Albert B Reynolds

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Adenoma formation following limited ablation of p120-catenin in the mouse intestine
    Whitney G Smalley-Freed
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e19880. 2011
  2. pmc A novel role for p120 catenin in E-cadherin function
    Renee C Ireton
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 159:465-76. 2002
  3. pmc ReCLIP (reversible cross-link immuno-precipitation): an efficient method for interrogation of labile protein complexes
    Andrew L Smith
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16206. 2011
  4. pmc The molecular evolution of the p120-catenin subfamily and its functional associations
    Robert H Carnahan
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15747. 2010
  5. pmc An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth
    Michael R Dohn
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    J Cell Biol 184:437-50. 2009
  6. pmc The evolutionary history of the catenin gene family during metazoan evolution
    Zi Ming Zhao
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    BMC Evol Biol 11:198. 2011
  7. ncbi request reprint Exposing p120 catenin's most intimate affair
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell 141:20-2. 2010
  8. doi request reprint Epithelial organization: new perspective on α-catenin from an ancient source
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA
    Curr Biol 21:R430-2. 2011
  9. pmc p120-catenin: Past and present
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, 438 Preston Building Nashville, TN 37232 684, USA
    Biochim Biophys Acta 1773:2-7. 2007
  10. ncbi request reprint Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, 440 PRB, 2220 Pierce Ave, Nashville, TN 37232 6840, USA
    Semin Cell Dev Biol 15:657-63. 2004

