L A Rollins-Smith

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Metamorphosis and the amphibian immune system
    L A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Immunol Rev 166:221-30. 1998
  2. ncbi Neuroendocrine-immune system interactions in amphibians: implications for understanding global amphibian declines
    L A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Immunol Res 23:273-80. 2001
  3. ncbi Antimicrobial peptide defenses against pathogens associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Comp Immunol 26:63-72. 2002
  4. ncbi Activity of antimicrobial skin peptides from ranid frogs against Batrachochytrium dendrobatidis, the chytrid fungus associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and Pediatrics, Vanderbilt University, Medical Center North, A 5301, Nashville, TN 37232, USA
    Dev Comp Immunol 26:471-9. 2002
  5. ncbi Predicted disease susceptibility in a Panamanian amphibian assemblage based on skin peptide defenses
    Douglas C Woodhams
    Department of Microbiology and Immunology, Vanderbilt University, A5301 Medical Center North, Nashville, Tennessee 37232, USA
    J Wildl Dis 42:207-18. 2006
  6. ncbi Antimicrobial peptide defenses of the mountain yellow-legged frog (Rana muscosa)
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 30:831-42. 2006
  7. ncbi Population trends associated with skin peptide defenses against chytridiomycosis in Australian frogs
    Douglas C Woodhams
    School of Tropical Biology, James Cook University, 4811, Townsville, QLD, Australia
    Oecologia 146:531-40. 2006
  8. ncbi Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populations
    Louise A Rollins-Smith
    Department of Microbiology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 29:589-98. 2005
  9. ncbi Antimicrobial peptide defenses of the Tarahumara frog, Rana tarahumarae
    Louise A Rollins-Smith
    Department of Microbiology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 297:361-7. 2002
  10. ncbi An amphibian model to test the effects of xenobiotic chemicals on development of the hematopoietic system
    Louise A Rollins-Smith
    Department of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Environ Toxicol Chem 23:2863-7. 2004

Collaborators

Detail Information

Publications18

  1. ncbi Metamorphosis and the amphibian immune system
    L A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Immunol Rev 166:221-30. 1998
    ....
  2. ncbi Neuroendocrine-immune system interactions in amphibians: implications for understanding global amphibian declines
    L A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Immunol Res 23:273-80. 2001
    ..This article will review our current understanding of the neuroendocrine immune system interactions in amphibians and address the question of whether environmental stressors may contribute to immunosuppression and amphibian declines...
  3. ncbi Antimicrobial peptide defenses against pathogens associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Comp Immunol 26:63-72. 2002
    ..It suggests that this innate defense mechanism may play a role in preventing or limiting infection by these organisms...
  4. ncbi Activity of antimicrobial skin peptides from ranid frogs against Batrachochytrium dendrobatidis, the chytrid fungus associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and Pediatrics, Vanderbilt University, Medical Center North, A 5301, Nashville, TN 37232, USA
    Dev Comp Immunol 26:471-9. 2002
    ..This may provide some natural resistance to infection, but if environmental factors inhibit the synthesis and release of the skin peptides, the pathogen could gain the advantage...
  5. ncbi Predicted disease susceptibility in a Panamanian amphibian assemblage based on skin peptide defenses
    Douglas C Woodhams
    Department of Microbiology and Immunology, Vanderbilt University, A5301 Medical Center North, Nashville, Tennessee 37232, USA
    J Wildl Dis 42:207-18. 2006
    ..This supports the hypothesis that B. dendrobatidis is a generalist pathogen and that species possessing an innate immunologic defense at the time of disease emergence are more likely to survive...
  6. ncbi Antimicrobial peptide defenses of the mountain yellow-legged frog (Rana muscosa)
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 30:831-42. 2006
    ..dendrobatidis in nature. Possible differences in the antimicrobial peptide repertoires and life history traits of the two species that may account for differences in susceptibility are discussed...
  7. ncbi Population trends associated with skin peptide defenses against chytridiomycosis in Australian frogs
    Douglas C Woodhams
    School of Tropical Biology, James Cook University, 4811, Townsville, QLD, Australia
    Oecologia 146:531-40. 2006
    ..Further research is needed to assess whether this non-specific immune defense may be useful in predicting disease susceptibility in other species...
  8. ncbi Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populations
    Louise A Rollins-Smith
    Department of Microbiology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 29:589-98. 2005
    ....
  9. ncbi Antimicrobial peptide defenses of the Tarahumara frog, Rana tarahumarae
    Louise A Rollins-Smith
    Department of Microbiology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 297:361-7. 2002
    ..Therefore, the observed susceptibility of these frogs to this pathogen in the wild may be due to the effects of additional environmental factors that impair this innate defense mechanism, leading to the observed population declines...
  10. ncbi An amphibian model to test the effects of xenobiotic chemicals on development of the hematopoietic system
    Louise A Rollins-Smith
    Department of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Environ Toxicol Chem 23:2863-7. 2004
    ....
  11. ncbi Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Antimicrob Agents Chemother 47:1157-60. 2003
    ..Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an alpha-helical structure is important for their effectiveness against this pathogen...
  12. ncbi An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae)
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Regul Pept 124:173-8. 2005
    ..The hemolytic activity of fallaxin was very low (HC50>200 microM). A second peptide, comprising residues (1-22) of fallaxin, was also isolated from the skin secretions but this component was inactive against the microorganisms tested...
  13. ncbi Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells
    Scott E VanCompernolle
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 21st Ave. South, Medical Center North, Room AA5206, Nashville, TN 37232-2363, USA
    J Virol 79:11598-606. 2005
    ..Thus, amphibian-derived antimicrobial peptides show promise as topical inhibitors of mucosal HIV transmission and provide novel tools to understand the complex biology of HIV capture by DCs...
  14. ncbi Life-history trade-offs influence disease in changing climates: strategies of an amphibian pathogen
    Douglas C Woodhams
    Department of Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Ecology 89:1627-39. 2008
    ..These results demonstrate that B. dendrobatidis populations can grow at high rates across a broad range of environmental temperatures and help to explain why it is so successful in cold montane environments...
  15. ncbi UVB dose-toxicity thresholds and steady-state DNA-photoproduct levels during chronic irradiation of inbred Xenopus laevis tadpoles
    Iovanna Pandelova
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, USA
    Photochem Photobiol 82:1080-7. 2006
    ..We suggest that threshold effects due to DNA repair should generally be considered in assessments of effects of genotoxic agents on species-specific population decreases and human health risks...
  16. ncbi Effects of chytrid and carbaryl exposure on survival, growth and skin peptide defenses in foothill yellow-legged frogs
    Carlos Davidson
    Environmental Studies Program, San Francisco State University, 1600 Holloway Avenue, San Francisco CA 94132, USA
    Environ Sci Technol 41:1771-6. 2007
    ..Skin peptide defenses were significantly reduced after exposure to carbaryl suggesting that pesticides may inhibit this innate immune defense and increase susceptibility to disease...
  17. ncbi Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:498-506. 2007
    ....
  18. ncbi Characterization of a peptide from skin secretions of male specimens of the frog, Leptodactylus fallax that stimulates aggression in male frogs
    Jay D King
    Department of Biology, University of Missouri-St. Louis, St. Louis, MO 63121, USA
    Peptides 26:597-601. 2005
    ..It is suggested that this peptide may play an important role in initiating the competitive male-male interactions that are associated with the onset of reproductive behavior in L. fallax...