Vasiliy V Polosukhin

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats
    Hoyin Mok
    Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Virol 81:13710-22. 2007
  2. ncbi request reprint Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice
    Vasiliy V Polosukhin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Exp Lung Res 38:135-46. 2012
  3. ncbi request reprint Variability of interalveolar septal remodeling after bleomycin treatment in mice
    Vasiliy V Polosukhin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Ultrastruct Pathol 29:53-64. 2005
  4. pmc Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease
    Vasiliy V Polosukhin
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 184:317-27. 2011
  5. doi request reprint Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium
    Vasiliy V Polosukhin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    J Pathol 224:203-11. 2011
  6. ncbi request reprint Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia
    Vasiliy V Polosukhin
    Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Virchows Arch 451:793-803. 2007
  7. pmc Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis
    Amber L Degryse
    Department of Medicine, Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 299:L442-52. 2010
  8. pmc TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment
    Amber L Degryse
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 300:L887-97. 2011
  9. ncbi request reprint Telomerase deficiency does not alter bleomycin-induced fibrosis in mice
    Amber L Degryse
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Exp Lung Res 38:124-34. 2012
  10. pmc Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis
    Harikrishna Tanjore
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 180:657-65. 2009

Detail Information

Publications35

  1. pmc Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats
    Hoyin Mok
    Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Virol 81:13710-22. 2007
    ..These results represent an important first step toward the use of VRPs encoding RSV proteins as a prophylactic vaccine for RSV...
  2. ncbi request reprint Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice
    Vasiliy V Polosukhin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Exp Lung Res 38:135-46. 2012
    ..Thus, this model can be utilized to investigate mechanisms of airway remodeling...
  3. ncbi request reprint Variability of interalveolar septal remodeling after bleomycin treatment in mice
    Vasiliy V Polosukhin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Ultrastruct Pathol 29:53-64. 2005
    ..The findings indicate that studies investigating the pathogenesis of lung fibrosis should focus on septal remodeling as well as analysis of fibrotic foci and measurement of collagen content...
  4. pmc Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease
    Vasiliy V Polosukhin
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 184:317-27. 2011
    ..Although airway inflammation can persist for years after smoking cessation in patients with chronic obstructive pulmonary disease (COPD), the mechanisms of persistent inflammation are largely unknown...
  5. doi request reprint Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium
    Vasiliy V Polosukhin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    J Pathol 224:203-11. 2011
    ..These data indicate an important effect of hypoxia-inducible signalling on airway epithelial cell differentiation and identify a new potential target to limit mucus production in COPD...
  6. ncbi request reprint Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia
    Vasiliy V Polosukhin
    Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Virchows Arch 451:793-803. 2007
    ..These findings suggest that the HIF-1alpha pathway is activated in response to subepithelial remodeling and contributes to progressive premalignant epithelial lesions in the airways of tobacco smokers with chronic airway inflammation...
  7. pmc Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis
    Amber L Degryse
    Department of Medicine, Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 299:L442-52. 2010
    ..With repetitive bleomycin, fibrotic remodeling persisted 10 wk after the eighth dose. Repetitive intratracheal bleomycin results in marked lung fibrosis with prominent AEC hyperplasia, features reminiscent of UIP...
  8. pmc TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment
    Amber L Degryse
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 300:L887-97. 2011
    ..Attenuation of TGFβ signaling in lung epithelium provides protection from bleomycin-induced fibrosis, indicating a critical role for the epithelium in transducing the profibrotic effects of this cytokine...
  9. ncbi request reprint Telomerase deficiency does not alter bleomycin-induced fibrosis in mice
    Amber L Degryse
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Exp Lung Res 38:124-34. 2012
    ..Additional genetic or environmental factors may be necessary for development of fibrosis in the presence of telomerase deficiency...
  10. pmc Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis
    Harikrishna Tanjore
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 180:657-65. 2009
    ..Lung fibroblasts are key mediators of fibrosis resulting in accumulation of excessive interstitial collagen and extracellular matrix, but their origins are not well defined...
  11. ncbi request reprint Characterization of fibroblast-specific protein 1 in pulmonary fibrosis
    William E Lawson
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T 1217 MCN, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 171:899-907. 2005
    ..Therefore, FSP1 is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis...
  12. pmc Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs
    William E Lawson
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 108:10562-7. 2011
    ..These data support the concept that ER stress produces a dysfunctional epithelial cell phenotype that facilitates fibrotic remodeling. ER stress pathways may serve as important therapeutic targets in idiopathic pulmonary fibrosis...
  13. pmc IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Respir Cell Mol Biol 48:711-6. 2013
    ..STAT6 KO mTECs showed increased periodic acid-Schiff staining with IL-17A but not with IL-13. Thus, asthma therapies targeting STAT6 may increase IL-17A protein expression, without preventing IL-17A-induced mucus production...
  14. pmc Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin
    William E Lawson
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University School of Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Am J Pathol 167:1267-77. 2005
    ..Thus, SP-C functions to limit lung inflammation, inhibit collagen accumulation, and restore normal lung structure after bleomycin...
  15. pmc Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice
    Rinat Zaynagetdinov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
    Am J Respir Cell Mol Biol 42:564-71. 2010
