Bryan E Shepherd

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Impact of definitions of loss to follow-up on estimates of retention, disease progression, and mortality: application to an HIV program in Mozambique
    Bryan E Shepherd
    Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 2158, USA
    Am J Epidemiol 178:819-28. 2013
  2. pmc Using audit information to adjust parameter estimates for data errors in clinical trials
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    Clin Trials 9:721-9. 2012
  3. pmc Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses
    Shannon S Allen
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    Respir Res 9:36. 2008
  4. pmc Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in Zambia
    John R Koethe
    Centre for Infectious Diseases Research in Zambia, Plot 1275 Lubuto Road, Lusaka, Zambia
    J Int AIDS Soc 14:19. 2011
  5. pmc Estimating the optimal CD4 count for HIV-infected persons to start antiretroviral therapy
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Epidemiology 21:698-705. 2010
  6. ncbi request reprint The cost of checking proportional hazards
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, U S A
    Stat Med 27:1248-60. 2008
  7. pmc Cross-cohort heterogeneity encountered while validating a model for HIV disease progression among antiretroviral initiators
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    J Clin Epidemiol 62:729-37. 2009
  8. pmc Sensitivity Analyses Comparing Time-to-Event Outcomes Existing Only in a Subset Selected Postrandomization
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University, Nashville, TN 37232 e mail
    J Am Stat Assoc 102:573-82. 2007
  9. pmc Accounting for data errors discovered from an audit in multiple linear regression
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Biometrics 67:1083-91. 2011
  10. pmc Sensitivity analyses comparing time-to-event outcomes only existing in a subset selected postrandomization and relaxing monotonicity
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Biometrics 67:1100-10. 2011

Detail Information

Publications56

  1. pmc Impact of definitions of loss to follow-up on estimates of retention, disease progression, and mortality: application to an HIV program in Mozambique
    Bryan E Shepherd
    Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 2158, USA
    Am J Epidemiol 178:819-28. 2013
    ..Selection of LTF definitions should be based on the study outcome, available data on clinical encounters, and the patients' visit schedules; we suggest some general guidelines. ..
  2. pmc Using audit information to adjust parameter estimates for data errors in clinical trials
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    Clin Trials 9:721-9. 2012
    ..In an earlier study, using data from a nonrandomized study, Shepherd and Yu developed statistical methods to incorporate audit results into study estimates and demonstrated that audit data could be used to eliminate bias...
  3. pmc Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses
    Shannon S Allen
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    Respir Res 9:36. 2008
    ..The purpose of this study is to investigate if target antigens of the sarcoidosis immune response can be identified by molecular analysis of sarcoidosis granulomas...
  4. pmc Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in Zambia
    John R Koethe
    Centre for Infectious Diseases Research in Zambia, Plot 1275 Lubuto Road, Lusaka, Zambia
    J Int AIDS Soc 14:19. 2011
    ..The relationship between nutrition and inflammation-related serum biomarkers and early treatment outcomes (e.g., less than 90 days) in this population is not well described...
  5. pmc Estimating the optimal CD4 count for HIV-infected persons to start antiretroviral therapy
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Epidemiology 21:698-705. 2010
    ..We sought to expand this understanding using a novel statistical approach proposed by Robins et al...
  6. ncbi request reprint The cost of checking proportional hazards
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, U S A
    Stat Med 27:1248-60. 2008
    ..77 as opposed to 0.95 for CI accounting for the PH check. The impact of checking the PH assumption is greatest when the p-value of the test for PH is close to the test's chosen Type I error probability...
  7. pmc Cross-cohort heterogeneity encountered while validating a model for HIV disease progression among antiretroviral initiators
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    J Clin Epidemiol 62:729-37. 2009
    ..To evaluate a model for predicting time to AIDS or death among HIV-infected persons initiating highly active antiretroviral therapy (HAART)...
  8. pmc Sensitivity Analyses Comparing Time-to-Event Outcomes Existing Only in a Subset Selected Postrandomization
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University, Nashville, TN 37232 e mail
    J Am Stat Assoc 102:573-82. 2007
    ..We propose nonparametric, semiparametric, and parametric methods for estimating the survival causal effect. We apply these methods to the first Phase III preventative HIV vaccine trial, VaxGen's trial of AIDSVAX B/B...
