D Robertson

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation
    I Biaggioni
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232
    Circ Res 61:779-86. 1987
  2. ncbi The future of clinical research
    D Robertson
    Department of Medicine, Vanderbilt University, Nashville, Tenn, USA
    J Investig Med 48:309-11. 2000
  3. ncbi Linking molecular and bedside research: designing a clinical research infrastructure
    D Robertson
    General Clinical Research Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    J Mol Med (Berl) 79:686-94. 2001
  4. ncbi Familial orthostatic tachycardia due to norepinephrine transporter deficiency
    D Robertson
    Autonomic Dysfunction Center, AA3228 MCN, Vanderbilt University, Nashville, TN 37232 2195, USA
    Ann N Y Acad Sci 940:527-43. 2001
  5. ncbi Orthostatic intolerance and the postural tachycardia syndrome: genetic and environment pathophysiologies. Neurolab Autonomic Team
    D Robertson
    Center for Space Physiology and Medicine, Clinical Research Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Pflugers Arch 441:R48-51. 2000
  6. ncbi Distribution and observed associations of orthostatic blood pressure changes in elderly general medicine outpatients
    D Robertson
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee 37232 2195, USA
    Am J Med Sci 315:287-95. 1998
  7. ncbi Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency
    J R Shannon
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, Nashville 37232 2195, USA
    N Engl J Med 342:541-9. 2000
  8. ncbi The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome
    E M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Neurology 69:790-8. 2007
  9. ncbi Water drinking as a treatment for orthostatic syndromes
    John R Shannon
    Nathan Blaser Shy Drager Research Program, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee, USA
    Am J Med 112:355-60. 2002
  10. ncbi Animal model of neuropathic tachycardia syndrome
    R P Carson
    Departments of Pharmacology, Medicine, and Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Hypertension 37:1357-61. 2001

Collaborators

Detail Information

Publications50

  1. ncbi Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation
    I Biaggioni
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232
    Circ Res 61:779-86. 1987
    ..These findings raise the possibility that adenosine is an endogenous modulator of respiration in man...
  2. ncbi The future of clinical research
    D Robertson
    Department of Medicine, Vanderbilt University, Nashville, Tenn, USA
    J Investig Med 48:309-11. 2000
    ..Robertson. AFMR continues to be an organization looking to the future, and the clinical investigator will be an important part of the future...
  3. ncbi Linking molecular and bedside research: designing a clinical research infrastructure
    D Robertson
    General Clinical Research Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    J Mol Med (Berl) 79:686-94. 2001
    ..The GCRC model can provide a conceptual base on which new international patient-oriented research infrastructures can develop...
  4. ncbi Familial orthostatic tachycardia due to norepinephrine transporter deficiency
    D Robertson
    Autonomic Dysfunction Center, AA3228 MCN, Vanderbilt University, Nashville, TN 37232 2195, USA
    Ann N Y Acad Sci 940:527-43. 2001
    ..Analysis of the protein produced by the mutant cDNA in transfected cells demonstrated greater than 98% reduction in activity relative to normal. NE, DHPG/NE, and heart rate correlated with the mutant allele in this family...
  5. ncbi Orthostatic intolerance and the postural tachycardia syndrome: genetic and environment pathophysiologies. Neurolab Autonomic Team
    D Robertson
    Center for Space Physiology and Medicine, Clinical Research Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Pflugers Arch 441:R48-51. 2000
    ..This leads to poor clearance of norepinephrine from synapses, with consequent raised heart rate. Clinical features of these syndromes are presented...
  6. ncbi Distribution and observed associations of orthostatic blood pressure changes in elderly general medicine outpatients
    D Robertson
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee 37232 2195, USA
    Am J Med Sci 315:287-95. 1998
    ..These factors may help physicians in identifying older persons at risk for having orthostatic hypotension...
  7. ncbi Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency
    J R Shannon
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, Nashville 37232 2195, USA
    N Engl J Med 342:541-9. 2000
    ..We tested the hypothesis that impaired functioning of the norepinephrine transporter contributes to the pathophysiologic mechanism of orthostatic intolerance...
  8. ncbi The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome
    E M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Neurology 69:790-8. 2007
    ..Previous studies of patients with postural tachycardia syndrome (POTS) have been hampered by relatively small cohorts, failure to control medications and diet, and inconsistent testing procedures...
  9. ncbi Water drinking as a treatment for orthostatic syndromes
    John R Shannon
    Nathan Blaser Shy Drager Research Program, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee, USA
    Am J Med 112:355-60. 2002
    ..We tested the hypothesis that water drinking can be used as a practical treatment for patients with orthostatic and postprandial hypotension, as well as those with orthostatic tachycardia...
