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Genomes and Genes | Jane ShearerSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Quinides of roasted coffee enhance insulin action in conscious ratsJane Shearer
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
J Nutr 133:3529-32. 2003..These results demonstrate that DIFEQ increases whole-body glucose disposal independently of skeletal muscle Rg...- AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxideJane Shearer
Department of Molecular Physiology and Biophysics, 702 Light Hall, Vanderbilt University, Nashville, TN, 37232 0615, USA
Diabetes 53:1429-35. 2004..In addition, AICAR-induced increases in K(g) but not K(f) were abolished by l-NAME in the majority of muscles examined. This shows that the mechanisms by which AMPK stimulates glucose and LCFA uptake are distinct... - Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase IIPatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 56:2476-84. 2007..The aim of this study was to determine the role of limitations in glucose phosphorylation in the control of MGU during either physiological insulin stimulation (4 mU x kg(-1) x min(-1)) or exercise with chow or high-fat feeding... 
Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscleJane Shearer
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
Biochim Biophys Acta 1782:586-92. 2008..In conclusion, cardiac insulin resistance and glucose uptake is largely corrected by a reduction in FABP3 in vivo without contemporaneous deleterious effects on cardiac function...
Hexokinase II protein content is a determinant of exercise endurance capacity in the mousePatrick T Fueger
Department of Molecular Physiology ans Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
J Physiol 566:533-41. 2005..In conclusion, adaptations that increase HK protein content and/or functional activity such as regular exercise contribute to increased muscular endurance...- 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivoR Richard Pencek
Department of Molecular Physiology and Biophysics, Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Diabetes 54:355-60. 2005..These findings have important implications for the targeting of AMP kinase for the treatment of insulin resistance, using AMP analogs... - AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivoJane Shearer
Dept. of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232-0615, USA
Am J Physiol Endocrinol Metab 287:E871-7. 2004..These results demonstrate that, in vivo, AMPK stimulation increases LCFA but not glucose clearance by a NOS-independent mechanism... - Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporterPatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Physiol 582:801-12. 2007..Finally, studies in GLUT4(-/-)HK(Tg) show that HK II improves exercise tolerance, independent of its effects on MGU... - Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistanceJane Shearer
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 54:3133-9. 2005..In conclusion, a partial reduction in H-FABP protein normalizes fasting glucose levels and improves whole-body insulin sensitivity in HFD-fed mice despite obesity... - Portal vein caffeine infusion enhances net hepatic glucose uptake during a glucose load in conscious dogsR Richard Pencek
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
J Nutr 134:3042-6. 2004..5 +/- 3.8 vs. 5.5 +/- 1.5 micromol/(kg . min)]. These findings indicate that physiologic circulating levels of caffeine can enhance NHGU during a glucose load, and the added glucose consumed by the liver is in part converted to lactate... - Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exerciseJane Shearer
Dept of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, Nashville, TN 37232 0615, USA
Am J Physiol Endocrinol Metab 288:E292-7. 2005..These results show that, in vivo, H-FABP has reciprocal effects on glucose and LCFA utilization and whole body fuel homeostasis when metabolic demands are elevated by exercise... - Long chain fatty acid uptake in vivo: comparison of [125I]-BMIPP and [3H]-bromopalmitateJane Shearer
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
Lipids 43:703-11. 2008..Exercise preferentially exacerbates the breakdown of [3H]-BROMO, making [125I]-BMIPP the analogue of choice for prolonged (>30 min) experimental protocols with elevated metabolic demands... - Novel aspects of skeletal muscle glycogen and its regulation during rest and exerciseJane Shearer
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
Exerc Sport Sci Rev 32:120-6. 2004..These differences result in additional levels of regulation allowing granules to be regulated individually or regionally within the cell during both rest and exercise... - New perspectives on the storage and organization of muscle glycogenJane Shearer
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
Can J Appl Physiol 27:179-203. 2002..Glycogen regulation takes place not only by allosteric regulation of enzymes, but also due to other factors such as subcellular location, granule size, and association with various glycogen-related proteins... - Increases in glycogenin and glycogenin mRNA accompany glycogen resynthesis in human skeletal muscleJane Shearer
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Am J Physiol Endocrinol Metab 289:E508-14. 2005..This may facilitate rapid glycogen resynthesis by providing the glycogenin backbone of proglycogen, the major component of glycogen synthesized in early recovery... - Glycogenin activity and mRNA expression in response to volitional exhaustion in human skeletal muscleJane Shearer
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
J Appl Physiol 99:957-62. 2005..Results show that glycogenin becomes inactivated with glycogen catabolism and that this event coincides with an increase in glycogenin gene expression as exercise and glycogenolysis progress... - Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained micePatrick T Fueger
Duke University Medical Center, Department of Pharmacology and Cancer Biology, 4321 Medical Park Drive, Suite 200, Durham, NC 27704, USA
J Physiol 562:925-35. 2005..The control of MGU is distributed rather than confined to a single rate-limiting step such as glucose transport as glucose transport and phosphorylation can both become barriers to skeletal muscle glucose influx...