Jonathan S Schildcrout

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint A prognostic model based on readily available clinical data enriched a pre-emptive pharmacogenetic testing program
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, 2525 West End Ave, Suite 1100, Nashville, TN 37203, USA Department of Anesthesiology, Vanderbilt University School of Medicine, 1211 21st Avenue South, Nashville, TN 37212, USA Electronic address
    J Clin Epidemiol 72:107-15. 2016
  2. pmc Outcome vector dependent sampling with longitudinal continuous response data: stratified sampling based on summary statistics
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Biometrics 69:405-16. 2013
  3. pmc Outcome-dependent sampling for longitudinal binary response data based on a time-varying auxiliary variable
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Ave South, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
    Stat Med 31:2441-56. 2012
  4. pmc Analyses of longitudinal, hospital clinical laboratory data with application to blood glucose concentrations
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Stat Med 30:3208-20. 2011
  5. pmc An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical records
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2156, USA
    J Biomed Inform 43:914-23. 2010
  6. pmc Outcome-dependent sampling from existing cohorts with longitudinal binary response data: study planning and analysis
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 2323 Medical Center North, Nashville, Tennessee 37232, USA
    Biometrics 67:1583-93. 2011
  7. pmc Longitudinal studies of binary response data following case-control and stratified case-control sampling: design and analysis
    Jonathan S Schildcrout
    Departments of Biostatistics and Anesthesiology, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 2323 Medical Center North, Nashville, Tennessee 37232, USA
    Biometrics 66:365-73. 2010
  8. pmc On outcome-dependent sampling designs for longitudinal binary response data with time-varying covariates
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    Biostatistics 9:735-49. 2008
  9. ncbi request reprint Analysis of longitudinal laboratory data in the presence of common selection mechanisms: a view toward greater emphasis on pre-marketing pharmaceutical safety
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University, Nashville, TN 37232 2158, U S A
    Stat Med 27:2248-66. 2008
  10. ncbi request reprint Marginalized models for moderate to long series of longitudinal binary response data
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biometrics 63:322-31. 2007

Detail Information

Publications36

  1. doi request reprint A prognostic model based on readily available clinical data enriched a pre-emptive pharmacogenetic testing program
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, 2525 West End Ave, Suite 1100, Nashville, TN 37203, USA Department of Anesthesiology, Vanderbilt University School of Medicine, 1211 21st Avenue South, Nashville, TN 37212, USA Electronic address
    J Clin Epidemiol 72:107-15. 2016
    ..We describe the development, implementation, and evaluation of a model to pre-emptively select patients for genotyping based on medication exposure risk...
  2. pmc Outcome vector dependent sampling with longitudinal continuous response data: stratified sampling based on summary statistics
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Biometrics 69:405-16. 2013
    ....
  3. pmc Outcome-dependent sampling for longitudinal binary response data based on a time-varying auxiliary variable
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Ave South, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
    Stat Med 31:2441-56. 2012
    ....
  4. pmc Analyses of longitudinal, hospital clinical laboratory data with application to blood glucose concentrations
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Stat Med 30:3208-20. 2011
    ..To illustrate these points, we present a detailed analysis of the relationship between blood glucose levels and insulin doses on the basis of data from an intensive care unit...
  5. pmc An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical records
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2156, USA
    J Biomed Inform 43:914-23. 2010
    ..The phenotypes studied include type II diabetes and type II diabetes controls, peripheral arterial disease and peripheral arterial disease controls, normal cardiac conduction as measured by electrocardiography, and senile cataracts...
  6. pmc Outcome-dependent sampling from existing cohorts with longitudinal binary response data: study planning and analysis
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 2323 Medical Center North, Nashville, Tennessee 37232, USA
    Biometrics 67:1583-93. 2011
    ..We also assume that these data would be ascertained by analyzing stored blood samples, the cost of which limits the sample size...
  7. pmc Longitudinal studies of binary response data following case-control and stratified case-control sampling: design and analysis
    Jonathan S Schildcrout
    Departments of Biostatistics and Anesthesiology, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 2323 Medical Center North, Nashville, Tennessee 37232, USA
    Biometrics 66:365-73. 2010
    ..The research is motivated by a longitudinal study following case-control sampling of the time course of attention deficit hyperactivity disorder (ADHD) symptoms...
  8. pmc On outcome-dependent sampling designs for longitudinal binary response data with time-varying covariates
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    Biostatistics 9:735-49. 2008
    ....
  9. ncbi request reprint Analysis of longitudinal laboratory data in the presence of common selection mechanisms: a view toward greater emphasis on pre-marketing pharmaceutical safety
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University, Nashville, TN 37232 2158, U S A
    Stat Med 27:2248-66. 2008
    ....
