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| L RobertsSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
IsoprostanesL Jackson Roberts
Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
J Lipid Res 50:S219-23. 2009..These findings will be summarized as well...- The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidationL Jackson Roberts
Department of Pharmacology, 522 RRB, Vanderbilt University, Nashville, TN 37232 6602, USA
Brain Pathol 15:143-8. 2005..Oxygen concentration differentially modulates the formation of isoprostanes and isofurans. As oxygen concentrations increase, the formation of isofurans is favored whereas the formation of isoprostanes becomes disfavored... - The relationship between dose of vitamin E and suppression of oxidative stress in humansL Jackson Roberts
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Free Radic Biol Med 43:1388-93. 2007..This study provides information on the dosage of vitamin E that decreases systemic oxidant stress in vivo in humans and informs the planning and evaluation of clinical studies that assess the efficacy of vitamin E to mitigate disease... - Inhibition of heme protein redox cycling: reduction of ferryl heme by iron chelators and the role of a novel through-protein electron transfer pathwayL Jackson Roberts
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Free Radic Biol Med 44:257-60. 2008 - The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidationL Jackson Roberts
Departments of Pharmacology and Medicine, 522 RRB, Vanderbilt University, Nashville, TN 37232 6602, USA
Chem Phys Lipids 128:173-86. 2004..Oxygen concentrations differentially modulate the formation of isoprostanes and isofurans; at elevated oxygen concentrations, the formation of isofurans is favored whereas the formation of isoprostanes is disfavored... - Oxidant stress modulates murine allergic airway responsesMegha Talati
Department of Medicine, T 1217 MCN, Vanderbilt University, Nashville, TN 37232, USA
Free Radic Biol Med 40:1210-9. 2006..Oxidant stress plays a role in the production of airway responsiveness... - Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometrySean S Davies
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 27232 6602, USA
Nat Protoc 2:2079-91. 2007..IsoK/LG-lysyl-lactam adducts are measured by liquid chromatography tandem mass spectrometry after proteolytic digestion of extracted proteins, solid-phase extraction and preparative HPLC... - Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein EHong Yang
Department of Pathology, Meharry Medical College, Nashville, Tenn 37208, USA
Circ Res 95:1075-81. 2004..These observations implied that endogenously produced hydrogen peroxide, but not superoxide anions, contributed to the formation of oxidized lipids and the development of atherosclerosis in ApoE-/- mice... - Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failureOlivier Boutaud
Department of Pharmacology, Medicine, and Chemistry, Vanderbilt University, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 107:2699-704. 2010..These findings also provide a hypothesis for potential therapeutic applications for acetaminophen in diseases involving hemoprotein-mediated oxidative injury... - Degree of heteroplasmy reflects oxidant damage in a large family with the mitochondrial DNA A8344G mutationJeffrey A Canter
Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 519 Light Hall, Nashville, TN 37232 0700, USA
Free Radic Biol Med 38:678-83. 2005..The most important novel finding from this family is that some currently asymptomatic individuals with moderate heteroplasmy have evidence of ongoing free-radical mediated oxidant injury... - Localization of isoketal adducts in vivo using a single-chain antibodySean S Davies
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
Free Radic Biol Med 36:1163-74. 2004..We conclude that isoketal adducts form in epithelial cells as a result of high oxygen exposure and that this single-chain antibody provides a valuable tool to localize the formation of isoketal adducts in tissues in vivo... - The Shanghai Women's Asthma and Allergy Study: objectives, design, and recruitment resultsTina V Hartert
Division of Allergy, Pulmonary and Critical Care Medicine, School of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
Am J Epidemiol 167:1387-96. 2008..This paper describes the study objectives, design, population demographics, and recruitment results... - Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmiasPenelope A Boyden
Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Cardiovasc Pharmacol 50:480-6. 2007..Furthermore, we review what is known about the generation of such in the highly remodeled post myocardial infarction substrate. We suggest prevention of adduction of these highly reactive compounds would be antiarrhythmic... - Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonylsVenkataraman Amarnath
