Marylyn Ritchie

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Visualizing SNP statistics in the context of linkage disequilibrium using LD-Plus
    William S Bush
    Department of Molecular Physiology, Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
    Bioinformatics 26:578-9. 2010
  2. pmc A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e9363. 2010
  3. pmc Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies
    Alison A Motsinger
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232 0700, USA
    Hum Genomics 2:318-28. 2006
  4. pmc Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies
    Thorsten Lehr
    Boehringer Ingelheim Pharma GmbH and Co, KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany
    BioData Min 4:4. 2011
  5. pmc Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error
    Alison A Motsinger-Reif
    Bioinformatics Research Center, Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
    BMC Res Notes 1:65. 2008
  6. pmc Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction
    William S Bush
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    BMC Bioinformatics 9:238. 2008
  7. pmc An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    BMC Bioinformatics 5:49. 2004
  8. pmc LD-Spline: Mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium
    William S Bush
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    BioData Min 2:7. 2009
  9. pmc The effects of linkage disequilibrium in large scale SNP datasets for MDR
    Benjamin J Grady
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    BioData Min 4:11. 2011
  10. pmc Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis
    Marylyn D Ritchie
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, 519 Light Hall, Nashville, TN 37232 0700, USA
    Genome Med 1:65. 2009

Detail Information

Publications66

  1. pmc Visualizing SNP statistics in the context of linkage disequilibrium using LD-Plus
    William S Bush
    Department of Molecular Physiology, Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
    Bioinformatics 26:578-9. 2010
    ....
  2. pmc A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e9363. 2010
    ....
  3. pmc Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies
    Alison A Motsinger
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232 0700, USA
    Hum Genomics 2:318-28. 2006
    ..MDR can be a powerful tool in reaching these goals when used appropriately...
  4. pmc Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies
    Thorsten Lehr
    Boehringer Ingelheim Pharma GmbH and Co, KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany
    BioData Min 4:4. 2011
    ..abstract:..
  5. pmc Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error
    Alison A Motsinger-Reif
    Bioinformatics Research Center, Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
    BMC Res Notes 1:65. 2008
    ..Additionally, we compare the performance of GENN to that of another computational method - Multifactor Dimensionality Reduction (MDR)...
  6. pmc Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction
    William S Bush
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    BMC Bioinformatics 9:238. 2008
    ..We sought to improve the ability of MDR to detect gene-gene interactions by replacing classification error with a different measure to score model quality...
  7. pmc An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    BMC Bioinformatics 5:49. 2004
    ..One advantage of the MDR method is that it provides an internal prediction error for validation. We summarize our use of this internal prediction error for model validation...
  8. pmc LD-Spline: Mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium
    William S Bush
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    BioData Min 2:7. 2009
    ..CONCLUSION: LD-Spline is an integrated database routine that quickly and effectively defines the genomic region marked by a SNP using linkage disequilibrium, with a SNP-centric block definition algorithm...
  9. pmc The effects of linkage disequilibrium in large scale SNP datasets for MDR
    Benjamin J Grady
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    BioData Min 4:11. 2011
    ..abstract:..
  10. pmc Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis
    Marylyn D Ritchie
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, 519 Light Hall, Nashville, TN 37232 0700, USA
    Genome Med 1:65. 2009
    ..This and other pathway-based approaches are likely to continue to emerge in the GWAS literature, as they provide a powerful strategy to detect important modest single-locus effects and gene-gene interaction effects...
  11. pmc Exploring epistasis in candidate genes for rheumatoid arthritis
    Marylyn D Ritchie
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical Center, 21st Avenue South and Garland Avenue, Nashville, Tennessee 37232, USA
    BMC Proc 1:S70. 2007
    ..This comparison should be extended in future studies with both simulated and real data...
  12. pmc ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci
    Stephen D Turner
    Center for Human Genetics Research, Departments of Molecular Physiology and Biophysics and Biomedical Informatics, Vanderbilt University, Nashville, TN, USA
    BioData Min 3:5. 2010
    ..Non-additive gene-gene interactions, which are not often explored, are thought to be one source of this "missing" heritability...
  13. pmc Using biological knowledge to uncover the mystery in the search for epistasis in genome-wide association studies
    Marylyn D Ritchie
    Department of Molecular Physiology, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232 0700, USA
    Ann Hum Genet 75:172-82. 2011
    ..I discuss a number of these approaches and propose that a comprehensive approach will likely be most fruitful for searching for epistasis in large-scale genomic studies of the current state-of-the-art and into the future...
  14. ncbi request reprint Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies
    Marylyn D Ritchie
    Vanderbilt University Medical Center, Department of Molecular Physiology and Biophysics, 519 Light Hall, Center for Human Genetics Research, Nashville, TN 37232 0700, USA
    Pharmacogenomics 6:823-34. 2005
    ..This computational technology is described in detail in this review, and its application in pharmacogenomic studies is demonstrated...
