Fritz F Parl

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Glutathione S-transferase genotypes and cancer risk
    Fritz F Parl
    Department of Pathology and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Lett 221:123-9. 2005
  2. doi request reprint Estrogen metabolism and breast cancer: a risk model
    Fritz F Parl
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Ann N Y Acad Sci 1155:68-75. 2009
  3. doi request reprint Implementation of a closed-loop reporting system for critical values and clinical communication in compliance with goals of the joint commission
    Fritz F Parl
    Clinical Chemistry Laboratory, Department of Pathology, TVC 4918, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Clin Chem 56:417-23. 2010
  4. pmc Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction
    Philip S Crooke
    Department of Mathematics, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 20:1502-15. 2011
  5. ncbi request reprint In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol
    Sheila Dawling
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Chem Res Toxicol 17:1258-64. 2004
  6. pmc A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24
    Kathryn S Higginbotham
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 21:1565-73. 2012
  7. ncbi request reprint Estrogens, enzyme variants, and breast cancer: a risk model
    Philip S Crooke
    Department of Pathology, TVC 4918, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 15:1620-9. 2006
  8. ncbi request reprint Cytochrome P450 1B1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation
    Alexandra R Belous
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 67:812-7. 2007
  9. ncbi request reprint Sequential action of phase I and II enzymes cytochrome p450 1B1 and glutathione S-transferase P1 in mammary estrogen metabolism
    David L Hachey
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Cancer Res 63:8492-9. 2003
  10. pmc Targeted multiplex imaging mass spectrometry with single chain fragment variable (scfv) recombinant antibodies
    Gwendoline Thiery
    Mass Spectrometry Research Center, School of Medicine, Vanderbilt University, Nashville, TN, USA
    J Am Soc Mass Spectrom 23:1689-96. 2012

