RICHARD CHARLES SHELTON

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint A randomized, double-blind, active-control study of sertraline versus venlafaxine XR in major depressive disorder
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tenn, USA
    J Clin Psychiatry 67:1674-81. 2006
  2. ncbi request reprint Adjunctive use of modafinil in bipolar patients: just another stimulant or not?
    Richard C Shelton
    Vanderbilt University, 1500 21st Avenue, South, Suite 2200, Nashville, TN 37212, USA
    Curr Psychiatry Rep 10:520-4. 2008
  3. pmc Amygdala temporal dynamics: temperamental differences in the timing of amygdala response to familiar and novel faces
    Jennifer U Blackford
    Department of Psychiatry, Vanderbilt University Medical School, Nashville, Tennessee, USA
    BMC Neurosci 10:145. 2009
  4. ncbi request reprint Olanzapine/fluoxetine combination for treatment-resistant depression: a controlled study of SSRI and nortriptyline resistance
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    J Clin Psychiatry 66:1289-97. 2005
  5. ncbi request reprint Olanzapine/fluoxetine combination for bipolar depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Expert Rev Neurother 6:33-9. 2006
  6. ncbi request reprint The nature of the discontinuation syndrome associated with antidepressant drugs
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
    J Clin Psychiatry 67:3-7. 2006
  7. doi request reprint Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A
    R C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuroscience 158:1406-15. 2009
  8. pmc Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression
    Richard C Shelton
    Vanderbilt University, 1500 21st Avenue South, Suite 2200, Nashville, TN 37212, USA
    Prog Neurobiol 91:275-99. 2010
  9. pmc The molecular neurobiology of depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, 1500 21st Avenue, South, Suite 2200, Nashville, TN 37212, USA
    Psychiatr Clin North Am 30:1-11. 2007
  10. doi request reprint Long-term management of depression: tips for adjusting the treatment plan as the patient's needs change
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Psychiatry 70:32-7. 2009

Research Grants

Detail Information

Publications64

  1. ncbi request reprint A randomized, double-blind, active-control study of sertraline versus venlafaxine XR in major depressive disorder
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tenn, USA
    J Clin Psychiatry 67:1674-81. 2006
    ..The objective of the current multisite study was to compare relatively higher doses of sertraline (i.e., 150 mg/day) and venlafaxine extended release (XR) (225 mg/day) in outpatients with major depressive disorder...
  2. ncbi request reprint Adjunctive use of modafinil in bipolar patients: just another stimulant or not?
    Richard C Shelton
    Vanderbilt University, 1500 21st Avenue, South, Suite 2200, Nashville, TN 37212, USA
    Curr Psychiatry Rep 10:520-4. 2008
    ..Given the limited options for bipolar depression, modafinil should be considered in patients who have not responded to approved treatments, although more research is needed...
  3. pmc Amygdala temporal dynamics: temperamental differences in the timing of amygdala response to familiar and novel faces
    Jennifer U Blackford
    Department of Psychiatry, Vanderbilt University Medical School, Nashville, Tennessee, USA
    BMC Neurosci 10:145. 2009
    ....
  4. ncbi request reprint Olanzapine/fluoxetine combination for treatment-resistant depression: a controlled study of SSRI and nortriptyline resistance
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    J Clin Psychiatry 66:1289-97. 2005
    ....
  5. ncbi request reprint Olanzapine/fluoxetine combination for bipolar depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Expert Rev Neurother 6:33-9. 2006
    ..However, many clinicians find management of weight gain in olanzapine treated patients a challenge. In addition, weight, waist circumference, lipids and glucose should be monitored...
  6. ncbi request reprint The nature of the discontinuation syndrome associated with antidepressant drugs
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
    J Clin Psychiatry 67:3-7. 2006
    ..As a result, it is vital that both patients and their relatives, especially caregivers, be provided with adequate education and a realistic and objective appraisal of expected outcomes upon initiation of antidepressant treatment...
  7. doi request reprint Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A
    R C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuroscience 158:1406-15. 2009
    ..The correlation of 5-HT(2A) receptor levels with PKA activity in the depressed group suggests that abnormalities of 5-HT(2A) receptor abundance may depend on receptor uncoupling and heterologous regulation by PKA...
  8. pmc Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression
    Richard C Shelton
    Vanderbilt University, 1500 21st Avenue South, Suite 2200, Nashville, TN 37212, USA
    Prog Neurobiol 91:275-99. 2010
    ..Mediational analysis suggests a bi-directional association between adiposity and depression, with inflammation possibly playing an intermediary role...
