Genomes and Genes
Jonathan S Schildcrout
Affiliation: Vanderbilt University
- Outcome vector dependent sampling with longitudinal continuous response data: stratified sampling based on summary statisticsJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
Biometrics 69:405-16. 2013....
- Outcome-dependent sampling for longitudinal binary response data based on a time-varying auxiliary variableJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Ave South, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
Stat Med 31:2441-56. 2012....
- Analyses of longitudinal, hospital clinical laboratory data with application to blood glucose concentrationsJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
Stat Med 30:3208-20. 2011..To illustrate these points, we present a detailed analysis of the relationship between blood glucose levels and insulin doses on the basis of data from an intensive care unit...
- Longitudinal studies of binary response data following case-control and stratified case-control sampling: design and analysisJonathan S Schildcrout
Departments of Biostatistics and Anesthesiology, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 2323 Medical Center North, Nashville, Tennessee 37232, USA
Biometrics 66:365-73. 2010..The research is motivated by a longitudinal study following case-control sampling of the time course of attention deficit hyperactivity disorder (ADHD) symptoms...
- On outcome-dependent sampling designs for longitudinal binary response data with time-varying covariatesJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
Biostatistics 9:735-49. 2008....
- Analysis of longitudinal laboratory data in the presence of common selection mechanisms: a view toward greater emphasis on pre-marketing pharmaceutical safetyJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University, Nashville, TN 37232 2158, U S A
Stat Med 27:2248-66. 2008....
- Outcome-dependent sampling from existing cohorts with longitudinal binary response data: study planning and analysisJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 2323 Medical Center North, Nashville, Tennessee 37232, USA
Biometrics 67:1583-93. 2011..We also assume that these data would be ascertained by analyzing stored blood samples, the cost of which limits the sample size...
- Marginalized models for moderate to long series of longitudinal binary response dataJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biometrics 63:322-31. 2007..Data from the Madras Longitudinal Schizophrenia Study (Thara et al., 1994, Acta Psychiatrica Scandinavica 90, 329-336) are analyzed...
- Ambient air pollution and asthma exacerbations in children: an eight-city analysisJonathan S Schildcrout
Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN 27232 2158, USA
Am J Epidemiol 164:505-17. 2006..01, 1.10) and 1.05 (95% CI: 1.01, 1.09), respectively. The authors believe that the observed carbon monoxide and nitrogen dioxide associations can probably be attributed to mobile-source emissions, though more research is required...
- Regression analysis of longitudinal binary data with time-dependent environmental covariates: bias and efficiencyJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
Biostatistics 6:633-52. 2005..We find that the impact of covariance model choice depends highly on the specific structure of the data features, and that key aspects should be examined before choosing a weighting scheme...
- An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical recordsJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2156, USA
J Biomed Inform 43:914-23. 2010..The phenotypes studied include type II diabetes and type II diabetes controls, peripheral arterial disease and peripheral arterial disease controls, normal cardiac conduction as measured by electrocardiography, and senile cataracts...
- Duration of upper and lower extremity peripheral nerve blockade is prolonged with dexamethasone when added to ropivacaine: a retrospective database analysisStephanie B Rasmussen
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5614, USA
Pain Med 14:1239-47. 2013..The purpose of this study was to examine the effect of adding dexamethasone to ropivacaine on duration of nerve blocks of the upper and lower extremity...
- Estimating baseline kidney function in hospitalized patients with impaired kidney functionEdward D Siew
Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Clin J Am Soc Nephrol 7:712-9. 2012..No consensus exists on how to optimally determine baseline kidney function when multiple preadmission creatinine measurements are available...
- Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia riskMarylyn D Ritchie
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA
Circulation 127:1377-85. 2013..ECG QRS duration, a measure of cardiac intraventricular conduction, varies ≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant arrhythmias...
- Development of inpatient risk stratification models of acute kidney injury for use in electronic health recordsMichael E Matheny
Geriatric Research Education Clinical Center, Tennessee Valley Health System, Veterans Health Administration, Nashville, TN, USA
Med Decis Making 30:639-50. 2010....
- Modulators of normal electrocardiographic intervals identified in a large electronic medical recordAndrea H Ramirez
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
Heart Rhythm 8:271-7. 2011..Traditional electrocardiographic (ECG) reference ranges were derived from studies in communities or clinical trial populations. The distribution of ECG parameters in a large population presenting to a healthcare system has not been studied...
- Intraoperative risk factors for acute respiratory distress syndrome in critically ill patientsChristopher G Hughes
Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
Anesth Analg 111:464-7. 2010..However, research examining intraoperative factors such as fluid resuscitation, mechanical ventilation strategies, and blood administration on the postoperative development of ARDS is lacking...
