Research Topics

Genomes and Genes

Species

Richard M Peek

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. Suarez G, Romero Gallo J, Piazuelo M, Sierra J, Delgado A, Washington M, et al. Nod1 Imprints Inflammatory and Carcinogenic Responses toward the Gastric Pathogen Helicobacter pylori. Cancer Res. 2019;79:1600-1611 pubmed publisher
    ..SIGNIFICANCE: These findings suggest that manipulation of NOD1 may represent a novel strategy to prevent or treat pathologic outcomes induced by H. pylori infection. ..
  2. Noto J, Rose K, Hachey A, Delgado A, Romero Gallo J, Wroblewski L, et al. Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression. Mol Cell Proteomics. 2019;18:352-371 pubmed publisher
  3. Noto J, Piazuelo M, Chaturvedi R, Bartel C, Thatcher E, Delgado A, et al. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Am J Physiol Gastrointest Liver Physiol. 2013;305:G786-96 pubmed publisher
    ..Collectively, these results indicate that H. pylori suppresses miR-320, upregulates Mcl-1, and decreases apoptosis in a cagA-dependent manner, which likely confers an increased risk for gastric carcinogenesis. ..
  4. Suarez G, Romero Gallo J, Piazuelo M, Wang G, Maier R, Forsberg L, et al. Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach. Cancer Res. 2015;75:1749-59 pubmed publisher
    ..These results indicate that peptidoglycan deacetylation plays an important role in modulating host inflammatory responses to H. pylori, allowing the bacteria to persist and induce carcinogenic consequences in the gastric niche. ..
  5. Noto J, Peek R. Micronutrients: A double-edged sword in microbial-induced gastric carcinogenesis. Trends Cancer. 2015;1:136-144 pubmed
    ..Further, these fundamental concepts provide a framework for understanding mechanisms driving the development of other malignancies that arise from foci of gastrointestinal inflammation. ..
  6. Abreu M, Peek R. Gastrointestinal malignancy and the microbiome. Gastroenterology. 2014;146:1534-1546.e3 pubmed publisher
    ..Strategies to manipulate the microbiome, or the immune response to such bacteria, could be developed to prevent or treat certain gastrointestinal cancers. ..
  7. Amieva M, Peek R. Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology. 2016;150:64-78 pubmed publisher
  8. Peek R, Fiske C, Wilson K. Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Physiol Rev. 2010;90:831-58 pubmed publisher
    ..pylori-infected individuals who can then be targeted for therapeutic intervention. ..
  9. Wroblewski L, Peek R. Helicobacter pylori, Cancer, and the Gastric Microbiota. Adv Exp Med Biol. 2016;908:393-408 pubmed publisher
    ..pylori infection that may augment the risk of developing gastric cancer. ..

More Information

Publications15

  1. Varga M, Piazuelo M, Romero Gallo J, Delgado A, Suarez G, Whitaker M, et al. TLR9 activation suppresses inflammation in response to Helicobacter pylori infection. Am J Physiol Gastrointest Liver Physiol. 2016;311:G852-G858 pubmed publisher
    ..pylori in a cag T4SS-dependent manner. These results suggest that H. pylori utilizes the cag T4SS to manipulate the intensity of the host immune response. ..
  2. Varga M, Peek R. DNA Transfer and Toll-like Receptor Modulation by Helicobacter pylori. Curr Top Microbiol Immunol. 2017;400:169-193 pubmed publisher
  3. Suarez G, Romero Gallo J, Sierra J, Piazuelo M, Krishna U, Gomez M, et al. Genetic Manipulation of Helicobacter pylori Virulence Function by Host Carcinogenic Phenotypes. Cancer Res. 2017;77:2401-2412 pubmed publisher
    ..i>Cancer Res; 77(9); 2401-12. ©2017 AACR. ..
  4. Noto J, Romero Gallo J, Piazuelo M, Peek R. The Mongolian Gerbil: A Robust Model of Helicobacter pylori-Induced Gastric Inflammation and Cancer. Methods Mol Biol. 2016;1422:263-80 pubmed publisher
    ..pylori-inflammation and cancer as well as the current materials and methods for utilizing this model of microbially induced disease. ..
  5. Noto J, Peek R. Micronutrients: A Double-Edged Sword in Microbe-Induced Gastric Carcinogenesis. Trends Cancer. 2015;1:136-144 pubmed publisher
    ..Further, these fundamental concepts provide a framework for understanding mechanisms driving the development of other malignancies that arise from foci of gastrointestinal inflammation. ..
  6. Noto J, Peek R. Helicobacter pylori Makes a Molecular Incision to Gain Epithelial Entry. Cell Host Microbe. 2017;22:434-436 pubmed publisher
    ..2017) show that a secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylori to access the basolateral compartment and trigger pathogenesis. ..