John Penn

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Vascular endothelial growth factor in eye disease
    J S Penn
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Prog Retin Eye Res 27:331-71. 2008
  2. ncbi request reprint Angiostatic effect of penetrating ocular injury: role of pigment epithelium-derived factor
    John S Penn
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8808, USA
    Invest Ophthalmol Vis Sci 47:405-14. 2006
  3. ncbi request reprint Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurity
    John S Penn
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, 2115 21st Avenue South, 8016 Medical Center East, Nashville, TN 37232 8808, USA
    Invest Ophthalmol Vis Sci 44:5423-9. 2003
  4. ncbi request reprint Inhibition of retinal neovascularization by soluble EphA2 receptor
    Jin Chen
    Department of Medicine, Division of Rheumatology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Exp Eye Res 82:664-73. 2006
  5. ncbi request reprint Arterial oxygen fluctuation and retinopathy of prematurity in very-low-birth-weight infants
    Jackie R York
    Department of Neonatology, Vanderbilt University, Nashville, TN 37232, USA
    J Perinatol 24:82-7. 2004
  6. ncbi request reprint High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 48:4733-40. 2007
  7. pmc Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR
    Joshua M Barnett
    Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 48:907-15. 2007
  8. ncbi request reprint Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization
    Xiang Q Werdich
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 8000 Medical Center East, Nashville, TN 37232, USA
    Invest Ophthalmol Vis Sci 47:5047-56. 2006
  9. pmc Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina
    Andrei A Kramerov
    Ophthalmology Research Laboratories, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90048, USA
    Am J Pathol 168:1722-36. 2006
  10. ncbi request reprint Animal models of oxygen-induced retinopathy
    Ashima Madan
    Stanford University School of Medicine, S 228 Grant Building, 300 Pasteur Dr, Stanford, CA 94305 5208, USA
    Front Biosci 8:d1030-43. 2003

