Research Topics
| Louise A Rollins-SmithSummaryAffiliation: Vanderbilt University Country: USA Publications
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Detail Information
Publications
Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populationsLouise A Rollins-Smith
Department of Microbiology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
Dev Comp Immunol 29:589-98. 2005....- Immune defenses of Xenopus laevis against Batrachochytrium dendrobatidisLouise A Rollins-Smith
Department of Microbiology and Immunology and Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 USA
Front Biosci (Schol Ed) 1:68-91. 2009..Development of an immunization protocol in X. laevis that induces effective defenses may suggest better strategies for protecting vulnerable species such as B. boreas... - Antimicrobial peptide defenses of the mountain yellow-legged frog (Rana muscosa)Louise A Rollins-Smith
Department of Microbiology and Immunology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
Dev Comp Immunol 30:831-42. 2006..dendrobatidis in nature. Possible differences in the antimicrobial peptide repertoires and life history traits of the two species that may account for differences in susceptibility are discussed... - Amphibian immune defenses against chytridiomycosis: impacts of changing environmentsLouise A Rollins-Smith
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Integr Comp Biol 51:552-62. 2011..We also briefly review what is known about the impacts of temperature, environmental chemicals, and stress on the host-pathogen interactions and suggest future directions for research... - Antimicrobial peptide defenses of the Tarahumara frog, Rana tarahumaraeLouise A Rollins-Smith
Department of Microbiology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
Biochem Biophys Res Commun 297:361-7. 2002..Therefore, the observed susceptibility of these frogs to this pathogen in the wild may be due to the effects of additional environmental factors that impair this innate defense mechanism, leading to the observed population declines... - Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declinesLouise A Rollins-Smith
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Antimicrob Agents Chemother 47:1157-60. 2003..Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an alpha-helical structure is important for their effectiveness against this pathogen... - An amphibian model to test the effects of xenobiotic chemicals on development of the hematopoietic systemLouise A Rollins-Smith
Department of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Environ Toxicol Chem 23:2863-7. 2004.... - The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declinesLouise A Rollins-Smith
Department of Microbiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Biochim Biophys Acta 1788:1593-9. 2009..However, this defense must also accommodate potentially beneficial microbes on the skin that compete or inhibit growth of the pathogens. How this delicate balancing act is accomplished is an important area of future research... - Antimicrobial peptide defenses against pathogens associated with global amphibian declinesLouise A Rollins-Smith
Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Dev Comp Immunol 26:63-72. 2002..It suggests that this innate defense mechanism may play a role in preventing or limiting infection by these organisms... - Activity of antimicrobial skin peptides from ranid frogs against Batrachochytrium dendrobatidis, the chytrid fungus associated with global amphibian declinesLouise A Rollins-Smith
Departments of Microbiology and Immunology and Pediatrics, Vanderbilt University, Medical Center North, A 5301, Nashville, TN 37232, USA
Dev Comp Immunol 26:471-9. 2002..This may provide some natural resistance to infection, but if environmental factors inhibit the synthesis and release of the skin peptides, the pathogen could gain the advantage... - Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the South African clawed frog, Xenopus laevisJeremy P Ramsey
Department of Microbiology and Immunology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
Infect Immun 78:3981-92. 2010..dendrobatidis. These data strongly suggest that both innate and adaptive immune defenses are involved in the resistance of X. laevis to lethal B. dendrobatidis infections... - Predicted disease susceptibility in a Panamanian amphibian assemblage based on skin peptide defensesDouglas C Woodhams
Department of Microbiology and Immunology, Vanderbilt University, A5301 Medical Center North, Nashville, Tennessee 37232, USA
J Wildl Dis 42:207-18. 2006..This supports the hypothesis that B. dendrobatidis is a generalist pathogen and that species possessing an innate immunologic defense at the time of disease emergence are more likely to survive... - Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cellsScott E VanCompernolle
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 21st Ave. South, Medical Center North, Room AA5206, Nashville, TN 37232-2363, USA
J Virol 79:11598-606. 2005..Thus, amphibian-derived antimicrobial peptides show promise as topical inhibitors of mucosal HIV transmission and provide novel tools to understand the complex biology of HIV capture by DCs... - Norepinephrine depletion of antimicrobial peptides from the skin glands of Xenopus laevisWhitney M Gammill
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Dev Comp Immunol 37:19-27. 2012..Mass spectrometry and histology confirmed that glands are depleted after two injections. Periodic acid-Schiff staining indicated that mucus gland secretion was also induced by norepinephrine... - An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae)Louise A Rollins-Smith
Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Regul Pept 124:173-8. 2005..The hemolytic activity of fallaxin was very low (HC50>200 microM). A second peptide, comprising residues (1-22) of fallaxin, was also isolated from the skin secretions but this component was inactive against the microorganisms tested... - Life-history trade-offs influence disease in changing climates: strategies of an amphibian pathogenDouglas C Woodhams
Department of Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA
Ecology 89:1627-39. 2008..These results demonstrate that B. dendrobatidis populations can grow at high rates across a broad range of environmental temperatures and help to explain why it is so successful in cold montane environments... - Population trends associated with skin peptide defenses against chytridiomycosis in Australian frogsDouglas C Woodhams
School of Tropical Biology, James Cook University, 4811, Townsville, QLD, Australia
Oecologia 146:531-40. 2006..Further research is needed to assess whether this non-specific immune defense may be useful in predicting disease susceptibility in other species... - Characterization of a peptide from skin secretions of male specimens of the frog, Leptodactylus fallax that stimulates aggression in male frogsJay D King
Department of Biology, University of Missouri-St. Louis, St. Louis, MO 63121, USA
Peptides 26:597-601. 2005..It is suggested that this peptide may play an important role in initiating the competitive male-male interactions that are associated with the onset of reproductive behavior in L. fallax... - Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)J Michael Conlon
Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
Toxicon 50:498-506. 2007.... - Effects of chytrid and carbaryl exposure on survival, growth and skin peptide defenses in foothill yellow-legged frogsCarlos Davidson
Environmental Studies Program, San Francisco State University, 1600 Holloway Avenue, San Francisco CA 94132, USA
Environ Sci Technol 41:1771-6. 2007..Skin peptide defenses were significantly reduced after exposure to carbaryl suggesting that pesticides may inhibit this innate immune defense and increase susceptibility to disease... - UVB dose-toxicity thresholds and steady-state DNA-photoproduct levels during chronic irradiation of inbred Xenopus laevis tadpolesIovanna Pandelova
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, USA
Photochem Photobiol 82:1080-7. 2006..We suggest that threshold effects due to DNA repair should generally be considered in assessments of effects of genotoxic agents on species-specific population decreases and human health risks...