Research Topics
| Todd W RiceSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United StatesTodd W Rice
Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 40:1487-98. 2012..The objective of this study was to determine whether bacterial coinfection increased the morbidity and mortality of 2009 influenza A...
How to do human-subjects research if you do not have an institutional review boardTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Respir Care 53:1362-7. 2008..Clinicians at these facilities have viable options for obtaining IRB approval and legally conducting such research. This paper outlines the available options and their pros and cons...
Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failureTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 39:967-74. 2011..e., trophic) enteral nutrition would decrease episodes of gastrointestinal intolerance/complications and improve outcomes as compared to initial full-energy enteral nutrition in patients with acute respiratory failure...- The historical, ethical, and legal background of human-subjects researchTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Respir Care 53:1325-9. 2008..Since their inception, the principles of conducting human research, IRBs, and the Code for Federal Regulations have all advanced substantially. This paper describes the history and current status of human-subjects-research regulations... - Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid statusTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
Crit Care 15:R86. 2011..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status... - Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDSTodd W Rice
MSc, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
Chest 132:410-7. 2007..We hypothesized that the pulse oximetric saturation (Spo(2))/Fio(2) (S/F) ratio can be substituted for the P/F ratio in assessing the oxygenation criterion of ALI... - Pleural effusions in superior vena cava syndrome: prevalence, characteristics, and proposed pathophysiologyTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
Curr Opin Pulm Med 13:324-7. 2007..This review highlights recent data detailing the prevalence and characteristics of pleural effusions occurring in patients with superior vena cava syndrome... 
Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfaTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Vasc Health Risk Manag 2:3-18. 2006..Observational data from the uncontrolled administration of heparin or statins in septic patients will also be reviewed...- Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injuryTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
JAMA 306:1574-81. 2011.... - Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial designTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Clin Chest Med 27:733-54; abstract xi. 2006..Delineating outcomes attributable to the lung injury will improve the power of studies to detect significant treatment effects. Future collaborative studies will be needed to investigate longer-term clinical outcomes... - Prevalence and characteristics of pleural effusions in superior vena cava syndromeTodd W Rice
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, and Saint Thomas Hospital, Nashville, Tennessee 37232 2650, USA
Respirology 11:299-305. 2006..The prevalence and characteristics of pleural effusions occurring in adults with the superior vena cava (SVC) syndrome are unknown. The purpose of the present study was to characterize these pleural effusions... - The superior vena cava syndrome: clinical characteristics and evolving etiologyTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Medicine (Baltimore) 85:37-42. 2006..Dyspnea at rest, cough, and chest pain were more frequent in the patients with malignancy. Procedures performed for diagnostic or treatment purposes did not increase morbidity or mortality... - Variation in enteral nutrition delivery in mechanically ventilated patientsTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Nutrition 21:786-92. 2005..We determined the variability in enteral feeding practices in mechanically ventilated patients in four adult intensive care units of a tertiary-care, referral hospital... - Therapeutic intervention and targets for sepsisTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232 2650, USA
Annu Rev Med 56:225-48. 2005..Following a review of recent advances in sepsis treatment, we briefly discuss a few of the new, promising therapeutic strategies currently being investigated... - Drotrecogin alfa (activated) for the treatment of severe sepsis and septic shockTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232, USA
Am J Med Sci 328:205-14. 2004..Despite concern over its relatively high cost, analysis has demonstrated that recombinant human activated protein C is as cost-effective as other commonly used treatments in the intensive care unit... - New additions to the intensive care armamentariumTodd W Rice
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232 2650, USA
