T Pincus

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis
    Cecilia P Chung
    Department of Medicine, Vanderbilt University School of Medicine, 1161 21st Ave, Nashville, TN 37232, USA
    Arthritis Res Ther 8:R186. 2006
  2. pmc Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Ann Rheum Dis 63:931-9. 2004
  3. ncbi request reprint Complexities in the quantitative assessment of patients with rheumatic diseases in clinical trials and clinical care
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 23:S1-9. 2005
  4. ncbi request reprint Patients seen for standard rheumatoid arthritis care have significantly better articular, radiographic, laboratory, and functional status in 2000 than in 1985
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 4500, USA
    Arthritis Rheum 52:1009-19. 2005
  5. ncbi request reprint Continuous indices of core data set measures in rheumatoid arthritis clinical trials: lower responses to placebo than seen with categorical responses with the American College of Rheumatology 20% criteria
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 4500, USA
    Arthritis Rheum 52:1031-6. 2005
  6. ncbi request reprint Further development of a physical function scale on a MDHAQ [corrected] for standard care of patients with rheumatic diseases
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Rheumatol 32:1432-9. 2005
  7. ncbi request reprint Uniform databases in early arthritis: specific measures to complement classification criteria and indices of clinical change
    T Pincus
    Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Clin Exp Rheumatol 21:S79-88. 2003
  8. ncbi request reprint Methotrexate as the "anchor drug" for the treatment of early rheumatoid arthritis
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 21:S179-85. 2003
  9. ncbi request reprint A proposed approach to recognise "near-remission" quantitatively without formal joint counts or laboratory tests: a patient self-report questionnaire routine assessment of patient index data (RAPID) score as a guide to a "continuous quality
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 24:S-60-5; quiz S-66-73. 2006
  10. ncbi request reprint Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip: face validity of self-report questionnaire ratings
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232, USA
    J Rheumatol 32:533-9. 2005

Detail Information

Publications108 found, 100 shown here

  1. pmc Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis
    Cecilia P Chung
    Department of Medicine, Vanderbilt University School of Medicine, 1161 21st Ave, Nashville, TN 37232, USA
    Arthritis Res Ther 8:R186. 2006
    ..15, 95% CI 1.02 to 1.29, P = 0.03). In conclusion, a higher Framingham risk score is independently associated with the presence of coronary calcification in patients with RA...
  2. pmc Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Ann Rheum Dis 63:931-9. 2004
    ..However, survey and clinical trial data indicate greater efficacy for non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 specific inhibitors...
  3. ncbi request reprint Complexities in the quantitative assessment of patients with rheumatic diseases in clinical trials and clinical care
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 23:S1-9. 2005
    ....
  4. ncbi request reprint Patients seen for standard rheumatoid arthritis care have significantly better articular, radiographic, laboratory, and functional status in 2000 than in 1985
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 4500, USA
    Arthritis Rheum 52:1009-19. 2005
    ..This study was undertaken to determine whether the clinical status of patients with rheumatoid arthritis (RA) has improved on average in recent years...
  5. ncbi request reprint Continuous indices of core data set measures in rheumatoid arthritis clinical trials: lower responses to placebo than seen with categorical responses with the American College of Rheumatology 20% criteria
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 4500, USA
    Arthritis Rheum 52:1031-6. 2005
    ....
  6. ncbi request reprint Further development of a physical function scale on a MDHAQ [corrected] for standard care of patients with rheumatic diseases
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Rheumatol 32:1432-9. 2005
    ..3-0.5 units lower than HAQ scores...
  7. ncbi request reprint Uniform databases in early arthritis: specific measures to complement classification criteria and indices of clinical change
    T Pincus
    Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Clin Exp Rheumatol 21:S79-88. 2003
    ..However, the availability of an infrastructure of standard data in all RA databases would enhance clinical research in early RA...
  8. ncbi request reprint Methotrexate as the "anchor drug" for the treatment of early rheumatoid arthritis
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 21:S179-85. 2003
    ..These data establish that methotrexate is the anchor drug and probably should be the first DMARD used in the majority of patients with RA at this time...
  9. ncbi request reprint A proposed approach to recognise "near-remission" quantitatively without formal joint counts or laboratory tests: a patient self-report questionnaire routine assessment of patient index data (RAPID) score as a guide to a "continuous quality
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 24:S-60-5; quiz S-66-73. 2006
    ....
