Richard Peek

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1
    Jennifer M Noto
    Jr, 2215 Garland Ave, Medical Research Bldg IV 1030C, Nashville, TN 37232
    Am J Physiol Gastrointest Liver Physiol 305:G786-96. 2013
  2. pmc Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties
    Ramakrishnan Sitaraman
    Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Microbiol 50:1014-8. 2012
  3. pmc "Targeted disruption of the epithelial-barrier by Helicobacter pylori"
    Lydia E Wroblewski
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cell Commun Signal 9:29. 2011
  4. pmc Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    BMC Genomics 10:3. 2009
  5. ncbi request reprint Orchestration of aberrant epithelial signaling by Helicobacter pylori CagA
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Sci STKE 2005:pe14. 2005
  6. ncbi request reprint Pathogenesis of Helicobacter pylori infection
    Richard M Peek
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Springer Semin Immunopathol 27:197-215. 2005
  7. ncbi request reprint Events at the host-microbial interface of the gastrointestinal tract IV. The pathogenesis of Helicobacter pylori persistence
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, and Department of Veterans Affairs Medical Center, Nashville, TN 37232 2279, USA
    Am J Physiol Gastrointest Liver Physiol 289:G8-12. 2005
  8. ncbi request reprint Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Cancer Res 65:8583-6. 2005
  9. ncbi request reprint Helicobacter infection and gastric neoplasia
    Richard M Peek
    Division of Gastroenterology, Department of Medicine and Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Pathol 208:233-48. 2006
  10. ncbi request reprint Coming unglued
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Clin Cancer Res 12:2951-4. 2006

Detail Information

Publications77

  1. pmc Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1
    Jennifer M Noto
    Jr, 2215 Garland Ave, Medical Research Bldg IV 1030C, Nashville, TN 37232
    Am J Physiol Gastrointest Liver Physiol 305:G786-96. 2013
    ..Collectively, these results indicate that H. pylori suppresses miR-320, upregulates Mcl-1, and decreases apoptosis in a cagA-dependent manner, which likely confers an increased risk for gastric carcinogenesis...
  2. pmc Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties
    Ramakrishnan Sitaraman
    Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Microbiol 50:1014-8. 2012
    ..Inactivation of PldD inhibited activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), indicating that H. pylori hemolytic phospholipases also harbor MAPK-activating properties...
  3. pmc "Targeted disruption of the epithelial-barrier by Helicobacter pylori"
    Lydia E Wroblewski
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cell Commun Signal 9:29. 2011
    ..In this review, we summarize recent research into the mechanisms through which H. pylori disrupts intercellular junctions and disrupts the gastric epithelial barrier...
  4. pmc Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    BMC Genomics 10:3. 2009
    ..In this study, we analyzed the genome sequences of an H. pylori strain (98-10) isolated from a patient with gastric cancer and an H. pylori strain (B128) isolated from a patient with gastric ulcer disease...
  5. ncbi request reprint Orchestration of aberrant epithelial signaling by Helicobacter pylori CagA
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Sci STKE 2005:pe14. 2005
    ..These data implicate the cag island as a key mediator of pathogenic epithelial responses that may heighten the risk for gastric cancer...
  6. ncbi request reprint Pathogenesis of Helicobacter pylori infection
    Richard M Peek
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Springer Semin Immunopathol 27:197-215. 2005
    ..pylori-host interactions will not only improve targeted diagnostic and therapeutic modalities, but may also provide insights into other diseases that arise within the context of pathogen-initiated inflammatory states...
  7. ncbi request reprint Events at the host-microbial interface of the gastrointestinal tract IV. The pathogenesis of Helicobacter pylori persistence
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, and Department of Veterans Affairs Medical Center, Nashville, TN 37232 2279, USA
    Am J Physiol Gastrointest Liver Physiol 289:G8-12. 2005
    ....
  8. ncbi request reprint Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Cancer Res 65:8583-6. 2005
    ....
  9. ncbi request reprint Helicobacter infection and gastric neoplasia
    Richard M Peek
    Division of Gastroenterology, Department of Medicine and Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Pathol 208:233-48. 2006
    ....
  10. ncbi request reprint Coming unglued
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Clin Cancer Res 12:2951-4. 2006
  11. pmc Helicobacter pylori infection and disease: from humans to animal models
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Dis Model Mech 1:50-5. 2008
    ..Animal models have provided an invaluable resource with which to study H. pylori pathogenesis and carcinogenesis, and have permitted the development of a focused approach to selectively target human populations at high-risk of disease...
