheng
Center for Health Services Research, Department of Medicine, Vanderbilt University, Nashville, TN 37232 8300, USA
Am J Epidemiol 162:1123-31. 2005..The resources from the cohort will be valuable in future studies of environmental exposures and biomarkers for the risk of cancer and other chronic diseases... - Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormonesGong Yang
Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
Breast Cancer Res Treat 94:63-70. 2005..No similar effect modification was found for premenopausal breast cancer, however. These data suggest that the SULT1A1 Arg213His polymorphism may modify the effect of endogenous sex hormone exposures on postmenopausal breast cancer risk... - MTHFR genotypes and breast cancer survival after surgery and chemotherapy: a report from the Shanghai Breast Cancer StudyMartha J Shrubsole
Department of Medicine, Division of Internal Medicine, Vanderbilt School of Medicine, Vanderbilt University, Nashville, TN 37232 2587, USA
Breast Cancer Res Treat 91:73-9. 2005..97, 95% CI: 1.10-7.98, p for trend=0.04). The A1298C genotypes were not significantly associated with risk of death. This study suggests that the MTHFR C677T polymorphisms may affect long-term survival from advanced breast cancer... - Physical activity and risk of endometrial cancer: a report from the Shanghai endometrial cancer studyCharles E Matthews
Division of General Internal Medicine, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Medical Center East, Suite 6100, Nashville, TN 37232 8300, USA
Cancer Epidemiol Biomarkers Prev 14:779-85. 2005..These findings suggest that both lifestyle activities of lower intensity (e.g., walking and doing household chores) and intentional exercise can reduce endometrial cancer risk... - Genetic polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinomaGong Yang
Vanderbilt Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
Cancer 103:52-8. 2005....
Research Grants
- Soy Food and Coronary Heart Disease in WomenXiao Ou Shu; Fiscal Year: 2007....
- Cohort Study of Cancer-Inhibitory Dietary Factors in MenXiao Ou Shu; Fiscal Year: 2007..The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men. ..
- Vanderbilt-Shanghai Chronic Disease Research Training ProgramXiao Ou Shu; Fiscal Year: 2009..This program will have significant impact on chronic disease research and prevention in China, and possibly extend to other developing countries. ..
- Cohort Study of Cancer-Inhibitory Dietary Factors in MenXiao Ou Shu; Fiscal Year: 2010..The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men. ..
- Breast Cancer Survival: Lifestyle and Genetic DeterminantsXiao Ou Shu; Fiscal Year: 2010..The proposed study, built on successfully implemented cohort studies, will be extremely timely and cost-efficient. ..
- Soyfood, gene polymorphisms and endometrial cancer riskXiao Ou Shu; Fiscal Year: 2010..abstract_text> ..
- Cohort Study of Cancer inhibitory Factors in MenXiao Ou Shu; Fiscal Year: 2006....
- MALIGNANT GERM CELL TUMORS IN CHILDRENXiao Shu; Fiscal Year: 2001..The relatively large sample size will provide sufficient statistical power to address the hypotheses being investigated. ..
- Soyfood, gene polymorphisms and endometrial cancer riskXiao Ou Shu; Fiscal Year: 2005..Consumption level of soyfood is high and hysterectomy rates are extremely low among Chinese women, providing a unique opportunity to test the hypotheses posed in the application that are difficult to be evaluated in the U.S. population. ..
- Breast Cancer Survival: Lifestyle and Genetic DeterminantsXiao Ou Shu; Fiscal Year: 2009..The proposed study, built on successfully implemented cohort studies, will be extremely timely and cost-efficient. ..