Louise A Rollins-Smith

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populations
    Louise A Rollins-Smith
    Department of Microbiology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 29:589-98. 2005
  2. ncbi request reprint Immune defenses of Xenopus laevis against Batrachochytrium dendrobatidis
    Louise A Rollins-Smith
    Department of Microbiology and Immunology and Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 USA
    Front Biosci (Schol Ed) 1:68-91. 2009
  3. ncbi request reprint Antimicrobial peptide defenses of the mountain yellow-legged frog (Rana muscosa)
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 30:831-42. 2006
  4. doi request reprint Amphibian immune defenses against chytridiomycosis: impacts of changing environments
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Integr Comp Biol 51:552-62. 2011
  5. doi request reprint The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines
    Louise A Rollins-Smith
    Department of Microbiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Biochim Biophys Acta 1788:1593-9. 2009
  6. ncbi request reprint An amphibian model to test the effects of xenobiotic chemicals on development of the hematopoietic system
    Louise A Rollins-Smith
    Department of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Environ Toxicol Chem 23:2863-7. 2004
  7. pmc Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Antimicrob Agents Chemother 47:1157-60. 2003
  8. ncbi request reprint Antimicrobial peptide defenses of the Tarahumara frog, Rana tarahumarae
    Louise A Rollins-Smith
    Department of Microbiology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 297:361-7. 2002
  9. ncbi request reprint Activity of antimicrobial skin peptides from ranid frogs against Batrachochytrium dendrobatidis, the chytrid fungus associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and Pediatrics, Vanderbilt University, Medical Center North, A 5301, Nashville, TN 37232, USA
    Dev Comp Immunol 26:471-9. 2002
  10. ncbi request reprint Antimicrobial peptide defenses against pathogens associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Comp Immunol 26:63-72. 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populations
    Louise A Rollins-Smith
    Department of Microbiology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 29:589-98. 2005
    ....
  2. ncbi request reprint Immune defenses of Xenopus laevis against Batrachochytrium dendrobatidis
    Louise A Rollins-Smith
    Department of Microbiology and Immunology and Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 USA
    Front Biosci (Schol Ed) 1:68-91. 2009
    ..Development of an immunization protocol in X. laevis that induces effective defenses may suggest better strategies for protecting vulnerable species such as B. boreas...
  3. ncbi request reprint Antimicrobial peptide defenses of the mountain yellow-legged frog (Rana muscosa)
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 30:831-42. 2006
    ..dendrobatidis in nature. Possible differences in the antimicrobial peptide repertoires and life history traits of the two species that may account for differences in susceptibility are discussed...
  4. doi request reprint Amphibian immune defenses against chytridiomycosis: impacts of changing environments
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Integr Comp Biol 51:552-62. 2011
    ..We also briefly review what is known about the impacts of temperature, environmental chemicals, and stress on the host-pathogen interactions and suggest future directions for research...
  5. doi request reprint The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines
    Louise A Rollins-Smith
    Department of Microbiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Biochim Biophys Acta 1788:1593-9. 2009
    ..However, this defense must also accommodate potentially beneficial microbes on the skin that compete or inhibit growth of the pathogens. How this delicate balancing act is accomplished is an important area of future research...
  6. ncbi request reprint An amphibian model to test the effects of xenobiotic chemicals on development of the hematopoietic system
    Louise A Rollins-Smith
    Department of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Environ Toxicol Chem 23:2863-7. 2004
    ....
  7. pmc Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Antimicrob Agents Chemother 47:1157-60. 2003
    ..Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an alpha-helical structure is important for their effectiveness against this pathogen...
  8. ncbi request reprint Antimicrobial peptide defenses of the Tarahumara frog, Rana tarahumarae
    Louise A Rollins-Smith
    Department of Microbiology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 297:361-7. 2002
    ..Therefore, the observed susceptibility of these frogs to this pathogen in the wild may be due to the effects of additional environmental factors that impair this innate defense mechanism, leading to the observed population declines...
  9. ncbi request reprint Activity of antimicrobial skin peptides from ranid frogs against Batrachochytrium dendrobatidis, the chytrid fungus associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and Pediatrics, Vanderbilt University, Medical Center North, A 5301, Nashville, TN 37232, USA
    Dev Comp Immunol 26:471-9. 2002
    ..This may provide some natural resistance to infection, but if environmental factors inhibit the synthesis and release of the skin peptides, the pathogen could gain the advantage...
  10. ncbi request reprint Antimicrobial peptide defenses against pathogens associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Comp Immunol 26:63-72. 2002
    ..It suggests that this innate defense mechanism may play a role in preventing or limiting infection by these organisms...
  11. pmc The invasive chytrid fungus of amphibians paralyzes lymphocyte responses
    J Scott Fites
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Science 342:366-9. 2013
    ..Their production was absent in zoospores and reduced by nikkomycin Z, suggesting that they may be components of the cell wall. Evasion of host immunity may explain why this pathogen has devastated amphibian populations worldwide. ..