  9. pmc Accounting for data errors discovered from an audit in multiple linear regression
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Biometrics 67:1083-91. 2011
    ....
  10. pmc Sensitivity analyses comparing time-to-event outcomes only existing in a subset selected postrandomization and relaxing monotonicity
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Biometrics 67:1100-10. 2011
    ..g., infection status k years after randomization is unknown for some because of staggered study entry). We illustrate our method using data from an HIV vaccine trial...
  11. ncbi request reprint Sensitivity analyses comparing outcomes only existing in a subset selected post-randomization, conditional on covariates, with application to HIV vaccine trials
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biometrics 62:332-42. 2006
    ..We apply our methods to the world's first phase III HIV vaccine trial...
  12. pmc Postpartum discontinuation of antiretroviral therapy and risk of maternal AIDS-defining events, non-AIDS-defining events, and mortality among a cohort of HIV-1-infected women in the United States
    Vlada V Melekhin
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    AIDS Patient Care STDS 24:279-86. 2010
    ..Larger studies with longer follow-up are indicated to assess this association...
  13. pmc An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats
    Hoyin Mok
    Departments of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Virol 82:11410-8. 2008
    ..Aberrant cytokine gene expression was not detected in these animals. Together, these results represent an important first step toward the use of VRPs encoding hMPV F proteins as a prophylactic vaccine for hMPV...
  14. pmc Active cocaine use is associated with lack of HIV-1 virologic suppression independent of nonadherence to antiretroviral therapy: use of a rapid screening tool during routine clinic visits
    Daniel A Rasbach
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    AIDS Care 25:109-17. 2013
    ..46; 95% confidence interval (95% CI): 0.22-0.98) but marijuana use was not (aOR: 1.08; 95% CI: 0.72-1.62). This result strengthens the evidence of a direct effect of cocaine on virologic control, independent of nonadherence to ART...
  15. pmc Comparison of visual inspection with acetic acid and cervical cytology to detect high-grade cervical neoplasia among HIV-infected women in India
    Vikrant V Sahasrabuddhe
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Cancer 130:234-40. 2012
    ....
  16. ncbi request reprint Haemoglobin recovery among HIV-1 infected patients on zidovudine-based antiretroviral therapy and other regimens in north-central Nigeria
    Deidra D Parrish
    Vanderbilt Institute for Global Health, Nashville, TN, USA
    Int J STD AIDS 25:355-9. 2014
    ..These results have implications for decisions regarding when to initiate, switch from or avoid the use of zidovudine...
  17. pmc Risk factors for delayed initiation of combination antiretroviral therapy in rural north central Nigeria
    Muktar H Aliyu
    Departments of Preventive Medicine, Medicine, and Biostatistics, Vanderbilt Institute for Global Health, Nashville, TN Westat, Rockville, MD Friends in Global Health, Abuja, Nigeria US Centers for Disease Control and Prevention, Abuja, Nigeria and the Department of Pediatrics, Vanderbilt Institute for Global Health, Nashville, TN
    J Acquir Immune Defic Syndr 65:e41-9. 2014
    ..Nigeria has the second largest number of persons living with HIV/AIDS in the world. We examined patient characteristics, time to ART initiation, retention, and mortality at 5 rural facilities in Kwara and Niger states of Nigeria...
  18. pmc Antiretroviral therapy initiation before, during, or after pregnancy in HIV-1-infected women: maternal virologic, immunologic, and clinical response
    Vlada V Melekhin
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 4:e6961. 2009
    ..The effect of timing of HAART initiation relative to pregnancy on maternal virologic, immunologic and clinical outcomes has not been assessed...
  19. pmc Non-AIDS-defining events among HIV-1-infected adults receiving combination antiretroviral therapy in resource-replete versus resource-limited urban setting
    C William Wester
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    AIDS 25:1471-9. 2011
    ..To compare incidence and distribution of non-AIDS-defining events (NADEs) among HIV-1-infected adults receiving combination antiretroviral therapy (cART) in urban sub-Saharan African versus United States settings...