Departments of Pathology and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Chem Res Toxicol 17:410-5. 2004..Only 1,4-dicarbonyls are likely to participate in the proposed mechanism, thereby conferring unique sensitivity of this class of compounds to scavenging by PM... - Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathwaySean S Davies
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
Chem Phys Lipids 128:85-99. 2004.... - Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insultSean S Davies
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Free Radic Biol Med 47:1014-8. 2009.... - Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activationOlivier Boutaud
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
J Biol Chem 278:16926-8. 2003..They also demonstrate that a physiological stimulus is sufficient to lead to the lipid modification of proteins through the levuglandin pathway in human platelets... - Cimetidine does not prevent lung injury in newborn premature infantsRobert B Cotton
Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232, USA
Pediatr Res 59:795-800. 2006..We conclude that cimetidine does not reduce lung injury in newborn premature infants receiving O2 and mechanical ventilation. It is possible that cimetidine was not an adequate CYP inhibitor in this context... - Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidationL Jackson Roberts
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
Cell Mol Life Sci 59:808-20. 2002.... - F2-isoprostanes as an indicator and risk factor for coronary heart diseaseSean S Davies
Division of Clinical Pharmacology and Department of Pharmacology, Vanderbilt University, Nashville, TN 37221, USA
Free Radic Biol Med 50:559-66. 2011..This review focuses on the evidence that specific PUFA peroxidation products, the F(2)-isoprostanes, are useful biomarkers that could potentially be utilized as indicators of CHD... - Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicitySean S Davies
Departments of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
Biochemistry 45:15756-67. 2006.... - Inhaled nitric oxide attenuates hyperoxic lung injury in lambsRobert B Cotton
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Pediatr Res 59:142-6. 2006..However, this study provides no direct evidence that NO is inhibiting CYP-mediated oxidant lung injury... - Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's diseaseThomas J Montine
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Ann Neurol 52:175-9. 2002..These results should guide the organization of clinical trials now being planned for patients with Alzheimer's disease... - Quantification of dinor, dihydro metabolites of F2-isoprostanes in urine by liquid chromatography/tandem mass spectrometrySean S Davies
Department of Pharmacology, Vanderbilt University, Nashville, TN 27232, USA
Anal Biochem 348:185-91. 2006..77y = 67.2x-0.5). The levels of F2-IsoP-M detected in spot urines from 40 normal subjects were 38.1+/-19.1 ng/mg creatinine (mean+/-SD). This method provides an accurate and rapid assay to assess oxidative status in vivo... - The isoprostanes: their role as an index of oxidant stress status in human pulmonary diseaseJason D Morrow
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
Am J Respir Crit Care Med 166:S25-30. 2002.... - The Tennessee Children's Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseasesTina V Hartert
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Respirology 15:691-9. 2010..The primary goals are to investigate both the acute and the long-term health consequences of varying severity and aetiology of clinically significant viral respiratory tract infections on early childhood outcomes... - Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tensionJoshua P Fessel
Departments of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 99:16713-8. 2002.... - Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channelsKoji Fukuda
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA
Circ Res 97:1262-9. 2005..These data suggest Na+ channel dysfunction evoked by lipid peroxidation is a candidate mechanism for ischemia-related conduction abnormalities and arrhythmias... - Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome functionSean S Davies
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 27232-6602, USA
FASEB J 16:715-7. 2002..These findings suggest that IsoKs/NeuroKs/LGs can inhibit proteasome activity and, if overproduced, may have relevance to the pathogenesis of neurodegenerative diseases... - Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body diseaseJoshua P Fessel
