Genomes and Genes
Jonathan S Schildcrout
Affiliation: Vanderbilt University
- Outcome-dependent sampling for longitudinal binary response data based on a time-varying auxiliary variableJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Ave South, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
Stat Med 31:2441-56. 2012....
- Analyses of longitudinal, hospital clinical laboratory data with application to blood glucose concentrationsJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
Stat Med 30:3208-20. 2011..To illustrate these points, we present a detailed analysis of the relationship between blood glucose levels and insulin doses on the basis of data from an intensive care unit...
- An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical recordsJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2156, USA
J Biomed Inform 43:914-23. 2010..The phenotypes studied include type II diabetes and type II diabetes controls, peripheral arterial disease and peripheral arterial disease controls, normal cardiac conduction as measured by electrocardiography, and senile cataracts...
- Outcome-dependent sampling from existing cohorts with longitudinal binary response data: study planning and analysisJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 2323 Medical Center North, Nashville, Tennessee 37232, USA
Biometrics 67:1583-93. 2011..We also assume that these data would be ascertained by analyzing stored blood samples, the cost of which limits the sample size...
- Longitudinal studies of binary response data following case-control and stratified case-control sampling: design and analysisJonathan S Schildcrout
Departments of Biostatistics and Anesthesiology, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 2323 Medical Center North, Nashville, Tennessee 37232, USA
Biometrics 66:365-73. 2010..The research is motivated by a longitudinal study following case-control sampling of the time course of attention deficit hyperactivity disorder (ADHD) symptoms...
- On outcome-dependent sampling designs for longitudinal binary response data with time-varying covariatesJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
Biostatistics 9:735-49. 2008....
- Analysis of longitudinal laboratory data in the presence of common selection mechanisms: a view toward greater emphasis on pre-marketing pharmaceutical safetyJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University, Nashville, TN 37232 2158, U S A
Stat Med 27:2248-66. 2008....
- Marginalized models for moderate to long series of longitudinal binary response dataJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biometrics 63:322-31. 2007..Data from the Madras Longitudinal Schizophrenia Study (Thara et al., 1994, Acta Psychiatrica Scandinavica 90, 329-336) are analyzed...
- Ambient air pollution and asthma exacerbations in children: an eight-city analysisJonathan S Schildcrout
Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN 27232 2158, USA
Am J Epidemiol 164:505-17. 2006..01, 1.10) and 1.05 (95% CI: 1.01, 1.09), respectively. The authors believe that the observed carbon monoxide and nitrogen dioxide associations can probably be attributed to mobile-source emissions, though more research is required...
- Regression analysis of longitudinal binary data with time-dependent environmental covariates: bias and efficiencyJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
Biostatistics 6:633-52. 2005..We find that the impact of covariance model choice depends highly on the specific structure of the data features, and that key aspects should be examined before choosing a weighting scheme...
- Estimating baseline kidney function in hospitalized patients with impaired kidney functionEdward D Siew
Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Clin J Am Soc Nephrol 7:712-9. 2012..No consensus exists on how to optimally determine baseline kidney function when multiple preadmission creatinine measurements are available...
- Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia riskMarylyn D Ritchie
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA
Circulation 127:1377-85. 2013..ECG QRS duration, a measure of cardiac intraventricular conduction, varies ≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant arrhythmias...
- Development of inpatient risk stratification models of acute kidney injury for use in electronic health recordsMichael E Matheny
Geriatric Research Education Clinical Center, Tennessee Valley Health System, Veterans Health Administration, Nashville, TN, USA
Med Decis Making 30:639-50. 2010....
- Modulators of normal electrocardiographic intervals identified in a large electronic medical recordAndrea H Ramirez
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
Heart Rhythm 8:271-7. 2011..Traditional electrocardiographic (ECG) reference ranges were derived from studies in communities or clinical trial populations. The distribution of ECG parameters in a large population presenting to a healthcare system has not been studied...
- The impact of peripheral nerve techniques on hospital stay following major orthopedic surgeryMark J Lenart
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA
Pain Med 13:828-34. 2012..To determine the impact of regional anesthesia on hospital stay for selected orthopedic procedures compared with traditional pain control modalities...
