Todd W Rice

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States
    Todd W Rice
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 40:1487-98. 2012
  2. ncbi request reprint The historical, ethical, and legal background of human-subjects research
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Respir Care 53:1325-9. 2008
  3. pmc Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 39:967-74. 2011
  4. ncbi request reprint A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
    Todd W Rice
    Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:1685-94. 2010
  5. pmc Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 306:1574-81. 2011
  6. ncbi request reprint How to do human-subjects research if you do not have an institutional review board
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Respir Care 53:1362-7. 2008
  7. ncbi request reprint Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS
    Todd W Rice
    MSc, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Chest 132:410-7. 2007
  8. ncbi request reprint Pleural effusions in superior vena cava syndrome: prevalence, characteristics, and proposed pathophysiology
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Curr Opin Pulm Med 13:324-7. 2007
  9. pmc Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfa
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Vasc Health Risk Manag 2:3-18. 2006
  10. ncbi request reprint Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial design
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Chest Med 27:733-54; abstract xi. 2006

Detail Information

Publications37

  1. pmc Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States
    Todd W Rice
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 40:1487-98. 2012
    ..The objective of this study was to determine whether bacterial coinfection increased the morbidity and mortality of 2009 influenza A...
  2. ncbi request reprint The historical, ethical, and legal background of human-subjects research
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Respir Care 53:1325-9. 2008
    ..Since their inception, the principles of conducting human research, IRBs, and the Code for Federal Regulations have all advanced substantially. This paper describes the history and current status of human-subjects-research regulations...
  3. pmc Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 39:967-74. 2011
    ..e., trophic) enteral nutrition would decrease episodes of gastrointestinal intolerance/complications and improve outcomes as compared to initial full-energy enteral nutrition in patients with acute respiratory failure...
  4. ncbi request reprint A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
    Todd W Rice
    Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:1685-94. 2010
    ..To evaluate whether TAK-242, a small-molecule inhibitor of Toll-like receptor-4-mediated signaling, suppresses cytokine levels and improves 28-day all-cause mortality rates in patients with severe sepsis...
  5. pmc Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 306:1574-81. 2011
    ....
  6. ncbi request reprint How to do human-subjects research if you do not have an institutional review board
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Respir Care 53:1362-7. 2008
    ..Clinicians at these facilities have viable options for obtaining IRB approval and legally conducting such research. This paper outlines the available options and their pros and cons...
  7. ncbi request reprint Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS
    Todd W Rice
    MSc, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Chest 132:410-7. 2007
    ..We hypothesized that the pulse oximetric saturation (Spo(2))/Fio(2) (S/F) ratio can be substituted for the P/F ratio in assessing the oxygenation criterion of ALI...
  8. ncbi request reprint Pleural effusions in superior vena cava syndrome: prevalence, characteristics, and proposed pathophysiology
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Curr Opin Pulm Med 13:324-7. 2007
    ..This review highlights recent data detailing the prevalence and characteristics of pleural effusions occurring in patients with superior vena cava syndrome...
  9. pmc Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfa
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Vasc Health Risk Manag 2:3-18. 2006
    ..Observational data from the uncontrolled administration of heparin or statins in septic patients will also be reviewed...
  10. ncbi request reprint Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial design
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Chest Med 27:733-54; abstract xi. 2006
    ..Delineating outcomes attributable to the lung injury will improve the power of studies to detect significant treatment effects. Future collaborative studies will be needed to investigate longer-term clinical outcomes...
  11. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
    ..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status...
  12. ncbi request reprint Drotrecogin alfa (activated) for the treatment of severe sepsis and septic shock