  10. ncbi request reprint Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip: face validity of self-report questionnaire ratings
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232, USA
    J Rheumatol 32:533-9. 2005
    ..To analyze correlational validity of self-report responses regarding patient preference between 2 drugs at the conclusion of a crossover double-blind clinical trial in patients with osteoarthritis (OA) of the knee or hip...
  11. ncbi request reprint Will racial and ethnic disparities in health be resolved primarily outside of standard medical care?
    Theodore Pincus
    Division of Rheumatology Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4500, USA
    Ann Intern Med 141:224-5. 2004
  12. pmc Should contemporary rheumatoid arthritis clinical trials be more like standard patient care and vice versa?
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Ann Rheum Dis 63:ii32-ii39. 2004
    ....
  13. ncbi request reprint Development of a multi-dimensional health assessment questionnaire (MDHAQ) for the infrastructure of standard clinical care
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 23:S19-28. 2005
    ..The MDHAQ can be used in the infrastructure of rheumatology care to include quantitative data in standard care of all patients with all rheumatic diseases...
  14. pmc Declines in number of tender and swollen joints in patients with rheumatoid arthritis seen in standard care in 1985 versus 2001: possible considerations for revision of inclusion criteria for clinical trials
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA, and Jyväskylä Central Hospital, Finland
    Ann Rheum Dis 65:878-83. 2006
    ....
  15. ncbi request reprint Rheumatology function tests: quantitative physical measures to monitor morbidity and predict mortality in patients with rheumatic diseases
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 23:S85-9. 2005
    ..Physical measures of function also were significant predictors of mortality in two cohorts of patients with RA, one monitored between 1973 and 1988, and a second between 1985 and 1990...
  16. ncbi request reprint Saving time and improving care with a multidimensional health assessment questionnaire: 10 practical considerations
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4500, USA
    J Rheumatol 33:448-54. 2006
  17. ncbi request reprint Improving survival in inflammatory rheumatic diseases: a neglected goal?
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Curr Rheumatol Rep 8:401-3. 2006
  18. ncbi request reprint A 3-page standard protocol to evaluate rheumatoid arthritis (SPERA): efficient capture of essential data for clinical trials and observational studies
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 23:S114-9. 2005
    ....
  19. ncbi request reprint Evidence-based practice and practice-based evidence
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University Medical Center, School of Medicine, Nashville, TN 37232 4500, USA
    Nat Clin Pract Rheumatol 2:114-5. 2006
  20. pmc Most visits of most patients with rheumatoid arthritis to most rheumatologists do not include a formal quantitative joint count
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Ann Rheum Dis 65:820-2. 2006
    ..To ask rheumatologists about the likelihood of performing a formal joint count at each visit of a patient with rheumatoid arthritis (RA) in standard clinical care...
  21. ncbi request reprint The American College of Rheumatology (ACR) Core Data Set and derivative "patient only" indices to assess rheumatoid arthritis
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 23:S109-13. 2005
    ....
  22. ncbi request reprint A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University, Nashville, Tennessee 37232-4500, USA
    Arthritis Rheum 44:1587-98. 2001
    ..Acetaminophen was associated with fewer adverse events...
  23. ncbi request reprint An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in
    T Pincus
    Division of Rheumatology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Arthritis Rheum 48:625-30. 2003
    ....
  24. ncbi request reprint Databases of patients with early rheumatoid arthritis in the USA
    T Sokka
    Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Clin Exp Rheumatol 21:S146-53. 2003
    ..Further observation of recent cohorts of patients with early RA over the next decade should be informative regarding whether aggressive intervention strategies and new DMARDs and biologic agents lead to improved long-term outcomes...
  25. pmc Work disability in early rheumatoid arthritis: higher rates but better clinical status in Finland compared with the US
    C P Chung
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 4500, USA
    Ann Rheum Dis 65:1653-7. 2006
    ..To analyse and compare work disability attributed to rheumatoid arthritis in two cohorts of patients with early disease: one in the US and the other in Finland...
  26. ncbi request reprint Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Rheumatol 27:1020-7. 2000
    ..To analyze results of treatment of osteoarthritis (OA) with acetaminophen and the nonsteroidal antiinflammatory drugs (NSAID) through a patient survey...