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Neurochem 85:645-50. 2003.... - Modification of proteins by isoketal-containing oxidized phospholipidsCynthia J Brame
Departments of Pharmacology and Medicine, Vanderbilt University, Nashville, Tennessee 27232-6602, USA
J Biol Chem 279:13447-51. 2004.... - Identification of oxidized derivatives of neuroketalsNathalie Bernoud-Hubac
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6602, USA
Biochemistry 41:11466-71. 2002.... - Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesisIrene Zagol-Ikapitte
Departments of Pharmacology, Pathology, and Medicine, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
Chem Res Toxicol 23:240-50. 2010.... - Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginineIrene Zagol-Ikapitte
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6602, USA
Biochemistry 43:5503-10. 2004..The soluble characteristic of these molecules provides a potential strategy for development of biological markers of lipid modification of proteins following cyclooxygenase activity or lipid peroxidation... - Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanesDejan Milatovic
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Neurovirol 8:295-305. 2002.... - Lipid peroxidation in aging brain and Alzheimer's diseaseThomas J Montine
Department of Pharmacology, Pathology, and Medicine and the Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA
Free Radic Biol Med 33:620-6. 2002.... - Measurement of products of docosahexaenoic acid peroxidation, neuroprostanes, and neurofuransKyle O Arneson
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Methods Enzymol 433:127-43. 2007..This review outlines in detail proper sample handling, extraction and hydrolysis of the F(4)-NPs and NFs from tissue membrane phospholipids or biological fluids, and purification and derivatization of the compounds for analysis by GC/MS... - Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitroSean S Davies
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Ocul Pharmacol Ther 19:45-54. 2003..Our findings suggest that bimatoprost can act as prodrug for FP receptor activation and questions the concept of a "prostamide receptor" agonist... - Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cellsZefen Wang
Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA
Free Radic Biol Med 47:1221-9. 2009..These data demonstrate that overexpression of Cu/Zn-SOD and/or catalase is associated with upregulation of AhR and its target genes, such as xenobiotic-metabolizing enzymes... - Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient miceZhongmao Guo
Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA
Free Radic Biol Med 44:343-52. 2008..These results suggest that overexpression of GPx4 inhibits the development of atherosclerosis by decreasing lipid peroxidation and inhibiting the sensitivity of vascular cells to oxidized lipids... - Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acidSamuel S Fam
Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 277:36076-84. 2002..Thus, these studies have identified novel, highly reactive A/J-ring isoprostane-like compounds that are derived from docosahexaenoic acid in vivo... - Mass spectrometric quantification of F2-isoprostanes as indicators of oxidant stressJason D Morrow
Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
Methods Mol Biol 186:57-66. 2002 - Isoketals form cytotoxic phosphatidylethanolamine adducts in cellsC Blake Sullivan
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, Nashville, TN, USA
J Lipid Res 51:999-1009. 2010..2 muM). These results indicate that cellular PE is a significant target of IsoKs, and that formation of PE adducts may mediate some of the biological effects of IsoKs relevant to disease... - Hyperadrenergic postural tachycardia syndrome in mast cell activation disordersCyndya Shibao
Division of Clinical Pharmacology, Department of Medicine and Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
Hypertension 45:385-90. 2005..These patients often present with a typical hyperadrenergic response, but beta-blockers should be used with great caution, if at all, and treatment directed against mast cell mediators may be required... - Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic jugloneAaron J Przybysz
Department of Pharmacology, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
Mech Ageing Dev 130:357-69. 2009..Our studies provide a foundation for developing a molecular understanding of how age affects cytoprotective transcriptional pathways... - Insights into oxidative stress: the isoprostanesPaolo Montuschi
Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