  12. pmc Role of innate immunity in Helicobacter pylori-induced gastric malignancy
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232 2279, USA
    Physiol Rev 90:831-58. 2010
    ..pylori-infected individuals who can then be targeted for therapeutic intervention...
  13. pmc Prevention of Gastric Cancer: When is Treatment of Helicobacter Pylori Warranted?
    Richard M Peek
    Division of Gastroenterology Departments of Medicine and Cancer Biology Vanderbilt University School of Medicine Nashville, TN, USA 37232 Department of Veterans Affairs Medical Center Nashville, TN, USA 37212
    Therap Adv Gastroenterol 1:19-31. 2008
    ....
  14. ncbi request reprint Prevention of colorectal cancer through the use of COX-2 selective inhibitors
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, 1161 21st Avenue South, C 2104 Medical Center North, Nashville, TN 37232 2279, USA
    Cancer Chemother Pharmacol 54:S50-6. 2004
    ..These findings indicate that a widely used and relatively safe class of drugs may represent a viable and effective anticancer strategy for a disease that causes over a half-million deaths per year...
  15. pmc Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, TN 37232 2279, USA
    Cancer Res 68:379-87. 2008
    ..In addition to defining factors that mediate H. pylori-induced cancer, these results provide insight into mechanisms that may regulate the development of other malignancies arising within the context of inflammatory states...
  16. pmc Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia
    Ki Taek Nam
    Nashville Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232 0443, USA
    Gastroenterology 136:1288-96. 2009
    ..We previously determined that loss of amphiregulin (AR) promotes SPEM induced by acute oxyntic atrophy. We have now examined whether SPEM in the AR-/- mouse predisposes the stomach to gastric neoplasia...
  17. pmc Effect of Helicobacter pylori eradication on gastric carcinogenesis
    Judith Romero-Gallo
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Lab Invest 88:328-36. 2008
    ..The effectiveness of eradication is dependent upon the timing of intervention, providing insights into mechanisms that may regulate the development of malignancies arising within the context of inflammatory states...
  18. pmc Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family
    Jinxiong Wei
    Department of Surgery, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Gastroenterology 134:1412-23. 2008
    ..Accumulating evidence suggests that both p73 and p63 play important roles in regulation of apoptosis, cell differentiation, and therapeutic drug sensitivity...
  19. ncbi request reprint The role of persistence in Helicobacter pylori pathogenesis
    Dawn A Israel
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0252, USA
    Curr Opin Gastroenterol 22:3-7. 2006
    ..The aim of this article is to provide an overview of recent advances into mechanisms of H. pylori persistence and to incorporate these findings into our current understanding of H. pylori pathogenesis...
  20. pmc Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells
    Jinxiong Wei
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 139:1333-43. 2010
    ..These bacteria colonize a significant part of the world's population. We investigated the molecular mechanisms of p53 regulation in H pylori-infected cells...
  21. ncbi request reprint Helicobacter pylori strain-specific modulation of gastric mucosal cellular turnover: implications for carcinogenesis
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    J Gastroenterol 37:10-6. 2002
    ..The combination of increased proliferation without a concordant increase in apoptosis may therefore contribute to the heightened retention of mutagenized cells, which over decades may increase the subsequent risk for gastric cancer...
  22. pmc Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice
    Seth R Ogden
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 2279, USA
    Cancer Res 70:30-5. 2010
    ..Collectively, these studies indicate that H. pylori-mediated induction of MMP-7 may serve to protect the gastric mucosa from pathophysiologic processes that promote carcinogenesis...
  23. pmc Activation of beta-catenin by carcinogenic Helicobacter pylori
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 102:10646-51. 2005
    ..cag- strains or uninfected persons. These results indicate that H. pylori-induced dysregulation of beta-catenin-dependent pathways may explain in part the augmentation in the risk of gastric cancer conferred by this pathogen...
  24. pmc Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center Nashville, TN, USA
    Gut Microbes 3:48-56. 2012
    ..Inhibition of polyamine synthesis or SMO could abrogate the development of this cell population that may represent precursors for neoplastic transformation...