  12. pmc Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the South African clawed frog, Xenopus laevis
    Jeremy P Ramsey
    Department of Microbiology and Immunology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Infect Immun 78:3981-92. 2010
    ..dendrobatidis. These data strongly suggest that both innate and adaptive immune defenses are involved in the resistance of X. laevis to lethal B. dendrobatidis infections...
  13. doi request reprint Skin peptides protect juvenile leopard frogs (Rana pipiens) against chytridiomycosis
    James D Pask
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Exp Biol 216:2908-16. 2013
    ..dendrobatidis infections, and it is important for biologists to recognize that this defense is especially important for newly metamorphosed frogs in which the adaptive immune system is still immature. ..
  14. ncbi request reprint Predicted disease susceptibility in a Panamanian amphibian assemblage based on skin peptide defenses
    Douglas C Woodhams
    Department of Microbiology and Immunology, Vanderbilt University, A5301 Medical Center North, Nashville, Tennessee 37232, USA
    J Wildl Dis 42:207-18. 2006
    ..This supports the hypothesis that B. dendrobatidis is a generalist pathogen and that species possessing an innate immunologic defense at the time of disease emergence are more likely to survive...
  15. pmc Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells
    Scott E VanCompernolle
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 21st Ave South, Medical Center North, Room AA5206, Nashville, TN 37232 2363, USA
    J Virol 79:11598-606. 2005
    ..Thus, amphibian-derived antimicrobial peptides show promise as topical inhibitors of mucosal HIV transmission and provide novel tools to understand the complex biology of HIV capture by DCs...
  16. doi request reprint Norepinephrine depletion of antimicrobial peptides from the skin glands of Xenopus laevis
    Whitney M Gammill
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Comp Immunol 37:19-27. 2012
    ..Mass spectrometry and histology confirmed that glands are depleted after two injections. Periodic acid-Schiff staining indicated that mucus gland secretion was also induced by norepinephrine...
  17. ncbi request reprint Life-history trade-offs influence disease in changing climates: strategies of an amphibian pathogen
    Douglas C Woodhams
    Department of Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Ecology 89:1627-39. 2008
    ..These results demonstrate that B. dendrobatidis populations can grow at high rates across a broad range of environmental temperatures and help to explain why it is so successful in cold montane environments...
  18. ncbi request reprint An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae)
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Regul Pept 124:173-8. 2005
    ..The hemolytic activity of fallaxin was very low (HC50>200 microM). A second peptide, comprising residues (1-22) of fallaxin, was also isolated from the skin secretions but this component was inactive against the microorganisms tested...
  19. ncbi request reprint Population trends associated with skin peptide defenses against chytridiomycosis in Australian frogs
    Douglas C Woodhams
    School of Tropical Biology, James Cook University, 4811, Townsville, QLD, Australia
    Oecologia 146:531-40. 2006
    ..Further research is needed to assess whether this non-specific immune defense may be useful in predicting disease susceptibility in other species...
  20. doi request reprint Nikkomycin Z is an effective inhibitor of the chytrid fungus linked to global amphibian declines
    Whitney M Holden
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Electronic address
    Fungal Biol 118:48-60. 2014
    ..These studies suggest that nikkomycin Z would be an effective treatment to significantly reduce the fungal burden in frogs infected by B. dendrobatidis. ..
  21. ncbi request reprint Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:498-506. 2007
    ....
  22. ncbi request reprint Effects of chytrid and carbaryl exposure on survival, growth and skin peptide defenses in foothill yellow-legged frogs
    Carlos Davidson
    Environmental Studies Program, San Francisco State University, 1600 Holloway Avenue, San Francisco CA 94132, USA
    Environ Sci Technol 41:1771-6. 2007
    ..Skin peptide defenses were significantly reduced after exposure to carbaryl suggesting that pesticides may inhibit this innate immune defense and increase susceptibility to disease...
  23. ncbi request reprint Characterization of a peptide from skin secretions of male specimens of the frog, Leptodactylus fallax that stimulates aggression in male frogs
    Jay D King
    Department of Biology, University of Missouri St Louis, St Louis, MO 63121, USA
    Peptides 26:597-601. 2005
    ..It is suggested that this peptide may play an important role in initiating the competitive male-male interactions that are associated with the onset of reproductive behavior in L. fallax...
  24. ncbi request reprint UVB dose-toxicity thresholds and steady-state DNA-photoproduct levels during chronic irradiation of inbred Xenopus laevis tadpoles
    Iovanna Pandelova
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, USA
    Photochem Photobiol 82:1080-7. 2006
    ..We suggest that threshold effects due to DNA repair should generally be considered in assessments of effects of genotoxic agents on species-specific population decreases and human health risks...