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Genomes and Genes | Melinda E SandersSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Differentiating proteomic biomarkers in breast cancer by laser capture microdissection and MALDI MSMelinda E Sanders
Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Proteome Res 7:1500-7. 2008..Several of the m/ z features used in the classifiers were identified by LC-MS/MS and two were confirmed by immunohistochemistry...
Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsiesMelinda E Sanders
Department of Pathology, Vanderbilt University Medical Center and Medical School, Nashville, TN 37232, USA
Cancer 106:1453-61. 2006..Radial scars (RS) are benign breast lesions that have been implicated as independent risk factors for invasive breast carcinoma (IBC)...- The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of long-term follow-upMelinda E Sanders
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 5310, USA
Cancer 103:2481-4. 2005..At the time the biopsies in the current study were originally examined, small DCIS was not diagnosed and, by default, these women were treated by biopsy only... - A multistage association study identifies a breast cancer genetic locus at NCOA7Kathryn S P Higginbotham
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Cancer Res 71:3881-8. 2011..These observations provide consistent evidence that genetic variants at the NCOA7 locus may confer a reduced risk of breast cancer... - Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer riskWilliam D Dupont
Department of Biostatistics, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
Cancer 116:8-19. 2010..Women who are diagnosed with benign proliferative breast disease are at increased risk for the subsequent development of breast cancer... - Histologic associations and long-term cancer risk in columnar cell lesions of the breast: a retrospective cohort and a nested case-control studyFouad I Boulos
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Cancer 113:2415-21. 2008..However, the few retrospective outcome studies performed have failed to establish an increased risk for recurrence or carcinoma on long-term follow-up... - Excellent survival, cancer type, and Nottingham grade after atypical lobular hyperplasia on initial breast biopsyBernadette K McLaren
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561, USA
Cancer 107:1227-33. 2006..Treatment of women with ALH should be influenced by their modest elevation in breast cancer risk and the good prognosis and low mortality of many of these cancers... 
A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24Kathryn S Higginbotham
Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Cancer Epidemiol Biomarkers Prev 21:1565-73. 2012..We conducted a multistage genetic association study in a series of independent epidemiologic breast cancer study populations to identify novel breast cancer risk variants...- A novel histology-directed strategy for MALDI-MS tissue profiling that improves throughput and cellular specificity in human breast cancerDale S Cornett
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Mol Cell Proteomics 5:1975-83. 2006..The higher performance characteristics offered by the new workflow promises to be a significant advancement toward the next generation of tissue profiling studies... - Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk predictionPhilip S Crooke
Department of Mathematics, Vanderbilt University, Nashville, TN 37232, USA
Cancer Epidemiol Biomarkers Prev 20:1502-15. 2011..Current models of breast cancer risk prediction do not directly reflect mammary estrogen metabolism or genetic variability in exposure to carcinogenic estrogen metabolites... - Discordant cellular response to presurgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplificationJustin M Balko
Vanderbilt University Medical Center, 2200 Pierce Ave, 777 PRB, Nashville, TN 37232 6307, USA
Mol Cancer Ther 11:2301-5. 2012..Second, they suggest that the role of activating mutations in RAS, although rare in breast cancer, may need to be explored in the context of ER+ breast tumors... - Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapiesBrian D Lehmann
Department of Biochemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Invest 121:2750-67. 2011..These data may be useful in biomarker selection, drug discovery, and clinical trial design that will enable alignment of TNBC patients to appropriate targeted therapies... - Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistanceJustin M Balko
Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
Nat Med 18:1052-9. 2012..Thus, DUSP4 downregulation activates the Ras-ERK pathway in BLBC, resulting in an attenuated response to anti-cancer chemotherapy... - Molecular analysis of tumor margins by MALDI mass spectrometry in renal carcinomaStacey R Oppenheimer
Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA
J Proteome Res 9:2182-90. 2010..This work demonstrates the utility of MALDI MS for the analysis of tumor tissue in the elucidation of aberrant molecular changes in the tumor microenvironment... - Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiationJoshua A Bauer
Departments of Biochemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Clin Cancer Res 16:681-90. 2010..To identify molecular markers of pathologic response to neoadjuvant paclitaxel/radiation treatment, protein and gene expression profiling were done on pretreatment biopsies... - Heritable variation of ERBB2 and breast cancer riskJoan P Breyer
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0275, USA
Cancer Epidemiol Biomarkers Prev 18:1252-8. 2009..In contrast, we observed no association of ERBB2 single nucleotide polymorphism haplotypes with breast cancer predisposition... - Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancersMarta Guix
Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
J Clin Oncol 26:897-906. 2008.... - Direct analysis of laser capture microdissected cells by MALDI mass spectrometryBaogang J Xu
Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA
J Am Soc Mass Spectrom 13:1292-7. 2002..The reported tissue preparation procedure and subsequent analysis by MALDI MS provide a new methodology for protein discovery involving LCM captured cells... - Can we know what to do when DCIS is diagnosed?Melinda E Sanders
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Oncology (Williston Park) 25:852-6. 2011..Despite the 20-year-old dogma that all patients treated with breast conservation should receive postoperative radiation, a subset of patients who can be successfully treated by excision alone has been identified... - Proteomics in diagnostic pathology: profiling and imaging proteins directly in tissue sectionsPierre Chaurand
Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University, Nashville TN, 37232-8575, USA
Am J Pathol 165:1057-68. 2004..The present article reviews the state of the art of the technology and its complementarity with traditional histopathological analyses... - Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicityFrederick Y Wu
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Cancer Res 66:2162-72. 2006..These data suggest that cytoplasmic p27 can exert oncogenic functions by modulating Akt stability, cell survival, and tumorigenicity... - Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1Rebecca S Muraoka
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Mol Cell Biol 23:8691-703. 2003....