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc Vascular endothelial growth factor in eye disease
    J S Penn
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Prog Retin Eye Res 27:331-71. 2008
    ..The potential disadvantages of inhibiting VEGF will be discussed, as will the rationales for targeting other VEGF-related modulators of angiogenesis...
  2. ncbi request reprint Angiostatic effect of penetrating ocular injury: role of pigment epithelium-derived factor
    John S Penn
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8808, USA
    Invest Ophthalmol Vis Sci 47:405-14. 2006
    ..To characterize the angiostatic effect of penetrating ocular injury and to begin to explore its mechanism, with an emphasis on the role of pigment epithelium-derived factor (PEDF)...
  3. ncbi request reprint Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurity
    John S Penn
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, 2115 21st Avenue South, 8016 Medical Center East, Nashville, TN 37232 8808, USA
    Invest Ophthalmol Vis Sci 44:5423-9. 2003
    ..This experiment was designed to test the effect of administration of exogenous PAI-1 on retinal neovascularization (NV) in an animal model of retinopathy of prematurity (ROP)...
  4. ncbi request reprint Inhibition of retinal neovascularization by soluble EphA2 receptor
    Jin Chen
    Department of Medicine, Division of Rheumatology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Exp Eye Res 82:664-73. 2006
    ..Because soluble Eph receptor significantly inhibited pathologic retinal angiogenesis without affecting normal intraretinal vessels, it may be a promising agent for treatment of retinal angiogenesis in a number of human ocular diseases...
  5. ncbi request reprint Arterial oxygen fluctuation and retinopathy of prematurity in very-low-birth-weight infants
    Jackie R York
    Department of Neonatology, Vanderbilt University, Nashville, TN 37232, USA
    J Perinatol 24:82-7. 2004
    ..To determine the influence of arterial oxygen fluctuation on development of threshold ROP...
  6. ncbi request reprint High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 48:4733-40. 2007
    ..To test the hypothesis that in experimental retinopathy of prematurity (ROP), retinal neovascularization (NV) and vessel tortuosity have distinct spatial and temporal links with receptor and postreceptor ion demand...
  7. pmc Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR
    Joshua M Barnett
    Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 48:907-15. 2007
    ..The susceptibilities of MMP-2(-/-) and -9(-/-) mice to preretinal neovascularization were investigated in a mouse model of oxygen-induced retinopathy...
  8. ncbi request reprint Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization
    Xiang Q Werdich
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 8000 Medical Center East, Nashville, TN 37232, USA
    Invest Ophthalmol Vis Sci 47:5047-56. 2006
    ..The purpose of this study was to characterize the roles of SFKs in vascular endothelial growth factor (VEGF)-mediated retinal angiogenesis...
  9. pmc Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina
    Andrei A Kramerov
    Ophthalmology Research Laboratories, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90048, USA
    Am J Pathol 168:1722-36. 2006
    ..Based on its retinal localization, CK2 may be considered a new immunohistochemical astrocytic marker, and combination of CK2 inhibitors and octreotide may be a promising future treatment for proliferative retinopathies...
  10. ncbi request reprint Animal models of oxygen-induced retinopathy
    Ashima Madan
    Stanford University School of Medicine, S 228 Grant Building, 300 Pasteur Dr, Stanford, CA 94305 5208, USA
    Front Biosci 8:d1030-43. 2003
    ....
  11. ncbi request reprint Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygen-induced retinopathy
    Xiang Q Werdich
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, 8016 Medical Center East, 2115 21st Avenue South, Nashville, TN 37232 8808, USA
    Exp Eye Res 79:623-30. 2004
    ..If a similar threshold exists for humans, it could explain why some oxygen-treated premature infants develop retinopathy and others do not, despite similar gestational ages, birth weights and clinical courses...
  12. ncbi request reprint Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity
    Gary W McCollum
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, 8016 Medical Center East, Nashville, TN 37232 8808, USA
    Exp Eye Res 78:987-95. 2004
    ..Reduction of angiogenesis by the inhibition of tyrosine kinase activity may be a viable route to the development of effective chemotherapies applicable to eye disease...
  13. ncbi request reprint Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis
    Lawrence E Bullard
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 44:1722-31. 2003
    ..This study was undertaken to begin to define the precise role of MAP kinases in VEGF signal transduction related to angiogenesis...
  14. ncbi request reprint Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California)
    Gerard A Lutty
    Wilmer Ophthalmological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Mol Vis 12:532-80. 2006
    ..The meeting also suggested promising potential therapeutic interventions on the horizon for ROP...
  15. ncbi request reprint Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function
    Robert E Anderson
    Department of Cell Biology, University of Oklahoma Health Sciences Center, and Dean A McGee Eye Institute, Oklahoma City, OK, USA
    Lipids 39:1121-4. 2004
    ....
  16. ncbi request reprint 15(S)-HETE production in human retinal microvascular endothelial cells by hypoxia: Novel role for MEK1 in 15(S)-HETE induced angiogenesis
    Arun K Bajpai
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Invest Ophthalmol Vis Sci 48:4930-8. 2007
    ..To examine for the expression of 15-lipoxygenase 1 (15-LOX1) and 15-LOX2 in human retinal microvascular endothelial cells (HRMVECs) and study the role of arachidonic acid metabolites of these enzymes in angiogenesis...

Research Grants15

  1. Molecular Basis of Retinal Angiogenesis
    John Penn; Fiscal Year: 2009
    ..In each case, we will follow classic loss-of-function/gain-of-function experimental strategies. ..
  2. Molecular Basis of Retinal Angiogenesis
    John Penn; Fiscal Year: 2007
    ..In each case, we will follow classic loss-of-function/gain-of-function experimental strategies. ..
  3. Symposium on Retinal/ Choroidal Angiogenesis
    John Penn; Fiscal Year: 2004
    ..J. Donald M. Gass, M.D. has agreed to write an introduction. In this application we request funds to support travel and registration costs of 20 young investigators and 2 keynote speakers. ..
  4. Retinopathy of prematurity: Understand its pathogenesis
    John Penn; Fiscal Year: 2004
    ..abstract_text> ..
  5. RETINOPATHY OF PREMATURITY--UNDERSTAND ITS PATHOGENESIS
    John Penn; Fiscal Year: 2000
    ....
  6. Molecular Basis of Retinal Angiogenesis
    John S Penn; Fiscal Year: 2010
    ..Our final aim will be to determine the therapeutic efficacy of PPAR- /d -specific antagonism in relevant animal models of retinal vascular disease. ..