  10. ncbi Animal model of neuropathic tachycardia syndrome
    R P Carson
    Departments of Pharmacology, Medicine, and Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Hypertension 37:1357-61. 2001
    ..This animal model may help us better understand the pathophysiology of autonomic dysfunction and lead to development of therapeutic interventions...
  11. ncbi Smoking and mechanisms of cardiovascular control
    D Robertson
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
    Am Heart J 115:258-63. 1988
    ..Little current data are available documenting the efficacy of centrally acting antihypertensive agents and converting-enzyme inhibitors with regard to preventing nicotine's acute cardiovascular effects...
  12. pmc Sympathetic and baroreceptor reflex function in neurally mediated syncope evoked by tilt
    R Mosqueda-Garcia
    Syncope Service in the Autonomic Dysfunction Unit, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2195, USA
    J Clin Invest 99:2736-44. 1997
    ..These data challenge the view that excessive generalized sympathetic activation is the precursor of the hemodynamic abnormality underlying recurrent neurally mediated syncope...
  13. ncbi Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency
    I Biaggioni
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Lancet 2:1170-2. 1987
    ..88, p less than 0.05). Urinary noradrenaline increased from undetectable levels to 338 and 511 micrograms/24 h. Standing time (a correlate of functional capacity) also increased significantly in both patients. No side-effects were noted...
  14. ncbi Effects of nicotine on brain stem mechanisms of cardiovascular control
    C J Tseng
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee
    J Pharmacol Exp Ther 265:1511-8. 1993
    ..Clonidine had no effect on nicotine response in the three groups of rats. In conclusion, nicotine administration within the RVLM increases renal sympathetic nerve activity and blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)..
  15. pmc A cross-sectional study contrasting olfactory function in autonomic disorders
    E M Garland
    Autonomic Dysfunction Center, AA3228 Medical Center North, Vanderbilt University, Nashville, TN 37232 2195, USA
    Neurology 76:456-60. 2011
    ..To compare odor identification function in patients with peripheral or central autonomic neurodegeneration and in patients with intact autonomic neurons but undetectable norepinephrine...
  16. pmc Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space
    Andrew C Ertl
    Vanderbilt University Medical Center, Nashville, TN, USA
    J Physiol 538:321-9. 2002
    ..Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels...
  17. pmc Psychiatric profile and attention deficits in postural tachycardia syndrome
    V Raj
    Department of Psychiatry, Vanderbilt University School of Medicine, 1500 21st Ave, South, Nashville, TN 37212, USA
    J Neurol Neurosurg Psychiatry 80:339-44. 2009
    ..Patients with POTS were formally assessed for psychiatric disorders and inattention and compared with patients with attention deficit hyperactivity disorder (ADHD) and control subjects...
  18. ncbi Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation
    D Robertson
    Department of Pharmacology, Vanderbilt University, Nashville, Tenn 37232 2195
    Hypertension 18:1-8. 1991
    ..Most currently recognized patients are young or middle-aged adults. The diagnosis is established by the observation of severe orthostatic hypotension in a patient whose plasma norepinephrine/dopamine ratio is much less than one...
  19. ncbi Vestibular influences on autonomic cardiovascular control in humans
    I Biaggioni
    Department of Medicine, Vanderbilt University, Nashville TN 37232 2135, USA
    J Vestib Res 8:35-41. 1998
    ..Several factors may explain the apparent discordance of these results, but more research is needed before we can define the potential importance of vestibular input to cardiovascular regulation and orthostatic tolerance in humans...
  20. ncbi The physiological conundrum of hyperadrenergic orthostatic intolerance
    J Jordan
    Department of Medicine, Vanderhilt University Nashville, Tennessee 37232 2195, USA
    Chin J Physiol 40:1-8. 1997
    ..The emergence of partial dysautonomia as an important mechanism of orthostatic intolerance may lead to a substantial alteration in therapeutic approach...
  21. ncbi Orthostatic intolerance in Behcet's disease
    T Tellioglu
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Auton Neurosci 89:96-9. 2001
    ..The contribution of an immunological damage to components of neural pathways in the pathogenesis of the autonomic involvement can be assumed...
  22. ncbi The mitochondrial common deletion in Parkinson's disease and related movement disorders
    J Zhang
    Division of Neuropathology, Vanderbilt University Medical Center, C3321 Medical Center North, Nashville, TN 37232, USA
    Parkinsonism Relat Disord 8:165-70. 2002
    ....