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232, USA
    Am J Med Sci 328:205-14. 2004
    ..Despite concern over its relatively high cost, analysis has demonstrated that recombinant human activated protein C is as cost-effective as other commonly used treatments in the intensive care unit...
  13. ncbi request reprint Chylothorax as a result of chronic lymphocytic leukemia: case report and review of the literature
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    South Med J 97:291-4. 2004
    ..We describe a patient who developed chylothorax secondary to chronic lymphocytic leukemia. In addition, the pathogenesis, diagnosis, and treatment of chylothorax are reviewed...
  14. ncbi request reprint Therapeutic intervention and targets for sepsis
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232 2650, USA
    Annu Rev Med 56:225-48. 2005
    ..Following a review of recent advances in sepsis treatment, we briefly discuss a few of the new, promising therapeutic strategies currently being investigated...
  15. ncbi request reprint Variation in enteral nutrition delivery in mechanically ventilated patients
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nutrition 21:786-92. 2005
    ..We determined the variability in enteral feeding practices in mechanically ventilated patients in four adult intensive care units of a tertiary-care, referral hospital...
  16. ncbi request reprint The superior vena cava syndrome: clinical characteristics and evolving etiology
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Medicine (Baltimore) 85:37-42. 2006
    ..Dyspnea at rest, cough, and chest pain were more frequent in the patients with malignancy. Procedures performed for diagnostic or treatment purposes did not increase morbidity or mortality...
  17. ncbi request reprint Prevalence and characteristics of pleural effusions in superior vena cava syndrome
    Todd W Rice
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, and Saint Thomas Hospital, Nashville, Tennessee 37232 2650, USA
    Respirology 11:299-305. 2006
    ..The prevalence and characteristics of pleural effusions occurring in adults with the superior vena cava (SVC) syndrome are unknown. The purpose of the present study was to characterize these pleural effusions...
  18. ncbi request reprint New additions to the intensive care armamentarium
    Todd W Rice
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232 2650, USA
    Drugs Today (Barc) 40:157-70. 2004
    ..Unfortunately, randomized, blinded, placebo-controlled trials showing improvement in long-term outcomes such as mortality and length of stay are still lacking...
  19. pmc Markers of inflammation and coagulation may be modulated by enteral feeding strategy
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    JPEN J Parenter Enteral Nutr 36:732-40. 2012
    ..Although enteral nutrition (EN) is provided to most mechanically ventilated patients, the effect of specific feeding strategies on circulating markers of coagulation and inflammation is unknown...
  20. pmc Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure
    Allan J Walkey
    Department of Medicine, The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA
    Crit Care Med 38:2329-34. 2010
    ..We examined the association between plasma adiponectin and clinical outcomes in critically ill patients with acute respiratory failure...
  21. pmc Structure, process, and annual ICU mortality across 69 centers: United States critical illness and injury trials group critical illness outcomes study*
    William Checkley
    1Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD 2Division of Pulmonary, Allergy, and Critical Care, Emory University, Atlanta, GA 3Division of Pulmonary and Critical Care, Intermountain Medical Center and University of Utah, Salt Lake City, UT 4Division of Pulmonary and Critical Care, University of Medicine and Dentistry of New Jersey, Newark, NJ 5Division of Pulmonary, Critical Care, and Environmental Medicine, University of Missouri Columbia, Columbia, MO 6Division of Pulmonary and Critical Care, Meharry Medical College, Nashville, TN 7Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 8Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 9Department of Surgical Critical Care, University of Maryland, Baltimore, MD 10Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, Cleveland, OH 11Division of Acute Care Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 12Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, USA
    Crit Care Med 42:344-56. 2014
    ..Hospital-level variations in structure and process may affect clinical outcomes in ICUs. We sought to characterize the organizational structure, processes of care, use of protocols, and standardized outcomes in a large sample of U.S. ICUs...
  22. pmc Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest
    David R Janz
    Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 40:3135-9. 2012
    ..To determine whether higher levels of PaO2 are associated with in-hospital mortality and poor neurological status at hospital discharge in patients treated with mild therapeutic hypothermia after sudden cardiac arrest...
