RAY PEEBLES

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking
    Daniel L Venarske
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37230 8300 USA
    J Infect Dis 193:1536-43. 2006
  2. pmc Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion
    Georgios T Stathopoulos
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 182:1273-81. 2010
  3. doi request reprint A new horizon in asthma: inhibiting ILC function
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, T 1218 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Sci Transl Med 5:174fs7. 2013
  4. pmc PGI2 as a regulator of inflammatory diseases
    Stacy L Dorris
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Mediators Inflamm 2012:926968. 2012
  5. pmc Mechanisms of respiratory syncytial virus modulation of airway immune responses
    Matthew T Lotz
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Curr Allergy Asthma Rep 12:380-7. 2012
  6. ncbi request reprint The complex relationship between respiratory syncytial virus and allergy in lung disease
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Viral Immunol 16:25-34. 2003
  7. ncbi request reprint Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 175:8253-9. 2005
  8. pmc Novel concepts in virally induced asthma
    Matthew M Huckabee
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Mol Allergy 7:2. 2009
  9. ncbi request reprint Oxidant stress modulates murine allergic airway responses
    Megha Talati
    Department of Medicine, T 1217 MCN, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 40:1210-9. 2006
  10. ncbi request reprint Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 174:525-32. 2005

Detail Information

Publications51

  1. ncbi request reprint The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking
    Daniel L Venarske
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37230 8300 USA
    J Infect Dis 193:1536-43. 2006
    ....
  2. pmc Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion
    Georgios T Stathopoulos
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 182:1273-81. 2010
    ..Because eosinophils can be found in malignant pleural effusions (MPE) from mice and humans, we asked whether IL-5 is involved in the pathogenesis of MPE...
  3. doi request reprint A new horizon in asthma: inhibiting ILC function
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, T 1218 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Sci Transl Med 5:174fs7. 2013
    ..Innate lymphoid cells (ILCs) produce cytokines that drive allergic responses in asthma and can be inhibited by lipoxin A4 (Barnig et al., this issue)...
  4. pmc PGI2 as a regulator of inflammatory diseases
    Stacy L Dorris
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Mediators Inflamm 2012:926968. 2012
    ..PGI(2) regulates both the innate and adaptive immune systems and its effects are, for the most part, thought to be anti-inflammatory or immunosuppressive in nature, which may have implications for its further clinical use...
  5. pmc Mechanisms of respiratory syncytial virus modulation of airway immune responses
    Matthew T Lotz
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Curr Allergy Asthma Rep 12:380-7. 2012
    ..In addition, effective immune system regulation of IL-10 expression and T regulatory cell (Treg) airway accumulation are essential for effective RSV clearance...
  6. ncbi request reprint The complex relationship between respiratory syncytial virus and allergy in lung disease
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Viral Immunol 16:25-34. 2003
    ..We also review the published murine models that combine RSV infection and allergic sensitization that attempt to explain the complex relationship between these two factors in regard to lung immunopathology and physiologic dysfunction...
  7. ncbi request reprint Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 175:8253-9. 2005
    ..These results elucidate the pathways by which COX inhibition exerts a critical effect of the pulmonary allergen-induced inflammatory response and confirm that COX products are important regulators of allergic inflammation...
  8. pmc Novel concepts in virally induced asthma
    Matthew M Huckabee
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Mol Allergy 7:2. 2009
    ....
  9. ncbi request reprint Oxidant stress modulates murine allergic airway responses
    Megha Talati
    Department of Medicine, T 1217 MCN, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 40:1210-9. 2006
    ..Oxidant stress plays a role in the production of airway responsiveness...
  10. ncbi request reprint Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 174:525-32. 2005
    ..These results illustrate the central role played by products derived from the COX pathway in the regulation of allergic immune responses...
  11. ncbi request reprint Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    J Allergy Clin Immunol 116:550-7. 2005
    ....
  12. ncbi request reprint Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation
    Ruxana T Sadikot
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 170:1091-8. 2003
    ..Therapies targeted to NF-kappaB in lung epithelium may be beneficial in treating inflammatory lung diseases...
  13. pmc A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 182:5317-21. 2009
    ..Therefore, therapeutic intervention inhibiting IL-13 production could have adverse consequences by up-regulating Th17 inflammation in certain disease states...