  23. ncbi Adenosine produces pulmonary vasoconstriction in sheep. Evidence for thromboxane A2/prostaglandin endoperoxide-receptor activation
    I Biaggioni
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232
    Circ Res 65:1516-25. 1989
    ..To our knowledge, this is the first clear evidence for adenosine-induced vasoconstriction outside the kidney and for an interaction between adenosine and eicosanoid mechanisms...
  24. pmc The effect of donepezil treatment on cardiovascular mortality
    K Sato
    Department of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Pharmacol Ther 88:335-8. 2010
    ..46-0.99) and 0.54 (P = 0.042, 95% confidence interval 0.30-0.98), respectively. The apparent survival benefit in donepezil-treated patients should not be overinterpreted. Prospective clinical trials are warranted...
  25. ncbi Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension
    N R Keller
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, AA3228 MCN, Nashville, TN 37232 2195, USA
    Neuroscience 139:931-46. 2006
    ....
  26. ncbi Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?
    E M Garland
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Am J Med 111:546-52. 2001
    ..Unfortunately, the Chiari I malformation and orthostatic intolerance connection is almost entirely unsupported by peer-reviewed literature. The purpose of this article is to provide an objective review of the available information...
  27. ncbi Chronic hypotension. In the shadow of hypertension
    D Robertson
    Department of Medicine, Vanderbilt University, Nashville, TN 37232-2195
    Am J Hypertens 5:200S-205S. 1992
    ..The differentiation of these and other causes of symptomatic hypotension may in many cases lead to beneficial therapy...
  28. ncbi Noradrenergic lesioning with an anti-dopamine beta-hydroxylase immunotoxin
    M J Picklo
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232
    Brain Res 666:195-200. 1994
    ..75 and 15 micrograms, respectively. The anti-D beta H immunotoxin will be a useful tool in the study of the peripheral noradrenergic system in adult and neonatal animals...
  29. ncbi Fragile X gene premutation in multiple system atrophy
    E M Garland
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 2195, USA
    J Neurol Sci 227:115-8. 2004
    ..6% displayed CGG expansions in the suspected range. This is similar to the frequency reported in the normal population, suggesting that this expansion does not play a major role in the MSA phenotype...
  30. pmc Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons
    J Zhang
    Departments of Pathology, Medicine, and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Pathol 154:1423-9. 1999
    ..Moreover, oxidative damage to nucleic acid is largely restricted to cytoplasm with both RNA and mitochondrial DNA as targets...
  31. ncbi Electronic publishing of science: better late than never
    D Robertson
    Department of Medicine, Pharmacology, and Neurology, and the Clinical Research Center, Vanderbilt University, Nashville, Tennessee 37232-2195, USA
    Am J Med 110:370-2. 2001
    ..There is a growing disjunction between the efficiency of science and the inefficiency of scientific reporting. Electronic publication as proposed for PubMedCentral is a logical solution to this problem...
  32. ncbi Increased sympathetic activation in idiopathic orthostatic intolerance: role of systemic adrenoreceptor sensitivity
    Jens Jordan
    Clinical Research Center, Franz Volhard Clinic, Charite, Berlin, Germany
    Hypertension 39:173-8. 2002
    ..Our findings suggest that the hyperadrenergic features of OI cannot be completely explained by systemic hypersensitivity of postsynaptic alpha(1)- and beta-adrenoreceptors but rather originates in enhanced sympathetic activation...
  33. ncbi Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia
    Terry Ketch
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Circulation 105:2518-23. 2002
    ..Such excursions may derive from endogenous factors such as stress or drowsiness, which result in quite high and quite low pressures, respectively. They may also derive from exogenous factors such as drugs or environmental influences...
  34. ncbi Baroreflex buffering and susceptibility to vasoactive drugs
    Jens Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 105:1459-64. 2002
    ..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known...
  35. ncbi Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance
    Christoph Schroeder
    Clinical Research Center, Helios Klinkum Berlin, Germany
    Circulation 105:347-53. 2002
    ..Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance...
  36. doi Aliskiren combined with losartan in type 2 diabetes and nephropathy
    Hans Henrik Parving
    Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 358:2433-46. 2008
    ....
  37. ncbi Proteomic analysis reveals a novel set of cell wall proteins in a transformed tobacco cell culture that synthesises secondary walls as determined by biochemical and morphological parameters
    K A Blee
    Division of Biochemistry, School of Biological Sciences, Royal Holloway and Bedford New College, University of London, Egham, Surrey, UK
    Planta 212:404-15. 2001
    ..However an Mr-32,000 chitinase, an Mr-34,000 peroxidase, an Mr-65,000 polyphenoloxidase/laccase and possibly an Mr-68,000 xylanase could be identified as well as structural proteins...