  20. pmc Tuberculosis risk before and after highly active antiretroviral therapy initiation: does HAART increase the short-term TB risk in a low incidence TB setting?
    April C Pettit
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2582, USA
    J Acquir Immune Defic Syndr 57:305-10. 2011
    ..To evaluate the short-term and long-term effects of highly active antiretroviral therapy (HAART) on tuberculosis (TB) risk compared with risk without HAART in a low TB incidence setting...
  21. doi request reprint Race and sex differences in antiretroviral therapy use and mortality among HIV-infected persons in care
    Diana C Lemly
    School of Medicine, Department of Biostatistics, Vanderbilt University, Nashville, TN 37203, USA
    J Infect Dis 199:991-8. 2009
    ..There are conflicting data regarding race, sex, and mortality among persons infected with human immunodeficiency virus (HIV). We studied all-cause mortality among persons in care during the highly-active antiretroviral therapy (HAART) era...
  22. pmc The relationship between injection and noninjection drug use and HIV disease progression
    Han Zhu Qian
    Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Subst Abuse Treat 41:14-20. 2011
    ..Injection drug use is associated with poor HIV outcomes even among persons receiving highly active antiretroviral therapy (HAART), but there are limited data on the relationship between noninjection drug use and HIV disease progression...
  23. pmc Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL
    Kyra A Oswald-Richter
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    J Clin Immunol 32:1129-40. 2012
    ....
  24. pmc Virologic, immunologic and clinical responses in foreign-born versus US-born HIV-1 infected adults initiating antiretroviral therapy: an observational cohort study
    Deidra D Parrish
    Vanderbilt University Institute for Global Health, Nashville, Tennessee, USA
    PLoS ONE 7:e52336. 2012
    ..This study aimed to determine whether there is a difference in these outcomes in a United States setting between foreign-born and US-born patients...
  25. pmc An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapy
    John R Koethe
    Department of Medicine, Division of Infectious Diseases, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Infect Dis 53:952-60. 2011
    ....
  26. ncbi request reprint Absolute count and percentage of CD4+ lymphocytes are independent predictors of disease progression in HIV-infected persons initiating highly active antiretroviral therapy
    Todd Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Infect Dis 195:425-31. 2007
    ....
  27. pmc Optimizing PMTCT service delivery in rural North-Central Nigeria: protocol and design for a cluster randomized study
    Muktar H Aliyu
    Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN, USA
    Contemp Clin Trials 36:187-97. 2013
    ....
  28. pmc Measuring the quality of observational study data in an international HIV research network
    Stephany N Duda
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33908. 2012
    ..The authors recommend that all participants in observational cohorts use data audits to assess and improve the quality of data and to guide future data collection and abstraction efforts at the point of care...
  29. pmc Hemoglobin may contribute to sex differences in mortality among HIV-infected persons in care
    Vlada V Melekhin
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 7:e44999. 2012
    ..Anemia is a known predictor of HIV-related mortality. We assessed whether anemia contributed to the sex difference in mortality in our cohort...
  30. pmc HIV/AIDS-related attitudes and practices among traditional healers in Zambézia Province, Mozambique
    Carolyn M Audet
    Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Altern Complement Med 18:1133-41. 2012
    ..To document HIV knowledge, treatment practices, and the willingness of traditional healers to engage with the health system in Zambézia Province, Mozambique...
  31. pmc A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Respir Crit Care Med 185:508-16. 2012
    ..Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, their mechanism remains unclear...
  32. pmc Sex with women among men who have sex with men in China: prevalence and sexual practices
    Jun Tao
    Vanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN 37203, USA
    AIDS Patient Care STDS 27:524-8. 2013
    ..HIV prevention intervention programs should break the bridging role of HIV transmission in MSMW population...
  33. pmc Predictors of adherence to antiretroviral therapy in rural Zambia
    James G Carlucci
    Institute of Global Health, Departments of Pediatrics and Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 0242, USA
    J Acquir Immune Defic Syndr 47:615-22. 2008
    ..We sought to assess travel to point-of-care for ART as a potential barrier to adherence in rural Zambia, within the context of patient demographics, perceived stigma, and selected clinical indices...