  27. pmc Are American College of Rheumatology 50% response criteria superior to 20% criteria in distinguishing active aggressive treatment in rheumatoid arthritis clinical trials reported since 1997? A meta-analysis of discriminant capacities
    C P Chung
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232 4500, USA
    Ann Rheum Dis 65:1602-7. 2006
    ....
  28. ncbi request reprint Underestimation of the efficacy, effectiveness, tolerability, and safety of weekly low-dose methotrexate in information presented to physicians and patients
    T Pincus
    Department of Medicine, Division of Rheumatology, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Clin Exp Rheumatol 28:S68-79. 2010
    ....
  29. ncbi request reprint A proposed 30-45 minute 4 page standard protocol to evaluate rheumatoid arthritis (SPERA) that includes measures of inflammatory activity, joint damage, and longterm outcomes
    T Pincus
    Vanderbilt University School of Medicine, Department of Medicine, Nashville, TN 37232 4500, USA
    J Rheumatol 26:473-80. 1999
    ..The SPERA is feasible to acquire most known relevant measures of activity, damage, and outcomes in RA in 30-45 min in usual clinical settings, to provide a complete database for analyses of longterm outcomes...
  30. ncbi request reprint An Early Rheumatoid Arthritis Treatment Evaluation Registry (ERATER) in the United States
    T Sokka
    Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 23:S178-81. 2005
    ..This essay describes the background regarding the identification of the cohort, methods for data collection, and observations to date...
  31. ncbi request reprint Markers for work disability in rheumatoid arthritis
    T Sokka
    Jyvaskyla Central Hospital, Department of Medicine, Finland
    J Rheumatol 28:1718-22. 2001
    ..Improved work disability outcomes in RA will require attention to social, economic, and political issues, and wider physician and public education concerning RA, in addition to improved medical management of disease...
  32. ncbi request reprint A historical perspective concerning population-based and clinical studies of early arthritis and early rheumatoid arthritis
    T Sokka
    Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Exp Rheumatol 21:S5-14. 2003
    ..These studies and others described elsewhere in this supplement have contributed to the foundations for the clinical approach to early arthritis in the 21st century...
  33. ncbi request reprint Evidence from clinical trials and long-term observational studies that disease-modifying anti-rheumatic drugs slow radiographic progression in rheumatoid arthritis: updating a 1983 review
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University School of Medicine, 203 Oxford House, Nashville, TN 37232 4500, USA
    Rheumatology (Oxford) 41:1346-56. 2002
    ..Documentation of improved long-term outcomes requires long-term observational data over 5-20 yr to supplement data from randomized controlled clinical trials over 6-24 months...
  34. ncbi request reprint Relative versus absolute goals of therapies for RA: ACR 20 or ACR 50 responses versus target values for "near remission" of DAS or single measures
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4500, USA
    Clin Exp Rheumatol 22:S50-6. 2004
    ..These findings suggest that absolute targets, including remission, may be realistic contemporary goals, with aggressive treatment strategies and more effective DMARDs and biologic agents...
  35. ncbi request reprint Quantitative documentation of benefit/risk of new therapies for rheumatoid arthritis: patient questionnaires as an optimal measure in standard care
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4500, USA
    Clin Exp Rheumatol 22:S26-33. 2004
    ..We suggest that quantitative measurement may be incorporated into standard clinical care most easily and effectively by asking each patient to complete a simple 1-page questionnaire at each visit to a rheumatologist...
  36. ncbi request reprint Quantitative joint assessment in rheumatoid arthritis
    T Sokka
    Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 23:S58-62. 2005
    ..This article reviews selected methods for the performance of joint counts, with discussion of their advantages and limitations in the assessment of patients with rheumatoid arthritis...
  37. ncbi request reprint Complexities in defining remission in rheumatic diseases
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 24:S-1-6. 2006
    ..Thus, the subject of remission remains under active discussion in the rheumatology community...
  38. ncbi request reprint Clinical evidence for osteoarthritis as an inflammatory disease
    T Pincus
    Division of Rheumatology, Vanderbilt University Medical Center, 203 Oxford House, Box 5, Nashville, TN 37232-4500, USA
    Curr Rheumatol Rep 3:524-34. 2001
    ..A recent crossover clinical trial indicated significantly greater efficacy of the NSAID, diclofenac/misoprostol, versus acetaminophen for most patients with OA...
