Research Topics
Genomes and Genes | Albert B ReynoldsSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
The evolutionary history of the catenin gene family during metazoan evolutionZi Ming Zhao
School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
BMC Evol Biol 11:198. 2011..We present a detailed evolutionary study of the whole catenin family to provide a better understanding of how this family has evolved in metazoans, and by extension, the evolution of cell-cell adhesion...
Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancerAlbert B Reynolds
Department of Cancer Biology, Vanderbilt University, 440 PRB, 2220 Pierce Ave, Nashville, TN 37232 6840, USA
Semin Cell Dev Biol 15:657-63. 2004..Thus, it is possible that the classic observation of E-cadherin-deficiency in metastatic cancer may in some cases be due to p120 downregulation rather than better understood mechanisms acting at the level of E-cadherin transcription...- Exposing p120 catenin's most intimate affairAlbert B Reynolds
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Cell 141:20-2. 2010..2010) present the first crystal structure of p120 in complex with cadherin, revealing molecular details of the functional interface and providing sophisticated new tools for dissecting p120's role in cell-cell adhesion... 
Epithelial organization: new perspective on α-catenin from an ancient sourceAlbert B Reynolds
Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA
Curr Biol 21:R430-2. 2011..New evidence from a primitive slime mold, however, suggests that α- and β-catenins may have engaged this function independently, long before cadherins arrived on the scene...- p120-catenin: Past and presentAlbert B Reynolds
Department of Cancer Biology, Vanderbilt University, 438 Preston Building Nashville, TN 37232 684, USA
Biochim Biophys Acta 1773:2-7. 2007..The anecdotal parts have no particular purpose, but are mostly unpublished and perhaps of interest to some... - Emerging roles for p120-catenin in cell adhesion and cancerAlbert B Reynolds
Department of Cancer Biology, Vanderbilt University, 771PRB, 2220 Pierce Ave, Nashville, TN 37232 6840, USA
Oncogene 23:7947-56. 2004..This review summarizes recent progress in understanding mechanisms of p120 action, and discusses new implications with respect to roles for p120 in disease and cancer... - p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligationXiaobo Xia
Department of Cancer Biology, Vanderbilt University Medical Center, 771 Preston Research Building, Nashville, TN 37232, USA
Exp Cell Res 312:3336-48. 2006..The data suggest that p120 dephosphorylation at these sites is modulated by multiple cell surface receptors primarily through PKC-dependent pathways, but these changes do not seem to reduce p120/cadherin affinity... - Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-cateninAndrew L Smith
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
Mol Biol Cell 23:99-110. 2012..These data are consistent with a model in which p120 dynamically regulates Rho-GTPase activity at the cadherin complex through transient interaction with several of its up- and downstream effectors, including ROCK1... - EGFR signaling to p120-catenin through phosphorylation at Y228Deborah J Mariner
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6840, USA
J Cell Sci 117:1339-50. 2004.... - Generation and characterization of a novel phospho-specific monoclonal antibody to p120-catenin serine 879Meredith H Vaughan
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6840, USA
Hybridoma (Larchmt) 26:407-15. 2007..p120 MAb pS879 should facilitate efforts to identify the role of S879 phosphorylation and to map signaling pathways that modify p120 function through activation of PKC... - p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and RhoGregg A Wildenberg
Department of Cancer Biology, 438 Preston Building, Vanderbilt University, Nashville, TN 37232, USA
Cell 127:1027-39. 2006..We propose that Rac activation links diverse signaling systems to AJ assembly by controlling transient p190RhoGAP interactions with p120 and localized inhibition of Rho... - PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathwayMeredith V Brown
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Exp Cell Res 315:39-49. 2009..Using Va2 cells and PDGF stimulation, we show for the first time that PDGFR-mediated phosphorylation at this site is dependent on PKCalpha, a conventional PKC isoform implicated previously in disruption of adherens junctions... - Serine and threonine phospho-specific antibodies to p120-cateninXiaobo Xia
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Hybrid Hybridomics 23:343-51. 2004..The antibodies should markedly accelerate efforts to delineate the roles of individual p120 modifications and will be particularly useful in identifying upstream signaling events that regulate p120 function... - An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growthMichael R Dohn
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
J Cell Biol 184:437-50. 2009..Although H-Ras bypasses p120, a unifying theme for all three oncogenes is the requirement to suppress ROCK, which may act as a gatekeeper for the transition to anchorage independence... 