  15. ncbi request reprint Trends in genomic variation: a view of some of the latest technologies
    Marylyn D Ritchie
    Vanderbilt University, Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Nashville, TN 37232, USA
    Drug Discov Today 10:1417-8. 2005
  16. pmc Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis
    Sarah A Pendergrass
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN, USA
    BioData Min 3:10. 2010
    ....
  17. ncbi request reprint Bioinformatics approaches for detecting gene-gene and gene-environment interactions in studies of human disease
    Marylyn D Ritchie
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232 0700, USA
    Neurosurg Focus 19:E2. 2005
    ..Finally, the author describes the future directions for this technique and related methodologies...
  18. ncbi request reprint Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
    Lance W Hahn
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Bioinformatics 19:376-82. 2003
    ..In this paper, we describe the MDR approach and an MDR software package...
  19. pmc Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record
    Marylyn D Ritchie
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Am J Hum Genet 86:560-72. 2010
    ....
  20. pmc Machine learning for detecting gene-gene interactions: a review
    Brett A McKinney
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical School, Nashville, Tennessee, USA
    Appl Bioinformatics 5:77-88. 2006
    ..We conclude with some ideas about how these methods and others can be integrated into a comprehensive and flexible framework for data mining and knowledge discovery in human genetics...
  21. pmc Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias
    William S Bush
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    Pharmacogenomics 10:1043-53. 2009
    ..Here, we report an evaluation of the variation and haplotype structure in six key components of the rhythmonome...
  22. ncbi request reprint Multilocus analysis of hypertension: a hierarchical approach
    Scott M Williams
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Hered 57:28-38. 2004
    ..5% of the time. Thus, our data indicate epistatic interactions play a major role in hypertension susceptibility. Our data also support a model where multiple pathways need to be affected in order to predispose to hypertension...
  23. pmc Genetic determinants of response to warfarin during initial anticoagulation
    Ute I Schwarz
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
    N Engl J Med 358:999-1008. 2008
    ....
  24. pmc Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Schizophr Res 106:208-17. 2008
    ..We also observed a significant main effect in DTNBP1, which survived correction for multiple comparisons, and numerous nominally significant effects in several genes...
  25. ncbi request reprint Human genomic association studies: a primer for the infectious diseases specialist
    Alison A Motsinger
    School of Medicine, Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    J Infect Dis 195:1737-44. 2007
    ..Our goal is to provide the infectious diseases specialist with information that will aid in the critical evaluation of publications that include human genomic analyses...
  26. pmc Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Hum Hered 67:183-92. 2009
    ..Previously unknown aspects of MDR performance were the power to detect interactive effects given large numbers of non-model loci or varying degrees of heterogeneity among multiple epistatic disease models...
  27. pmc An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3
    Todd L Edwards
    Department of Molecular Physiology and Biophysics and Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee 37232, USA
    Am J Med Genet B Neuropsychiatr Genet 150:721-35. 2009
    ....
  28. ncbi request reprint A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction
    Digna R Velez
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee
    Genet Epidemiol 31:306-15. 2007
    ..These results suggest that balanced accuracy should be used instead of accuracy for the MDR analysis of epistasis in imbalanced datasets...
  29. doi request reprint Genome simulation approaches for synthesizing in silico datasets for human genomics
    Marylyn D Ritchie
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA
    Adv Genet 72:1-24. 2010
    ..Many of the hallmark features of biological datasets can be synthesized in silico; still much research is needed to enhance our capabilities to create datasets that capture the natural complexity of biological datasets...
  30. pmc Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases
    Marylyn D Ritchie
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN, 37232 0700, USA
    BMC Bioinformatics 4:28. 2003
    ....
  31. pmc Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome
    Dawood Darbar
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37323 6602, USA
    J Am Coll Cardiol 51:836-42. 2008
    ..The goal of this study was to identify markers of torsades de pointes (TdP) in patients with drug-associated long QT syndrome (LQTS)...
  32. pmc GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease
    Alison A Motsinger
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    BMC Bioinformatics 7:39. 2006
    ..The goal of this study was to evaluate the power of GPNN for identifying high-order gene-gene interactions. We were also interested in applying GPNN to a real data analysis in Parkinson's disease...
  33. ncbi request reprint Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    AIDS 19:1341-9. 2005
    ..The objective of this study was to determine if NRTI-associated peripheral neuropathy is associated with European mitochondrial haplogroups...
  34. ncbi request reprint The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction
    Alison A Motsinger
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0700, USA
    Genet Epidemiol 30:546-55. 2006
    ..The validity of this reduction was confirmed with data from an Alzheimer's disease (AD) study...