  25. pmc Eosinophils and mast cells in chronic gastritis: possible implications in carcinogenesis
    M Blanca Piazuelo
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hum Pathol 39:1360-9. 2008
    ..In contrast, in the high-risk area, eosinophils might promote a T helper 1-type response leading to progression of precancerous lesions...
  26. ncbi request reprint Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis
    M Constanza Camargo
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, 2215 Garland Avenue, 1005 MRB IV, Nashville, TN 37232 0252, USA
    Cancer Epidemiol Biomarkers Prev 15:1674-87. 2006
    ..Polymorphisms of interleukin-1B (IL1B) and its receptor antagonist (IL1RN) genes have been inconsistently associated with gastric cancer risk. We examined these associations by performing meta-analyses...
  27. pmc Local and systemic immune and inflammatory responses to Helicobacter pylori strains
    Niranjan Bhat
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Diagn Lab Immunol 12:1393-400. 2005
    ..Furthermore, given the relationships demonstrated by multivariate analysis, determination of gastric juice antibodies may provide a better representation of serum, rather than secretory, immune response...
  28. pmc Helicobacter pylori genotyping and sequencing using paraffin-embedded biopsies from residents of colombian areas with contrasting gastric cancer risks
    Liviu A Sicinschi
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Helicobacter 13:135-45. 2008
    ....
  29. pmc Global analysis of Helicobacter pylori gene expression in human gastric mucosa
    James E Graham
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Gastroenterology 123:1637-48. 2002
    ..Helicobacter pylori inhabits a highly restricted ecological niche in the human gastric mucosa. Microbial gene expression in the context of persistent infection remains largely uncharacterized...
  30. pmc p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7
    Seth R Ogden
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Mol Biol Cell 19:4110-21. 2008
    ..These results indicate that selective and coordinated induction of mmp-7 expression by H. pylori cag(+) isolates may explain in part the augmentation in gastric cancer risk associated with these strains...
  31. pmc Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential
    Natasha Schneider
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    J Infect Dis 199:1218-21. 2009
    ..These results indicate that CagA variants are linked with premalignant lesions in distinct populations and that epithelial responses to these strains are selective based upon locale...
  32. ncbi request reprint Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin
    Timothy L Cover
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Cancer Res 63:951-7. 2003
    ..pylori-infected persons may result from strain-dependent variations in VacA structure...
  33. ncbi request reprint Characterization of expression of a functionally conserved Helicobacter pylori methyltransferase-encoding gene within inflamed mucosa and during in vitro growth
    Hiroaki Takeuchi
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Medical Center, 1161 21st Avenue South, Nashville, TN, USA
    J Infect Dis 186:1186-9. 2002
    ..In vitro, hpyIM expression was higher during log-phase growth and was required for normal bacterial morphology, suggesting that hpyIM expression may be growth-phase regulated within the gastric niche...
  34. pmc Race, African ancestry, and Helicobacter pylori infection in a low-income United States population
    Meira Epplein
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 20:826-34. 2011
    ..Gastric cancer incidence in African Americans is twice that of whites, and differing prevalence of Helicobacter pylori strain-specific isolates may help explain the disparity...
  35. pmc Helicobacter pylori and gastric cancer: factors that modulate disease risk
    Lydia E Wroblewski
    Division of Gastroenterology, Vanderbilt University School of Medicine, 2215 Garland Ave, 1030C MRB IV, Nashville, TN 37232 2279, USA
    Clin Microbiol Rev 23:713-39. 2010
    ..Since H. pylori inhibits the gastric epithelium of half of the world, it is crucial that we continue to gain understanding of host and microbial factors that increase the risk of developing more severe clinical outcomes...
  36. pmc Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer
    Barbara G Schneider
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0252, USA
    Int J Cancer 127:2588-97. 2010
    ....
  37. pmc Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection
    Holly M Scott Algood
    Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA
    J Immunol 183:5837-46. 2009
    ..In contrast to many chronic inflammatory diseases in which IL-17RA signaling promotes an inflammatory response, IL-17RA signaling down-regulates the chronic mononuclear inflammation elicited by H. pylori infection...
  38. pmc Delineation of a carcinogenic Helicobacter pylori proteome
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    Mol Cell Proteomics 8:1947-58. 2009
    ..pylori proteins to use in vaccine development and for screening persons infected with strains most likely to induce severe disease...