  9. pmc The molecular neurobiology of depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, 1500 21st Avenue, South, Suite 2200, Nashville, TN 37212, USA
    Psychiatr Clin North Am 30:1-11. 2007
    ..Doing so could lead to the development of novel interventions that could target specific points of vulnerability, allowing an improved matching of patient to treatment based on differential abnormalities at the cellular level...
  10. doi request reprint Long-term management of depression: tips for adjusting the treatment plan as the patient's needs change
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Psychiatry 70:32-7. 2009
    ..By anticipating and adjusting treatment to meet patients' changing needs over time, clinicians can help them achieve and maintain remission from depression...
  11. doi request reprint St John's wort (Hypericum perforatum) in major depression
    Richard C Shelton
    Department of Psychiatry, Mood Disorders Program, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Psychiatry 70:23-7. 2009
    ..Current evidence does not support its use, and, because of potential drug interactions, St John's wort is not a benign treatment...
  12. pmc Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    Int J Neuropsychopharmacol 12:1223-32. 2009
    ..These data continue to support the significance of abnormalities of these two key kinases, and suggest linkages between molecular endophenotypes and specific clinical phenotypes...
  13. ncbi request reprint Augmentation strategies to increase antidepressant efficacy
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Clin Psychiatry 68:18-22. 2007
    ..Beyond antidepressants and antipsychotics, alternative augmentation strategies include emerging pharmacologic treatments and nonpharmacologic strategies...
  14. doi request reprint Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Acta Psychiatr Scand 117:253-9. 2008
    ..Atypical antipsychotics (AAPs) have been hypothesized to be beneficial in treatment-resistant depression (TRD). This paper will review a biochemical rationale and will summarize the data regarding the effectiveness of AAPs in TRD...
  15. pmc Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
    R C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Mol Psychiatry 16:751-62. 2011
    ..The results of this study indicate that post-mortem brain tissue samples from BA10, a region that is involved in reward-related behavior, show evidence of local inflammatory, apoptotic, and oxidative stress in MDD...
  16. ncbi request reprint The combination of olanzapine and fluoxetine in mood disorders
    Richard C Shelton
    1500 21 Avenue, South, Suite 2200, Nashville, TN 37212, USA
    Expert Opin Pharmacother 4:1175-83. 2003
    ..These problems will have to be vigorously addressed in order to achieve a substantial market penetration for these conditions...
  17. ncbi request reprint The use of antidepressants in novel combination therapies
    Richard C Shelton
    Adult Psychiatry Division, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212 8646, USA
    J Clin Psychiatry 64:14-8. 2003
    ..However, more research is needed to corroborate these early results...
  18. pmc Inflammation in depression: is adiposity a cause?
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Dialogues Clin Neurosci 13:41-53. 2011
    ....
  19. ncbi request reprint The dual-action hypothesis: does pharmacology matter?
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, 1500 21st Ave, South, Suite 2200, Nashville, TN 37212, USA
    J Clin Psychiatry 65:5-10. 2004
    ..This review compares the neurobiology of single- and dual-action mechanisms...
  20. ncbi request reprint Differential expression of pentraxin 3 in fibroblasts from patients with major depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37211, USA
    Neuropsychopharmacology 29:126-32. 2004
    ..The results are of potential importance because PTX3 is a member of the long pentraxin subfamily of acute-phase proteins, which is inducible by IL-1beta, and may play roles in neuroimmunity and neuroprotection...
  21. ncbi request reprint Risperidone and paroxetine given singly and in combination for bipolar depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    J Clin Psychiatry 65:1715-9. 2004
    ..The current study was intended to evaluate the effects of the novel antipsychotic risperidone, the selective serotonin reup-take inhibitor (SSRI) paroxetine, and the combination in patients with bipolar disorder...
  22. pmc Sequence of improvement in depressive symptoms across cognitive therapy and pharmacotherapy
    Sunil S Bhar
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Affect Disord 110:161-6. 2008
    ..The authors examined the patterns of improvement in cognitive and vegetative symptoms of major depression in individuals treated with cognitive therapy (CT) or pharmacotherapy (PT)...
