Claus Schneider

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Chemistry and biology of vitamin E
    Claus Schneider
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232 6602, USA
    Mol Nutr Food Res 49:7-30. 2005
  2. pmc Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities
    Claus Schneider
    Department of Pharmacology, Vanderbilt University School of Medicine, 23rd Ave at Pierce, Nashville, TN 37232 6602, USA
    Biochem J 385:57-64. 2005
  3. pmc Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2
    Claus Schneider
    Department of Pharmacology, Division of Clinical Pharmacology, 23rd Avenue South at Pierce, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Am Chem Soc 128:720-1. 2006
  4. pmc An update on products and mechanisms of lipid peroxidation
    Claus Schneider
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232 6602, USA
    Mol Nutr Food Res 53:315-21. 2009
  5. pmc On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant
    Gianguido Coffa
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 280:38756-66. 2005
  6. pmc Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120
    Claus Schneider
    Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:18941-5. 2007
  7. pmc Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marina
    Benlian Gao
    Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 284:22087-98. 2009
  8. ncbi request reprint A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality
    Yuxiang Zheng
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 283:5138-47. 2008
  9. pmc Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis
    Katrin Niisuke
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    J Lipid Res 50:1448-55. 2009
  10. doi request reprint Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products
    Claus Schneider
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Chem Res Toxicol 21:895-903. 2008