Curr Med Chem 14:703-17. 2007..Measurement of F(2)-IsoPs may provide a uniquely valuable approach to understanding of the clinical pharmacology of antioxidants... - The in vivo gene expression signature of oxidative stressEun Soo Han
Department of Biological Science, University of Tulsa, Tulsa, Oklahoma, USA
Physiol Genomics 34:112-26. 2008..A retrospective comparison with previous studies shows that induction of these p53 target genes is a conserved expression response to oxidative stress, in vivo and in vitro, in different species and different cells/organs... - Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosisQitao Ran
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, TX, USA
J Gerontol A Biol Sci Med Sci 62:932-42. 2007..Our data indicate that lifelong reduction in Gpx4 increased life span and reduced/retarded age-related pathology most likely through alterations in sensitivity of tissues to apoptosis... - Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tensionManisha Patel
Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurochem 104:264-70. 2008..These results demonstrate seizure-induced increase in IsoF formation and its correlation with changes in hippocampal pO2 and mitochondrial dysfunction... - Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant ratsShumei Meng
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Am J Physiol Regul Integr Comp Physiol 283:R732-8. 2002..05). In conclusion, salt-sensitive hypertension in the S rat is accompanied by marked decreases in renal medullary SOD and greater renal oxidative stress and renal damage than in R rats... - Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia miceSusan E Browne
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
Free Radic Biol Med 36:938-42. 2004..We show that treatment with a catalytic antioxidant corrects the neurobehavioral deficit in these mice... - Isoprostanes and related products of lipid peroxidation in neurodegenerative diseasesKathleen S Montine
Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, 325 9th Ave, Seattle, WA 98104, USA
Chem Phys Lipids 128:117-24. 2004..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD... - A nomenclature system for isofuransDouglass F Taber
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA
Prostaglandins Other Lipid Mediat 73:47-50. 2004..As a result, there is a need for a systematic nomenclature for this class of natural products. A facile system that will allow the ready differentiation of each of the isomeric structures comprising the family of isofurans is presented... - Stability of measurements of biomarkers of oxidative stress in blood over 36 hoursTianying Wu
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 13:1399-402. 2004..45 for 0 to 24 hours and 0.09 for 0 to 36 hours. We conclude that measurements of fluorescent oxidation products in blood remain stable for up to 36 hours and may be used in large prospective epidemiologic studies of chronic diseases... - Enzyme immunoassays for 15-F2T isoprostane-M, an urinary biomarker for oxidant stressDiane M Sasaki
Oxford Biomedical Research, P.O. Box 522, Oxford, MI 48371, USA
Adv Exp Med Biol 507:537-41. 2002 - Covalent binding of isoketals to ethanolamine phospholipidsNathalie Bernoud-Hubac
INSERM U585, Physiopathologie des Lipides et Membranes, INSA Lyon, 69621 Villeurbanne, France
Free Radic Biol Med 37:1604-11. 2004..These studies identify in vitro novel isoketal adducts. This provides the basis to explore the formation of isoketal-aminophospholipid adducts in vivo and the biological consequences of the formation of these adducts... - Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosisQitao Ran
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7400 Merton Mintor Boulevard, San Antonio, TX 78229, USA
J Biol Chem 279:55137-46. 2004..These data demonstrate that Gpx4 plays a role in vivo in the mechanism of apoptosis induced by oxidative stress that most likely occurs through oxidative damage to mitochondrial phospholipids such as cardiolipin... - Isoprostanes: markers and mediators of oxidative stressPaolo Montuschi
Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
FASEB J 18:1791-800. 2004..Products of the isoprostane pathway have been found to exert potent biological actions and therefore may participate as physiological mediators of disease... - Oxidative stress and multi-organ failure in hospitalized elderly peopleJames S Powers
J Am Geriatr Soc 56:1150-2. 2008 - Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levelsWalter F Ward
Department of Physiology MSC 7756, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
J Gerontol A Biol Sci Med Sci 60:847-51. 2005.... - Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolasesDiana M Stafforini
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