  23. ncbi request reprint Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
    J Clin Psychiatry 68:1014-23. 2007
    ..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
  24. ncbi request reprint Treatment with venlafaxine extended release after SSRI nonresponse or intolerance: a randomized comparison of standard- and higher-dosing strategies
    Michael E Thase
    University of Pittsburgh Medical Center, Department of Psychiatry, Pittsburgh, PA 15213 2593, USA
    J Clin Psychopharmacol 26:250-8. 2006
    ....
  25. ncbi request reprint Evidence for the efficacy of duloxetine in treating mild, moderate, and severe depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Int Clin Psychopharmacol 22:348-55. 2007
    ....
  26. ncbi request reprint Use of atypical antipsychotics for treatment-resistant major depressive disorder
    George I Papakostas
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    Curr Psychiatry Rep 10:481-6. 2008
    ..This review summarizes the existing data regarding the effectiveness of these medications in treating TRD, including biochemical rationale and clinical data...
  27. ncbi request reprint Do venlafaxine XR and paroxetine equally influence negative and positive affect?
    Gabriel S Dichter
    Department of Psychology, College of Arts and Sciences, Wilson Hall, Vanderbilt University, Nashville TN 37203, USA
    J Affect Disord 85:333-9. 2005
    ....
  28. ncbi request reprint Treating bipolar depression
    Richard C Shelton
    Vanderbilt University School of Medicine, Nashville, TN, USA
    J Fam Pract . 2003
  29. ncbi request reprint St John's wort for the treatment of depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Lancet Neurol 1:275. 2002
  30. doi request reprint Fluoxetine and olanzapine combination therapy in treatment-resistant major depression: review of efficacy and safety data
    William Victor Bobo
    Vanderbilt University School of Medicine, Department of Psychiatry, 1500 21st Ave South, Village at Vanderbilt, Nashville, TN 37212, USA
    Expert Opin Pharmacother 10:2145-59. 2009
    ..There has been growing evidence supporting the use of atypical antipsychotic drugs as adjunctive treatments in patients with major depression who fail to respond adequately to antidepressants...
  31. doi request reprint Efficacy, safety and tolerability of Symbyax for acute-phase management of treatment-resistant depression
    William V Bobo
    Department of Psychiatry, Vanderbilt University School of Medicine, South Suite 2200, Village at Vanderbilt, Nashville, TN 37212, USA
    Expert Rev Neurother 10:651-70. 2010
    ..As such, the exact place of OFC among the available therapeutic options for TRD is not fully understood at this time...
  32. doi request reprint Converting from brand-name to generic clozapine: a review of effectiveness and tolerability data
    William V Bobo
    Department of Psychiatry, School of Medicine, Vanderbilt University, 1601 23rd Avenue South, Suite 3035, Nashville, TN 37212, USA
    Am J Health Syst Pharm 67:27-37. 2010
    ..The effectiveness and tolerability of switching patients' therapy from brand-name to generic clozapine are reviewed...
  33. doi request reprint Therapeutic options for treatment-resistant depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    CNS Drugs 24:131-61. 2010
    ....
  34. doi request reprint Risperidone long-acting injectable (Risperdal Consta®) for maintenance treatment in patients with bipolar disorder
    William V Bobo
    Department of Psychiatry, Vanderbilt University School of Medicine, 1500 21st Ave, South, Suite 2200, Village at Vanderbilt, Nashville, TN 37212, USA
    Expert Rev Neurother 10:1637-58. 2010
    ..Responder-enriched designs and exclusion of important clinical subgroups in the double-blind trials may limit translation of these results to routine care settings...
  35. ncbi request reprint Prevention of relapse following cognitive therapy vs medications in moderate to severe depression
    Steven D Hollon
    Department of Psychology, Vanderbilt University, 306 Wilson Hall Nashville, TN 37203, USA
    Arch Gen Psychiatry 62:417-22. 2005
    ..Antidepressant medication prevents the return of depressive symptoms, but only as long as treatment is continued...
  36. ncbi request reprint Presenting characteristics of depressed outpatients as a function of recurrence: preliminary findings from the STAR*D clinical trial
    Steven D Hollon
    Department of Psychology, Vanderbilt University, 306 Wilson Hall, Nashville, TN 37203, United States
    J Psychiatr Res 40:59-69. 2006
    ..Recurrent depression predicts risk for subsequent episodes, but it is unclear how it relates to demographic features, course of illness, and clinical presentation...
  37. ncbi request reprint Assessing the effects of bupropion SR on mood dimensions of depression
    Andrew J Tomarken
    Department of Psychology, College of Arts and Sciences, Vanderbilt University, Nashville, TN 37203, USA
    J Affect Disord 78:235-41. 2004
    ....