  38. ncbi Inflammatory eye, skin, and bowel disease in spondyloarthritis: genetic, phenotypic, and environmental factors
    S Brophy
    Epidemiology Department, Royal National Hospital for Rheumatic Diseases, Bath, UK
    J Rheumatol 28:2667-73. 2001
    ..The susceptibility factors for these inflammatory conditions may be additive or have a synergistic effect on each other. There is evidence for a shared gene hypothesis...
  39. ncbi Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery
    F Leulier
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK
    Cell Death Differ 13:1663-74. 2006
    ..Consistently, we show that DIAP2 binds active drICE. Since DIAP2 associates with Hid, we propose a model whereby Hid co-ordinately targets both DIAP1 and DIAP2 to unleash drICE...
  40. ncbi Artificial gravity: a possible countermeasure for post-flight orthostatic intolerance
    Steven T Moore
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Acta Astronaut 56:867-76. 2005
    ..More data is necessary to evaluate this hypothesis, but if it were proven correct, in-flight short-radius centrifugation may help counteract orthostatic intolerance after space flight...
  41. pmc Second consensus statement on the diagnosis of multiple system atrophy
    S Gilman
    Department of Neurology, University of Michigan, 300 N Ingalls St, 3D15, Ann Arbor, MI 48109 5489, USA
    Neurology 71:670-6. 2008
    ..Since then, clinical, laboratory, neuropathologic, and imaging studies have advanced the field, requiring a fresh evaluation of diagnostic criteria. We held a second consensus conference in 2007 and present the results here...
  42. ncbi Mechanisms of postspaceflight orthostatic hypotension: low alpha1-adrenergic receptor responses before flight and central autonomic dysregulation postflight
    Janice V Meck
    Human Adaptation and Countermeasures Office, Space and Life Sciences Directorate, National Aeronautics and Space Administrattion Johnson Space Center, Houston, TX 77058, USA
    Am J Physiol Heart Circ Physiol 286:H1486-95. 2004
    ....
  43. ncbi Effects of long-term estrogen replacement therapy on growth hormone response to pyridostigmine in healthy postmenopausal women
    T van Amelsvoort
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychoneuroendocrinology 28:101-12. 2003
    ..We studied the effect of prolonged use of estrogen replacement therapy (ERT) on central cholinergic tone in healthy postmenopausal women...
  44. pmc The Ca(2+) status of the endoplasmic reticulum is altered by induction of calreticulin expression in transgenic plants
    S Persson
    Dpartment of Botany, North Carolina State University, Raleigh, North Carolina 27695-7612, USA
    Plant Physiol 126:1092-104. 2001
    ..Together these data are consistent with the hypothesis that increasing CRT in the ER increases the ER Ca(2+) stores and thereby enhances the survival of plants grown in low Ca(2+) medium...
  45. pmc Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 544:653-64. 2002
    ..We conclude that modulation of muscle sympathetic neural outflow by muscle metaboreceptors and skin nociceptors is preserved during short duration spaceflight...
  46. ncbi The nature of the autonomic dysfunction in multiple system atrophy
    Samir M Parikh
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, AA 3228 MCN, Nashville, TN 37232 2195, USA
    J Neurol Sci 200:1-10. 2002
    ..We will review recent evidence bearing on autonomic tone in MSA and discuss their therapeutic implications, particularly in terms of the possible development of a bionic baroreflex for better control of blood pressure...
  47. ncbi Silencing of a meristematic gene using geminivirus-derived vectors
    C Peele
    Department of Botany, North Carolina State University, Raleigh, NC 27695, USA
    Plant J 27:357-66. 2001
    ..Our results demonstrate that geminivirus-derived vectors can be used to study genes involved in meristem function in intact plants...
  48. ncbi Origin of the noradrenergic innervation of the superior olivary complex in the rat
    W H Mulders
    The Auditory Laboratory, Department of Physiology, The University of Western Australia, WA 6907, Nedlands, Australia
    J Chem Neuroanat 21:313-22. 2001
    ..The small numbers of double-labelled neurones found in the locus coeruleus indicate a very divergent non-selective noradrenergic input to the SOC...
  49. ncbi Ageing and water homeostasis
    David Robertson
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, Nashville TN 37232 2195, USA
    Novartis Found Symp 242:265-75; discussion 275-8. 2002
    ..Ingestion of water is a major determinant of blood pressure in the elderly population. Volume homeostasis is importantly affected by posture and large changes in plasma volume may occur within 30 minutes when upright posture is assumed...
  50. ncbi Genetic basis of clinical catecholamine disorders
    Emily M Garland
    Department of Pharmacology, Autonomic Dysfunction Center, Department of Medicine, Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Ann N Y Acad Sci 971:506-14. 2002
    ....