  39. ncbi request reprint How can the risk of long-term consequences of rheumatoid arthritis be reduced?
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Nashville, TN 37232, USA
    Best Pract Res Clin Rheumatol 15:139-70. 2001
    ..Patient self-report questionnaires appear to provide the least expensive and most effective measures toward this goal...
  40. ncbi request reprint Partial control of Core Data Set measures and Disease Activity Score (DAS) measures of inflammation does not prevent long-term joint damage: evidence from longitudinal observations over 5-20 years
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4500, USA
    Clin Exp Rheumatol 20:S42-7. 2002
    ....
  41. ncbi request reprint Quantitative target values of predictors of mortality in rheumatoid arthritis as possible goals for therapeutic interventions: an alternative approach to remission or ACR20 responses?
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 4500, USA
    J Rheumatol 28:1723-34. 2001
    ..Better control of quantitative markers that predict early mortality could provide a valuable approach to improving outcomes in RA...
  42. ncbi request reprint Educational program for physicians to reduce use of non-steroidal anti-inflammatory drugs among community-dwelling elderly persons: a randomized controlled trial
    W A Ray
    Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Med Care 39:425-35. 2001
    ..Because NSAIDs frequently cause serious gastrointestinal (GI) and other complications among elderly patients, expert guidelines for osteoarthritis recommend acetaminophen-based regimens, which are safer and often as effective as NSAIDs...
  43. ncbi request reprint Mortality in rheumatoid arthritis: 2008 update
    T Sokka
    Department of Medicine, Jyvaskyla Central Hospital, Jyvaskyla, Finland
    Clin Exp Rheumatol 26:S35-61. 2008
    ..Functional and global measures as well as comorbidities generally are the most significant predictors of premature death...
  44. ncbi request reprint Benefit/risk of therapies for rheumatoid arthritis: underestimation of the "side effects" or risks of RA leads to underestimation of the benefit/risk of therapies
    T Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4500, USA
    Clin Exp Rheumatol 22:S2-11. 2004
    ..It appears that the benefit/risk ratio of therapies for RA has increased substantially over the last two decades, and the outlook for patients with RA is much better at this time than in previous years...
  45. doi request reprint RAPID3, an index to assess and monitor patients with rheumatoid arthritis, without formal joint counts: similar results to DAS28 and CDAI in clinical trials and clinical care
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:773-8, viii. 2009
    ..In all rheumatic diseases RAPID3 is able to provide a baseline quantitative value, and to quantitatively monitor and document improvement or worsening over time...
  46. ncbi request reprint Contemporary disease modifying antirheumatic drugs (DMARD) in patients with recent onset rheumatoid arthritis in a US private practice: methotrexate as the anchor drug in 90% and new DMARD in 30% of patients
    Tuulikki Sokka
    Vanderbilt University, Nashville, Tennessee 37232, USA
    J Rheumatol 29:2521-4. 2002
    ....
  47. ncbi request reprint An index of patient reported outcomes (PRO-Index) discriminates effectively between active and control treatment in 4 clinical trials of adalimumab in rheumatoid arthritis
    Theodore Pincus
    Vanderbilt University Medical Center, 203 Oxford House, Nashville, TN 37232, USA
    J Rheumatol 33:2146-52. 2006
    ....
  48. doi request reprint Remission and rheumatoid arthritis: data on patients receiving usual care in twenty-four countries
    Tuulikki Sokka
    Jyvaskyla Central Hospital, Jyvaskyla, Finland, and Medcare Oy, Aänekoski, Finland
    Arthritis Rheum 58:2642-51. 2008
    ..To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA)...
  49. ncbi request reprint Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors
    Cecilia P Chung
    Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Arthritis Rheum 52:3045-53. 2005
    ..To compare the prevalence and severity of coronary-artery atherosclerosis in patients with early and established rheumatoid arthritis (RA) and controls...
  50. ncbi request reprint Most patients receiving routine care for rheumatoid arthritis in 2001 did not meet inclusion criteria for most recent clinical trials or american college of rheumatology criteria for remission
    Tuulikki Sokka
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Rheumatol 30:1138-46. 2003
    ....
  51. ncbi request reprint Pain, function, and RAPID scores: vital signs in chronic diseases, analogous to pulse and temperature in acute diseases and blood pressure and cholesterol in long-term health
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, NYU Medical Center, New York, NY, USA
    Bull NYU Hosp Jt Dis 66:155-65. 2008
    ....