  38. ncbi request reprint Use of treatment algorithms for depression
    Madhukar H Trivedi
    Mood Disorders Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Clin Psychiatry 67:1458-65. 2006
  39. ncbi request reprint Signal transduction abnormalities in melancholic depression
    Demet Akin
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Int J Neuropsychopharmacol 8:5-16. 2005
    ..These data further implicate signal transduction abnormalities in melancholic major depression, particularly PKA and PKC. This suggests an abnormality of factors controlling the expression or degradation of these enzymes...
  40. ncbi request reprint A randomized, double-blind, crossover trial of modafinil on mood
    Indu Taneja
    Department of Pharmacology, Dysfunction Center, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232 2195, USA
    J Clin Psychopharmacol 27:76-9. 2007
    ..The findings may have implications for clinical practice, in particular for the adjunctive use of modafinil in treatment-resistant depression...
  41. doi request reprint Olanzapine monotherapy for acute depression in patients with bipolar I or II disorder: results of an 8-week open label trial
    William V Bobo
    Department of Psychiatry, Vanderbilt University School of Medicine Nashville, Tennessee 37212, USA
    Hum Psychopharmacol 25:30-6. 2010
    ..Olanzapine may be an effective, well-tolerated option for treating acute non-psychotic depression across a variety of bipolar disorder subtypes...
  42. ncbi request reprint Detection of an mRNA polymorphism by differential display
    Shan Liang
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA
    Methods Mol Biol 317:279-85. 2006
    ..Polymorphic transcripts of a single gene differing by one tandem repeat sequence of four nucleotides (TGAT) in the 3' noncoding region were detected...
  43. ncbi request reprint Bipolar depression: best practices for the outpatient
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    CNS Spectr 12:1-14. 2007
    ..Two case studies are presented to elucidate the best practices for the varying clinical states of bipolar disorder...
  44. ncbi request reprint Early- and late-onset startle modulation in unipolar depression
    Gabriel S Dichter
    Department of Psychology, College of Arts and Science, Vanderbilt University, Nashville, Tennessee 37203, USA
    Psychophysiology 41:433-40. 2004
    ....
  45. ncbi request reprint Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features
    A John Rush
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9086, USA
    J Affect Disord 87:43-55. 2005
    ..This study evaluated the clinical and sociodemographic features associated with various degrees of concurrent comorbidity in adult outpatients with nonpsychotic major depressive disorder (MDD)...
  46. ncbi request reprint Decreased serotonin 5-HT2A receptor-stimulated phosphoinositide signaling in fibroblasts from melancholic depressed patients
    Demet Akin
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Neuropsychopharmacology 29:2081-7. 2004
    ..The data raise the possibility that the reduced 5-HT(2A) receptor-induced PI hydrolysis is intrinsic to the receptor itself or its coupling to Gq protein, and is not related to altered availability of the 5-HT(2A) receptor, Gq or PLC...
  47. pmc Early adverse events, HPA activity and rostral anterior cingulate volume in MDD
    Michael T Treadway
    Department of Psychology, Vanderbilt University, Nashville, TN, USA
    PLoS ONE 4:e4887. 2009
    ..In the present study, we sought to evaluate the relationships between grey matter volume, early adverse events and cortisol levels in MDD...
  48. pmc Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase
    Harish C Prasad
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 8548, USA
    Proc Natl Acad Sci U S A 102:11545-50. 2005
    ....
  49. doi request reprint Agomelatine for the treatment of major depressive disorder
    Regina M Carney
    Vanderbilt University Medical Center, Department of Psychiatry, 1500 21st Avenue, South, Suite 2200, Nashville, TN 37212, USA
    Expert Opin Pharmacother 12:2411-9. 2011
    ..Given equivalence or modest superiority to existing, generic alternatives, the acceptability in a third-party reimbursement environment is questionable. Future clinical trials are needed to establish an appropriate market niche...
  50. ncbi request reprint Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder
    Michelle S Mazei-Robison
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 8548, USA
    Neuropharmacology 49:724-36. 2005
    ..Interestingly, the A559V variant was previously identified in a subject with bipolar disorder [. Molecular Psychiatry 5, 275], a psychiatric disorder that has a significant number of overlapping symptoms with ADHD...
  51. ncbi request reprint Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression
    Regina L Myers
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 8548, USA
    Biol Psychiatry 61:167-73. 2007
    ..Genomic variation in the regulatory region of the serotonin (5-HT) 2A receptor gene (HTR2A) may contribute to altered levels of 5-HT2A receptor and to psychiatric disease...