  34. pmc Estimated mortality of adult HIV-infected patients starting treatment with combination antiretroviral therapy
    CONSTANTIN THEODORE YIANNOUTSOS
    Department of Biostatistics, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202, USA
    Sex Transm Infect 88:i33-43. 2012
    ..To provide estimates of mortality among HIV-infected patients starting combination antiretroviral therapy...
  35. pmc The pediatric burden of human coronaviruses evaluated for twenty years
    H Keipp Talbot
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pediatr Infect Dis J 28:682-7. 2009
    ..The epidemiology of human coronaviruses (HCoVs) has not been established using reverse transcription polymerase chain reaction techniques in a specimen collection that spans decades...
  36. pmc Does douching increase risk for sexually transmitted infections? A prospective study in high-risk adolescents
    Cynthia S Tsai
    Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Obstet Gynecol 200:38.e1-8. 2009
    ..The objective of the study was to examine the association between douching and 4 sexually transmitted infections (STIs)...
  37. pmc Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101
    Kyra Oswald-Richter
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Clin Immunol 30:157-66. 2010
    ..We previously reported immune recognition of Mycobacterium peptides from peripheral cells of 26 sarcoidosis subjects, 24 PPD- healthy volunteers, and eight with latent tuberculosis infection...
  38. pmc Risk factors and prevalence of tuberculosis, human immunodeficiency virus, syphilis, hepatitis B virus, and hepatitis C virus among prisoners in Pakistan
    Abdul M Kazi
    Departments of Preventive Medicine, Biostatistics and Pediatrics, Vanderbilt University Institute for Global Health, 2215 Garland Ave, Nashville, TN 37232 0242, USA
    Int J Infect Dis 14:e60-6. 2010
    ..The objective of this study was to evaluate the burden of sexual- and injection drug use-related infections in male prisoners in Karachi, Pakistan...
  39. pmc Serum phosphate predicts early mortality in adults starting antiretroviral therapy in Lusaka, Zambia: a prospective cohort study
    Douglas C Heimburger
    Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
    PLoS ONE 5:e10687. 2010
    ..We assessed the association of serum phosphate with early mortality among HIV-infected adults with severe malnutrition and/or advanced immunosuppression...
  40. pmc Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis
    Rana Hajizadeh
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
    J Clin Immunol 27:445-54. 2007
    ....
  41. pmc Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis
    Wonder P Drake
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
    Infect Immun 75:527-30. 2007
    ..0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis...
  42. doi request reprint Clinical impact of blood cultures contaminated with coagulase-negative staphylococci at an academic medical center
    Yuri F van der Heijden
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Infect Control Hosp Epidemiol 32:623-5. 2011
    ..For the 85 patients whose cultures were determined to be contaminated, chart abstractions revealed substantial unnecessary antibiotic administration, additional laboratory tests and procedures, and hospital readmissions...
  43. pmc Human rhinoviruses in severe respiratory disease in very low birth weight infants
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232 2007, USA
    Pediatrics 129:e60-7. 2012
    ..To assess incidence, burden of illness, and risk factors for human rhinoviruses (HRVs) in a cohort of very low birth weight (VLBW) infants...
  44. pmc Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2
    Thomas J Utley
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:10209-14. 2008
    ..RSV budding was independent of the ESCRT machinery, the only well-defined budding mechanism for enveloped RNA viruses. Therefore, RSV uses a virus budding mechanism that is controlled by FIP2...
  45. pmc Serum Phosphate Predicts Early Mortality among Underweight Adults Starting ART in Zambia: A Novel Context for Refeeding Syndrome?
    John R Koethe
    Centre for Infectious Diseases Research in Zambia, Plot 1275 Lubuto Road, P O Box 34681, Lusaka 10101, Zambia Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, A2200 MCN, 1161 21st Avenue South, Nashville, TN 37232 2582, USA Vanderbilt Institute for Global Health, 2525 West End Avenue, Suite 750, Nashville, TN 37203, USA
    J Nutr Metab 2013:545439. 2013
    ..The association of low pretreatment serum phosphate level and early ART mortality among undernourished individuals may represent a variant of the refeeding syndrome. Further studies of cellular metabolism in this population are needed...
