R S Peebles

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Respiratory syncytial virus (RSV)-induced airway hyperresponsiveness in allergically sensitized mice is inhibited by live RSV and exacerbated by formalin-inactivated RSV
    R S Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2582, USA
    J Infect Dis 182:671-7. 2000
  2. ncbi request reprint Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 165:1154-60. 2002
  3. ncbi request reprint Respiratory syncytial virus infection does not increase allergen-induced type 2 cytokine production, yet increases airway hyperresponsiveness in mice
    R S Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2582, USA
    J Med Virol 63:178-88. 2001
  4. ncbi request reprint Immune interaction between respiratory syncytial virus infection and allergen sensitization critically depends on timing of challenges
    R S Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Infect Dis 184:1374-9. 2001
  5. pmc Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor
    K Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2582, USA
    Thorax 57:524-7. 2002
  6. ncbi request reprint Allergen-induced changes in airway responsiveness are not related to indices of airway edema
    R S Peebles
    Division of Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore 21224, USA
    J Allergy Clin Immunol 107:805-11. 2001
  7. ncbi request reprint Immune-mediated disease pathogenesis in respiratory syncytial virus infection
    B S Graham
    Department of Medicine, A 4103 MCN, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 2582, USA
    Immunopharmacology 48:237-47. 2000
  8. doi request reprint Infections and asthma: new insights into old ideas
    C M Sevin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Exp Allergy 40:1142-54. 2010
  9. pmc Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity
    G Y Park
    Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, University of Illinois, Chicago, IL, USA
    Clin Exp Immunol 150:245-54. 2007
  10. ncbi request reprint Dietary antioxidants and adult asthma
    T V Hartert
    Vanderbilt University School of Medicine, Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Nashville, Tennessee 37232 2650, USA
    Curr Opin Allergy Clin Immunol 1:421-9. 2001

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Respiratory syncytial virus (RSV)-induced airway hyperresponsiveness in allergically sensitized mice is inhibited by live RSV and exacerbated by formalin-inactivated RSV
    R S Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2582, USA
    J Infect Dis 182:671-7. 2000
    ..This study suggests that immune modulation with RSV vaccination can have profound effects on RSV-induced airway disease and that prevention of airway hyperresponsiveness is an important end point in vaccine development...
  2. ncbi request reprint Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 165:1154-60. 2002
    ..We conclude that in the BALB/c mouse, COX inhibition with either a COX-1 or COX-2 inhibitor during allergen sensitization augments production of IL-13 and increases airway hyperresponsiveness...
  3. ncbi request reprint Respiratory syncytial virus infection does not increase allergen-induced type 2 cytokine production, yet increases airway hyperresponsiveness in mice
    R S Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2582, USA
    J Med Virol 63:178-88. 2001
    ....
  4. ncbi request reprint Immune interaction between respiratory syncytial virus infection and allergen sensitization critically depends on timing of challenges
    R S Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Infect Dis 184:1374-9. 2001
    ..These data provide evidence that RSV-associated AHR occurs in hosts with allergic responses and that allergic inflammation is diminished when preceded by RSV infection...
  5. pmc Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor
    K Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2582, USA
    Thorax 57:524-7. 2002
    ..The purpose of this study was to evaluate the effect of Y-27632 in a murine model of allergic and virally induced AHR...
  6. ncbi request reprint Allergen-induced changes in airway responsiveness are not related to indices of airway edema
    R S Peebles
    Division of Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore 21224, USA
    J Allergy Clin Immunol 107:805-11. 2001
    ..CONCLUSIONS: Airway responsiveness in asthma increases after exposure to allergen in the absence of increased indirect indices of edema. The role of edema in this phenomenon should therefore be tested more vigorously...
  7. ncbi request reprint Immune-mediated disease pathogenesis in respiratory syncytial virus infection
    B S Graham
    Department of Medicine, A 4103 MCN, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 2582, USA
    Immunopharmacology 48:237-47. 2000
    ..This model suggests strategies for the development of new vaccine and immunotherapeutic interventions, and creates a framework for asking additional questions about the immunopathogenesis of RSV...
  8. doi request reprint Infections and asthma: new insights into old ideas
    C M Sevin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Exp Allergy 40:1142-54. 2010
    ..Bacterial, viral, fungal, and parasitic infections have each been examined and provide a framework for these novel concepts...