  52. ncbi request reprint Increased augmentation index in rheumatoid arthritis and its relationship to coronary artery atherosclerosis
    Ingrid Avalos
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2681, USA
    J Rheumatol 34:2388-94. 2007
    ..We examined the hypothesis that augmentation index and pulse wave velocity are increased in RA, and are related to coronary artery atherosclerosis...
  53. ncbi request reprint A practical guide to scoring a Multi-Dimensional Health Assessment Questionnaire (MDHAQ) and Routine Assessment of Patient Index Data (RAPID) scores in 10-20 seconds for use in standard clinical care, without rulers, calculators, websites or computers
    Theodore Pincus
    NYU Hospital for Joint Diseases, 301 East 17 Street, New York, NY 10003, USA
    Best Pract Res Clin Rheumatol 21:755-87. 2007
    ..This chapter provides a brief tutorial designed to instruct rheumatologists and their staffs regarding how to use and score the MDHAQ and RAPID in standard clinical care...
  54. ncbi request reprint Quantitative measures and indices to assess rheumatoid arthritis in clinical trials and clinical care
    Theodore Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Rheum Dis Clin North Am 30:725-51, vi. 2004
    ..Therefore, the measures have been combined into pooled indices that can be applied to individual patients in clinical research and clinical care...
  55. ncbi request reprint Clinical trials in rheumatic diseases: designs and limitations
    Theodore Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Rheum Dis Clin North Am 30:701-24, v-vi. 2004
    ..Therefore, long-term databases are needed to supplement clinical trials in analyzing results of therapy for rheumatoid arthritis...
  56. ncbi request reprint Are patient questionnaire scores as "scientific" as laboratory tests for rheumatology clinical care?
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, NYU Langone Medical Center, New York, New York 10003, USA
    Bull NYU Hosp Jt Dis 68:130-9. 2010
    ..Advances in therapy require laboratory science, but patient questionnaires provide optimal "scientific" data for clinical care...
  57. ncbi request reprint How useful are combinations of blood tests in "rheumatic panels" in diagnosis of rheumatic diseases?
    M J Lichtenstein
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    J Gen Intern Med 3:435-42. 1988
    ..A careful history and physical examination along with serial ordering of a few selected tests appear optimal to establish a clinical diagnosis of a rheumatic disease...
  58. ncbi request reprint Quantitative measures to assess patients with rheumatic diseases: 2006 update
    Theodore Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Rheum Dis Clin North Am 32:29-36. 2006
  59. ncbi request reprint Advantages and limitations of quantitative measures to assess rheumatoid arthritis: joint counts, radiographs, laboratory tests, and patient questionnaires
    Theodore Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4500, USA
    Bull NYU Hosp Jt Dis 64:32-9. 2006
    ..A multidimensional health assessment questionnaire is useful in all rheumatic diseases, with scoring templates and medical history information to save time for the rheumatologist and patient in standard care...
  60. doi request reprint The HAQ compared with the MDHAQ: "keep it simple, stupid" (KISS), with feasibility and clinical value as primary criteria for patient questionnaires in usual clinical care
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:787-98, ix. 2009
    ..Both the HAQ and MDHAQ involve 2 sides of one sheet of paper, and are completed by patients in 5 to 10 minutes. The HAQ requires 42 seconds to score, compared with 5 to 10 seconds for RAPID3 on the MDHAQ...
  61. ncbi request reprint Patient questionnaires and formal education level as prospective predictors of mortality over 10 years in 97% of 1416 patients with rheumatoid arthritis from 15 United States private practices
    Theodore Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 4500, USA
    J Rheumatol 31:229-34. 2004
    ....
  62. ncbi request reprint Quantitative measures for assessing rheumatoid arthritis in clinical trials and clinical care
    Theodore Pincus
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, 203 Oxford House, Box 5, Nashville, TN 37232 4500, USA
    Best Pract Res Clin Rheumatol 17:753-81. 2003
    ..The most simple and effective method of collecting important long-term data from patients in routine clinical care is through patient self-report questionnaires...
  63. pmc Lipoprotein subclasses determined by nuclear magnetic resonance spectroscopy and coronary atherosclerosis in patients with rheumatoid arthritis
    Cecilia P Chung
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    J Rheumatol 37:1633-8. 2010
    ....