    ..These findings are in agreement with previous pharmacologic studies suggesting a deleterious role for A(2B) receptor signaling in chronic lung inflammation...
  16. ncbi request reprint Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway
    Dong Sheng Cheng
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 178:6504-13. 2007
    ....
  17. pmc β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin
    Harikrishna Tanjore
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 187:630-9. 2013
    ..Objectives: We aimed to determine the role of β-catenin in alveolar epithelium during bleomycin-induced lung fibrosis...
  18. ncbi request reprint Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury
    M Brett Everhart
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 176:4995-5005. 2006
    ..Therefore, sustained NF-kappaB activation correlates with severity of lung injury, and interdiction in the NF-kappaB pathway is beneficial even after the onset of lung inflammation...
  19. pmc Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis
    Georgios T Stathopoulos
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:18514-9. 2007
    ..These studies indicate that NF-kappaB signaling in airway epithelium is integral to tumorigenesis in the urethane model and identify the NF-kappaB pathway as a potential target for chemoprevention of lung cancer...
  20. ncbi request reprint Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis
    Georgios T Stathopoulos
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Exp Metastasis 25:43-51. 2008
    ..In conclusion, using bioluminescent detection of NF-kappaB activation in mouse lug adenocarcinoma cells, we found a negative impact of p65/RelA on NSCLC metastasis...
  21. pmc A critical role for macrophages in promotion of urethane-induced lung carcinogenesis
    Rinat Zaynagetdinov
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 187:5703-11. 2011
    ..Together, these studies elucidate an important role for macrophages in lung tumor promotion and indicate that these cells have distinct roles during different stages of lung carcinogenesis...
  22. pmc NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity
    Wei Han
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:4786-94. 2013
    ..Together, these results indicate that NADPH oxidase limits LPS-induced NF-κB transcriptional activity through regulation of intracellular redox state...
  23. pmc An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats
    Hoyin Mok
    Departments of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Virol 82:11410-8. 2008
    ..Aberrant cytokine gene expression was not detected in these animals. Together, these results represent an important first step toward the use of VRPs encoding hMPV F proteins as a prophylactic vaccine for hMPV...
  24. pmc Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis
    Edilson Torres-González
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, Georgia, USA
    Am J Respir Cell Mol Biol 46:748-56. 2012
    ..These results indicate that the aging lung is more susceptible to injury and fibrosis associated with endoplasmic reticulum stress, apoptosis of type II lung epithelial cells, and activation of profibrotic pathways...
  25. pmc Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC
    Peter F Crossno
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Chest 137:969-73. 2010
    ..These findings demonstrate that subclinical fibrotic changes may be present in family members of patients with SFTPC mutation-associated interstitial lung disease and suggest that ABCA3 variants could affect disease pathogenesis...
  26. doi request reprint Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection
    William E Lawson
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1119-26. 2008
    ..Activation of these pathways may result from altered surfactant protein processing or chronic herpesvirus infection...
  27. pmc PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression
    Weisong Zhou
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 301:L615-22. 2011
    ..PGI(2) induction of Nqo 1 provides a possible novel mechanism by which this prostanoid protects against bleomycin-induced mortality and identifies a potential therapeutic target for human ALI...
  28. pmc Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice
    James R Sheller
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Exp Lung Res 35:883-95. 2009
    ..NF-kappa B represents a potential target for pharmacologic intervention in human asthma...
  29. pmc Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice
    Huimin Zhang
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4114 MRB III, Nashville, TN 37232, USA
    Am J Pathol 171:1113-26. 2007
    ..In addition, bleomycin-exposed Id1(-/-) mice showed increased lung collagen accumulation and fibrogenesis, suggesting that Id1 up-regulation in the lung may play a critical role in lung homeostasis...
  30. pmc Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress
    Elena N Atochina-Vasserman
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Physiol Renal Physiol 304:F1295-307. 2013
    ..Our results indicate an important role for AQP11 to prevent glucose-induced oxidative stress in proximal tubules...
  31. pmc The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice
    Qiufang Cheng
    Hematology Oncology Division, Department of Pathology, Vanderbilt University, 777 MRB II, 2220 Pierce Ave, Nashville, TN 37232 6307, USA
    Blood 106:3055-7. 2005
    ..Activated fXI is thought to function primarily as a fIX activator; however, our observation suggests that fXI may have functions in regulation of inflammation or tissue repair distinct from its role in coagulation...
  32. pmc A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction
    Martin L Moore
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Virol 83:4185-94. 2009
    ..We identified the F protein of RSV line 19 as a factor that plays a role in pulmonary mucin expression in the setting of RSV infection...
  33. pmc Imaging mass spectrometry of intact proteins from alcohol-preserved tissue specimens: bypassing formalin fixation
    Pierre Chaurand
    Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 8575, USA
    J Proteome Res 7:3543-55. 2008
    ..Using mouse organs, several key steps involved in the tissue dehydration process have been investigated to assess the potential of such preserved specimens for profiling and imaging mass spectrometry investigations...
  34. ncbi request reprint A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis
    Linda Connelly
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 282:10028-35. 2007
    ..These results show that increased p100/p52 disrupts normal ductal development and provides insight into the mechanism by which this may contribute to human breast cancer...
  35. ncbi request reprint Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation
    M Brett Everhart
    Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Leukoc Biol 77:173-80. 2005
    ..Optimizing this methodology provides an important tool for the study of specific genes and their contribution to alveolar macrophage function in vivo...