  23. pmc Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score
    Pratik P Pandharipande
    Department of Anesthesiology, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:1317-21. 2009
    ....
  24. ncbi request reprint Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 34:2271-81. 2006
    ....
  25. pmc A history of smoking is associated with improved survival in patients treated with mild therapeutic hypothermia following cardiac arrest
    Jeremy S Pollock
    Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, United States Electronic address
    Resuscitation 85:99-103. 2014
    ..To assess the association between smoking and survival with a good neurologic outcome in patients following cardiac arrest treated with mild therapeutic hypothermia (TH)...
  26. doi request reprint Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit*
    Michael H Hooper
    Department of Medicine, Division of Pulmonary, and Critical Care Medicine, Eastern Viriginia Medical School, Norfolk, VA, USA
    Crit Care Med 40:2096-101. 2012
    ....
  27. pmc Navigating the institutional review board approval process in a multicenter observational critical care study
    Carmen C Polito
    1Divison of Pulmonary and Critical Care Medicine, Emory University, Atlanta, GA 2Division of Trauma, Critical Care and Emergency Surgery, University of Arizona, Tuscon, AZ 3Departments of Medicine and Surgery, University of Maryland, Baltimore, MD 4Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN
    Crit Care Med 42:1105-9. 2014
    ..To characterize variation in the institutional review board application process of a multicenter, observational critical care study...
  28. doi request reprint Coagulopathy in critically ill patients: part 1: platelet disorders
    Todd W Rice
    Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN, USA
    Chest 136:1622-30. 2009
    ..Guidelines for treating thrombocytopenia and platelet dysfunction are also provided...
  29. doi request reprint Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testing
    Arthur P Wheeler
    Medical Intensive Care Unit, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1210 MCN Vanderbilt Medical Center, Nashville, TN 37232 2650, USA
    Chest 137:185-94. 2010
    ..Limitations and pitfalls of diagnostic testing are highlighted...
  30. pmc Flash mob research: a single-day, multicenter, resident-directed study of respiratory rate
    Matthew W Semler
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Chest 143:1740-4. 2013
    ..We used a novel flash mob research approach to evaluate the accuracy of recorded respiratory rates in inpatients...
  31. pmc Obstructive sleep apnea is common in idiopathic pulmonary fibrosis
    Lisa H Lancaster
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 5735, USA
    Chest 136:772-8. 2009
    ..Our goal was to analyze OSA in an outpatient population of stable patients with idiopathic pulmonary fibrosis (IPF)...
  32. pmc How soon should we start interventional feeding in the ICU?
    Richard D Fremont
    aDivision of Pulmonary and Critical Care Medicine, Meharry Medical College bDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Curr Opin Gastroenterol 30:178-81. 2014
    ..Most clinicians have viewed nutrition as part of patient care but not as a therapeutic intervention. Recent studies have looked at type and timing of nutrition to determine whether they affect important clinical outcomes...
  33. doi request reprint Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients*
    Todd W Rice
    Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 40:778-86. 2012
    ..The effect of treatment guidelines on clinical outcomes in general and specifically for trauma patients has not been well-studied. We hypothesized that better compliance with guidelines would be associated with improved clinical outcomes...
  34. pmc Unrecognized glucose intolerance is common in pulmonary arterial hypertension
    Meredith E Pugh
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    J Heart Lung Transplant 30:904-11. 2011
    ..We aimed to define the prevalence of elevated HbA(1c) in PAH patients and to correlate HbA(1c) levels with functional assessment...
  35. ncbi request reprint Splenosis: a review
    Richard D Fremont
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    South Med J 100:589-93. 2007
    ..Splenosis usually occurs within the abdominal and pelvic cavities, but patients have been described with intrathoracic, subcutaneous, intrahepatic and intracranial lesions...
  36. ncbi request reprint Atrial plasmacytoma and hypercalcemia
    Lori A Brame
    Indiana University School of Medicine, Division of Endocrinology, Emerson Hall 421, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Endocr Pract 9:225-8. 2003
    ..To describe a patient with hypercalcemia due to multiple myeloma and an associated atrial plasmacytoma...
  37. ncbi request reprint Obesity in acute lung injury: The "weight" is over
    Todd W Rice
    Chest 131:333-4. 2007

Research Grants2