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Genomes and Genes | Claus SchneiderSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Chemistry and biology of vitamin EClaus Schneider
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232 6602, USA
Mol Nutr Food Res 49:7-30. 2005....- Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activitiesClaus Schneider
Department of Pharmacology, Vanderbilt University School of Medicine, 23rd Ave at Pierce, Nashville, TN 37232 6602, USA
Biochem J 385:57-64. 2005..We conclude that, whereas the mRNA transcript for the spliced COX-1 is present in various human tissues, the corresponding protein is either not formed or subject to rapid proteolytic degradation... - An update on products and mechanisms of lipid peroxidationClaus Schneider
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232 6602, USA
Mol Nutr Food Res 53:315-21. 2009..Understanding of the mechanism of formation of bis-allylic hydroperoxides has led to increased appreciation of the central role of the intermediate peroxyl radical in determining the outcome of lipid peroxidation... - Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2Claus Schneider
Department of Pharmacology, Division of Clinical Pharmacology, 23rd Avenue South at Pierce, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
J Am Chem Soc 128:720-1. 2006..The product is a unique diendoperoxide, potentially representing the parent compound of a novel group of lipid mediators... - On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutantGianguido Coffa
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 280:38756-66. 2005..This provides evidence that both tail-first and carboxylate end-first binding of substrate can be associated with S or R partnerships in product formation in the same active site... - Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marinaBenlian Gao
Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
J Biol Chem 284:22087-98. 2009..Our findings place together in strong association the reactions of allene oxide synthesis and an ionic reaction intermediate in the AOS-catalyzed transformation... - Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120Claus Schneider
Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 104:18941-5. 2007.... - A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionalityYuxiang Zheng
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
J Biol Chem 283:5138-47. 2008.... - Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesisKatrin Niisuke
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
J Lipid Res 50:1448-55. 2009..These findings provide new insights into the reactions of linoleic acid hydroperoxides and extend the known range of catalytic activities of catalase-related hemoproteins... - Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized productsClaus Schneider
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
Chem Res Toxicol 21:895-903. 2008.... - Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenalClaus Schneider
Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
Lipids 40:1155-62. 2005.... - Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skinZheyong Yu
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Arch Biochem Biophys 455:188-96. 2006..The substrate preference of mouse eLOX3 and the unique occurrence of an 8S-LOX enzyme in mouse skin point to a potential LOX pathway for the production of epoxyalcohol in murine epidermal differentiation... - Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalphaZheyong Yu
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, 23rd Ave at Pierce, Nashville, TN 37232 6602, USA
Lipids 42:491-7. 2007..Formation of a ligand for the nuclear receptor PPARalpha may be one possibility by which 12R-LOX and eLOX3 contribute to epidermal differentiation... - The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomeraseZheyong Yu
Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 100:9162-7. 2003..Our results provide strong biochemical evidence for a functional linkage of 12R-LOX and eLOX3 and clues into skin biochemistry and the etiology of ichthyosiform diseases in humans... - Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decompositionWei Liu
Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA
Free Radic Biol Med 50:166-78. 2011.... - Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2Surafel Mulugeta
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA
J Lipid Res 51:575-85. 2010.... - Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivityKristina E Furse
Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
Biochemistry 45:3206-18. 2006..Instead, a combination of oxygen channeling, steric shielding, and selective radical trapping appears to be responsible. This work adds a dynamic perspective to the strong foundation of static structural data available for these enzymes... - Cyclooxygenases and lipoxygenases in cancerClaus Schneider
Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN, 37232, USA
Cancer Metastasis Rev 30:277-94. 2011.... - The hepoxilin connection in the epidermisAlan R Brash
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
FEBS J 274:3494-502. 2007..The natural occurrence of the specific hepoxilin products, and their biological role, whether structural or signaling, remain to be defined... - Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3Zheyong Yu
Department of Pharmacology, Vanderbilt University School of Medicine, 23rd Ave at Pierce, Nashville, TN 37232 6602, USA
Biochim Biophys Acta 1686:238-47. 2005.... - Identification of two cyclooxygenase active site residues, Leucine 384 and Glycine 526, that control carbon ring cyclization in prostaglandin biosynthesisClaus Schneider
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 279:4404-14. 2004..This result suggests that oxygenation specificity can be determined by the orientation of the reacting fatty acid radical and is not a predetermined outcome based solely on the structure of the cyclooxygenase active site... - Control of oxygenation in lipoxygenase and cyclooxygenase catalysisClaus Schneider
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Chem Biol 14:473-88. 2007..We present four mechanistic models, not mutually exclusive, that could account for the specific reactions of molecular oxygen with a fatty acid in the LOX or COX active site... - COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytesNoemi Tejera