  64. ncbi request reprint Eosinophilia-myalgia syndrome: patient status 2-4 years after onset
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Rheumatol Suppl 46:19-24; discussion 24-5. 1996
    ....
  65. pmc Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis
    Young Hee Rho
    Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    Arthritis Rheum 60:1906-14. 2009
    ..The purpose of this study was to examine the hypothesis that adipocytokines modulate inflammation and radiographic joint damage in patients with RA...
  66. pmc Inflammation-associated insulin resistance: differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms
    Cecilia P Chung
    Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Arthritis Rheum 58:2105-12. 2008
    ....
  67. pmc Amino-terminal fragment of the prohormone brain-type natriuretic peptide in rheumatoid arthritis
    Joseph Solus
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    Arthritis Rheum 58:2662-9. 2008
    ..This study was undertaken to test the hypothesis that NT-proBNP concentrations are elevated in patients with RA and are associated with coronary artery calcification and markers of inflammation...
  68. doi request reprint A Standard Protocol to Evaluate Rheumatoid Arthritis (SPERA) for efficient capture of essential data from a patient and a health professional in a uniform "scientific" format
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, Room 1608, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:843-50, xi. 2009
    ..The SPERA is presented as an example of a possible approach to develop a uniform common format for collecting core data in usual clinical care...
  69. ncbi request reprint A multidimensional health assessment questionnaire (MDHAQ) for all patients with rheumatic diseases to complete at all visits in standard clinical care
    Theodore Pincus
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Bull NYU Hosp Jt Dis 65:150-60. 2007
    ..The MDHAQ is useful in all rheumatic diseases by saving time, documenting changes in status over long periods, and by improving rheumatology care and outcomes...
  70. doi request reprint Radiographic measures to assess patients with rheumatoid arthritis: advantages and limitations
    Yusuf Yazici
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and New York University Hospital for Joint Diseases, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:723-9, vi. 2009
    ..Whereas prevention of radiographic progression is certainly desirable, it appears that prevention of functional disability is far more important for successful patient outcomes...
  71. doi request reprint A biopsychosocial model to complement a biomedical model: patient questionnaire data and socioeconomic status usually are more significant than laboratory tests and imaging studies in prognosis of rheumatoid arthritis
    Lauren McCollum
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, 301 East 17th Street, Room 1608, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:699-712, v. 2009
    ..Socioeconomic status may be regarded as a surrogate for the importance of patient actions, in addition to actions of health professionals, in the course and outcomes of rheumatic and other chronic diseases...
  72. ncbi request reprint Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis
    Cecilia P Chung
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Atherosclerosis 196:756-63. 2008
    ..In conclusion, patients with RA have a higher prevalence of the metabolic syndrome than control subjects. Inflammation-associated metabolic syndrome is a mechanism that may contribute to increased coronary-artery atherosclerosis in RA...
  73. doi request reprint How to collect an MDHAQ to provide rheumatology vital signs (function, pain, global status, and RAPID3 scores) in the infrastructure of rheumatology care, including some misconceptions regarding the MDHAQ
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York University School of Medicine, New York, NY, USA
    Rheum Dis Clin North Am 35:799-812, x. 2009
    ..Patient questionnaires designed for usual clinical care, such as the MDHAQ, save time and improve the quality and documentation of the visit for the patient and the physician...
  74. doi request reprint A multi-dimensional health assessment questionnaire (MDHAQ) and routine assessment of patient index data (RAPID3) scores are informative in patients with all rheumatic diseases
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:819-27, x. 2009
    ..The MDHAQ is useful in rheumatic diseases, to improve management documentation and outcomes. MDHAQ data for physical function, pain, global status, and RAPID3 scores appear preferable to no quantitative data...
  75. doi request reprint Patient questionnaires in rheumatoid arthritis: advantages and limitations as a quantitative, standardized scientific medical history
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:735-43, vii. 2009
    ..Patient questionnaires are useful to monitor patient status in usual clinical care, with almost no effort on the part of the physician and staff if distributed by the receptionist in the infrastructure of office practice...
  76. doi request reprint Complexities in assessment of rheumatoid arthritis: absence of a single gold standard measure
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, 301 East 17th Street, Room 1608, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:687-97, v. 2009
    ..Further elucidation of these differences may be informative in efforts to advance quantitative scientific patient assessment and management in rheumatic diseases, with improved patient outcomes...
