Sachin Patel

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Eur J Neurosci 21:1057-69. 2005
  2. pmc Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala
    Sachin Patel
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    Neuropsychopharmacology 34:2699-709. 2009
  3. pmc Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation
    Sachin Patel
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 27:2821-9. 2008
  4. pmc Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses
    Teniel S Ramikie
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuron 81:1111-25. 2014
  5. pmc Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation
    Daniel J Hermanson
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:1291-8. 2013
  6. pmc CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling
    Brian C Shonesy
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:456-63. 2013
  7. pmc Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation
    Joshua J Sumislawski
    Department of Psychiatry, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuropsychopharmacology 36:2750-61. 2011
  8. pmc Dissociable effects of CB1 receptor blockade on anxiety-like and consummatory behaviors in the novelty-induced hypophagia test in mice
    Joyonna C Gamble-George
    Department of Psychiatry, Vanderbilt University School of Medicine, Robinson Research Building, Rm 724B, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 228:401-9. 2013
  9. ncbi request reprint Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 318:304-11. 2006
  10. ncbi request reprint U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance
    David J Rademacher
    Medical College of Wisconsin, Dept of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 288:H2694-701. 2005

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Eur J Neurosci 21:1057-69. 2005
    ....
  2. pmc Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala
    Sachin Patel
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    Neuropsychopharmacology 34:2699-709. 2009
    ..We suggest stress-induced enhancement of eCB-mediated suppression of inhibitory transmission in the BLA could contribute to affective dysregulation associated with chronic stress...
  3. pmc Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation
    Sachin Patel
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 27:2821-9. 2008
    ..The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed...
  4. pmc Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses
    Teniel S Ramikie
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuron 81:1111-25. 2014
    ....
  5. pmc Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation
    Daniel J Hermanson
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:1291-8. 2013
    ..Our data suggest a key role for COX-2 in the regulation of eCB signaling and indicate that substrate-selective pharmacology represents a viable approach for eCB augmentation with broad therapeutic potential. ..
  6. pmc CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling
    Brian C Shonesy
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:456-63. 2013
    ..These findings provide mechanistic insights into the molecular regulation of striatal endocannabinoid signaling with implications for physiological control of motor function...
  7. pmc Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation
    Joshua J Sumislawski
    Department of Psychiatry, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuropsychopharmacology 36:2750-61. 2011
    ..These data indicate that chronic stress reversibly gates eCB synaptic plasticity at inhibitory synapses in the amygdala, and in vivo augmentation of 2-AG levels prevents both behavioral and synaptic adaptations to chronic stress...
  8. pmc Dissociable effects of CB1 receptor blockade on anxiety-like and consummatory behaviors in the novelty-induced hypophagia test in mice
    Joyonna C Gamble-George
    Department of Psychiatry, Vanderbilt University School of Medicine, Robinson Research Building, Rm 724B, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 228:401-9. 2013
    ....
  9. ncbi request reprint Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 318:304-11. 2006
    ..These results suggest that pharmacological modulation of this system could represent a new approach to the treatment of anxiety-related psychiatric disorders...
  10. ncbi request reprint U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance
    David J Rademacher
    Medical College of Wisconsin, Dept of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 288:H2694-701. 2005
    ..These results suggest that MCA production of eCBs is not regulated by constriction per se but likely via a signaling pathway that is specific for TXA(2) receptors and not 5-HT receptors...
  11. ncbi request reprint Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Neuropsychopharmacology 30:508-15. 2005
    ....
  12. ncbi request reprint Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:5431-8. 2004
    ....
  13. ncbi request reprint Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuropsychopharmacology 30:497-507. 2005
    ....
  14. ncbi request reprint Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition
    Jeanne L Seagard
    Zablocki Dept of Veterans Affairs Medical Center, Research Service 151, 5000 W National Ave, Milwaukee, WI 53295, USA
    Am J Physiol Heart Circ Physiol 286:H992-1000. 2004
    ....
  15. pmc The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Br J Pharmacol 139:1005-13. 2003
    ....
  16. ncbi request reprint Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 306:880-8. 2003
    ....
  17. ncbi request reprint Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 284:H1570-6. 2003
    ..Microinjection of WIN-55212-2 had no effect on the baroreflex. These data suggest that endocannabinoids can modulate the excitability of NTS neurons involved in the baroreceptor reflex, leading to modulation of baroreflex regulation...
  18. ncbi request reprint The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53223, USA
    Neurosci Lett 335:95-8. 2002
    ..These data suggest that suppression of endogenous cannabinergic neurotransmission results in increased cortical activity in response to physiological sensory stimulation...