- The impact of peripheral nerve techniques on hospital stay following major orthopedic surgeryMark J Lenart
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA
Pain Med 13:828-34. 2012..To determine the impact of regional anesthesia on hospital stay for selected orthopedic procedures compared with traditional pain control modalities...
- Obesity and oxidative stress predict AKI after cardiac surgeryFrederic T Billings
Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Am Soc Nephrol 23:1221-8. 2012..001). In conclusion, obesity independently predicts AKI after cardiac surgery, and oxidative stress may partially mediate this association...
- Prevalence and Clinical Significance of Discrepancies within Three Computerized Pre-Admission Medication ListsJosh F Peterson
Department of Biomedical Informatics, Vanderbilt University, Nashville, TN
AMIA Annu Symp Proc 2010:642-6. 2010..Potentially harmful medication discrepancies were found within all lists. The authors concluded no single list was sufficiently accurate to avoid serious medication errors...
- Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome scienceJoshua C Denny
Office of Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
Circulation 122:2016-21. 2010..The extent to which this can be demonstrated in cohorts derived from electronic medical records is unknown...
- Expansion of the surgical Apgar score across all surgical subspecialties as a means to predict postoperative mortalityPaul Q Reynolds
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Anesthesiology 114:1305-12. 2011..To date, evaluation of this scoring system has been limited to general and vascular services. The authors attempt to externally validate and expand the Surgical Apgar Score across a wide breadth of surgical subspecialties...
- Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health recordAndrea H Ramirez
Department of Medicine, Vanderbilt University in Nashville, TN 37232, USA
Pharmacogenomics 13:407-18. 2012..Electronic health record (EHR) systems linked to biobanks may allow for pharmacogenomic analysis, but they have not yet been used for this purpose...
- A computerized provider order entry intervention for medication safety during acute kidney injury: a quality improvement reportAllison B McCoy
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
Am J Kidney Dis 56:832-41. 2010..Frequently, prescribers fail to account for changing kidney function when prescribing medications. We evaluated the use of a computerized provider order entry intervention to improve medication management during acute kidney injury...
- Improving needle visualization by novice residents during an in-plane ultrasound nerve block simulation using an in-plane multiangle needle guideRajnish K Gupta
Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee, USA
Pain Med 14:1600-7. 2013..We hypothesized that an in-plane, multiangle needle guide can help reduce the time it takes novice regional anesthesiologists to perform a simulated ultrasound-guided nerve-targeting procedure and enhance the visualization of the needle...
- Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillationJessica T Delaney
Division of Cardiovascular Medicine, Departments of Medicine, Vanderbilt University School of Medicine, 2215B Garland Avenue, Room 1275 MRB IV, Room 1275 MRB IV, Nashville, TN 37232 6602, USA
Europace 16:485-90. 2014..In a cohort of patients with atrial fibrillation (AF), we examined whether there was an association between common variants in SCN10A and both the PR interval during normal sinus rhythm and the heart rate response during AF...
- Risk of burnout in perioperative clinicians: a survey study and literature reviewSteve A Hyman
Department of Anesthesiology, Veterans Affairs Medical Center Nashville, Tennessee Valley Veterans Affairs Healthcare System, Nashville, Tennessee 37205, USA
Anesthesiology 114:194-204. 2011..Previous studies have not evaluated all healthcare workers within a single work unit. This study evaluates the risk of burnout in all medical personnel in one perioperative unit...
- Medication administration discrepancies persist despite electronic orderingFern Fitzhenry
Department of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203, USA
J Am Med Inform Assoc 14:756-64. 2007....
- Biobanks and electronic medical records: enabling cost-effective researchErica Bowton
Institute for Clinical and Translational Research, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
Sci Transl Med 6:234cm3. 2014..Here, we present a model that highlights potential advantages for genomic discovery and describe the operational infrastructure that facilitated multiple simultaneous discovery efforts. ..
- Selective local anesthetic placement using ultrasound guidance and neurostimulation for infraclavicular brachial plexus blockClifford Bowens
Department of Anesthesiology, Vanderbilt Medical Center, Nashville, TN 37232 5614, USA
Anesth Analg 110:1480-5. 2010....
- Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel studyCarol A Trenga
Research Scientist, EPA NW Research Center for Particulate Air Pollution and Health, Department of Environmental Health, Box 354695, University of Washington, Seattle, WA 98195 4695, USA
Chest 129:1614-22. 2006....
- Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosisChristopher H Goss
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Am J Respir Crit Care Med 169:816-21. 2004..91-1.93; 95% CI). Annual average exposures to particulate air pollution was associated with an increased risk of pulmonary exacerbations and a decline in lung function, suggesting a role of environmental exposures on prognosis in CF...