  39. pmc Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan
    Takafumi Ando
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    Clin Diagn Lab Immunol 9:167-75. 2002
    ..Inactivation of HP0638 does not alter epithelial responses mediated by the cag island in vitro. Assessment of apoptosis in vitro identified a group of H. pylori isolates that induce more severe gastric inflammation and atrophy...
  40. ncbi request reprint Helicobacter pylori and gastrointestinal tract adenocarcinomas
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
    Nat Rev Cancer 2:28-37. 2002
    ....
  41. pmc Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor
    Daniel P O'Brien
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232 2279, USA
    J Biol Chem 283:23922-30. 2008
    ..pylori cag(+) strains induce up-regulation of a cognate cellular receptor in vitro and in vivo in a cag-dependent manner, representing the first evidence of regulation of an H. pylori host receptor by the cag pathogenicity island...
  42. pmc Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    Gastroenterology 136:1297-1307, e1-3. 2009
    ..Because EGFR signaling regulates cell survival, we investigated whether activation of EGFR following H pylori infection promotes gastric epithelial survival...
  43. ncbi request reprint Orchestration of dysregulated epithelial turnover by a manipulative pathogen
    Lydia E Wroblewski
    Department of Medicine, Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Host Microbe 2:209-11. 2007
    ..In this issue, Mimuro et al. shed light on mechanisms by which Helicobacter pylori attenuates apoptosis in the gastric epithelium to facilitate its persistence within the human stomach...
  44. ncbi request reprint Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells
    Sarah Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Infect Dis 196:95-103. 2007
    ..The aim of the present study was to determine whether H. pylori could up-regulate the expression of the epidermal growth factor receptor (EGFR), a critical gene in the carcinogenic process...
  45. ncbi request reprint The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation
    Daniel P O'Brien
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    J Biol Chem 281:13317-23. 2006
    ..pylori-infected mice. These results indicate that DAF may regulate H. pylori-epithelial cell interactions relevant to pathogenesis...
  46. pmc Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling
    Toni A Nagy
    Division of Gastroenterology, Departments of Medicine and Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Infect Dis 199:641-51. 2009
    ..pylori-induced cell migration. These results indicate that PI3K-AKT signaling regulates pathophysiologic responses to H. pylori that may lower the threshold for carcinogenesis...
  47. ncbi request reprint Host response to Helicobacter pylori infection before initiation of the adaptive immune response
    Holly M Scott Algood
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    FEMS Immunol Med Microbiol 51:577-86. 2007
    ..It is speculated that inappropriate waning of the innate immune response during early stages of infection may be a factor that contributes to H. pylori persistence...
  48. pmc Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation
    Lydia E Wroblewski
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    Gastroenterology 136:236-46. 2009
    ..We determined whether MLCK was activated by H pylori and defined the mechanisms through which such activation dysregulates gastric epithelial barrier function...
  49. ncbi request reprint Helicobacter pylori protein HP0222 belongs to Arc/MetJ family of transcriptional regulators
    Andrei Popescu
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232, USA
    Proteins 59:303-11. 2005
    ..To assess possible involvement of HP0222 in acid resistance, we constructed and assayed an H. pylori HP0222 null mutant. We propose that HP0222 is a novel transcriptional regulator in H. pylori...
  50. ncbi request reprint Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression
    Sachiyo Nomura
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2733, USA
    Gastroenterology 128:1292-305. 2005
    ....
  51. ncbi request reprint Subproteomes of soluble and structure-bound Helicobacter pylori proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry
    Steffen Backert
    Otto von Guericke University, Dept of Medical Microbiology, Magdeburg, Germany
    Proteomics 5:1331-45. 2005
    ..pylori proteome. Such subproteomes in the public domain will be effective instruments for identifying new virulence factors and antigens of potential diagnostic and/or curative value against infections with this important pathogen...
  52. ncbi request reprint Intestinal malignancy and campylobacter jejuni
    Richard M Peek
    Gastroenterology 127:1266-7; discussion 1267-8. 2004
  53. ncbi request reprint Intoxicated cells and stomach ulcers
    Richard M Peek
    Nat Genet 33:328-30. 2003
  54. ncbi request reprint Clandestine intracellular delivery of Helicobacter pylori CagA: guess who's coming to dinner?
    Richard M Peek
    Gastroenterology 127:669-72. 2004
  55. ncbi request reprint New insights into microbially initiated gastric malignancies: beyond the usual suspects
    Richard M Peek
    Gastroenterology 123:1739-40; discussion 1740-1. 2002
  56. ncbi request reprint Hereditary diffuse gastric cancer: more answers or more questions?