J Biol Chem 281:4616-23. 2006..Our results suggested that PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo... - Dietary flavonoids fail to suppress F2-isoprostane formation in vivoJoye K Willcox
Department of Food Science, North Carolina State University, Raleigh, NC 27695-7624, USA
Free Radic Biol Med 34:795-9. 2003..We conclude that under these experimental conditions, quercetin, catechin, and epicatechin do not suppress lipid peroxidation in vivo... - Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammationJoseph P Gaut
Department of Surgery, Washington University, St Louis, MO 63110, USA
Free Radic Biol Med 40:1494-501. 2006..To examine the oxidation hypothesis of disease, optimal antioxidant regimens that block oxidative reactions in animals and humans need to be identified... - Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive ratsLourdes A Fortepiani
Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216-4505, USA
Hypertension 41:640-5. 2003..These data suggest that the PMR rats, but not ovx rats, may be a suitable model for the study of postmenopausal hypertension, and that oxidative stress plays a role in the increased BP... - Urinary F2-isoprostane metabolite levels in children with sleep-disordered breathingHawley E Montgomery-Downs
Department of Psychology, West Virginia University, Morgantown, WV 26506-6040, USA
Sleep Breath 10:211-5. 2006..The absence of increased levels of urinary F2-isoprostane metabolites in children with sleep-disordered breathing suggests that oxidative stress is not a significant feature of pediatric sleep-disordered breathing... - Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processesQitao Ran
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio TX 78229 3900, USA
Free Radic Biol Med 35:1101-9. 2003..Our data demonstrate that MEFs from Gpx4(+/-) mice are more sensitive to oxidative stress because of reduced expression of PHGPx... - Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidationMeri Vanharanta
Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
Atherosclerosis 160:465-9. 2002..Our present data suggest that low serum enterolactone concentration is associated with enhanced in vivo lipid peroxidation in men... - The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4Ina Hubatsch
Department of Biochemistry, Uppsala University, SE-75123 Uppsala, Sweden
Chem Res Toxicol 15:1114-8. 2002..These studies have therefore defined a potentially important route by which cyclopentenone IsoPs are metabolized that may serve as a mechanism for the inactivation of these highly reactive compounds... - Evidence of oxidative stress in full-term healthy infantsJames K Friel
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Pediatr Res 56:878-82. 2004..5 mo. These data suggest that the human infant is under oxidative stress early in infancy and further study may be warranted to assess the potential benefits of antioxidant supplementation for either the mother or the infant... - Superoxide formation and interaction with nitric oxide modulate systemic arterial pressure and renal function in salt-depleted dogsUtpal K Dutta
Department of Physiology, SL 39, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
Exp Biol Med (Maywood) 231:269-76. 2006..These data show that low salt intake enhances O(2)(-) activity that influences renal and systemic hemodynamics and thus may contribute to the regulation of arterial pressure in the salt-restricted state... - Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging StudyMadlyn I Frisard
Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
J Gerontol A Biol Sci Med Sci 62:752-9. 2007..The current study was designed to test whether nonagenarians have a relatively low metabolic rate and whether it is associated with low levels of oxidative stress relative to age... - Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularisPriscilla Ivester
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Alcohol Clin Exp Res 31:144-55. 2007....
Research Grants
- Oxidative Stress Na Channel Gating and ArrhythmiasL Roberts; Fiscal Year: 2007..These studies should improve our understanding of the mechanisms linking oxidant injury and arrhythmias and have the potential to identify novel antiarrhythmic therapeutic strategies. ..
- Reactive gamma-Ketoaldehydes in DementiaL Roberts; Fiscal Year: 2007..We will also explore a novel pharmacologic intervention, the ability of pyridoxamine to selectively prevent IsoK/NK adduction and mitigate the memory deficit in the mouse model. ..
- STRUCTURAL IDENTIFICATION OF PROSTAGLANDIN CONJUGATESL Roberts; Fiscal Year: 2007..Finally, we will test the hypothesis that free radicals and IsoPs play an important role in the renal failure that ensues in glactosamine treated rats, an animal model of the hepatorenal syndrome. ..