Michael J Rosen

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Endoscopic ultrasound to guide the combined medical and surgical management of pediatric perianal Crohn's disease
    Michael J Rosen
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, TN 37232 0696, USA
    Inflamm Bowel Dis 16:461-8. 2010
  2. pmc STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction
    Michael J Rosen
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA
    Inflamm Bowel Dis 17:2224-34. 2011
  3. pmc Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response
    Kshipra Singh
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 305:G225-40. 2013
  4. pmc STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines
    Michael J Rosen
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1849-58. 2013
  5. pmc High-throughput multi-analyte luminex profiling implicates eotaxin-1 in ulcerative colitis
    Lori A Coburn
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e82300. 2013
  6. doi request reprint Inpatient mortality analysis of paraesophageal hernia repair in octogenarians
    Benjamin K Poulose
    Department of Surgery, University Hospitals Case Medical Center, Lakeside 7010, Mailstop 5047, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Gastrointest Surg 12:1888-92. 2008
  7. pmc Ciliated hepatic foregut cysts in children
    Victor Zaydfudim
    Department of Surgery, Monroe Carell Jr Children s Hospital at Vanderbilt University, Nashville, TN, USA
    Pediatr Surg Int 26:753-7. 2010
  8. pmc Transactivation of EGFR by LPS induces COX-2 expression in enterocytes
    Steven J McElroy
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e38373. 2012
  9. pmc Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios
    Jörn Hendrik Weitkamp
    Division of Neonatology, Department of Pediatrics, Monroe Carell Jr Children s Hospital at Vanderbilt, 2215 B Garland Ave, 1125 MRB IV Light Hall, Nashville, TN 37232 0656, USA
    Gut 62:73-82. 2013
  10. pmc L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis
    Lori A Coburn
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33546. 2012

Collaborators

Detail Information

Publications10

  1. pmc Endoscopic ultrasound to guide the combined medical and surgical management of pediatric perianal Crohn's disease
    Michael J Rosen
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, TN 37232 0696, USA
    Inflamm Bowel Dis 16:461-8. 2010
    ....
  2. pmc STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction
    Michael J Rosen
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA
    Inflamm Bowel Dis 17:2224-34. 2011
    ..The study aims were to determine if mucosal STAT6 phosphorylation is increased in patients with UC, and if STAT6 inhibition attenuates IL-13-induced colon epithelial cell dysfunction...
  3. pmc Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response
    Kshipra Singh
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 305:G225-40. 2013
    ..Thus CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis, and impaired L-Arg availability may contribute to UC pathogenesis...
  4. pmc STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines
    Michael J Rosen
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1849-58. 2013
    ..These data implicate STAT6 in the pathogenesis of colitis in vivo with important roles in altering epithelial barrier function and regulating Th2-inducing cytokine production...
  5. pmc High-throughput multi-analyte luminex profiling implicates eotaxin-1 in ulcerative colitis
    Lori A Coburn
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e82300. 2013
    ..Our data implicate eotaxin-1 as an etiologic factor and therapeutic target in UC, and indicate that Luminex-based assays may be useful to assess IBD pathogenesis and to select patients for anti-cytokine/chemokine therapies. ..
  6. doi request reprint Inpatient mortality analysis of paraesophageal hernia repair in octogenarians
    Benjamin K Poulose
    Department of Surgery, University Hospitals Case Medical Center, Lakeside 7010, Mailstop 5047, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Gastrointest Surg 12:1888-92. 2008
    ..Paraesophageal hernia repair is often performed in an elderly population. Few studies have evaluated perioperative mortality in this group. We identified predictors of inpatient mortality using a nationally representative sample...
  7. pmc Ciliated hepatic foregut cysts in children
    Victor Zaydfudim
    Department of Surgery, Monroe Carell Jr Children s Hospital at Vanderbilt University, Nashville, TN, USA
    Pediatr Surg Int 26:753-7. 2010
    ..We report the presentation, evaluation, and surgical management of a symptomatic 17-year-old girl found to have a 6.5 x 4.5 cm CHFC and suggest that all patients with suspected CHFC undergo prompt evaluation and complete cyst excision...
  8. pmc Transactivation of EGFR by LPS induces COX-2 expression in enterocytes
    Steven J McElroy
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e38373. 2012
    ..Taken together, these data show that EGFR plays an important role in LPS-induction of COX-2 expression in enterocytes, which may be one mechanism for EGF in inhibition of NEC...
  9. pmc Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios
    Jörn Hendrik Weitkamp
    Division of Neonatology, Department of Pediatrics, Monroe Carell Jr Children s Hospital at Vanderbilt, 2215 B Garland Ave, 1125 MRB IV Light Hall, Nashville, TN 37232 0656, USA
    Gut 62:73-82. 2013
    ..Immaturity of gastrointestinal immune regulation may predispose preterm infants to NEC as FOXP3 T regulatory cells (Treg) are critical for intestinal immune homoeostasis...
  10. pmc L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis
    Lori A Coburn
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33546. 2012
    ..These preclinical studies indicate that L-Arg supplementation could be a potential therapy for IBD, and that one mechanism of action may be functional enhancement of iNOS activity...