Drugs Today (Barc) 40:157-70. 2004..Unfortunately, randomized, blinded, placebo-controlled trials showing improvement in long-term outcomes such as mortality and length of stay are still lacking... - Chylothorax as a result of chronic lymphocytic leukemia: case report and review of the literatureTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
South Med J 97:291-4. 2004..We describe a patient who developed chylothorax secondary to chronic lymphocytic leukemia. In addition, the pathogenesis, diagnosis, and treatment of chylothorax are reviewed... - A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsisTodd W Rice
Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 38:1685-94. 2010..To evaluate whether TAK-242, a small-molecule inhibitor of Toll-like receptor-4-mediated signaling, suppresses cytokine levels and improves 28-day all-cause mortality rates in patients with severe sepsis... - Plasma adiponectin and mortality in critically ill subjects with acute respiratory failureAllan J Walkey
Department of Medicine, The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA
Crit Care Med 38:2329-34. 2010..We examined the association between plasma adiponectin and clinical outcomes in critically ill patients with acute respiratory failure... - Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrestDavid R Janz
Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 40:3135-9. 2012..To determine whether higher levels of PaO2 are associated with in-hospital mortality and poor neurological status at hospital discharge in patients treated with mild therapeutic hypothermia after sudden cardiac arrest... - Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment scorePratik P Pandharipande
Department of Anesthesiology, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 37:1317-21. 2009.... - Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsisTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 34:2271-81. 2006..CONCLUSIONS: CytoFab is well tolerated in patients with severe sepsis, effectively reducing serum and BAL TNF-alpha and serum IL-6 concentrations and increasing the number of ventilator-free and ICU-free days at day 28... - Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit*Michael H Hooper
Department of Medicine, Division of Pulmonary, and Critical Care Medicine, Eastern Viriginia Medical School, Norfolk, VA, USA
Crit Care Med 40:2096-101. 2012.... - Coagulopathy in critically ill patients: part 1: platelet disordersTodd W Rice
Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN, USA
Chest 136:1622-30. 2009..Guidelines for treating thrombocytopenia and platelet dysfunction are also provided... - Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testingArthur P Wheeler
Medical Intensive Care Unit, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1210 MCN Vanderbilt Medical Center, Nashville, TN 37232 2650, USA
Chest 137:185-94. 2010..Limitations and pitfalls of diagnostic testing are highlighted... - Markers of inflammation and coagulation may be modulated by enteral feeding strategyJulie A Bastarache
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
JPEN J Parenter Enteral Nutr 36:732-40. 2012..Although enteral nutrition (EN) is provided to most mechanically ventilated patients, the effect of specific feeding strategies on circulating markers of coagulation and inflammation is unknown... - Obstructive sleep apnea is common in idiopathic pulmonary fibrosisLisa H Lancaster
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 5735, USA
Chest 136:772-8. 2009..Our goal was to analyze OSA in an outpatient population of stable patients with idiopathic pulmonary fibrosis (IPF)... - Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients*Todd W Rice
Vanderbilt University Medical Center, Nashville, TN, USA
Crit Care Med 40:778-86. 2012..The effect of treatment guidelines on clinical outcomes in general and specifically for trauma patients has not been well-studied. We hypothesized that better compliance with guidelines would be associated with improved clinical outcomes... - Unrecognized glucose intolerance is common in pulmonary arterial hypertensionMeredith E Pugh
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
J Heart Lung Transplant 30:904-11. 2011..We aimed to define the prevalence of elevated HbA(1c) in PAH patients and to correlate HbA(1c) levels with functional assessment... - Splenosis: a reviewRichard D Fremont
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
South Med J 100:589-93. 2007..Splenosis usually occurs within the abdominal and pelvic cavities, but patients have been described with intrathoracic, subcutaneous, intrahepatic and intracranial lesions... - Atrial plasmacytoma and hypercalcemiaLori A Brame
Indiana University School of Medicine, Division of Endocrinology, Emerson Hall 421, 545 Barnhill Drive, Indianapolis, IN 46202, USA
Endocr Pract 9:225-8. 2003..On autopsy, she was found to have disseminated myeloma and an atrial plasmacytoma. CONCLUSION: This case report emphasizes the need to consider a plasmacytoma as a manifestation of multiple myeloma when localizing symptoms are present... - Obesity in acute lung injury: The "weight" is overTodd W Rice
Chest 131:333-4. 2007
Research Grants
- Attenuating Inflammation via Protein-Calorie RestrictionTodd Rice; Fiscal Year: 2007....