  35. ncbi request reprint Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity
    Marylyn D Ritchie
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Genet Epidemiol 24:150-7. 2003
    ..Extending MDR to address genetic heterogeneity should be a priority for the continued methodological development of this new approach...
  36. ncbi request reprint Parallel multifactor dimensionality reduction: a tool for the large-scale analysis of gene-gene interactions
    William S Bush
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA
    Bioinformatics 22:2173-4. 2006
    ..AVAILABILITY: Parallel MDR is freely available for non-commercial research institutions. For full details see http://chgr.mc.vanderbilt.edu/ritchielab/pMDR. An open-source version of MDR software is available at http://www.epistasis.org...
  37. pmc Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation
    Dawood Darbar
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37323 6602, USA
    Heart Rhythm 4:743-9. 2007
    ....
  38. ncbi request reprint Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity
    Marylyn D Ritchie
    Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Infect Dis 43:779-82. 2006
    ..Decreased risk of hepatotoxicity was associated with MDR1 3435C-->T (odds ratio, 0.254; P=.021). An interaction between MDR1 and hepatitis B surface antigen status predicted risk with 82% accuracy (P<.001)...
  39. pmc PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA
    Bioinformatics 26:1205-10. 2010
    ..The primary outcome of this study was replication of seven previously known SNP-disease associations for these SNPs...
  40. ncbi request reprint Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study
    David W Haas
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN, 37203, USA
    J Infect Dis 194:1098-107. 2006
    ..Immune recovery during antiretroviral therapy is a complex phenotype that is influenced by multiple genetic variants. Future studies should validate these tentative associations and define underlying mechanisms...
  41. ncbi request reprint Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes
    Alison A Motsinger
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Neurogenetics 8:11-20. 2007
    ..These results suggest that significant epistasis, or gene-gene interactions, may exist even in the absence of statistically significant individual main effects...
  42. ncbi request reprint Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study
    Alison A Motsinger
    Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Pharmacogenet Genomics 16:837-45. 2006
    ..We examined whether long-term responses to efavirenz, and/or plasma efavirenz exposure, are better predicted by multilocus genetic interactions than by individual polymorphisms...
  43. pmc African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy
    Jeffrey A Canter
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 345 24th Ave North, Nashville, TN 37203, USA
    J Infect Dis 201:1703-7. 2010
    ..7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity...
  44. pmc Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    Mitochondrion 7:204-10. 2007
    ..In conclusion, the CPSI T1405N genotype appears to be an important new factor in predicting susceptibility to increased PAP following surgical repair of congenital cardiac defects in children...
  45. pmc Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing
    Dana C Crawford
    Vanderbilt University, Center for Human Genetics Research, 519 Light Hall, Nashville, TN 37232, USA
    Pharmacogenomics 8:487-96. 2007
    ..These future avenues will be best explored using diverse approaches encompassing clinical, statistical and genomic methods currently being developed for genotype-phenotype studies in human populations...
  46. ncbi request reprint Clinical applications of whole-genome association studies: future applications at the bedside
    Alison A Motsinger
    Vanderbilt University, Center for Human Genetics Research Department of Molecular Physiology and Biophysics, 519 Light Hall, Nashville, TN 37232, USA
    Expert Rev Mol Diagn 6:551-65. 2006
    ....
  47. ncbi request reprint Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy
    Asha R Kallianpur
    Department of Medicine, Divisions of General Internal Medicine and Public Health, Nashville, TN, USA
    AIDS 20:1503-13. 2006
    ..Since iron deficiency is associated with some types of PN, and iron is essential for mitochondrial function, we tested the hypothesis that hemochromatosis (HFE) gene mutations influence susceptibility to NRTI-induced PN...
  48. pmc Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy
    Chun Li
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Blood 113:3925-30. 2009
    ..08) and VKORC1 (P = .30) were not associated with stable warfarin dose. Thus, much of the information provided by CYP2C9 and VKORC1 genotypes during warfarin initiation is captured by the early INR response...
  49. ncbi request reprint STUDENTJAMA. The challenges of whole-genome approaches to common diseases
    Jason H Moore
    Vanderbilt University Medical School, Nashville, Tenn, USA
    JAMA 291:1642-3. 2004
  50. ncbi request reprint Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity
    John C Donaldson
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:29028-35. 2002
    ....
  51. ncbi request reprint Estrogens, enzyme variants, and breast cancer: a risk model
    Philip S Crooke
    Department of Pathology, TVC 4918, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 15:1620-9. 2006
    ..The model offers the opportunity to combine metabolic, genetic, and lifetime exposure data in assessing estrogens as a breast cancer risk factor...
  52. ncbi request reprint Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration
    Nah Young Shin
    Department of Cell and Developmental Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 279:38331-7. 2004
    ..Effective wound healing was achieved by CAS variants containing as few as four of the major sites, indicating sufficiency of partial SD signaling function in this cell migration response...
