Michael J Rosen
Affiliation: Vanderbilt University
- Endoscopic ultrasound to guide the combined medical and surgical management of pediatric perianal Crohn's diseaseMichael J Rosen
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, TN 37232 0696, USA
Inflamm Bowel Dis 16:461-8. 2010....
- STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunctionMichael J Rosen
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA
Inflamm Bowel Dis 17:2224-34. 2011..The study aims were to determine if mucosal STAT6 phosphorylation is increased in patients with UC, and if STAT6 inhibition attenuates IL-13-induced colon epithelial cell dysfunction...
- Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell responseKshipra Singh
Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Am J Physiol Gastrointest Liver Physiol 305:G225-40. 2013..Thus CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis, and impaired L-Arg availability may contribute to UC pathogenesis...
- STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokinesMichael J Rosen
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 190:1849-58. 2013..These data implicate STAT6 in the pathogenesis of colitis in vivo with important roles in altering epithelial barrier function and regulating Th2-inducing cytokine production...
- High-throughput multi-analyte luminex profiling implicates eotaxin-1 in ulcerative colitisLori A Coburn
Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
PLoS ONE 8:e82300. 2013..Our data implicate eotaxin-1 as an etiologic factor and therapeutic target in UC, and indicate that Luminex-based assays may be useful to assess IBD pathogenesis and to select patients for anti-cytokine/chemokine therapies. ..
- Inpatient mortality analysis of paraesophageal hernia repair in octogenariansBenjamin K Poulose
Department of Surgery, University Hospitals Case Medical Center, Lakeside 7010, Mailstop 5047, 11100 Euclid Avenue, Cleveland, OH 44106, USA
J Gastrointest Surg 12:1888-92. 2008..Paraesophageal hernia repair is often performed in an elderly population. Few studies have evaluated perioperative mortality in this group. We identified predictors of inpatient mortality using a nationally representative sample...
- Ciliated hepatic foregut cysts in childrenVictor Zaydfudim
Department of Surgery, Monroe Carell Jr Children s Hospital at Vanderbilt University, Nashville, TN, USA
Pediatr Surg Int 26:753-7. 2010..We report the presentation, evaluation, and surgical management of a symptomatic 17-year-old girl found to have a 6.5 x 4.5 cm CHFC and suggest that all patients with suspected CHFC undergo prompt evaluation and complete cyst excision...
- Transactivation of EGFR by LPS induces COX-2 expression in enterocytesSteven J McElroy
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
PLoS ONE 7:e38373. 2012..Taken together, these data show that EGFR plays an important role in LPS-induction of COX-2 expression in enterocytes, which may be one mechanism for EGF in inhibition of NEC...
- Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratiosJörn Hendrik Weitkamp
Division of Neonatology, Department of Pediatrics, Monroe Carell Jr Children s Hospital at Vanderbilt, 2215 B Garland Ave, 1125 MRB IV Light Hall, Nashville, TN 37232 0656, USA
Gut 62:73-82. 2013..Immaturity of gastrointestinal immune regulation may predispose preterm infants to NEC as FOXP3 T regulatory cells (Treg) are critical for intestinal immune homoeostasis...
- L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitisLori A Coburn
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
PLoS ONE 7:e33546. 2012..These preclinical studies indicate that L-Arg supplementation could be a potential therapy for IBD, and that one mechanism of action may be functional enhancement of iNOS activity...