  46. pmc 25-Hydroxyvitamin D levels after recovery from tuberculosis: Insights into pathogenesis
    Moises A Huaman
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, USA Electronic address
    Tuberculosis (Edinb) 94:51-4. 2014
    ..We assessed 25(OH)D levels after recovery from TB disease, and compared to levels in persons without TB disease...
  47. pmc Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats
    Hoyin Mok
    Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Virol 81:13710-22. 2007
    ..These results represent an important first step toward the use of VRPs encoding RSV proteins as a prophylactic vaccine for RSV...
  48. pmc Prevalence and predictors of colposcopic-histopathologically confirmed cervical intraepithelial neoplasia in HIV-infected women in India
    Vikrant V Sahasrabuddhe
    Institute for Global Health, Vanderbilt University, Nashville, Tennessee, USA
    PLoS ONE 5:e8634. 2010
    ..We sought to better establish prevalence estimates and evaluate risk factors of CIN among HIV-infected women in Pune, India using colposcopy and histopathology as diagnostic tools...
  49. pmc A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo
    John V Williams
    Pediatric Infectious Diseases, Vanderbilt University Medical Center, D 7235 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232
    J Virol 81:8315-24. 2007
    ..There was a dose-response relationship between the dose of DS7 and virus titer. Human Fab DS7 may have prophylactic or therapeutic potential against severe hMPV infection...
  50. pmc Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis
    Kyra A Oswald-Richter
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2363, USA
    Infect Immun 77:3740-8. 2009
    ..Inhibition of immune recognition with monoclonal antibody against Toll-like receptor 2 suggests that induction of innate immunity by mycobacteria contributes to the polarized Th1 immune response...
  51. pmc Hematopoietic stem-cell behavior in nonhuman primates
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University, Nashville, TN, USA
    Blood 110:1806-13. 2007
    ..Thus, our data suggest that the self-renewal capacity of mammalian stem cells in vivo is defined and evolutionarily conserved...
  52. ncbi request reprint Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones
    Cuixia Tian
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2905, USA
    J Immunol 180:3279-88. 2008
    ..Increased diversity in the VH gene repertoire of the two memory B cell groups derived from broader usage of VH gene segments, increased junctional diversity that was introduced by differential TdT activities, and somatic hypermutation...
  53. ncbi request reprint Mortality and burden of disease in a cohort of HIV-seropositive adults in Nairobi, Kenya
    Christina W Mwachari
    Centre for Respiratory Disease Research, Kenya Medical Research Institute, PO Box 54840, Nairobi, Kenya
    Int J STD AIDS 15:120-6. 2004
    ..0, 95% confidence interval 1.7-5.1). These findings may help to target high-risk populations and guide OI prevention and treatment strategies including decisions regarding initiation of antiretroviral therapy in sub-Saharan Africa...
  54. pmc Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
    Groesbeck P Parham
    School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA, and University Teaching Hospital, Lusaka, Zambia
    Gynecol Oncol 103:1017-22. 2006
    ..We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia...
  55. ncbi request reprint HIV-1 virologic and immunologic progression and initiation of antiretroviral therapy among HIV-1-infected subjects in a trial of the efficacy of recombinant glycoprotein 120 vaccine
    Peter B Gilbert
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
    J Infect Dis 192:974-83. 2005
    ..The pre-ART viral load and CD4+ lymphocyte count trajectories were also comparable between the groups. Evidently, the vaccine did not affect HIV-1 disease progression...
  56. ncbi request reprint Sampling designs for HIV molecular epidemiology with application to Honduras
    Bryan E Shepherd
    Department of Biostastics, Medical Education, University of Washington, Seattle, Washington 98195 7232, USA
    AIDS Res Hum Retroviruses 21:907-14. 2005
    ..We illustrate the approach through a study designed to survey the heterogeneity of subtype B strains in Honduras...