Collaborators

Detail Information

Publications38

  1. pmc Adenoma formation following limited ablation of p120-catenin in the mouse intestine
    Whitney G Smalley-Freed
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e19880. 2011
    ..Indeed, although technical issues precluded direct identification of mutations, β-catenin upregulation in human colon cancer almost invariably reflects mutations in APC and/or β-catenin...
  2. pmc A novel role for p120 catenin in E-cadherin function
    Renee C Ireton
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 159:465-76. 2002
    ..These data reveal a cooperative interaction between p120 and E-cadherin and a novel role for p120 that is likely indispensable in normal cells...
  3. pmc ReCLIP (reversible cross-link immuno-precipitation): an efficient method for interrogation of labile protein complexes
    Andrew L Smith
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16206. 2011
    ..ReCLIP therefore appears to provide an excellent alternative to currently available affinity-purification approaches, particularly for studies of labile complexes...
  4. pmc The molecular evolution of the p120-catenin subfamily and its functional associations
    Robert H Carnahan
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15747. 2010
    ..In vertebrates, p120 is essential in regulating surface expression and stability of all classical cadherins, and directly interacts with Kaiso, a BTB/ZF family transcription factor...
  5. pmc An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth
    Michael R Dohn
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    J Cell Biol 184:437-50. 2009
    ..Although H-Ras bypasses p120, a unifying theme for all three oncogenes is the requirement to suppress ROCK, which may act as a gatekeeper for the transition to anchorage independence...
  6. pmc The evolutionary history of the catenin gene family during metazoan evolution
    Zi Ming Zhao
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    BMC Evol Biol 11:198. 2011
    ..We present a detailed evolutionary study of the whole catenin family to provide a better understanding of how this family has evolved in metazoans, and by extension, the evolution of cell-cell adhesion...
  7. ncbi request reprint Exposing p120 catenin's most intimate affair
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell 141:20-2. 2010
    ..2010) present the first crystal structure of p120 in complex with cadherin, revealing molecular details of the functional interface and providing sophisticated new tools for dissecting p120's role in cell-cell adhesion...
  8. doi request reprint Epithelial organization: new perspective on α-catenin from an ancient source
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA
    Curr Biol 21:R430-2. 2011
    ..New evidence from a primitive slime mold, however, suggests that α- and β-catenins may have engaged this function independently, long before cadherins arrived on the scene...
  9. pmc p120-catenin: Past and present
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, 438 Preston Building Nashville, TN 37232 684, USA
    Biochim Biophys Acta 1773:2-7. 2007
    ..The anecdotal parts have no particular purpose, but are mostly unpublished and perhaps of interest to some...
  10. ncbi request reprint Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, 440 PRB, 2220 Pierce Ave, Nashville, TN 37232 6840, USA
    Semin Cell Dev Biol 15:657-63. 2004
    ..Thus, it is possible that the classic observation of E-cadherin-deficiency in metastatic cancer may in some cases be due to p120 downregulation rather than better understood mechanisms acting at the level of E-cadherin transcription...
  11. ncbi request reprint Emerging roles for p120-catenin in cell adhesion and cancer
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, 771PRB, 2220 Pierce Ave, Nashville, TN 37232 6840, USA
    Oncogene 23:7947-56. 2004
    ..This review summarizes recent progress in understanding mechanisms of p120 action, and discusses new implications with respect to roles for p120 in disease and cancer...
  12. ncbi request reprint p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation
    Xiaobo Xia
    Department of Cancer Biology, Vanderbilt University Medical Center, 771 Preston Research Building, Nashville, TN 37232, USA
    Exp Cell Res 312:3336-48. 2006
    ..The data suggest that p120 dephosphorylation at these sites is modulated by multiple cell surface receptors primarily through PKC-dependent pathways, but these changes do not seem to reduce p120/cadherin affinity...
  13. ncbi request reprint Generation and characterization of a novel phospho-specific monoclonal antibody to p120-catenin serine 879
    Meredith H Vaughan
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6840, USA
    Hybridoma (Larchmt) 26:407-15. 2007
    ..p120 MAb pS879 should facilitate efforts to identify the role of S879 phosphorylation and to map signaling pathways that modify p120 function through activation of PKC...
  14. pmc Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin
    Andrew L Smith
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Biol Cell 23:99-110. 2012
    ..These data are consistent with a model in which p120 dynamically regulates Rho-GTPase activity at the cadherin complex through transient interaction with several of its up- and downstream effectors, including ROCK1...
  15. ncbi request reprint EGFR signaling to p120-catenin through phosphorylation at Y228
    Deborah J Mariner
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6840, USA
    J Cell Sci 117:1339-50. 2004
    ....
  16. ncbi request reprint p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho
    Gregg A Wildenberg
    Department of Cancer Biology, 438 Preston Building, Vanderbilt University, Nashville, TN 37232, USA
    Cell 127:1027-39. 2006
    ..We propose that Rac activation links diverse signaling systems to AJ assembly by controlling transient p190RhoGAP interactions with p120 and localized inhibition of Rho...
  17. pmc p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice
    Whitney G Smalley-Freed
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Clin Invest 120:1824-35. 2010
    ..Thus, we conclude that p120 has an essential role in barrier function and epithelial homeostasis and survival in the intestine...
  18. ncbi request reprint Serine and threonine phospho-specific antibodies to p120-catenin
    Xiaobo Xia
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Hybrid Hybridomics 23:343-51. 2004
    ..The antibodies should markedly accelerate efforts to delineate the roles of individual p120 modifications and will be particularly useful in identifying upstream signaling events that regulate p120 function...
  19. pmc A core function for p120-catenin in cadherin turnover
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    J Cell Biol 163:525-34. 2003
