Anita M Preininger

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective
    Anita M Preininger
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6600, USA
    J Mol Biol 425:2288-98. 2013
  2. pmc Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins
    Heidi E Hamm
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Protein Sci 18:2326-35. 2009
  3. pmc Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins
    William M Oldham
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6600, USA
    Proc Natl Acad Sci U S A 104:7927-32. 2007
  4. pmc Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective
    Tarjani M Thaker
    Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA
    Methods Mol Biol 796:133-74. 2012
  5. pmc Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits
    Anita M Preininger
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    Biochemistry 48:2630-42. 2009
  6. pmc Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins
    Anita M Preininger
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    Biochemistry 47:10281-93. 2008
  7. pmc Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution
    Anita M Preininger
    Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
    Biochemistry 51:1911-24. 2012
  8. pmc Linking receptor activation to changes in Sw I and II of Gα proteins
    Heidi E Hamm
    Vanderbilt University Medical Center, Department of Pharmacology, Nashville, TN 37232 6600, United States
    J Struct Biol 184:63-74. 2013
  9. pmc Coupling efficiency of rhodopsin and transducin in bicelles
    Ali I Kaya
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, United States
    Biochemistry 50:3193-203. 2011
  10. pmc Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans
    Tarjani M Thaker
    Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Struct Biol 181:185-9. 2013

Collaborators

Detail Information

Publications14

  1. pmc Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective
    Anita M Preininger
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6600, USA
    J Mol Biol 425:2288-98. 2013
    ..The pairing of computational and experimental approaches will continue to provide powerful tools to probe the conformation and dynamics of receptor-mediated G protein activation...
  2. pmc Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins
    Heidi E Hamm
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Protein Sci 18:2326-35. 2009
    ..These results reveal unique insights into conformational changes which occur upon activation and deactivation of G proteins in solution...
  3. pmc Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins
    William M Oldham
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6600, USA
    Proc Natl Acad Sci U S A 104:7927-32. 2007
    ..The data identify a putative pathway of allosteric changes triggered by receptor binding and, together with previously published data, suggest elements of a mechanism for receptor-catalyzed nucleotide exchange...
  4. pmc Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective
    Tarjani M Thaker
    Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA
    Methods Mol Biol 796:133-74. 2012
    ..In this chapter, we review the methods that have revealed allosteric signaling through rhodopsin and transducin. These methods can be applied to a variety of GPCR-mediated signaling pathways...
  5. pmc Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits
    Anita M Preininger
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    Biochemistry 48:2630-42. 2009
    ..Combined with previous evidence in the literature, the structural analysis supports the critical role of electrostatics of the alpha5 helix dipole and overall conformational variability during nucleotide release...
  6. pmc Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins
    Anita M Preininger
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    Biochemistry 47:10281-93. 2008
    ..This work demonstrates that the myristoylated amino terminus of Galpha il proteins undergoes receptor-mediated changes during the dynamic process of G protein signaling...
  7. pmc Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution
    Anita M Preininger
    Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
    Biochemistry 51:1911-24. 2012
    ....
  8. pmc Linking receptor activation to changes in Sw I and II of Gα proteins
    Heidi E Hamm
    Vanderbilt University Medical Center, Department of Pharmacology, Nashville, TN 37232 6600, United States
    J Struct Biol 184:63-74. 2013
    ..The ability to merge available crystal structures with solution studies is a powerful tool to gain insight into conformational changes associated with receptor-mediated Gi protein activation. ..
  9. pmc Coupling efficiency of rhodopsin and transducin in bicelles
    Ali I Kaya
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, United States
    Biochemistry 50:3193-203. 2011
    ..These data suggest that a membrane-like structure is an important contributor to the formation and stability of functional receptor-G protein complexes and can extend the range of studies that investigate properties of these complexes...
  10. pmc Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans
    Tarjani M Thaker
    Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Struct Biol 181:185-9. 2013
    ..Taken together, these structures are consistent with the eukaryotic ACKs following a similar reaction mechanism as is proposed for the prokaryotic homologs...
  11. ncbi request reprint Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins
    William M Oldham
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6600, USA
    Nat Struct Mol Biol 13:772-7. 2006
    ..These data provide the first direct observation of R*-mediated conformational changes in G proteins and define the structural basis for GDP release from G alpha...
  12. ncbi request reprint G protein signaling: insights from new structures
    Anita M Preininger
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6600, USA
    Sci STKE 2004:re3. 2004
    ..In this Review, we discuss the latest findings and their implications for G protein-signaling paradigms...
  13. pmc Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates
    Michael Holinstat
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6600, USA
    Mol Pharmacol 76:301-13. 2009
    ..Hence, it is possible to disrupt lipid signaling pathways involved in stable clot formation without inhibiting early clot formation, offering a new potential target for antiplatelet therapy...
  14. ncbi request reprint Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation
    Martina Medkova
    Department of Pharmacology, Vanderbilt University Medical Center, 23rd Avenue South Pierce, 442 Robinson Research Building, Nashville, TN 37232 6600, USA
    Biochemistry 41:9962-72. 2002
    ..These solution studies reveal insights into conformational changes that occur dynamically in solution...