Division of Clinical Pharmacology, Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical School, Nashville, TN, USA
J Lipid Res 53:87-94. 2012..The contribution of COX-2 to the biosynthesis of dihydroxylated derivatives of arachidonic acid provides evidence for functional coupling with 5-LOX in activated human leukocytes... - Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathwaysMarkus Griesser
Division of Clinical Pharmacology, Department of Pharmacology, and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical School, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 108:6945-50. 2011..Identification of the highly oxygenated hemiketal eicosanoids provides evidence for a previously unrecognized biosynthetic cross-over of the 5-LOX and COX-2 pathways... - Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acidsClaus Schneider
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Adv Exp Med Biol 507:49-53. 2002 - Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragmentsMarkus Griesser
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA
J Lipid Res 50:2455-62. 2009..This transformation of the 5-lipoxygenase/cyclooxygenase-2 derived di-endoperoxide invokes the possibility of a novel pathway to formation of the classic lipid peroxidation products 4-HNE and MDA... - Detection and subcellular localization of two 15S-lipoxygenases in human corneaMin S Chang
Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 8000 MCE, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Invest Ophthalmol Vis Sci 46:849-56. 2005..The presence of both 15-LOXs in the human cornea prompted this study to delineate their roles in the human corneal epithelium... - Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcuminMarkus Griesser
Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 286:1114-24. 2011..It is possible, therefore, that oxidative transformation of curcumin, a prominent but previously unrecognized reaction, contributes to its cancer chemopreventive activity... - Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatographyClaus Schneider
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Methods Enzymol 433:145-57. 2007..3 mm i.d.) will be of great advantage, because sample sizes of a few nanograms can be analyzed using simple UV detection... - A comprehensive model of positional and stereo control in lipoxygenasesGianguido Coffa
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Biochem Biophys Res Commun 338:87-92. 2005..In this review, we meld together the factors that control product regio- and stereochemistry into a general model that can account for the specificity of individual lipoxygenase reactions... - Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidationClaus Schneider
Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 283:15539-43. 2008..These cross-molecular reactions of fatty acid peroxyls have also important implications for understanding of the basic initiation and propagation steps during lipid peroxidation and the nature of the products that arise... - Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenalClaus Schneider
Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
Chem Res Toxicol 17:937-41. 2004..Our results establish, moreover, that omega6 hydroxy fatty acids are potential precursors of reactive cytotoxic aldehydes in biological systems... - Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient miceClaus Schneider
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
J Invest Dermatol 122:691-8. 2004..Although mouse 8S-lipoxygenase and human 12R-lipoxygenase are not ortholog genes, we speculate that in mouse and humans the two different enzymes may fulfill equivalent functions in the progression of inflammatory dermatoses... - Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxisSang Hyun Lee
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6600, USA
Traffic 12:878-89. 2011..These results suggest that AA is required for the cSrc trafficking to the plasma membrane by controlling the formation/release of recycling endosomes from the ERC... - Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidationJames D West
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37232-0146, USA
Chem Res Toxicol 17:453-62. 2004..The results presented herein suggest that these molecules commonly activate certain signaling pathways that control cell death irrespective of their reactive properties... - Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomallaClaus Schneider
Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
Lipids 37:217-21. 2002..The significance of PGE acetylation is discussed in relation to the proposed mechanism of PGA synthesis in the coral... - Lipoxygenase-catalyzed formation of R-configuration hydroperoxidesClaus Schneider
Division of Clinical Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232-6602, USA
Prostaglandins Other Lipid Mediat 68:291-301. 2002..In this case, the evidence suggests that R/S switching can occur with the substrate binding in the normal conformation... - Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349Claus Schneider
Department of Pharmacology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 277:478-85. 2002..The findings may also explain the absolute conservation of Ser-530, the target of aspirin, throughout the families of cyclooxygenase enzymes... - Applications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistryAlan R Brash
Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Lipids 47:101-16. 2012.... - Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomallaKarin Valmsen
Department of Chemistry, Tallinn University of Technology, Estonia
Eur J Biochem 271:3533-8. 2004..homomalla and that the differences do not arise by isomerization of the products...
Research Grants
- Convergence of the COX-2 and 5-lipoxygenase pathwaysClaus Schneider; Fiscal Year: 2007..These studies could ultimately lead to new therapeutic regimens for the treatment of these diseases using established anti-inflammatory medications. ..
- Convergence of the COX-2 and 5-lipoxygenase pathwaysClaus Schneider; Fiscal Year: 2010..These studies could ultimately lead to new therapeutic regimens for the treatment of these diseases using established anti-inflammatory medications. ..