  10. ncbi request reprint Marginalized models for moderate to long series of longitudinal binary response data
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biometrics 63:322-31. 2007
    ..Data from the Madras Longitudinal Schizophrenia Study (Thara et al., 1994, Acta Psychiatrica Scandinavica 90, 329-336) are analyzed...
  11. ncbi request reprint Ambient air pollution and asthma exacerbations in children: an eight-city analysis
    Jonathan S Schildcrout
    Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN 27232 2158, USA
    Am J Epidemiol 164:505-17. 2006
    ..01, 1.10) and 1.05 (95% CI: 1.01, 1.09), respectively. The authors believe that the observed carbon monoxide and nitrogen dioxide associations can probably be attributed to mobile-source emissions, though more research is required...
  12. ncbi request reprint Regression analysis of longitudinal binary data with time-dependent environmental covariates: bias and efficiency
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
    Biostatistics 6:633-52. 2005
    ..We find that the impact of covariance model choice depends highly on the specific structure of the data features, and that key aspects should be examined before choosing a weighting scheme...
  13. doi request reprint Duration of upper and lower extremity peripheral nerve blockade is prolonged with dexamethasone when added to ropivacaine: a retrospective database analysis
    Stephanie B Rasmussen
    Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5614, USA
    Pain Med 14:1239-47. 2013
    ..The purpose of this study was to examine the effect of adding dexamethasone to ropivacaine on duration of nerve blocks of the upper and lower extremity...
  14. pmc Estimating baseline kidney function in hospitalized patients with impaired kidney function
    Edward D Siew
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Clin J Am Soc Nephrol 7:712-9. 2012
    ..No consensus exists on how to optimally determine baseline kidney function when multiple preadmission creatinine measurements are available...
  15. pmc Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk
    Marylyn D Ritchie
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA
    Circulation 127:1377-85. 2013
    ..ECG QRS duration, a measure of cardiac intraventricular conduction, varies ≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant arrhythmias...
  16. doi request reprint Development of inpatient risk stratification models of acute kidney injury for use in electronic health records
    Michael E Matheny
    Geriatric Research Education Clinical Center, Tennessee Valley Health System, Veterans Health Administration, Nashville, TN, USA
    Med Decis Making 30:639-50. 2010
    ....
  17. pmc Modulators of normal electrocardiographic intervals identified in a large electronic medical record
    Andrea H Ramirez
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Heart Rhythm 8:271-7. 2011
    ..Traditional electrocardiographic (ECG) reference ranges were derived from studies in communities or clinical trial populations. The distribution of ECG parameters in a large population presenting to a healthcare system has not been studied...
  18. doi request reprint Intraoperative risk factors for acute respiratory distress syndrome in critically ill patients
    Christopher G Hughes
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
    Anesth Analg 111:464-7. 2010
    ..However, research examining intraoperative factors such as fluid resuscitation, mechanical ventilation strategies, and blood administration on the postoperative development of ARDS is lacking...
  19. doi request reprint The impact of peripheral nerve techniques on hospital stay following major orthopedic surgery
    Mark J Lenart
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA
    Pain Med 13:828-34. 2012
    ..To determine the impact of regional anesthesia on hospital stay for selected orthopedic procedures compared with traditional pain control modalities...
  20. pmc Obesity and oxidative stress predict AKI after cardiac surgery
    Frederic T Billings
    Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Am Soc Nephrol 23:1221-8. 2012
    ..001). In conclusion, obesity independently predicts AKI after cardiac surgery, and oxidative stress may partially mediate this association...
  21. pmc Prevalence and Clinical Significance of Discrepancies within Three Computerized Pre-Admission Medication Lists
    Josh F Peterson
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN
    AMIA Annu Symp Proc 2010:642-6. 2010
    ..Potentially harmful medication discrepancies were found within all lists. The authors concluded no single list was sufficiently accurate to avoid serious medication errors...
  22. pmc Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science
    Joshua C Denny
    Office of Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
    Circulation 122:2016-21. 2010
    ..The extent to which this can be demonstrated in cohorts derived from electronic medical records is unknown...
  23. doi request reprint High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial
    Frederic T Billings
    Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee2Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
    JAMA 315:877-88. 2016
    ..Statins affect several mechanisms underlying acute kidney injury (AKI)...
  24. pmc A computerized provider order entry intervention for medication safety during acute kidney injury: a quality improvement report
    Allison B McCoy
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Kidney Dis 56:832-41. 2010
    ..Frequently, prescribers fail to account for changing kidney function when prescribing medications. We evaluated the use of a computerized provider order entry intervention to improve medication management during acute kidney injury...
  25. doi request reprint Expansion of the surgical Apgar score across all surgical subspecialties as a means to predict postoperative mortality
    Paul Q Reynolds
    Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Anesthesiology 114:1305-12. 2011
    ..To date, evaluation of this scoring system has been limited to general and vascular services. The authors attempt to externally validate and expand the Surgical Apgar Score across a wide breadth of surgical subspecialties...