  77. doi request reprint Quality control of a medical history: improving accuracy with patient participation, supported by a four-page version of the multidimensional health assessment questionnaire (MDHAQ)
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:851-60, xi. 2009
    ..This procedure engenders a more accurate patient history with no effort on the part of the physician, saving time for the physician and improving the quality of the medical record...
  78. ncbi request reprint Limitations of randomized clinical trials in chronic diseases: explanations and recommendations
    Theodore Pincus
    Division of Rheumatology and Immunology at Vanderbilt University Medical Center, Nashville, Tenn, USA
    Adv Mind Body Med 18:14-21. 2002
  79. doi request reprint Laboratory tests to assess patients with rheumatoid arthritis: advantages and limitations
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:731-4, vi-vii. 2009
    ..Physicians and patients would benefit from an improved understanding of the limitations of laboratory tests in diagnosis and management of patients with RA...
  80. doi request reprint Quantitative recording of physician clinical estimates, beyond a global estimate and formal joint count, in usual care: applying the scientific method, using a simple one-page worksheet
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, 301 East 17th Street, Room 1608, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:813-7, x. 2009
    ..All changes in medications are recorded. A template is available for a formal 42 joint count. The worksheet requires fewer than 15 seconds and has proven of considerable value in clinical care...
  81. ncbi request reprint Are excellent systematic reviews of clinical trials useful for patient care?
    Theodore Pincus
    Department of Medicine, Division of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA
    Nat Clin Pract Rheumatol 4:294-5. 2008
  82. doi request reprint Clues on the MDHAQ to identify patients with fibromyalgia and similar chronic pain conditions
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:865-9, xii. 2009
    ..Data from the MDHAQ provide clues to the presence of fibromyalgia/chronic pain conditions, including patients with inflammatory diseases who also have concomitant fibromyalgia/chronic pain conditions...
  83. doi request reprint Criterion contamination of depression scales in patients with rheumatoid arthritis: the need for interpretation of patient questionnaires (as all clinical measures) in the context of all information about the patient
    Theodore Pincus
    Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, Room 1608, New York, NY 10003, USA
    Rheum Dis Clin North Am 35:861-4, xi-xii. 2009
    ..The BDI was revised in 1996, as the Beck Depression Inventory-II (BDI-II), to eliminate the items reflecting somatic disease...
  84. pmc Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
    Young Hee Rho
    Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    Arthritis Rheum 61:1580-5. 2009
    ....
  85. ncbi request reprint The assessment of rheumatoid arthritis and the acceptability of self-report questionnaires in clinical practice
    Frederick Wolfe
    National Data Bank for Rheumatic Diseases, University of Kansas School of Medicine, Wichita, Kansas, USA
    Arthritis Rheum 49:59-63. 2003
    ..To assess the acceptability of self-report questionnaires (SRQ) in clinical practice and to understand the value that rheumatologists give to various assessment methods in rheumatoid arthritis...
  86. ncbi request reprint Time to score quantitative rheumatoid arthritis measures: 28-Joint Count, Disease Activity Score, Health Assessment Questionnaire (HAQ), Multidimensional HAQ (MDHAQ), and Routine Assessment of Patient Index Data (RAPID) scores
    Yusuf Yazici
    New York University Hospital for Joint Diseases, New York, New York 10003, USA
    J Rheumatol 35:603-9. 2008
    ..The measures studied were a 28-Joint Count, Disease Activity Score (DAS), Health Assessment Questionnaire (HAQ), Multidimensional HAQ (MDHAQ), and various Routine Assessment of Patient Index Data (RAPID) scores derived from the MDHAQ...
  87. ncbi request reprint Preliminary evaluation of a visual analog function scale for use in rheumatoid arthritis
    Frederick Wolfe
    Arthritis Research Center Foundation, University of Kansas School of Medicine, Wichita, KS 67214, USA
    J Rheumatol 32:1261-6. 2005
    ....
  88. ncbi request reprint Urgent care and tight control of rheumatoid arthritis as in diabetes and hypertension: better treatments but a shortage of rheumatologists
    Theodore Pincus
    Arthritis Rheum 46:851-4. 2002
  89. pmc Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study
    Antonio Naranjo
    Hospital de Gran Canaria Dr, Negrin, University of Las Palmas de Gran Canaria, Barranco de la Ballena s n 35011, Spain
    Arthritis Res Ther 10:R30. 2008
    ....