Research Grants

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Chemistry and biology of vitamin E
    Claus Schneider
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232 6602, USA
    Mol Nutr Food Res 49:7-30. 2005
    ....
  2. pmc Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities
    Claus Schneider
    Department of Pharmacology, Vanderbilt University School of Medicine, 23rd Ave at Pierce, Nashville, TN 37232 6602, USA
    Biochem J 385:57-64. 2005
    ..We conclude that, whereas the mRNA transcript for the spliced COX-1 is present in various human tissues, the corresponding protein is either not formed or subject to rapid proteolytic degradation...
  3. pmc Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2
    Claus Schneider
    Department of Pharmacology, Division of Clinical Pharmacology, 23rd Avenue South at Pierce, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Am Chem Soc 128:720-1. 2006
    ..The product is a unique diendoperoxide, potentially representing the parent compound of a novel group of lipid mediators...
  4. pmc An update on products and mechanisms of lipid peroxidation
    Claus Schneider
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232 6602, USA
    Mol Nutr Food Res 53:315-21. 2009
    ..Understanding of the mechanism of formation of bis-allylic hydroperoxides has led to increased appreciation of the central role of the intermediate peroxyl radical in determining the outcome of lipid peroxidation...
  5. pmc On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant
    Gianguido Coffa
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 280:38756-66. 2005
    ..This provides evidence that both tail-first and carboxylate end-first binding of substrate can be associated with S or R partnerships in product formation in the same active site...
  6. pmc Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120
    Claus Schneider
    Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:18941-5. 2007
    ....
  7. pmc Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marina
    Benlian Gao
    Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 284:22087-98. 2009
    ..Our findings place together in strong association the reactions of allene oxide synthesis and an ionic reaction intermediate in the AOS-catalyzed transformation...
  8. ncbi request reprint A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality
    Yuxiang Zheng
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 283:5138-47. 2008
    ....
  9. pmc Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis
    Katrin Niisuke
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    J Lipid Res 50:1448-55. 2009
    ..These findings provide new insights into the reactions of linoleic acid hydroperoxides and extend the known range of catalytic activities of catalase-related hemoproteins...
  10. doi request reprint Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products
    Claus Schneider
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Chem Res Toxicol 21:895-903. 2008
    ....
  11. pmc Isolation and characterization of two geometric allene oxide isomers synthesized from 9S-hydroperoxylinoleic acid by cytochrome P450 CYP74C3: stereochemical assignment of natural fatty acid allene oxides
    Alan R Brash
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 288:20797-806. 2013
    ..These results explain the origin of the cyclopentenone, provide insights into the mechanisms of allene oxide cyclization, and define the double bond geometry in naturally occurring allene oxides. ..
  12. pmc Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin
    Zheyong Yu
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Arch Biochem Biophys 455:188-96. 2006
    ..The substrate preference of mouse eLOX3 and the unique occurrence of an 8S-LOX enzyme in mouse skin point to a potential LOX pathway for the production of epoxyalcohol in murine epidermal differentiation...
  13. ncbi request reprint Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal
    Claus Schneider
    Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Lipids 40:1155-62. 2005
    ....
  14. ncbi request reprint Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha
    Zheyong Yu
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, 23rd Ave at Pierce, Nashville, TN 37232 6602, USA
    Lipids 42:491-7. 2007
    ..Formation of a ligand for the nuclear receptor PPARalpha may be one possibility by which 12R-LOX and eLOX3 contribute to epidermal differentiation...
  15. pmc The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase
    Zheyong Yu
    Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:9162-7. 2003
    ..Our results provide strong biochemical evidence for a functional linkage of 12R-LOX and eLOX3 and clues into skin biochemistry and the etiology of ichthyosiform diseases in humans...
  16. ncbi request reprint Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3
    Zheyong Yu
    Department of Pharmacology, Vanderbilt University School of Medicine, 23rd Ave at Pierce, Nashville, TN 37232 6602, USA
    Biochim Biophys Acta 1686:238-47. 2005
    ....
  17. pmc Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition
    Wei Liu
    Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 50:166-78. 2011
    ....
  18. pmc Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity
    Kristina E Furse
    Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:3206-18. 2006
    ..Instead, a combination of oxygen channeling, steric shielding, and selective radical trapping appears to be responsible. This work adds a dynamic perspective to the strong foundation of static structural data available for these enzymes...
  19. pmc Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2
    Surafel Mulugeta
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Lipid Res 51:575-85. 2010
    ....
  20. pmc Cyclooxygenases and lipoxygenases in cancer
    Claus Schneider
    Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Cancer Metastasis Rev 30:277-94. 2011
    ....
  21. ncbi request reprint The hepoxilin connection in the epidermis
    Alan R Brash
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    FEBS J 274:3494-502. 2007
    ..The natural occurrence of the specific hepoxilin products, and their biological role, whether structural or signaling, remain to be defined...
  22. pmc Control of oxygenation in lipoxygenase and cyclooxygenase catalysis
    Claus Schneider
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Chem Biol 14:473-88. 2007
    ..We present four mechanistic models, not mutually exclusive, that could account for the specific reactions of molecular oxygen with a fatty acid in the LOX or COX active site...
  23. ncbi request reprint Identification of two cyclooxygenase active site residues, Leucine 384 and Glycine 526, that control carbon ring cyclization in prostaglandin biosynthesis
    Claus Schneider
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 279:4404-14. 2004
    ..This result suggests that oxygenation specificity can be determined by the orientation of the reacting fatty acid radical and is not a predetermined outcome based solely on the structure of the cyclooxygenase active site...
  24. pmc COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes
    Noemi Tejera
    Division of Clinical Pharmacology, Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical School, Nashville, TN, USA
    J Lipid Res 53:87-94. 2012
    ..The contribution of COX-2 to the biosynthesis of dihydroxylated derivatives of arachidonic acid provides evidence for functional coupling with 5-LOX in activated human leukocytes...