    ..The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120...
  20. pmc PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway
    Meredith V Brown
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Exp Cell Res 315:39-49. 2009
    ..Using Va2 cells and PDGF stimulation, we show for the first time that PDGFR-mediated phosphorylation at this site is dependent on PKCalpha, a conventional PKC isoform implicated previously in disruption of adherens junctions...
  21. ncbi request reprint Regulation of p120-catenin nucleocytoplasmic shuttling activity
    Agnes Roczniak-Ferguson
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Sci 116:4201-12. 2003
    ..Thus, p120 has intrinsic nucleocytoplasmic shuttling activity that is modulated, in part, by extrinsic factors such as cadherin binding and interactions with the microtubule network...
  22. ncbi request reprint Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin
    Xiaobo Xia
    Department of Cancer Biology, Vanderbilt University, PRBII 771, Nashville, Tennessee 37232 6840, USA
    Biochemistry 42:9195-204. 2003
    ..These data directly link PKC activation to specific changes in p120 phosphorylation, and identify the target sites associated with the mechanism of PKC-dependent adhesive changes induced by agents such as histamine and PDBu...
  23. ncbi request reprint Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, 438 Preston Building, Nashville, Tennessee 37232, USA
    Dev Cell 10:21-31. 2006
    ..The data reveal an unexpected role for p120 in salivary acinar development and show that p120 ablation by itself induces effects consistent with a role in tumor progression...
  24. pmc Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters
    Caitlyn W Barrett
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    PLoS ONE 7:e51205. 2012
    ....
  25. pmc Monoclonal antibodies to DIPA: a novel binding partner of p120-catenin isoform 1
    Nicholas O Markham
    Department of Cancer Biology, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA
    Hybridoma (Larchmt) 31:246-54. 2012
    ....
  26. ncbi request reprint Altered expression of the catenin p120 in human cancer: implications for tumor progression
    Molly A Thoreson
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Differentiation 70:583-9. 2002
    ..Moreover, in some cases p120 loss appears to be an early event in tumor progression, possibly preceding loss of E-cadherin. Potential roles of p120 as a tumor suppressor or metastasis promoter are discussed...
  27. pmc p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7
    Seth R Ogden
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Mol Biol Cell 19:4110-21. 2008
    ..These results indicate that selective and coordinated induction of mmp-7 expression by H. pylori cag(+) isolates may explain in part the augmentation in gastric cancer risk associated with these strains...
  28. pmc p120-catenin is essential for terminal end bud function and mammary morphogenesis
    Sarah J Kurley
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Development 139:1754-64. 2012
    ..Our findings reveal an essential role for p120 in mammary morphogenesis...
  29. pmc Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci
    Jinming Gu
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Mol Biol Cell 15:3320-32. 2004
    ..We propose that the helicase of HDHB operates primarily during G1 to process endogenous DNA damage before the G1/S transition, and it is largely sequestered in the cytoplasm during S/G2...
  30. pmc WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl
    Nicole S Bryce
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e64533. 2013
    ..Epithelial morphogenesis is a dynamic process that involves coordination of signaling and actin cytoskeletal rearrangements...
  31. pmc The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane
    Yuri Fukumoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Exp Cell Res 314:52-67. 2008
    ..These data suggest that serine/threonine phosphorylation of p120 influences the dynamics of E-cadherin in junctions...
  32. ncbi request reprint The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation
    Toshihiko Ezaki
    Division of Gastroenterology 650 CRB, Department of Medicine, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Gastrointest Liver Physiol 293:G54-65. 2007
    ..Ascertaining the mechanism for this novel Cdx effect may improve our understanding of the regulation of cell-cell adhesion in the colonic epithelium...
  33. ncbi request reprint Protecting your tail: regulation of cadherin degradation by p120-catenin
    Andrew P Kowalczyk
    Departments of Dermatology and Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Opin Cell Biol 16:522-7. 2004
    ....
  34. ncbi request reprint Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation
    Marita Goodwin
    School for Biomedical Sciences, The University of Queensland, St Lucia, Brisbane 4072, Queensland, Australia
    J Biol Chem 278:20533-9. 2003
    ..The molecular requirements for E-cadherin to activate Rac signaling thus appear distinct from those that stimulate PI3-kinase, and we postulate that p120-ctn may play a central role in the E-cadherin-Rac signaling pathway...
  35. ncbi request reprint Involvement of p120 catenin in myopodial assembly and nerve-muscle synapse formation
    Raghavan Madhavan
    Department of Biology, Hong Kong University of Science and Technology, Kowloon, Hong Kong
    J Neurobiol 66:1511-27. 2006
    ..Our results indicate a novel role of p120ctn in agrin-induced myopodial assembly and suggest that myopodia increase muscle-nerve contacts and muscle's access to neural agrin to promote NMJ formation...
  36. pmc p120-catenin mediates inflammatory responses in the skin
    Mirna Perez-Moreno
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 124:631-44. 2006
    ..Although the underlying mechanism is likely complex, we show that p120 affects NFkB activation and immune homeostasis in part through regulation of Rho GTPases. These findings provide important new insights into p120 function...
  37. ncbi request reprint A novel interaction between kinesin and p120 modulates p120 localization and function
    Masahiro Yanagisawa
    Mayo Clinic Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:9512-21. 2004
    ..Taken together, the data suggest that kinesin affects both the targeting and activity of p120 at several cellular locations...
  38. pmc The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides
    Juliet M Daniel
    Department of Biology, LSB 331, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    Nucleic Acids Res 30:2911-9. 2002
    ..Kaiso thus appears to have two modes of DNA binding and transcriptional repression, both of which may be modulated by its interaction with the adhesion cofactor p120(ctn)...