  9. pmc Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity
    G Y Park
    Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, University of Illinois, Chicago, IL, USA
    Clin Exp Immunol 150:245-54. 2007
    ..COX-2 gene expression in airway epithelial cells has an important role in determining immunological response to infectious and allergic agents...
  10. ncbi request reprint Dietary antioxidants and adult asthma
    T V Hartert
    Vanderbilt University School of Medicine, Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Nashville, Tennessee 37232 2650, USA
    Curr Opin Allergy Clin Immunol 1:421-9. 2001
    ..One potential environmental factor that may relate to disease etiology is diet. This article will review the published evidence for the effects of dietary antioxidants on asthma incidence and disease control...
  11. pmc Viruses, dendritic cells and the lung
    R S Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Respir Res 2:245-9. 2001
    ....
  12. pmc Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle
    Paul E Moore
    Vanderbilt University School of Medicine, 2200 Children s Way, 11215 Doctor s Office Tower, Nashville, TN 37232 9500, USA
    Am J Respir Cell Mol Biol 35:559-64. 2006
    ....
  13. ncbi request reprint Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeutics
    Martin L Moore
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, T 1218 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Pharmacol Ther 112:405-24. 2006
    ..A better understanding of RSV molecular biology and RSV pathogenesis is facilitating rational vaccine design strategies and molecular targets for new therapeutics...
  14. pmc Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus
    Nicholas W Lukacs
    Department of Pathology, University of Michigan Medical School, 1301 Catherine St, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 169:977-86. 2006
    ..These data demonstrate that different RSV strains of the same antigenic subgroup can elicit differential immune responses that impact the phenotypic expression of RSV-induced illness...
  15. pmc IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse
    Weisong Zhou
    Department of Medicine, T 1218 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Microbes Infect 8:2880-9. 2006
    ..These results suggest that IL-13 modulates illness from RSV-infection...
  16. ncbi request reprint Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells
    Weisong Zhou
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    J Leukoc Biol 81:809-17. 2007
    ..These data indicate that PGI(2) analogs have an immune-suppressive effect on previously activated and differentiated CD4 T cells in vitro and suggest that PGI(2) may have a similar function in vivo...
  17. ncbi request reprint Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Immunol 178:1628-34. 2007
    ....
  18. ncbi request reprint Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity
    Martin L Moore
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 178:2651-4. 2007
    ..Also, oseltamivir, an important anti-influenza drug, inhibits the clearance of a respiratory virus that lacks a neuraminidase gene, RSV...
  19. ncbi request reprint Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2
    Ruxana T Sadikot
    Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA
    Eur J Immunol 37:1001-9. 2007
    ..Thus it is possible that inhibition of COX-2 or EP2 receptors could be an effective adjunctive treatment for severe or resistant P. aeruginosa pneumonia...
  20. pmc Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo
    Nancy A Jewell
    Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    J Virol 81:9790-800. 2007
    ....
  21. ncbi request reprint Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    J Allergy Clin Immunol 116:550-7. 2005
    ....
  22. ncbi request reprint Induction and function of lipocalin prostaglandin D synthase in host immunity
    Myungsoo Joo
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 179:2565-75. 2007
    ..Our study suggests a potential therapeutic usage of L-PGDS or PGD(2) against Pseudomonas pneumonia...
  23. pmc Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection
    Martin L Moore
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Viral Immunol 21:327-39. 2008
    ..Also, GM1/ASGM1-expressing cells are important for control of RSV in BALB/c mice, whereas STAT1(-/-) mice clear RSV by an alternative pathway...
  24. ncbi request reprint Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses
    Weisong Zhou
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 181:5360-7. 2008
    ....
  25. ncbi request reprint Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might think
    Martin L Moore
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Lung Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Allergy Clin Immunol 117:1036-9. 2006
    ..This review summarizes the current literature on the role of PGs and PG receptors in allergic lung inflammation...
  26. ncbi request reprint Oxidant stress modulates murine allergic airway responses
    Megha Talati
    Department of Medicine, T 1217 MCN, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 40:1210-9. 2006
    ..Oxidant stress plays a role in the production of airway responsiveness...