    William M Grady
    Gastroenterology 122:830-1; discussion 831-2. 2002
  57. ncbi request reprint Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity
    Andrew T Gewirtz
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Infect Dis 189:1914-20. 2004
    ..pylori flagellin plays no role in activating epithelial orchestration of inflammation. We conclude that H. pylori evades TLR5-mediated detection, which may contribute to its long-term persistence in individual hosts...
  58. ncbi request reprint Helicobacter pylori infection, not gastroesophageal reflux, is the major cause of inflammation and intestinal metaplasia of gastric cardiac mucosa
    John R Goldblum
    Center for Swallowing and Esophageal Disorders and Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 97:302-11. 2002
    ..pylori infection, and intestinal metaplasia in patients with GERD and Barrett's esophagus compared with age-matched controls...
  59. ncbi request reprint Elimination of Helicobacter pylori or acid in high-risk users of aspirin or nonsteroidal medications: final answer?
    Richard M Peek
    Gastroenterology 122:238-40. 2002
  60. ncbi request reprint Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa
    Howard C Crawford
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York, USA
    Gastroenterology 125:1125-36. 2003
    ..We determined whether H. pylori alters MMP-7 expression and investigated the molecular pathways required for these events...
  61. ncbi request reprint Natural variation in populations of persistently colonizing bacteria affect human host cell phenotype
    Rahul A Aras
    Departments of Medicine and Microbiology, New York University School of Medicine, New York, New York, USA
    J Infect Dis 188:486-96. 2003
    ..These findings indicate that within an individual host, intragenomic recombination between H. pylori repetitive DNA produces strain variants differing in their signals to host cells...
  62. pmc The effect of different strains of Helicobacter pylori on platelet aggregation
    Paul A Corcoran
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Can J Gastroenterol 21:367-70. 2007
    ..It has also been linked, less strongly, to cardiovascular disease. The mechanisms by which certain strains of H pylori induce platelet aggregation through interactions with platelet glycoprotein Ib have been previously described...
  63. pmc Genomic Comparison of cag pathogenicity island (PAI)-positive and -negative Helicobacter pylori strains: identification of novel markers for cag PAI-positive strains
    Courtney E Terry
    Department of Biology, The College of William and Mary, 214 Millington Hall, Landrum Drive, Williamsburg, VA 23187 8795, USA
    Infect Immun 73:3794-8. 2005
    ..A low G+C content of these two genes suggests they were acquired by horizontal transfer events...
  64. ncbi request reprint Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements
    Islay A Steele
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool, UK
    Am J Physiol Gastrointest Liver Physiol 293:G347-54. 2007
    ..Stimulation of Reg1 by H. pylori required the virulence factor CagA. These data indicate that expression of the putative growth factor Reg1 is controlled through separate promoter elements by gastrin and Helicobacter...
  65. ncbi request reprint IL1B polymorphisms and gastric cancer risk
    M Constanza Camargo
    Cancer Epidemiol Biomarkers Prev 16:635; author reply 635-6. 2007
  66. pmc Serological assays for identification of human gastric colonization by Helicobacter pylori strains expressing VacA m1 or m2
    Chandrabali Ghose
    Department of Microbiology, New York University School of Medicine, New York, New York, USA
    Clin Vaccine Immunol 14:442-50. 2007
    ..In an Asian-American population, serologic responses to VacA m region-specific antigens were not able to predict the risk of development of gastric cancer...
  67. ncbi request reprint Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells
    Yoshihisa Nozawa
    Pharmacology Research Laboratory, Taiho Pharmaceutical Co, Ltd, 224 2 Ebisuno, Hiraishi, Kawauchi cho, Tokushima, Japan
    Biochem Pharmacol 64:21-30. 2002
    ..pylori-induced NF-kappaB activity, resulting in IL-8 production...
  68. pmc Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells
    Song Ze Ding
    Department of Microbiology, The University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    FEMS Immunol Med Microbiol 53:385-94. 2008
    ..These results provide more insight into how H. pylori and MAPK modulate AP-1 subcomponents in gastric epithelial cells to alter the expression of downstream target genes and affect cellular functions...
