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Species | Bryan E ShepherdSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Using audit information to adjust parameter estimates for data errors in clinical trialsBryan E Shepherd
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
Clin Trials 9:721-9. 2012..In an earlier study, using data from a nonrandomized study, Shepherd and Yu developed statistical methods to incorporate audit results into study estimates and demonstrated that audit data could be used to eliminate bias...
Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responsesShannon S Allen
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
Respir Res 9:36. 2008..The purpose of this study is to investigate if target antigens of the sarcoidosis immune response can be identified by molecular analysis of sarcoidosis granulomas...- Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in ZambiaJohn R Koethe
Centre for Infectious Diseases Research in Zambia, Plot 1275 Lubuto Road, Lusaka, Zambia
J Int AIDS Soc 14:19. 2011..The relationship between nutrition and inflammation-related serum biomarkers and early treatment outcomes (e.g., less than 90 days) in this population is not well described... - Sensitivity Analyses Comparing Time-to-Event Outcomes Existing Only in a Subset Selected PostrandomizationBryan E Shepherd
Department of Biostatistics, Vanderbilt University, Nashville, TN 37232 e mail
J Am Stat Assoc 102:573-82. 2007..We propose nonparametric, semiparametric, and parametric methods for estimating the survival causal effect. We apply these methods to the first Phase III preventative HIV vaccine trial, VaxGen's trial of AIDSVAX B/B... - Cross-cohort heterogeneity encountered while validating a model for HIV disease progression among antiretroviral initiatorsBryan E Shepherd
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
J Clin Epidemiol 62:729-37. 2009..To evaluate a model for predicting time to AIDS or death among HIV-infected persons initiating highly active antiretroviral therapy (HAART)... - Accounting for data errors discovered from an audit in multiple linear regressionBryan E Shepherd
Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
Biometrics 67:1083-91. 2011.... - Estimating the optimal CD4 count for HIV-infected persons to start antiretroviral therapyBryan E Shepherd
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Epidemiology 21:698-705. 2010..We sought to expand this understanding using a novel statistical approach proposed by Robins et al... 
The cost of checking proportional hazardsBryan E Shepherd
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, U S A
Stat Med 27:1248-60. 2008..77 as opposed to 0.95 for CI accounting for the PH check. The impact of checking the PH assumption is greatest when the p-value of the test for PH is close to the test's chosen Type I error probability...- Sensitivity analyses comparing outcomes only existing in a subset selected post-randomization, conditional on covariates, with application to HIV vaccine trialsBryan E Shepherd
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biometrics 62:332-42. 2006..We apply our methods to the world's first phase III HIV vaccine trial... - Sensitivity analyses comparing time-to-event outcomes only existing in a subset selected postrandomization and relaxing monotonicityBryan E Shepherd
Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
Biometrics 67:1100-10. 2011..g., infection status k years after randomization is unknown for some because of staggered study entry). We illustrate our method using data from an HIV vaccine trial... - Postpartum discontinuation of antiretroviral therapy and risk of maternal AIDS-defining events, non-AIDS-defining events, and mortality among a cohort of HIV-1-infected women in the United StatesVlada V Melekhin
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
AIDS Patient Care STDS 24:279-86. 2010..Larger studies with longer follow-up are indicated to assess this association... - An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton ratsHoyin Mok
Departments of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
J Virol 82:11410-8. 2008..Aberrant cytokine gene expression was not detected in these animals. Together, these results represent an important first step toward the use of VRPs encoding hMPV F proteins as a prophylactic vaccine for hMPV... - Comparison of visual inspection with acetic acid and cervical cytology to detect high-grade cervical neoplasia among HIV-infected women in IndiaVikrant V Sahasrabuddhe
Vanderbilt University School of Medicine, Nashville, TN, USA
Int J Cancer 130:234-40. 2012.... - Antiretroviral therapy initiation before, during, or after pregnancy in HIV-1-infected women: maternal virologic, immunologic, and clinical responseVlada V Melekhin
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 4:e6961. 2009..The effect of timing of HAART initiation relative to pregnancy on maternal virologic, immunologic and clinical outcomes has not been assessed... - Race and sex differences in antiretroviral therapy use and mortality among HIV-infected persons in careDiana C Lemly
School of Medicine, Department of Biostatistics, Vanderbilt University, Nashville, TN 37203, USA
J Infect Dis 199:991-8. 2009..There are conflicting data regarding race, sex, and mortality among persons infected with human immunodeficiency virus (HIV). We studied all-cause mortality among persons in care during the highly-active antiretroviral therapy (HAART) era... - Tuberculosis risk before and after highly active antiretroviral therapy initiation: does HAART increase the short-term TB risk in a low incidence TB setting?April C Pettit
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2582, USA
J Acquir Immune Defic Syndr 57:305-10. 2011..To evaluate the short-term and long-term effects of highly active antiretroviral therapy (HAART) on tuberculosis (TB) risk compared with risk without HAART in a low TB incidence setting... - Non-AIDS-defining events among HIV-1-infected adults receiving combination antiretroviral therapy in resource-replete versus resource-limited urban settingC William Wester