  27. ncbi request reprint Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge
    Michael Y Viksman
    Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6801, USA
    Clin Immunol 104:77-85. 2002
    ..The different results obtained with the two challenge methods probably depend on higher local concentrations of allergen in the EB challenge. We suggest that activation of AM occurs following EB challenge with antigen in asthmatics...
  28. ncbi request reprint Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation
    Ruxana T Sadikot
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 170:1091-8. 2003
    ..Therapies targeted to NF-kappaB in lung epithelium may be beneficial in treating inflammatory lung diseases...
  29. ncbi request reprint The complex relationship between respiratory syncytial virus and allergy in lung disease
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Viral Immunol 16:25-34. 2003
    ..We also review the published murine models that combine RSV infection and allergic sensitization that attempt to explain the complex relationship between these two factors in regard to lung immunopathology and physiologic dysfunction...
  30. ncbi request reprint Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5
    Koichi Hashimoto
    Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
    Am J Respir Crit Care Med 170:306-12. 2004
    ..The impact of virus infection combined with allergic inflammation on mucus production may partially explain the more severe disease and airway hyperresponsiveness associated with RSV in the setting of atopy...
  31. pmc Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Virol 78:10303-9. 2004
    ..These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI(2) is a potential therapeutic target in the treatment of RSV...
  32. ncbi request reprint Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 174:525-32. 2005
    ..These results illustrate the central role played by products derived from the COX pathway in the regulation of allergic immune responses...
  33. ncbi request reprint Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells
    Weisong Zhou
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 178:702-10. 2007
    ..These findings suggest that PGI(2) signaling through the IP may exert anti-inflammatory effects by acting on DC...
  34. ncbi request reprint Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 175:8253-9. 2005
    ..These results elucidate the pathways by which COX inhibition exerts a critical effect of the pulmonary allergen-induced inflammatory response and confirm that COX products are important regulators of allergic inflammation...
  35. ncbi request reprint Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent
    Ioannis Kalomenidis
    Marianthi Simou Laboratory, Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, 45 47 Ipsilandou Str, 10675 Athens, Greece
    Chest 128:2978-83. 2005
    ..To establish a murine model of pneumothorax-associated pleural eosinophilia and to examine the role of interleukin (IL)-5 and IL-13 in the pathogenesis of this reaction...
  36. ncbi request reprint The role of IFN in respiratory syncytial virus pathogenesis
    Joan E Durbin
    Children s Research Institute, Children s Hospital, Columbus, OH 43205, USA
    J Immunol 168:2944-52. 2002
    ..These findings suggest that STAT1 activation by both type I (alphabeta) and type II (gamma) IFNs plays an important role in establishing a protective, Th1 Ag-specific immune response to RSV infection...
  37. ncbi request reprint Pleural fluid levels of vascular cell adhesion molecule-1 are elevated in eosinophilic pleural effusions
    Ioannis Kalomenidis
    Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, Athens, Greece
    Chest 124:159-66. 2003
    ....
  38. ncbi request reprint Viral infections, atopy, and asthma: is there a causal relationship?
    R Stokes Peebles
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Allergy Clin Immunol 113:S15-8. 2004
    ..This review will discuss existing data on RSV infection and respiratory complications later in life, as well as the link between RSV and allergic disease...
  39. ncbi request reprint A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapy
    R Stokes Peebles
    Am J Respir Cell Mol Biol 37:375-7. 2007
  40. pmc Pathogenesis of respiratory syncytial virus infection in the murine model
    R Stokes Peebles
    Vaccine Research Center, NIAID NIH, 40 Convent Drive, Building 40, Room 2502, Bethesda, MD 20892 3017, USA
    Proc Am Thorac Soc 2:110-5. 2005
    ..This article briefly reviews the clinical sequelae of RSV infection and then focuses on the mechanisms of viral pathogenesis...
  41. ncbi request reprint Anaphylaxis and anaphylactoid reactions. A guide to prevention, recognition, and emergent treatment
    Csaba Rusznak
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Postgrad Med 111:101-4, 107-8, 111-4. 2002
    ..In this article, Drs Rusznak and Peebles discuss the mechanisms of these reactions, common causative agents, preventive strategies, recognition, and treatment...
  42. ncbi request reprint Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions
    Ioannis Kalomenidis
    Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, 45 47 Ipsilandou Str, 10675 Athens, Greece
    Chest 127:2094-100. 2005
    ....