  53. pmc A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
    Gregory M Cooper
    Department of Genome Sciences, University of Washington, Seattle, WA98195, USA
    Blood 112:1022-7. 2008
    ..Randomized clinical trials that account for these 2 genes should therefore produce results that are definitive and broadly applicable...
  54. ncbi request reprint Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease
    Miguel L Soares
    Department of Molecular and Experimental Medicine, Division of Rheumatology Research and the WM Keck Autoimmune Disease Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Hum Mol Genet 14:543-53. 2005
    ..Thus, although the TTR V30M mutation is required for the disease in Portuguese patients, different genetic factors may govern the age of onset, as well as the occurrence of anticipation...
  55. ncbi request reprint Pacific Symposium on Biocomputing--computational approaches for pharmacogenomics
    Russell A Wilke
    Marshfield Clinic, Center for Human Genetics, and Department of Internal Medicine, 1000 N Oak Ave, Marshfield, WI 54449, and Department of Genetics, Stanford University, CA 94305 5120, USA
    Pharmacogenomics 6:111-3. 2005
  56. ncbi request reprint Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans
    Harumi Takahashi
    Department of Pharmacotherapy, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Pharmacogenet Genomics 16:101-10. 2006
    ....
  57. ncbi request reprint Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension
    Hironobu Sanada
    Third Department of Internal Medicine, Fukushima Medical University, School of Medicine, Fukushima City, Japan
    Clin Chem 52:352-60. 2006
    ..Salt-sensitive (SS) hypertension affects >30 million Americans and is often associated with low plasma renin activity. We tested the diagnostic validity of several candidate genes for SS and low-renin hypertension...
  58. ncbi request reprint Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital, Taipei, Taiwan
    Atherosclerosis 195:172-80. 2007
    ..These results are compatible with the concept of multilocus and multi-gene effects in complex diseases that would be missed with conventional approaches...
  59. ncbi request reprint ABCB1 and GST polymorphisms associated with TP53 status in breast cancer
    Silje H Nordgard
    Department of Genetics, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Pharmacogenet Genomics 17:127-36. 2007
    ..The goal of this study was to characterize the genetic variation in the ABCB1, GSTM1, GSTT1 and GSTP1 genes, as well as the haplotype structure in the ABCB1 gene...
  60. ncbi request reprint Problems with genome-wide association studies
    Scott M Williams
    Science 316:1840-2. 2007
  61. ncbi request reprint Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk
    Allison E Ashley-Koch
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Snyderman Genomic Sciences Building, Durham, NC 27710, USA
    Psychiatr Genet 17:221-6. 2007
    ..RELN shares a common biological pathway with APOE, and Persico et al. have observed transmission distortion of the APOE-2 allele in autism families...
  62. ncbi request reprint Novel methods for detecting epistasis in pharmacogenomics studies
    Alison A Motsinger
    North Carolina State University, Bioinformatics Research Center, Department of Statistics, Raleigh, NC 27695, USA
    Pharmacogenomics 8:1229-41. 2007
    ..The overall goal of this paper is to aid researchers in developing an analysis plan that accounts for gene-gene and gene-environment in their own work...
  63. ncbi request reprint Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky
    Christopher W Bartlett
    Center for Quantitative and Computational Biology and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA
    Genet Epidemiol 31:S61-7. 2007
    ..The difficulty of using (primarily) affected sib pair data in a gene x gene interaction analysis is explored...
  64. doi request reprint Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology
    Alison A Motsinger-Reif
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
    Genet Epidemiol 32:325-40. 2008
    ..Finally, we demonstrate the scalability of the GENN method with increasing numbers of variables--as many as 500,000 single nucleotide polymorphisms...
  65. ncbi request reprint Renin-angiotensin system gene polymorphisms and atrial fibrillation
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Circulation 109:1640-6. 2004
    ..We hypothesized that RAS genes might be among the susceptibility genes of nonfamilial structural AF and conducted a genetic case-control study to demonstrate this...
  66. ncbi request reprint Genetic heterogeneity is not as threatening as you might think
    Marylyn D Ritchie
    Genet Epidemiol 31:797-800. 2007

Research Grants2

  1. Analysis Tool for Heritable and Envirnonmental Network Associations
    Marylyn Ritchie; Fiscal Year: 2009
    ..As the field gains experience in analyzing large scale genomic data, it is crucial that we learn from each other and develop and codify the best strategies. ..
  2. Analysis Tool for Heritable and Envirnonmental Network Associations
    Marylyn D Ritchie; Fiscal Year: 2010
    ..As the field gains experience in analyzing large scale genomic data, it is crucial that we learn from each other and develop and codify the best strategies. ..