  14. pmc Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Virol 78:10303-9. 2004
    ..These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI(2) is a potential therapeutic target in the treatment of RSV...
  15. ncbi request reprint Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5
    Koichi Hashimoto
    Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
    Am J Respir Crit Care Med 170:306-12. 2004
    ..The impact of virus infection combined with allergic inflammation on mucus production may partially explain the more severe disease and airway hyperresponsiveness associated with RSV in the setting of atopy...
  16. pmc Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice
    Rinat Zaynagetdinov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
    Am J Respir Cell Mol Biol 42:564-71. 2010
    ..These findings are in agreement with previous pharmacologic studies suggesting a deleterious role for A(2B) receptor signaling in chronic lung inflammation...
  17. pmc Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection
    Martin L Moore
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Viral Immunol 21:327-39. 2008
    ..Also, GM1/ASGM1-expressing cells are important for control of RSV in BALB/c mice, whereas STAT1(-/-) mice clear RSV by an alternative pathway...
  18. ncbi request reprint Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells
    Weisong Zhou
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    J Leukoc Biol 81:809-17. 2007
    ..These data indicate that PGI(2) analogs have an immune-suppressive effect on previously activated and differentiated CD4 T cells in vitro and suggest that PGI(2) may have a similar function in vivo...
  19. ncbi request reprint Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells
    Weisong Zhou
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 178:702-10. 2007
    ..These findings suggest that PGI(2) signaling through the IP may exert anti-inflammatory effects by acting on DC...
  20. pmc The Tennessee Children's Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseases
    Tina V Hartert
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Respirology 15:691-9. 2010
    ..The primary goals are to investigate both the acute and the long-term health consequences of varying severity and aetiology of clinically significant viral respiratory tract infections on early childhood outcomes...
  21. pmc Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice
    James R Sheller
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Exp Lung Res 35:883-95. 2009
    ..NF-kappa B represents a potential target for pharmacologic intervention in human asthma...
  22. pmc Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammation
    Huiyong Yin
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Free Radic Biol Med 47:622-8. 2009
    ....
  23. ncbi request reprint Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses
    Weisong Zhou
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 181:5360-7. 2008
    ....
  24. pmc IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse
    Weisong Zhou
    Department of Medicine, T 1218 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Microbes Infect 8:2880-9. 2006
    ..These results suggest that IL-13 modulates illness from RSV-infection...
  25. ncbi request reprint Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 165:1154-60. 2002
    ..We conclude that in the BALB/c mouse, COX inhibition with either a COX-1 or COX-2 inhibitor during allergen sensitization augments production of IL-13 and increases airway hyperresponsiveness...
  26. pmc Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle
    Paul E Moore
    Vanderbilt University School of Medicine, 2200 Children s Way, 11215 Doctor s Office Tower, Nashville, TN 37232 9500, USA
    Am J Respir Cell Mol Biol 35:559-64. 2006
    ....
  27. ncbi request reprint Induction and function of lipocalin prostaglandin D synthase in host immunity
    Myungsoo Joo
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 179:2565-75. 2007
    ..Our study suggests a potential therapeutic usage of L-PGDS or PGD(2) against Pseudomonas pneumonia...
  28. ncbi request reprint Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge
    Michael Y Viksman
    Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6801, USA
    Clin Immunol 104:77-85. 2002
    ..The different results obtained with the two challenge methods probably depend on higher local concentrations of allergen in the EB challenge. We suggest that activation of AM occurs following EB challenge with antigen in asthmatics...
  29. ncbi request reprint Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might think
    Martin L Moore
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Lung Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Allergy Clin Immunol 117:1036-9. 2006
    ..This review summarizes the current literature on the role of PGs and PG receptors in allergic lung inflammation...
  30. pmc A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction
    Martin L Moore
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Virol 83:4185-94. 2009
    ..We identified the F protein of RSV line 19 as a factor that plays a role in pulmonary mucin expression in the setting of RSV infection...
  31. ncbi request reprint Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity
    Martin L Moore
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 178:2651-4. 2007
    ..Also, oseltamivir, an important anti-influenza drug, inhibits the clearance of a respiratory virus that lacks a neuraminidase gene, RSV...