- Obesity and oxidative stress predict AKI after cardiac surgeryFrederic T Billings
Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Am Soc Nephrol 23:1221-8. 2012..001). In conclusion, obesity independently predicts AKI after cardiac surgery, and oxidative stress may partially mediate this association...
- Prevalence and Clinical Significance of Discrepancies within Three Computerized Pre-Admission Medication ListsJosh F Peterson
Department of Biomedical Informatics, Vanderbilt University, Nashville, TN
AMIA Annu Symp Proc 2010:642-6. 2010..Potentially harmful medication discrepancies were found within all lists. The authors concluded no single list was sufficiently accurate to avoid serious medication errors...
- Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome scienceJoshua C Denny
Office of Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
Circulation 122:2016-21. 2010..The extent to which this can be demonstrated in cohorts derived from electronic medical records is unknown...
- Intraoperative risk factors for acute respiratory distress syndrome in critically ill patientsChristopher G Hughes
Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
Anesth Analg 111:464-7. 2010..However, research examining intraoperative factors such as fluid resuscitation, mechanical ventilation strategies, and blood administration on the postoperative development of ARDS is lacking...
- Expansion of the surgical Apgar score across all surgical subspecialties as a means to predict postoperative mortalityPaul Q Reynolds
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Anesthesiology 114:1305-12. 2011..To date, evaluation of this scoring system has been limited to general and vascular services. The authors attempt to externally validate and expand the Surgical Apgar Score across a wide breadth of surgical subspecialties...
- Duration of upper and lower extremity peripheral nerve blockade is prolonged with dexamethasone when added to ropivacaine: a retrospective database analysisStephanie B Rasmussen
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Pain Med 14:1239-47. 2013..The purpose of this study was to examine the effect of adding dexamethasone to ropivacaine on duration of nerve blocks of the upper and lower extremity...
- Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health recordAndrea H Ramirez
Department of Medicine, Vanderbilt University in Nashville, TN 37232, USA
Pharmacogenomics 13:407-18. 2012..Electronic health record (EHR) systems linked to biobanks may allow for pharmacogenomic analysis, but they have not yet been used for this purpose...
- A computerized provider order entry intervention for medication safety during acute kidney injury: a quality improvement reportAllison B McCoy
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
Am J Kidney Dis 56:832-41. 2010..Frequently, prescribers fail to account for changing kidney function when prescribing medications. We evaluated the use of a computerized provider order entry intervention to improve medication management during acute kidney injury...
- Risk of burnout in perioperative clinicians: a survey study and literature reviewSteve A Hyman
Department of Anesthesiology, Veterans Affairs Medical Center Nashville, Tennessee Valley Veterans Affairs Healthcare System, Nashville, Tennessee 37205, USA
Anesthesiology 114:194-204. 2011..Previous studies have not evaluated all healthcare workers within a single work unit. This study evaluates the risk of burnout in all medical personnel in one perioperative unit...
- Medication administration discrepancies persist despite electronic orderingFern Fitzhenry
Department of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203, USA
J Am Med Inform Assoc 14:756-64. 2007....
- Outcome vector dependent sampling with longitudinal continuous response data: stratified sampling based on summary statisticsJonathan S Schildcrout
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, U S A Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, U S A
Biometrics 69:405-16. 2013....
- Selective local anesthetic placement using ultrasound guidance and neurostimulation for infraclavicular brachial plexus blockClifford Bowens
Department of Anesthesiology, Vanderbilt Medical Center, Nashville, TN 37232 5614, USA
Anesth Analg 110:1480-5. 2010....
- Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel studyCarol A Trenga
Research Scientist, EPA NW Research Center for Particulate Air Pollution and Health, Department of Environmental Health, Box 354695, University of Washington, Seattle, WA 98195 4695, USA
Chest 129:1614-22. 2006....
- Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosisChristopher H Goss
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Am J Respir Crit Care Med 169:816-21. 2004..91-1.93; 95% CI). Annual average exposures to particulate air pollution was associated with an increased risk of pulmonary exacerbations and a decline in lung function, suggesting a role of environmental exposures on prognosis in CF...