Research Grants

Detail Information

Publications24

  1. ncbi request reprint Glutathione S-transferase genotypes and cancer risk
    Fritz F Parl
    Department of Pathology and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Lett 221:123-9. 2005
    ....
  2. doi request reprint Estrogen metabolism and breast cancer: a risk model
    Fritz F Parl
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Ann N Y Acad Sci 1155:68-75. 2009
    ..Our in silico model integrates diverse types of data and offers the exciting opportunity for researchers to combine metabolic and genetic data in assessing estrogenic exposure in relation to breast cancer risk...
  3. doi request reprint Implementation of a closed-loop reporting system for critical values and clinical communication in compliance with goals of the joint commission
    Fritz F Parl
    Clinical Chemistry Laboratory, Department of Pathology, TVC 4918, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Clin Chem 56:417-23. 2010
    ..Current practices of reporting critical laboratory values make it challenging to measure and assess the timeliness of receipt by the treating physician as required by The Joint Commission's 2008 National Patient Safety Goals...
  4. pmc Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction
    Philip S Crooke
    Department of Mathematics, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 20:1502-15. 2011
    ..Current models of breast cancer risk prediction do not directly reflect mammary estrogen metabolism or genetic variability in exposure to carcinogenic estrogen metabolites...
  5. ncbi request reprint In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol
    Sheila Dawling
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Chem Res Toxicol 17:1258-64. 2004
    ....
  6. pmc A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24
    Kathryn S Higginbotham
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 21:1565-73. 2012
    ..We conducted a multistage genetic association study in a series of independent epidemiologic breast cancer study populations to identify novel breast cancer risk variants...
  7. ncbi request reprint Estrogens, enzyme variants, and breast cancer: a risk model
    Philip S Crooke
    Department of Pathology, TVC 4918, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 15:1620-9. 2006
    ..The model offers the opportunity to combine metabolic, genetic, and lifetime exposure data in assessing estrogens as a breast cancer risk factor...
  8. ncbi request reprint Cytochrome P450 1B1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation
    Alexandra R Belous
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 67:812-7. 2007
    ..The results present direct proof of CYP1B1-mediated, E2-induced adduct formation and provide the experimental basis for future studies of estrogen carcinogenesis...
  9. ncbi request reprint Sequential action of phase I and II enzymes cytochrome p450 1B1 and glutathione S-transferase P1 in mammary estrogen metabolism
    David L Hachey
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Cancer Res 63:8492-9. 2003
    ....
  10. pmc Targeted multiplex imaging mass spectrometry with single chain fragment variable (scfv) recombinant antibodies
    Gwendoline Thiery
    Mass Spectrometry Research Center, School of Medicine, Vanderbilt University, Nashville, TN, USA
    J Am Soc Mass Spectrom 23:1689-96. 2012
    ....
  11. ncbi request reprint Immunohistochemical expression of estrogen receptor in enlarged lobular units with columnar alteration in benign breast biopsies: a nested case-control study
    Bernadette K McLaren
    Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Am J Surg Pathol 29:105-8. 2005
    ..These findings have implications for risk assessment in benign breast biopsies and are of particular interest given the controversy currently surrounding hormone replacement therapy...
  12. ncbi request reprint Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk
    Nady Roodi
    Department of Pathology, Program in Human Genetics and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Res 64:1233-6. 2004
    ..2%) of 203 patients. Compared with women with the -/- genotype, the relative risk of breast cancer for the +/+ genotype was 2.83 (95% confidence interval, 1.45-5.59; P = 0.002), suggesting a protective effect of the GSTM1 deletion...
  13. ncbi request reprint Calcium-phosphorus product and troponin-T values in renal failure
    Keith Wrenn
    Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, TN 7232 4700, USA
    Am J Emerg Med 24:836-8. 2006
    ..The purpose of this study was to see if there is a significant association between calcium-phosphorus product (CPP) and initial troponin-T values in patients with renal insufficiency...
  14. ncbi request reprint Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women
    Jeffrey A Canter
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical Center, Nasshville, Tennessee 37212, USA
    Cancer Res 65:8028-33. 2005
    ..31; P = 0.81). This study provides novel epidemiologic evidence that the mtDNA 10398A allele influences breast cancer susceptibility in African-American women. mtDNA polymorphisms may be underappreciated factors in breast carcinogenesis...
  15. pmc A multistage association study identifies a breast cancer genetic locus at NCOA7
    Kathryn S P Higginbotham
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 71:3881-8. 2011
    ..These observations provide consistent evidence that genetic variants at the NCOA7 locus may confer a reduced risk of breast cancer...
  16. ncbi request reprint Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer
    Asha R Kallianpur
    Department of Medicine, Division of General Internal Medicine, Vanderbilt University Medical Center, and VA Center for Health Services Research, Veterans Affairs Medical Center, Nashville, Tennessee, USA
    Cancer Epidemiol Biomarkers Prev 13:205-12. 2004
    ....
  17. ncbi request reprint Carcinogen-induced histone alteration in normal human mammary epithelial cells
    Chastity Bradley
    Department of Pathology, Vanderbilt University Medical Center, 4918 TVC, 22nd Avenue South Pierce, Nashville, TN 37232, USA
    Carcinogenesis 28:2184-92. 2007
    ....
  18. pmc Estrogen exposure, metabolism, and enzyme variants in a model for breast cancer risk prediction
    Fritz F Parl
    Department of Pathology, Vanderbilt University, Nashville, TN 37232
    Cancer Inform 7:109-21. 2009
    ..Instead of providing a general risk estimate our model would predict the risk for each individual woman based on her age, reproductive experiences as well as her genotypic profile...
  19. ncbi request reprint Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1
    Sheila Dawling
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 63:3127-32. 2003
    ..Thus, methoxyestrogens exert feedback inhibition on CYP1A1- and CYP1B1-mediated oxidative estrogen metabolism, thereby reducing the potential for estrogen-induced DNA damage...
  20. ncbi request reprint Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
    Kim M Smits
    University Maastricht, Maastricht, The Netherlands
    Int J Cancer 110:266-70. 2004
    ..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected...
  21. ncbi request reprint Breast cancer risk associated with estrogen receptor expression in epithelial hyperplasia lacking atypia and adjacent lobular units
    Helenice Gobbi
    Department of Anatomic Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Int J Cancer 113:857-9. 2005
    ..0-3.8). This risk was not affected by the ERalpha status of EHLA lesions. ERalpha expression in adjacent normal lobules increases the moderate breast cancer risk previously associated with EHLA...
  22. ncbi request reprint Estrogen receptor genotypes and haplotypes associated with breast cancer risk
    Bert Gold
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, USA
    Cancer Res 64:8891-900. 2004
    ..Genetic epidemiology study replication and functional assays of the haplotypes should permit a better understanding of the role of steroid receptor genetic variants and breast cancer risk...
  23. ncbi request reprint Glutathione S-transferases M1, T1, and P1 and breast cancer: a pooled analysis
    Florian D Vogl
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 13:1473-9. 2004
    ..The results conclusively show that single gene GST polymorphisms do not confer a substantial risk of breast cancer to its carriers. Furthermore, GSTs did not interact with smoking or reproductive history to modify cancer risk...
  24. ncbi request reprint Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review
    Valentina Paracchini
    Scientific Direction, Ospedale Maggiore, Milan, Italy
    Am J Epidemiol 165:115-25. 2007
    ..The observed effect of age on the association in Caucasians indicates that further studies are needed on the role of CYP1B1 Val432Leu in estrogen metabolism according to age, ethnicity, and menopausal status...

Research Grants6

  1. MAMMARY ESTROGEN METABOLISM AND BREAST CANCER RISK
    Fritz Parl; Fiscal Year: 2004
    ..The applicants will measure catechol estrogens in tissues selected by genotype and matched by menopausal status and body mass index and compare the results to those in their in vitro and cell line experiments. ..