  69. ncbi request reprint Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization
    Tomokazu Mizuno
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    World J Gastroenterol 11:6305-11. 2005
    ..To determine the role of interleukin (IL)-17 in gastric ulcerogenesis...
  70. pmc Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system
    Andrew C Goodwin
    Department of Biology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Microbiology 154:2231-40. 2008
    ..As a pathogen with a paucity of regulatory proteins, this dual regulation indicates that SabA expression is a tightly regulated process in H. pylori infection...
  71. ncbi request reprint A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains
    Takafumi Ando
    Departments of Medicine and Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Res 62:2385-9. 2002
    ..Although a direct function for hrgA in virulence could not be demonstrated, our data indicate that hrgA is a strain-specific gene that might be associated with gastric cancer among H. pylori isolates from Asian patients...
  72. ncbi request reprint Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Gastroenterology 124:1879-90. 2003
    ..We examined the effects of an H. pylori cancer-associated determinant (cagE), IL-1beta, and host gender in a transgenic hypergastrinemic (INS-GAS) murine model of gastric carcinogenesis...
  73. pmc Bacterial biota in reflux esophagitis and Barrett's esophagus
    Zhiheng Pei
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    World J Gastroenterol 11:7277-83. 2005
    ..To identify the bacterial flora in conditions such as Barrettos esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora...
  74. ncbi request reprint Persistence and pathogenesis: a great defense facilitates a good offense
    Richard M Peek
    Gastroenterology 122:2084-5. 2002
  75. ncbi request reprint The politics of H. pylori-challenged mice: liberal permissiveness versus conservative restriction
    Richard M Peek
    Gastroenterology 124:577-8. 2003
  76. pmc Novel 180- and 480-base-pair insertions in African and African-American strains of Helicobacter pylori
    Shannon L McNulty
    Department of Biology, The College of William and Mary, 214 Millington Hall, Landrum Drive, Williamsburg, VA 23187, USA
    J Clin Microbiol 42:5658-63. 2004
    ..Apparent differences between African-American and Caucasian-American H. pylori gene pools may bear on our understanding of H. pylori transmission and disease outcome...

Research Grants25

  1. Helicobacter pylori and gastrointestinal biology
    Richard Peek; Fiscal Year: 2007
    ..pylori'-induced injury and carcinogenesis in vivo. This study will help to identify people who are at great risk for stomach cancer. This will greatly improve diagnosis and therapy of H. pylori infections. ..
  2. Mechanism that regulate Helicobacter pylori-induced beta-caterin activation
    Richard Peek; Fiscal Year: 2009
    ..py/ori-induced B-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
  3. Helicobacter pylori and gastrointestinal biology
    Richard Peek; Fiscal Year: 2009
    ..pylori'-induced injury and carcinogenesis in vivo. This study will help to identify people who are at great risk for stomach cancer. This will greatly improve diagnosis and therapy of H. pylori infections. ..
  4. H. Pylori Relationship to Digestive Diseases and Cancer
    Richard M Peek; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: These studies will define bacterial and host factors that influence gastric cancer. Such findings may help to identify H. pylori-infected persons at high risk for gastric cancer, who thereby warrant therapy. ..
  5. TRAINING IN GASTROENTEROLOGY
    Richard Peek; Fiscal Year: 2007
    ..We are encouraged by our ability to successfully train academic investigators. 6 of the 8 individuals currently in training are currently planning careers in academic medicine ..
  6. Mechanism that regulate Helicobacter pylori-induced beta-catenin activation
    Richard Peek; Fiscal Year: 2007
    ..pylori-induced ?-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
  7. H.Pylori Relationship to Digestive Diseases and Cancer
    Richard Peek; Fiscal Year: 2007
    ..pylori-induced carcinogenesis and facilitate identification of potential therapeutic targets, but may also provide insights into other malignancies that arise within the context of inflammatory states. ..
  8. Inhibition of pathogen-induced NFkBmediated inflammation
    Richard Peek; Fiscal Year: 2005
    ..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..
  9. Helicobacter pylori and gastrointestinal biology
    Richard Peek; Fiscal Year: 2005
    ....
  10. Helicobacter pylori and gastrointestinal biology
    Richard M Peek; Fiscal Year: 2010
    ..pylori'-induced injury and carcinogenesis in vivo. This study will help to identify people who are at great risk for stomach cancer. This will greatly improve diagnosis and therapy of H. pylori infections. ..