H Sheng

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA
    H Sheng
    Department of Surgery, The Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 275:6628-35. 2000
  2. ncbi request reprint K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1
    H Sheng
    Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 61:2670-5. 2001
  3. ncbi request reprint Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth
    M Mann
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2279, USA
    Gastroenterology 120:1713-9. 2001
  4. ncbi request reprint Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells
    H Sheng
    Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 276:14498-504. 2001
  5. ncbi request reprint Prostaglandin E2 increases growth and motility of colorectal carcinoma cells
    H Sheng
    Departments of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2279, USA
    J Biol Chem 276:18075-81. 2001
  6. ncbi request reprint Transforming growth factor-beta1 promotes invasiveness after cellular transformation with activated Ras in intestinal epithelial cells
    K Fujimoto
    Department of Surgery, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Exp Cell Res 266:239-49. 2001
  7. pmc A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts
    C S Williams
    Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232-2279, USA
    Neoplasia 3:428-36. 2001

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA
    H Sheng
    Department of Surgery, The Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 275:6628-35. 2000
    ....
  2. ncbi request reprint K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1
    H Sheng
    Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 61:2670-5. 2001
    ..Thus, Akt/PKB activity is involved in K-Ras-induced expression of COX-2 and stabilization of COX-2 mRNA largely depends on the activation of Akt/PKB...
  3. ncbi request reprint Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth
    M Mann
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2279, USA
    Gastroenterology 120:1713-9. 2001
    ..Therefore, targeting of both the COX-2 and ErbB signaling pathways may represent a novel approach for the treatment and/or prevention of colorectal cancer in humans...
  4. ncbi request reprint Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells
    H Sheng
    Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 276:14498-504. 2001
    ..These findings delineate an important role for PI3K/Akt in Ras-mediated transformation of intestinal epithelial cells...
  5. ncbi request reprint Prostaglandin E2 increases growth and motility of colorectal carcinoma cells
    H Sheng
    Departments of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2279, USA
    J Biol Chem 276:18075-81. 2001
    ..Our results suggest that PGE(2) might enhance the invasive potential of colorectal carcinoma cells via activation of major intracellular signal transduction pathways not previously reported to be regulated by prostaglandins...
  6. ncbi request reprint Transforming growth factor-beta1 promotes invasiveness after cellular transformation with activated Ras in intestinal epithelial cells
    K Fujimoto
    Department of Surgery, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Exp Cell Res 266:239-49. 2001
    ..The enhancement of invasiveness was correlated with decreased E-cadherin levels and subcellular distribution of beta-catenin. The enhancement of oncogenic Ras-mediated cell transformation by TGF-beta1 occurs via TbetaRII...
  7. pmc A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts
    C S Williams
    Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232-2279, USA
    Neoplasia 3:428-36. 2001
    ..We conclude that SC-58125 primarily exerts a cytostatic effect in vivo, which is likely to be mediated through inhibition of progression through the G(2)/M phase of the cell cycle...