A core function for p120-catenin in cadherin turnoverMichael A Davis
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
J Cell Biol 163:525-34. 2003..The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120...- Regulation of p120-catenin nucleocytoplasmic shuttling activityAgnes Roczniak-Ferguson
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Cell Sci 116:4201-12. 2003..Thus, p120 has intrinsic nucleocytoplasmic shuttling activity that is modulated, in part, by extrinsic factors such as cadherin binding and interactions with the microtubule network... - Monoclonal antibodies to DIPA: a novel binding partner of p120-catenin isoform 1Nicholas O Markham
Department of Cancer Biology, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA
Hybridoma (Larchmt) 31:246-54. 2012.... - Adenoma formation following limited ablation of p120-catenin in the mouse intestineWhitney G Smalley-Freed
Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 6:e19880. 2011..Indeed, although technical issues precluded direct identification of mutations, β-catenin upregulation in human colon cancer almost invariably reflects mutations in APC and/or β-catenin... - Altered expression of the catenin p120 in human cancer: implications for tumor progressionMolly A Thoreson
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
Differentiation 70:583-9. 2002..Moreover, in some cases p120 loss appears to be an early event in tumor progression, possibly preceding loss of E-cadherin. Potential roles of p120 as a tumor suppressor or metastasis promoter are discussed... - A novel role for p120 catenin in E-cadherin functionRenee C Ireton
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Cell Biol 159:465-76. 2002..These data reveal a cooperative interaction between p120 and E-cadherin and a novel role for p120 that is likely indispensable in normal cells... - p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in miceWhitney G Smalley-Freed
Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Clin Invest 120:1824-35. 2010..Thus, we conclude that p120 has an essential role in barrier function and epithelial homeostasis and survival in the intestine... - p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7Seth R Ogden
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
Mol Biol Cell 19:4110-21. 2008..These results indicate that selective and coordinated induction of mmp-7 expression by H. pylori cag(+) isolates may explain in part the augmentation in gastric cancer risk associated with these strains... - Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-cateninXiaobo Xia
Department of Cancer Biology, Vanderbilt University, PRBII 771, Nashville, Tennessee 37232 6840, USA
Biochemistry 42:9195-204. 2003..These data directly link PKC activation to specific changes in p120 phosphorylation, and identify the target sites associated with the mechanism of PKC-dependent adhesive changes induced by agents such as histamine and PDBu... - Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary glandMichael A Davis
Department of Cancer Biology, Vanderbilt University, 438 Preston Building, Nashville, Tennessee 37232, USA
Dev Cell 10:21-31. 2006..The data reveal an unexpected role for p120 in salivary acinar development and show that p120 ablation by itself induces effects consistent with a role in tumor progression... - p120-catenin is essential for terminal end bud function and mammary morphogenesisSarah J Kurley
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
Development 139:1754-64. 2012..Our findings reveal an essential role for p120 in mammary morphogenesis... - The molecular evolution of the p120-catenin subfamily and its functional associationsRobert H Carnahan
Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 5:e15747. 2010..In vertebrates, p120 is essential in regulating surface expression and stability of all classical cadherins, and directly interacts with Kaiso, a BTB/ZF family transcription factor... - Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage fociJinming Gu
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
Mol Biol Cell 15:3320-32. 2004..We propose that the helicase of HDHB operates primarily during G1 to process endogenous DNA damage before the G1/S transition, and it is largely sequestered in the cytoplasm during S/G2... - Kaiso Directs the Transcriptional Corepressor MTG16 to the Kaiso Binding Site in Target PromotersCaitlyn W Barrett
Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
PLoS ONE 7:e51205. 2012.... - ReCLIP (reversible cross-link immuno-precipitation): an efficient method for interrogation of labile protein complexesAndrew L Smith
Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 6:e16206. 2011..ReCLIP therefore appears to provide an excellent alternative to currently available affinity-purification approaches, particularly for studies of labile complexes... - The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membraneYuri Fukumoto
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
Exp Cell Res 314:52-67. 2008..These data suggest that serine/threonine phosphorylation of p120 influences the dynamics of E-cadherin in junctions... - The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylationToshihiko Ezaki
Division of Gastroenterology 650 CRB, Department of Medicine, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA
Am J Physiol Gastrointest Liver Physiol 293:G54-65. 2007..Ascertaining the mechanism for this novel Cdx effect may improve our understanding of the regulation of cell-cell adhesion in the colonic epithelium... - Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formationMarita Goodwin
School for Biomedical Sciences, The University of Queensland, St Lucia, Brisbane 4072, Queensland, Australia
J Biol Chem 278:20533-9. 2003..The molecular requirements for E-cadherin to activate Rac signaling thus appear distinct from those that stimulate PI3-kinase, and we postulate that p120-ctn may play a central role in the E-cadherin-Rac signaling pathway... - Protecting your tail: regulation of cadherin degradation by p120-cateninAndrew P Kowalczyk
Departments of Dermatology and Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Curr Opin Cell Biol 16:522-7. 2004.... - A novel interaction between kinesin and p120 modulates p120 localization and functionMasahiro Yanagisawa
Mayo Clinic Cancer Center, Jacksonville, Florida 32224, USA
J Biol Chem 279:9512-21. 2004..Taken together, the data suggest that kinesin affects both the targeting and activity of p120 at several cellular locations... - p120-catenin mediates inflammatory responses in the skinMirna Perez-Moreno
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cell 124:631-44. 2006..Although the underlying mechanism is likely complex, we show that p120 affects NFkB activation and immune homeostasis in part through regulation of Rho GTPases. These findings provide important new insights into p120 function... - Involvement of p120 catenin in myopodial assembly and nerve-muscle synapse formationRaghavan Madhavan
Department of Biology, Hong Kong University of Science and Technology, Kowloon, Hong Kong
J Neurobiol 66:1511-27. 2006..Our results indicate a novel role of p120ctn in agrin-induced myopodial assembly and suggest that myopodia increase muscle-nerve contacts and muscle's access to neural agrin to promote NMJ formation... - The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotidesJuliet M Daniel
Department of Biology, LSB 331, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
Nucleic Acids Res 30:2911-9. 2002..Kaiso thus appears to have two modes of DNA binding and transcriptional repression, both of which may be modulated by its interaction with the adhesion cofactor p120(ctn)...