Research Topics
Genomes and Genes | RAY PEEBLESSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smokingDaniel L Venarske
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37230-8300 USA
J Infect Dis 193:1536-43. 2006..Compared with hospitalized patients with asthma who were RV negative, RV-positive patients were significantly more likely to be smokers and nonusers of ICSs...
Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusionGeorgios T Stathopoulos
Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Respir Crit Care Med 182:1273-81. 2010..Because eosinophils can be found in malignant pleural effusions (MPE) from mice and humans, we asked whether IL-5 is involved in the pathogenesis of MPE...
A new horizon in asthma: inhibiting ILC functionR Stokes Peebles
Department of Medicine, Vanderbilt University School of Medicine, T 1218 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
Sci Transl Med 5:174fs7. 2013..Innate lymphoid cells (ILCs) produce cytokines that drive allergic responses in asthma and can be inhibited by lipoxin A4 (Barnig et al., this issue)...- The complex relationship between respiratory syncytial virus and allergy in lung diseaseR Stokes Peebles
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Viral Immunol 16:25-34. 2003..We also review the published murine models that combine RSV infection and allergic sensitization that attempt to explain the complex relationship between these two factors in regard to lung immunopathology and physiologic dysfunction... - Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependentR Stokes Peebles
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 175:8253-9. 2005..These results elucidate the pathways by which COX inhibition exerts a critical effect of the pulmonary allergen-induced inflammatory response and confirm that COX products are important regulators of allergic inflammation... - Novel concepts in virally induced asthmaMatthew M Huckabee
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Clin Mol Allergy 7:2. 2009.... - Oxidant stress modulates murine allergic airway responsesMegha Talati
Department of Medicine, T 1217 MCN, Vanderbilt University, Nashville, TN 37232, USA
Free Radic Biol Med 40:1210-9. 2006..Oxidant stress plays a role in the production of airway responsiveness... - Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanismsKoichi Hashimoto
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 174:525-32. 2005..These results illustrate the central role played by products derived from the COX pathway in the regulation of allergic immune responses... - Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levelsKoichi Hashimoto
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2650, USA
J Allergy Clin Immunol 116:550-7. 2005..CONCLUSION: These results show that STAT 1 has an important regulatory role in RSV-induced alteration of airway function... - Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illnessKoichi Hashimoto
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
J Virol 78:10303-9. 2004..These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI(2) is a potential therapeutic target in the treatment of RSV... - Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5Koichi Hashimoto
Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
Am J Respir Crit Care Med 170:306-12. 2004..The impact of virus infection combined with allergic inflammation on mucus production may partially explain the more severe disease and airway hyperresponsiveness associated with RSV in the setting of atopy... - A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine productionDawn C Newcomb
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Immunol 182:5317-21. 2009..Therefore, therapeutic intervention inhibiting IL-13 production could have adverse consequences by up-regulating Th17 inflammation in certain disease states... - Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammationRuxana T Sadikot
Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 170:1091-8. 2003..Therapies targeted to NF-kappaB in lung epithelium may be beneficial in treating inflammatory lung diseases... - Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout miceRinat Zaynagetdinov
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
Am J Respir Cell Mol Biol 42:564-71. 2010..These findings are in agreement with previous pharmacologic studies suggesting a deleterious role for A(2B) receptor signaling in chronic lung inflammation... - Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infectionMartin L Moore
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
Viral Immunol 21:327-39. 2008..Also, GM1/ASGM1-expressing cells are important for control of RSV in BALB/c mice, whereas STAT1(-/-) mice clear RSV by an alternative pathway... - Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responsesWeisong Zhou
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 181:5360-7. 2008.... - Induction and function of lipocalin prostaglandin D synthase in host immunityMyungsoo Joo
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Immunol 179:2565-75. 2007..Our study suggests a potential therapeutic usage of L-PGDS or PGD(2) against Pseudomonas pneumonia... - Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammationHuiyong Yin
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Free Radic Biol Med 47:622-8. 2009.... - Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cellsWeisong Zhou
Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 178:702-10. 2007..These findings suggest that PGI(2) signaling through the IP may exert anti-inflammatory effects by acting on DC... - Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged miceJames R Sheller
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Exp Lung Res 35:883-95. 2009..NF-kappa B represents a potential target for pharmacologic intervention in human asthma... - The Tennessee Children's Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseasesTina V Hartert
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Respirology 15:691-9. 2010..The primary goals are to investigate both the acute and the long-term health consequences of varying severity and aetiology of clinically significant viral respiratory tract infections on early childhood outcomes... - Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cellsWeisong Zhou
Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
J Leukoc Biol 81:809-17. 2007..These data indicate that PGI(2) analogs have an immune-suppressive effect on previously activated and differentiated CD4 T cells in vitro and suggest that PGI(2) may have a similar function in vivo... - IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouseWeisong Zhou
Department of Medicine, T-1218 MCN, Vanderbilt University Medical Center, Nashville, TN 37232-2650, USA
Microbes Infect 8:2880-9. 2006..These results suggest that IL-13 modulates illness from RSV-infection... - Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth musclePaul E Moore
Vanderbilt University School of Medicine, 2200 Children s Way, 11215 Doctor s Office Tower, Nashville, TN 37232 9500, USA
Am J Respir Cell Mol Biol 35:559-64. 2006.... - Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in miceR Stokes Peebles
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Respir Crit Care Med 165:1154-60. 2002..We conclude that in the BALB/c mouse, COX inhibition with either a COX-1 or COX-2 inhibitor during allergen sensitization augments production of IL-13 and increases airway hyperresponsiveness... - Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might thinkMartin L Moore
Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Lung Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Allergy Clin Immunol 117:1036-9. 2006..This review summarizes the current literature on the role of PGs and PG receptors in allergic lung inflammation... - Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challengeMichael Y Viksman
Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224-6801, USA
Clin Immunol 104:77-85. 2002..The different results obtained with the two challenge methods probably depend on higher local concentrations of allergen in the EB challenge. We suggest that activation of AM occurs following EB challenge with antigen in asthmatics... - A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunctionMartin L Moore
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Virol 83:4185-94. 2009..We identified the F protein of RSV line 19 as a factor that plays a role in pulmonary mucin expression in the setting of RSV infection... - Viral infections, atopy, and asthma: is there a causal relationship?R Stokes Peebles
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
J Allergy Clin Immunol 113:S15-8. 2004..This review will discuss existing data on RSV infection and respiratory complications later in life, as well as the link between RSV and allergic disease... - Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunityMartin L Moore
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 178:2651-4. 2007..Also, oseltamivir, an important anti-influenza drug, inhibits the clearance of a respiratory virus that lacks a neuraminidase gene, RSV... - Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeuticsMartin L Moore
Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, T-1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232-2650, USA
Pharmacol Ther 112:405-24. 2006..A better understanding of RSV molecular biology and RSV pathogenesis is facilitating rational vaccine design strategies and molecular targets for new therapeutics... - STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infectionMartin L Moore
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN37232, USA
J Immunol 183:2016-26. 2009..Basophils were the primary source of IL-4 in the lung in RSV infection, and STAT1 was a negative regulator of virus-induced basophil IL-4 expression... - Bugs and asthma: a different disease?Dawn C Newcomb
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2650, USA
Proc Am Thorac Soc 6:266-71. 2009.... - Viral respiratory tract infections and asthma: the course aheadLouis A Rosenthal
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
J Allergy Clin Immunol 125:1212-7. 2010.... - Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c miceKate L Stokes
Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
J Virol 85:5782-93. 2011..We found that RSV clinical isolates induce variable pathogenesis in mice, and we established a mouse model of clinical isolate strain-dependent RSV pathogenesis that recapitulates key features of RSV disease... - The spectrum and treatment of angioedemaViviana M Temino
The Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Am J Med 121:282-6. 2008..Epinephrine should be administered if there is concern for laryngeal edema. Patients who have a known history of hereditary angioedema should receive C1 esterase inhibitor concentrate or fresh-frozen plasma... - Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adultsJohn V Williams