  25. ncbi request reprint Detection and subcellular localization of two 15S-lipoxygenases in human cornea
    Min S Chang
    Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 8000 MCE, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Invest Ophthalmol Vis Sci 46:849-56. 2005
    ..The presence of both 15-LOXs in the human cornea prompted this study to delineate their roles in the human corneal epithelium...
  26. pmc Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways
    Markus Griesser
    Division of Clinical Pharmacology, Department of Pharmacology, and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 108:6945-50. 2011
    ..Identification of the highly oxygenated hemiketal eicosanoids provides evidence for a previously unrecognized biosynthetic cross-over of the 5-LOX and COX-2 pathways...
  27. ncbi request reprint Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids
    Claus Schneider
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Adv Exp Med Biol 507:49-53. 2002
  28. pmc Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments
    Markus Griesser
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Lipid Res 50:2455-62. 2009
    ..This transformation of the 5-lipoxygenase/cyclooxygenase-2 derived di-endoperoxide invokes the possibility of a novel pathway to formation of the classic lipid peroxidation products 4-HNE and MDA...
  29. pmc Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcumin
    Markus Griesser
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 286:1114-24. 2011
    ..It is possible, therefore, that oxidative transformation of curcumin, a prominent but previously unrecognized reaction, contributes to its cancer chemopreventive activity...
  30. ncbi request reprint A comprehensive model of positional and stereo control in lipoxygenases
    Gianguido Coffa
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 338:87-92. 2005
    ..In this review, we meld together the factors that control product regio- and stereochemistry into a general model that can account for the specificity of individual lipoxygenase reactions...
  31. ncbi request reprint Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal
    Claus Schneider
    Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Chem Res Toxicol 17:937-41. 2004
    ..Our results establish, moreover, that omega6 hydroxy fatty acids are potential precursors of reactive cytotoxic aldehydes in biological systems...
  32. pmc Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation
    Claus Schneider
    Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 283:15539-43. 2008
    ..These cross-molecular reactions of fatty acid peroxyls have also important implications for understanding of the basic initiation and propagation steps during lipid peroxidation and the nature of the products that arise...
  33. ncbi request reprint Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography
    Claus Schneider
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Methods Enzymol 433:145-57. 2007
    ..3 mm i.d.) will be of great advantage, because sample sizes of a few nanograms can be analyzed using simple UV detection...
  34. ncbi request reprint Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice
    Claus Schneider
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Invest Dermatol 122:691-8. 2004
    ..Although mouse 8S-lipoxygenase and human 12R-lipoxygenase are not ortholog genes, we speculate that in mouse and humans the two different enzymes may fulfill equivalent functions in the progression of inflammatory dermatoses...
  35. pmc Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis
    Sang Hyun Lee
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6600, USA
    Traffic 12:878-89. 2011
    ..These results suggest that AA is required for the cSrc trafficking to the plasma membrane by controlling the formation/release of recycling endosomes from the ERC...
  36. pmc Applications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistry
    Alan R Brash
    Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Lipids 47:101-16. 2012
    ....
  37. ncbi request reprint Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation
    James D West
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37232 0146, USA
    Chem Res Toxicol 17:453-62. 2004
    ..The results presented herein suggest that these molecules commonly activate certain signaling pathways that control cell death irrespective of their reactive properties...
  38. ncbi request reprint Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla
    Claus Schneider
    Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Lipids 37:217-21. 2002
    ..The significance of PGE acetylation is discussed in relation to the proposed mechanism of PGA synthesis in the coral...
  39. pmc Oxidative metabolites of curcumin poison human type II topoisomerases
    Adam C Ketron
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochemistry 52:221-7. 2013
    ..Thus, even within the more complex spice formulation, oxidized curcumin intermediates appear to function as topoisomerase II poisons...
  40. ncbi request reprint Lipoxygenase-catalyzed formation of R-configuration hydroperoxides
    Claus Schneider
    Division of Clinical Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232 6602, USA
    Prostaglandins Other Lipid Mediat 68:291-301. 2002
    ..In this case, the evidence suggests that R/S switching can occur with the substrate binding in the normal conformation...
  41. ncbi request reprint Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349
    Claus Schneider
    Department of Pharmacology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:478-85. 2002
    ..The findings may also explain the absolute conservation of Ser-530, the target of aspirin, throughout the families of cyclooxygenase enzymes...
  42. pmc Facile synthesis of deuterated and [(14) C]labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools
    Odaine N Gordon
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical School, Nashville, TN, 37232, USA
    J Labelled Comp Radiopharm 56:696-9. 2013
    ..The compounds can be used as radiotracers in biotransformation studies and as isotopic standards for mass spectrometry-based quantification in pharmacokinetic analyses...
  43. ncbi request reprint Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla
    Karin Valmsen
    Department of Chemistry, Tallinn University of Technology, Estonia
    Eur J Biochem 271:3533-8. 2004
    ..homomalla and that the differences do not arise by isomerization of the products...

Research Grants5

  1. Convergence of the COX-2 and 5-lipoxygenase pathways
    Claus Schneider; Fiscal Year: 2007
    ..These studies could ultimately lead to new therapeutic regimens for the treatment of these diseases using established anti-inflammatory medications. ..
  2. Convergence of the COX-2 and 5-lipoxygenase pathways
    Claus Schneider; Fiscal Year: 2009
    ..These studies could ultimately lead to new therapeutic regimens for the treatment of these diseases using established anti-inflammatory medications. ..
  3. Convergence of the COX-2 and 5-lipoxygenase pathways
    Claus Schneider; Fiscal Year: 2010
    ..These studies could ultimately lead to new therapeutic regimens for the treatment of these diseases using established anti-inflammatory medications. ..
  4. Convergence of the COX-2 and 5-lipoxygenase pathways
    Claus Schneider; Fiscal Year: 2009
    ..These studies could ultimately lead to new therapeutic regimens for the treatment of these diseases using established anti-inflammatory medications. ..