  32. ncbi request reprint Viral infections, atopy, and asthma: is there a causal relationship?
    R Stokes Peebles
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Allergy Clin Immunol 113:S15-8. 2004
    ..This review will discuss existing data on RSV infection and respiratory complications later in life, as well as the link between RSV and allergic disease...
  33. pmc STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection
    Martin L Moore
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN37232, USA
    J Immunol 183:2016-26. 2009
    ..Basophils were the primary source of IL-4 in the lung in RSV infection, and STAT1 was a negative regulator of virus-induced basophil IL-4 expression...
  34. ncbi request reprint Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeutics
    Martin L Moore
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, T 1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Pharmacol Ther 112:405-24. 2006
    ..A better understanding of RSV molecular biology and RSV pathogenesis is facilitating rational vaccine design strategies and molecular targets for new therapeutics...
  35. pmc Viral respiratory tract infections and asthma: the course ahead
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Allergy Clin Immunol 125:1212-7. 2010
    ....
  36. pmc Bugs and asthma: a different disease?
    Dawn C Newcomb
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2650, USA
    Proc Am Thorac Soc 6:266-71. 2009
    ....
  37. pmc Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice
    Kate L Stokes
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    J Virol 85:5782-93. 2011
    ..We found that RSV clinical isolates induce variable pathogenesis in mice, and we established a mouse model of clinical isolate strain-dependent RSV pathogenesis that recapitulates key features of RSV disease...
  38. pmc Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults
    John V Williams
    Departments of Pediatric, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    J Infect Dis 192:1149-53. 2005
    ..9-312]; P=.03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations...
  39. ncbi request reprint Anaphylaxis and anaphylactoid reactions. A guide to prevention, recognition, and emergent treatment
    Csaba Rusznak
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Postgrad Med 111:101-4, 107-8, 111-4. 2002
    ..In this article, Drs Rusznak and Peebles discuss the mechanisms of these reactions, common causative agents, preventive strategies, recognition, and treatment...
  40. doi request reprint The spectrum and treatment of angioedema
    Viviana M Temino
    The Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Med 121:282-6. 2008
    ..Epinephrine should be administered if there is concern for laryngeal edema. Patients who have a known history of hereditary angioedema should receive C1 esterase inhibitor concentrate or fresh-frozen plasma...
  41. ncbi request reprint Highlights from the annual scientific assembly: patient-centered approaches to asthma management: strategies for treatment and management of asthma
    R Stokes Peebles
    Center for Lung Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    South Med J 95:775-9. 2002
    ....
  42. ncbi request reprint The role of IFN in respiratory syncytial virus pathogenesis
    Joan E Durbin
    Children s Research Institute, Children s Hospital, Columbus, OH 43205, USA
    J Immunol 168:2944-52. 2002
    ..These findings suggest that STAT1 activation by both type I (alphabeta) and type II (gamma) IFNs plays an important role in establishing a protective, Th1 Ag-specific immune response to RSV infection...
  43. ncbi request reprint Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Immunol 178:1628-34. 2007
    ....
  44. pmc Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus
    Nicholas W Lukacs
    Department of Pathology, University of Michigan Medical School, 1301 Catherine St, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 169:977-86. 2006
    ..These data demonstrate that different RSV strains of the same antigenic subgroup can elicit differential immune responses that impact the phenotypic expression of RSV-induced illness...
  45. ncbi request reprint Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2
    Ruxana T Sadikot
    Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA
    Eur J Immunol 37:1001-9. 2007
    ..Thus it is possible that inhibition of COX-2 or EP2 receptors could be an effective adjunctive treatment for severe or resistant P. aeruginosa pneumonia...
  46. pmc Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo
    Nancy A Jewell
    Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    J Virol 81:9790-800. 2007
    ....
  47. ncbi request reprint Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent
    Ioannis Kalomenidis
    Marianthi Simou Laboratory, Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, 45 47 Ipsilandou Str, 10675 Athens, Greece
    Chest 128:2978-83. 2005
    ..To establish a murine model of pneumothorax-associated pleural eosinophilia and to examine the role of interleukin (IL)-5 and IL-13 in the pathogenesis of this reaction...