  52. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases
    Martin B Keller
    Brown University, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1371-9. 2007
    ..We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment...
  53. ncbi request reprint Cognitive therapy vs medications in the treatment of moderate to severe depression
    Robert J Derubeis
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 62:409-16. 2005
    ..There is substantial evidence that antidepressant medications treat moderate to severe depression effectively, but there is less data on cognitive therapy's effects in this population...
  54. ncbi request reprint The effectiveness of St. John's Wort in major depressive disorder: a naturalistic phase 2 follow-up in which nonresponders were provided alternate medication
    Alan J Gelenberg
    University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    J Clin Psychiatry 65:1114-9. 2004
    ..A continuation study of an extract of St. John's wort (Hypericum perforatum) for depression was performed in follow-up to an acute study that found no significant difference between St. John's wort extract and placebo...
  55. ncbi request reprint Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional research
    Alan F Schatzberg
    Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
    J Clin Psychiatry 67:27-30. 2006
    ..This article summarizes recommendations with respect to future research as well as clinical management recommendations for SRI discontinuation syndrome...
  56. ncbi request reprint Randomized, double-blind, placebo-controlled crossover trials of venlafaxine for hot flashes after breast cancer
    Janet S Carpenter
    Indiana University, 1111 Middle Drive NU340D, Indianapolis, Indiana 46202, USA
    Oncologist 12:124-35. 2007
    ....
  57. ncbi request reprint Progressive resistance to a selective serotonin reuptake inhibitor but not to cognitive therapy in the treatment of major depression
    Yan Leykin
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104 6196, USA
    J Consult Clin Psychol 75:267-76. 2007
    ..If these findings are replicated in methodologically rigorous studies of paroxetine and other antidepressants, CT should be recommended, in preference to AD, for patients with multiple prior AD exposures...
  58. ncbi request reprint Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta-analysis of studies of newer agents
    George I Papakostas
    Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Biol Psychiatry 62:1217-27. 2007
    ..The goal of our work was to compare response rates among patients with MDD treated with either of these two broad categories of antidepressant drugs...
  59. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 68:1246-56. 2007
    ..To report second-year results from the 2-year maintenance phase of a long-term study to evaluate the efficacy and safety of venlafaxine extended release (ER) in preventing recurrence of depression...
  60. ncbi request reprint Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:826-31. 2007
    ..To examine the efficacy and overall tolerability of augmentation of standard antidepressants with atypical antipsychotic agents for treatment-resistant major depressive disorder...
  61. ncbi request reprint Efficacy and tolerability of adjunctive ziprasidone in treatment-resistant depression: a randomized, open-label, pilot study
    David L Dunner
    Center for Anxiety and Depression and the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA
    J Clin Psychiatry 68:1071-7. 2007
    ..To evaluate the efficacy and tolerability of adjunctive ziprasidone in subjects with treatment-resistant major depressive disorder (DSM-IV criteria) without psychotic features...
  62. pmc Antidepressant medications v. cognitive therapy in people with depression with or without personality disorder
    Jay C Fournier
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104 6196, USA
    Br J Psychiatry 192:124-9. 2008
    ..There is conflicting evidence about comorbid personality pathology in depression treatments...
  63. ncbi request reprint Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohort
    Lori L Davis
    Department of Veterans Affairs VA Medical Center, Tuscaloosa, Ala 35404, USA
    J Clin Psychiatry 68:1931-8. 2007
    ....
  64. ncbi request reprint The relation of patients' treatment preferences to outcome in a randomized clinical trial
    Yan Leykin
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Ther 38:209-17. 2007
    ..These results do not provide support for the claim that the external validity of randomized controlled trials suffers from this aspect of the randomization procedure...

Research Grants12

  1. 2/2-Ziprasidone Augmentation of SSRIs for Treatment-Resistant Depression (TRD)
    Richard Shelton; Fiscal Year: 2009
    ..We estimate that 180 of these patients will enter the double-blind phase. ..
  2. Signal Transduction in Depression
    Richard Shelton; Fiscal Year: 2007
    ..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. ..
  3. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  4. 2/2-Ziprasidone Augmentation of SSRIs for Treatment-Resistant Depression (TRD)
    RICHARD CHARLES SHELTON; Fiscal Year: 2010
    ..We estimate that 180 of these patients will enter the double-blind phase. ..