Vanderbilt University School of Medicine, Nashville, Tennessee, USA
AIDS 25:1471-9. 2011..To compare incidence and distribution of non-AIDS-defining events (NADEs) among HIV-1-infected adults receiving combination antiretroviral therapy (cART) in urban sub-Saharan African versus United States settings... - Dual analysis for mycobacteria and propionibacteria in sarcoidosis BALKyra A Oswald-Richter
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
J Clin Immunol 32:1129-40. 2012.... - Active cocaine use is associated with lack of HIV-1 virologic suppression independent of nonadherence to antiretroviral therapy: use of a rapid screening tool during routine clinic visitsDaniel A Rasbach
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
AIDS Care 25:109-17. 2013..46; 95% confidence interval (95% CI): 0.22-0.98) but marijuana use was not (aOR: 1.08; 95% CI: 0.72-1.62). This result strengthens the evidence of a direct effect of cocaine on virologic control, independent of nonadherence to ART... - An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapyJohn R Koethe
Department of Medicine, Division of Infectious Diseases, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Clin Infect Dis 53:952-60. 2011.... - The relationship between injection and noninjection drug use and HIV disease progressionHan Zhu Qian
Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN, USA
J Subst Abuse Treat 41:14-20. 2011..Injection drug use is associated with poor HIV outcomes even among persons receiving highly active antiretroviral therapy (HAART), but there are limited data on the relationship between noninjection drug use and HIV disease progression... - Absolute count and percentage of CD4+ lymphocytes are independent predictors of disease progression in HIV-infected persons initiating highly active antiretroviral therapyTodd Hulgan
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
J Infect Dis 195:425-31. 2007.... - Hemoglobin may contribute to sex differences in mortality among HIV-infected persons in careVlada V Melekhin
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
PLoS ONE 7:e44999. 2012..Anemia is a known predictor of HIV-related mortality. We assessed whether anemia contributed to the sex difference in mortality in our cohort... - Virologic, immunologic and clinical responses in foreign-born versus US-born HIV-1 infected adults initiating antiretroviral therapy: an observational cohort studyDeidra D Parrish
Vanderbilt University Institute for Global Health, Nashville, Tennessee, USA
PLoS ONE 7:e52336. 2012..This study aimed to determine whether there is a difference in these outcomes in a United States setting between foreign-born and US-born patients... - A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinovirusesE Kathryn Miller
Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
Am J Respir Crit Care Med 185:508-16. 2012..Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, their mechanism remains unclear... - Estimated mortality of adult HIV-infected patients starting treatment with combination antiretroviral therapyCONSTANTIN THEODORE YIANNOUTSOS
Department of Biostatistics, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202, USA
Sex Transm Infect 88:i33-43. 2012..To provide estimates of mortality among HIV-infected patients starting combination antiretroviral therapy... - Measuring the quality of observational study data in an international HIV research networkStephany N Duda
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 7:e33908. 2012..The authors recommend that all participants in observational cohorts use data audits to assess and improve the quality of data and to guide future data collection and abstraction efforts at the point of care... - The pediatric burden of human coronaviruses evaluated for twenty yearsH Keipp Talbot
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Pediatr Infect Dis J 28:682-7. 2009..The epidemiology of human coronaviruses (HCoVs) has not been established using reverse transcription polymerase chain reaction techniques in a specimen collection that spans decades... - Does douching increase risk for sexually transmitted infections? A prospective study in high-risk adolescentsCynthia S Tsai
Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN, USA
Am J Obstet Gynecol 200:38.e1-8. 2009..The objective of the study was to examine the association between douching and 4 sexually transmitted infections (STIs)... - Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101Kyra Oswald-Richter
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
J Clin Immunol 30:157-66. 2010..We previously reported immune recognition of Mycobacterium peptides from peripheral cells of 26 sarcoidosis subjects, 24 PPD- healthy volunteers, and eight with latent tuberculosis infection... - Predictors of adherence to antiretroviral therapy in rural ZambiaJames G Carlucci
Institute of Global Health, Departments of Pediatrics and Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 0242, USA
J Acquir Immune Defic Syndr 47:615-22. 2008..We sought to assess travel to point-of-care for ART as a potential barrier to adherence in rural Zambia, within the context of patient demographics, perceived stigma, and selected clinical indices... - Risk factors and prevalence of tuberculosis, human immunodeficiency virus, syphilis, hepatitis B virus, and hepatitis C virus among prisoners in PakistanAbdul M Kazi
Departments of Preventive Medicine, Biostatistics and Pediatrics, Vanderbilt University Institute for Global Health, 2215 Garland Ave, Nashville, TN 37232 0242, USA
Int J Infect Dis 14:e60-6. 2010..The objective of this study was to evaluate the burden of sexual- and injection drug use-related infections in male prisoners in Karachi, Pakistan... - Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosisWonder P Drake