Departments of Pediatric, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA
J Infect Dis 192:1149-53. 2005..9-312]; P=.03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations... - Anaphylaxis and anaphylactoid reactions. A guide to prevention, recognition, and emergent treatmentCsaba Rusznak
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Postgrad Med 111:101-4, 107-8, 111-4. 2002..In this article, Drs Rusznak and Peebles discuss the mechanisms of these reactions, common causative agents, preventive strategies, recognition, and treatment... - Highlights from the annual scientific assembly: patient-centered approaches to asthma management: strategies for treatment and management of asthmaR Stokes Peebles
Center for Lung Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA
South Med J 95:775-9. 2002.... - Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virusNicholas W Lukacs
Department of Pathology, University of Michigan Medical School, 1301 Catherine St, Ann Arbor, MI 48109 0602, USA
Am J Pathol 169:977-86. 2006..These data demonstrate that different RSV strains of the same antigenic subgroup can elicit differential immune responses that impact the phenotypic expression of RSV-induced illness... - The role of IFN in respiratory syncytial virus pathogenesisJoan E Durbin
Children s Research Institute, Children s Hospital, Columbus, OH 43205, USA
J Immunol 168:2944-52. 2002..These findings suggest that STAT1 activation by both type I (alphabeta) and type II (gamma) IFNs plays an important role in establishing a protective, Th1 Ag-specific immune response to RSV infection... - Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivoNancy A Jewell
Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
J Virol 81:9790-800. 2007.... - Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependentIoannis Kalomenidis
Marianthi Simou Laboratory, Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, 45 47 Ipsilandou Str, 10675 Athens, Greece
Chest 128:2978-83. 2005..To establish a murine model of pneumothorax-associated pleural eosinophilia and to examine the role of interleukin (IL)-5 and IL-13 in the pathogenesis of this reaction... - Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificitiesDavid M Aronoff
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
J Immunol 178:1628-34. 2007.... - Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2Ruxana T Sadikot
Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA
Eur J Immunol 37:1001-9. 2007..Thus it is possible that inhibition of COX-2 or EP2 receptors could be an effective adjunctive treatment for severe or resistant P. aeruginosa pneumonia... - Pleural fluid levels of vascular cell adhesion molecule-1 are elevated in eosinophilic pleural effusionsIoannis Kalomenidis
Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, Athens, Greece
Chest 124:159-66. 2003..CONCLUSION: The levels of VCAM-1 are increased in EPE, suggesting that VCAM-1 is important in the pathogenesis of EPE. Neither eotaxin nor RANTES is associated with pleural fluid eosinophilia... - Pathogenesis of respiratory syncytial virus infection in the murine modelR Stokes Peebles
Vaccine Research Center, NIAID NIH, 40 Convent Drive, Building 40, Room 2502, Bethesda, MD 20892 3017, USA
Proc Am Thorac Soc 2:110-5. 2005..This article briefly reviews the clinical sequelae of RSV infection and then focuses on the mechanisms of viral pathogenesis... - A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapyR Stokes Peebles
Am J Respir Cell Mol Biol 37:375-7. 2007 - Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusionsIoannis Kalomenidis
Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, 45 47 Ipsilandou Str, 10675 Athens, Greece
Chest 127:2094-100. 2005....
Research Grants
- The Role of PGI2 in Allergic InflammationRay Stokes Peebles; Fiscal Year: 2010..Prostaglandins are chemicals made by the body that can influence inflammation. PGI2 is a prostaglandin that may control asthma and we will study it in this project. ..
- The Role of IL-17 in RSV-induced Mucus and Airway ResponsivenessRay Stokes Peebles; Fiscal Year: 2010..Defining the role of IL-17A in the immunobiology of virally-mediated AR and mucus induction may result in novel targets for drug development. ..
- The Role of IL-17 in RSV-induced Mucus and Airway ResponsivenessRAY PEEBLES; Fiscal Year: 2009..Defining the role of IL-17A in the immunobiology of virally-mediated AR and mucus induction may result in novel targets for drug development. ..
- The Role of IL-17 in RSV-induced Mucus and Airway ResponsivenessRAY PEEBLES; Fiscal Year: 2007..Defining the role of IL-17A in the immunobiology of virally-mediated AR and mucus induction may result in novel targets for drug development. ..
- Prostacyclin (PG12) Regulation of Respiratory Syncytial Virus (RS)induced IllnessRAY PEEBLES; Fiscal Year: 2007..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
- PGE2 Regulation of Allergic Inflammation in the LungRAY PEEBLES; Fiscal Year: 2007..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. ..
- RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASER Peebles; Fiscal Year: 2003....
- The Role of PGI2 in Allergic InflammationRay Stokes Peebles; Fiscal Year: 2011..Prostaglandins are chemicals made by the body that can influence inflammation. PGI2 is a prostaglandin that may control asthma and we will study it in this project. ..