  48. ncbi request reprint A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapy
    R Stokes Peebles
    Am J Respir Cell Mol Biol 37:375-7. 2007
  49. ncbi request reprint Pleural fluid levels of vascular cell adhesion molecule-1 are elevated in eosinophilic pleural effusions
    Ioannis Kalomenidis
    Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, Athens, Greece
    Chest 124:159-66. 2003
    ....
  50. ncbi request reprint Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions
    Ioannis Kalomenidis
    Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, 45 47 Ipsilandou Str, 10675 Athens, Greece
    Chest 127:2094-100. 2005
    ....
  51. pmc Pathogenesis of respiratory syncytial virus infection in the murine model
    R Stokes Peebles
    Vaccine Research Center, NIAID NIH, 40 Convent Drive, Building 40, Room 2502, Bethesda, MD 20892 3017, USA
    Proc Am Thorac Soc 2:110-5. 2005
    ..This article briefly reviews the clinical sequelae of RSV infection and then focuses on the mechanisms of viral pathogenesis...

Research Grants19

  1. The Role of PGI2 in Allergic Inflammation
    Ray Stokes Peebles; Fiscal Year: 2010
    ..Prostaglandins are chemicals made by the body that can influence inflammation. PGI2 is a prostaglandin that may control asthma and we will study it in this project. ..
  2. The Role of IL-17 in RSV-induced Mucus and Airway Responsiveness
    Ray Stokes Peebles; Fiscal Year: 2010
    ..Defining the role of IL-17A in the immunobiology of virally-mediated AR and mucus induction may result in novel targets for drug development. ..
  3. The Role of PGI2 in Allergic Inflammation
    Ray Stokes Peebles; Fiscal Year: 2011
    ..Prostaglandins are chemicals made by the body that can influence inflammation. PGI2 is a prostaglandin that may control asthma and we will study it in this project. ..
  4. The Role of IL-17 in RSV-induced Mucus and Airway Responsiveness
    RAY PEEBLES; Fiscal Year: 2009
    ..Defining the role of IL-17A in the immunobiology of virally-mediated AR and mucus induction may result in novel targets for drug development. ..
  5. The Role of IL-17 in RSV-induced Mucus and Airway Responsiveness
    RAY PEEBLES; Fiscal Year: 2007
    ..Defining the role of IL-17A in the immunobiology of virally-mediated AR and mucus induction may result in novel targets for drug development. ..
  6. PGE2 Regulation of Allergic Inflammation in the Lung
    RAY PEEBLES; Fiscal Year: 2007
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. ..
  7. Prostacyclin (PG12) Regulation of RSV-induced Illness
    RAY PEEBLES; Fiscal Year: 2006
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  8. Prostacyclin (PG12) Regulation of RSV-induced Illness
    RAY PEEBLES; Fiscal Year: 2005
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  9. RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASE
    R Peebles; Fiscal Year: 2003
    ....
  10. PGE2 Regulation of Allergic Inflammation in the Lung
    R Peebles; Fiscal Year: 2005
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. ..
  11. Prostacyclin (PGI2) Regulation of RSV-induced Illness
    R Peebles; Fiscal Year: 2003
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  12. PGE2 Regulation of Allergic Inflammation in the Lung
    R Peebles; Fiscal Year: 2003
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. ..
  13. The Role of PGI2 in Allergic Inflammation
    RAY PEEBLES; Fiscal Year: 2009
    ..Prostaglandins are chemicals made by the body that can influence inflammation. PGI2 is a prostaglandin that may control asthma and we will study it in this project. ..
  14. Prostacyclin (PG12) Regulation of Respiratory Syncytial Virus (RS)induced Illness
    RAY PEEBLES; Fiscal Year: 2007
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  15. PGE2 Regulation of Allergic Inflammation in the Lung
    R Peebles; Fiscal Year: 2004
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. ..
  16. Prostacyclin (PG12) Regulation of RSV-induced Illness
    R Peebles; Fiscal Year: 2004
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  17. PGE2 Regulation of Allergic Inflammation in the Lung
    R Peebles; Fiscal Year: 2006
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. ..
  18. RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASE
    R Peebles; Fiscal Year: 2002
    ....