  90. ncbi request reprint Morning stiffness in patients with early rheumatoid arthritis is associated more strongly with functional disability than with joint swelling and erythrocyte sedimentation rate
    Yusuf Yazici
    Brooklyn Heights Arthritis Associates, Long Island College Hospital, Brooklyn, New York, USA
    J Rheumatol 31:1723-6. 2004
    ..To compare the level of morning stiffness in a cohort of patients with early rheumatoid arthritis (RA), assessed on a self-report questionnaire, to levels of patient self-report scores and clinical and laboratory variables...
  91. ncbi request reprint Why are only 50% of courses of anti-tumor necrosis factor agents continued for only 2 years in some settings? Need for longterm observations in standard care to complement clinical trials
    Theodore Pincus
    J Rheumatol 33:2372-5. 2006
  92. ncbi request reprint Development and validation of the health assessment questionnaire II: a revised version of the health assessment questionnaire
    Frederick Wolfe
    Arthritis Research Center Foundation, Wichita, Kansas, USA
    Arthritis Rheum 50:3296-305. 2004
    ..We undertook this study to develop and validate a revised version of the HAQ (the HAQ-II)...
  93. ncbi request reprint Patient questionnaires for clinical research and improved standard patient care: is it better to have 80% of the information in 100% of patients or 100% of the information in 5% of patients?
    Theodore Pincus
    J Rheumatol 32:575-7. 2005
  94. ncbi request reprint The disease activity score is not suitable as the sole criterion for initiation and evaluation of anti-tumor necrosis factor therapy in the clinic: discordance between assessment measures and limitations in questionnaire use for regulatory purposes
    Frederick Wolfe
    National Data Bank for Rheumatic Diseases, Wichita, Kansas 67214, USA
    Arthritis Rheum 52:3873-9. 2005
    ....
  95. ncbi request reprint Changes in Health Assessment Questionnaire disability scores over five years in patients with rheumatoid arthritis compared with the general population
    Tuulikki Sokka
    Jyvaskyla Central Hospital, Jyvaskyla, Finland
    Arthritis Rheum 54:3113-8. 2006
    ..To analyze longitudinal data over 5 years for changes in Health Assessment Questionnaire (HAQ) scores in patients with rheumatoid arthritis (RA) and age- and sex-matched controls from the general population...
  96. ncbi request reprint Radiographic benefit without clinical improvement in infliximab-treated patients with rheumatoid arthritis: comment on the article by Smolen et al
    Theodore Pincus
    Arthritis Rheum 52:4044-5; author reply 4045-7. 2005
  97. ncbi request reprint A composite disease activity scale for clinical practice, observational studies, and clinical trials: the patient activity scale (PAS/PAS-II)
    Frederick Wolfe
    National Data Bank for Rheumatic Diseases, University of Kansas School of Medicine, Wichita, Kansas 67214, USA
    J Rheumatol 32:2410-5. 2005
    ..To develop and validate a composite patient self-report disease activity scale for use in clinical practice and in observational studies and clinical trials...
  98. ncbi request reprint Shouldn't standard rheumatology clinical care be evidence-based rather than eminence-based, eloquence-based, or elegance-based?
    Theodore Pincus
    J Rheumatol 34:1-4. 2007
  99. ncbi request reprint N-of-1 trial of low-dose methotrexate and/or prednisolone in lieu of anti-CCP, MRI, or ultrasound, as first option in suspected rheumatoid arthritis?
    Theodore Pincus
    J Rheumatol 34:250-2. 2007
  100. ncbi request reprint Guidelines for monitoring of methotrexate therapy: "evidence-based medicine" outside of clinical trials
    Theodore Pincus
    Arthritis Rheum 48:2706-9. 2003
  101. ncbi request reprint Relative efficiencies of physician/assessor global estimates and patient questionnaire measures are similar to or greater than joint counts to distinguish adalimumab from control treatments in rheumatoid arthritis clinical trials
    Theodore Pincus
    New York University Hospital for Joint Diseases, New York, New York 10003, USA
    J Rheumatol 35:201-5. 2008
    ..To estimate relative efficiencies of the 7 rheumatoid arthritis (RA) Core Data Set measures to distinguish adalimumab from control treatments in 4 clinical trials...