  26. pmc Biobanks and electronic medical records: enabling cost-effective research
    Erica Bowton
    Institute for Clinical and Translational Research, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Sci Transl Med 6:234cm3. 2014
    ..Here, we present a model that highlights potential advantages for genomic discovery and describe the operational infrastructure that facilitated multiple simultaneous discovery efforts. ..
  27. doi request reprint A Multimodal Intervention Improves Postanesthesia Care Unit Handovers
    Matthew B Weinger
    From the Center for Research and Innovation in Systems Safety CRISS, Institute for Medicine and Public Health, Vanderbilt University, Nashville, Tennessee Health Services Research Division and the Geriatrics Research Education and Clinical Center, Veterans Affairs VA Tennessee Valley Healthcare System, Nashville Campus, Nashville, Tennessee Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee Center for Experiential Learning and Assessment, Department of Medical Education, Vanderbilt University School of Medicine, Nashville, Tennessee Perioperative Nursing and Nurse Education, Vanderbilt University Medical Center, Nashville, Tennessee Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee Center for Patient and Professional Advocacy, Vanderbilt University Medical Center, Nashville, Tennessee School of Nursing, Vanderbilt University, Nashville, Tennessee Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee and Health Information Management and Systems Division, School of Health and Rehabilitation Sciences, Ohio State University College of Medicine, Columbus, Ohio
    Anesth Analg 121:957-71. 2015
    ..Failures of communication are a major contributor to perioperative adverse events. Transitions of care may be particularly vulnerable. We sought to improve postoperative handovers...
  28. pmc Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation
    Jessica T Delaney
    Division of Cardiovascular Medicine, Departments of Medicine, Vanderbilt University School of Medicine, 2215B Garland Avenue, Room 1275 MRB IV, Room 1275 MRB IV, Nashville, TN 37232 6602, USA
    Europace 16:485-90. 2014
    ..In a cohort of patients with atrial fibrillation (AF), we examined whether there was an association between common variants in SCN10A and both the PR interval during normal sinus rhythm and the heart rate response during AF...
  29. pmc Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record
    Andrea H Ramirez
    Department of Medicine, Vanderbilt University in Nashville, TN 37232, USA
    Pharmacogenomics 13:407-18. 2012
    ..Electronic health record (EHR) systems linked to biobanks may allow for pharmacogenomic analysis, but they have not yet been used for this purpose...
  30. doi request reprint Selective local anesthetic placement using ultrasound guidance and neurostimulation for infraclavicular brachial plexus block
    Clifford Bowens
    Department of Anesthesiology, Vanderbilt Medical Center, Nashville, TN 37232 5614, USA
    Anesth Analg 110:1480-5. 2010
    ....
  31. doi request reprint Improving needle visualization by novice residents during an in-plane ultrasound nerve block simulation using an in-plane multiangle needle guide
    Rajnish K Gupta
    Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee, USA
    Pain Med 14:1600-7. 2013
    ..We hypothesized that an in-plane, multiangle needle guide can help reduce the time it takes novice regional anesthesiologists to perform a simulated ultrasound-guided nerve-targeting procedure and enhance the visualization of the needle...
  32. doi request reprint Risk of burnout in perioperative clinicians: a survey study and literature review
    Steve A Hyman
    Department of Anesthesiology, Veterans Affairs Medical Center Nashville, Tennessee Valley Veterans Affairs Healthcare System, Nashville, Tennessee 37205, USA
    Anesthesiology 114:194-204. 2011
    ..Previous studies have not evaluated all healthcare workers within a single work unit. This study evaluates the risk of burnout in all medical personnel in one perioperative unit...
  33. pmc Medication administration discrepancies persist despite electronic ordering
    Fern Fitzhenry
    Department of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203, USA
    J Am Med Inform Assoc 14:756-64. 2007
    ....
  34. doi request reprint Supervising anesthesiologists cannot be effectively compared according to their patients' postanesthesia care unit admission pain scores
    Jonathan P Wanderer
    From the Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee and Department of Anesthesiology, Jefferson Medical College, Philadelphia, Pennsylvania
    Anesth Analg 120:923-32. 2015
    ....
  35. ncbi request reprint Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel study
    Carol A Trenga
    Research Scientist, EPA NW Research Center for Particulate Air Pollution and Health, Department of Environmental Health, Box 354695, University of Washington, Seattle, WA 98195 4695, USA
    Chest 129:1614-22. 2006
    ....
  36. ncbi request reprint Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis
    Christopher H Goss
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Respir Crit Care Med 169:816-21. 2004
    ..91-1.93; 95% CI). Annual average exposures to particulate air pollution was associated with an increased risk of pulmonary exacerbations and a decline in lung function, suggesting a role of environmental exposures on prognosis in CF...