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
Infect Immun 75:527-30. 2007..0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis... - Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosisRana Hajizadeh
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
J Clin Immunol 27:445-54. 2007.... - Clinical impact of blood cultures contaminated with coagulase-negative staphylococci at an academic medical centerYuri F van der Heijden
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Infect Control Hosp Epidemiol 32:623-5. 2011..For the 85 patients whose cultures were determined to be contaminated, chart abstractions revealed substantial unnecessary antibiotic administration, additional laboratory tests and procedures, and hospital readmissions... - Serum phosphate predicts early mortality in adults starting antiretroviral therapy in Lusaka, Zambia: a prospective cohort studyDouglas C Heimburger
Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
PLoS ONE 5:e10687. 2010..We assessed the association of serum phosphate with early mortality among HIV-infected adults with severe malnutrition and/or advanced immunosuppression... - Human rhinoviruses in severe respiratory disease in very low birth weight infantsE Kathryn Miller
Department of Pediatrics, Vanderbilt University, Nashville, TN 37232 2007, USA
Pediatrics 129:e60-7. 2012..To assess incidence, burden of illness, and risk factors for human rhinoviruses (HRVs) in a cohort of very low birth weight (VLBW) infants... - Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2Thomas J Utley
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 105:10209-14. 2008..RSV budding was independent of the ESCRT machinery, the only well-defined budding mechanism for enveloped RNA viruses. Therefore, RSV uses a virus budding mechanism that is controlled by FIP2... - HIV/AIDS-related attitudes and practices among traditional healers in Zambézia Province, MozambiqueCarolyn M Audet
Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
J Altern Complement Med 18:1133-41. 2012..To document HIV knowledge, treatment practices, and the willingness of traditional healers to engage with the health system in Zambézia Province, Mozambique... - Hematopoietic stem-cell behavior in nonhuman primatesBryan E Shepherd
Department of Biostatistics, Vanderbilt University, Nashville, TN, USA
Blood 110:1806-13. 2007..Thus, our data suggest that the self-renewal capacity of mammalian stem cells in vivo is defined and evolutionarily conserved... - Prevalence and predictors of colposcopic-histopathologically confirmed cervical intraepithelial neoplasia in HIV-infected women in IndiaVikrant V Sahasrabuddhe
Institute for Global Health, Vanderbilt University, Nashville, Tennessee, USA
PLoS ONE 5:e8634. 2010..We sought to better establish prevalence estimates and evaluate risk factors of CIN among HIV-infected women in Pune, India using colposcopy and histopathology as diagnostic tools... - Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosisKyra A Oswald-Richter
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2363, USA
Infect Immun 77:3740-8. 2009..Inhibition of immune recognition with monoclonal antibody against Toll-like receptor 2 suggests that induction of innate immunity by mycobacteria contributes to the polarized Th1 immune response... - Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clonesCuixia Tian
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2905, USA
J Immunol 180:3279-88. 2008..Increased diversity in the VH gene repertoire of the two memory B cell groups derived from broader usage of VH gene segments, increased junctional diversity that was introduced by differential TdT activities, and somatic hypermutation... - Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton ratsHoyin Mok
Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
J Virol 81:13710-22. 2007..These results represent an important first step toward the use of VRPs encoding RSV proteins as a prophylactic vaccine for RSV... - A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivoJohn V Williams
Pediatric Infectious Diseases, Vanderbilt University Medical Center, D 7235 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232
J Virol 81:8315-24. 2007..There was a dose-response relationship between the dose of DS7 and virus titer. Human Fab DS7 may have prophylactic or therapeutic potential against severe hMPV infection... - Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, ZambiaGroesbeck P Parham
School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA, and University Teaching Hospital, Lusaka, Zambia
Gynecol Oncol 103:1017-22. 2006..We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia... - HIV-1 virologic and immunologic progression and initiation of antiretroviral therapy among HIV-1-infected subjects in a trial of the efficacy of recombinant glycoprotein 120 vaccinePeter B Gilbert
Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
J Infect Dis 192:974-83. 2005..The pre-ART viral load and CD4+ lymphocyte count trajectories were also comparable between the groups. Evidently, the vaccine did not affect HIV-1 disease progression... - Mortality and burden of disease in a cohort of HIV-seropositive adults in Nairobi, KenyaChristina W Mwachari
Centre for Respiratory Disease Research, Kenya Medical Research Institute, PO Box 54840, Nairobi, Kenya
Int J STD AIDS 15:120-6. 2004..0, 95% confidence interval 1.7-5.1). These findings may help to target high-risk populations and guide OI prevention and treatment strategies including decisions regarding initiation of antiretroviral therapy in sub-Saharan Africa... - Sampling designs for HIV molecular epidemiology with application to HondurasBryan E Shepherd
Department of Biostastics, Medical Education, University of Washington, Seattle, Washington 98195 7232, USA
AIDS Res Hum Retroviruses 21:907-14. 2005..We illustrate the approach through a study designed to survey the heterogeneity of subtype B strains in Honduras...