Pratik Pandharipande

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial
    Mayur B Patel
    Veterans Affairs VA, Tennessee Valley Healthcare System, Nashville VA Medical Center, 1310 24th Avenue South, Nashville, TN 37212, USA
    Trials 13:177. 2012
  2. ncbi request reprint Sedation in the intensive care unit
    S McGrane
    Department of Anesthesiology and Critical Care, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Minerva Anestesiol 78:369-80. 2012
  3. pmc Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients
    Stuart McGrane
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
    Crit Care 15:R78. 2011
  4. pmc Bench-to-bedside review: delirium in ICU patients - importance of sleep deprivation
    Gerald L Weinhouse
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Crit Care 13:234. 2009
  5. pmc Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care
    Pratik Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, 1310 24th Ave South, Nashville 37212, USA
    Crit Care 14:157. 2010
  6. pmc Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
  7. pmc Narcotic-based sedation regimens for critically ill mechanically ventilated patients
    Pratik Pandharipande
    Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Crit Care 9:247-8. 2005
  8. pmc Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients
    P P Pandharipande
    Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt Medical Center, 526 MAB, Nashville, TN, 37212, USA
    Intensive Care Med 35:1886-92. 2009
  9. pmc Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score
    Pratik P Pandharipande
    Department of Anesthesiology, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:1317-21. 2009
  10. ncbi request reprint Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill
    Pratik Pandharipande
    Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, 324 MAB, 1313 21st Avenue South, Nashville, TN 37232, USA
    Crit Care Clin 22:313-27, vii. 2006

Collaborators

Detail Information

Publications37

  1. pmc Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial
    Mayur B Patel
    Veterans Affairs VA, Tennessee Valley Healthcare System, Nashville VA Medical Center, 1310 24th Avenue South, Nashville, TN 37212, USA
    Trials 13:177. 2012
    ..However, there is no prospective randomized evidence available demonstrating the feasibility, outcome benefits, and safety for adrenergic blockade after TBI...
  2. ncbi request reprint Sedation in the intensive care unit
    S McGrane
    Department of Anesthesiology and Critical Care, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Minerva Anestesiol 78:369-80. 2012
    ....
  3. pmc Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients
    Stuart McGrane
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
    Crit Care 15:R78. 2011
    ..This study sought to investigate the relationship between two inflammatory biomarkers, procalcitonin and C-reactive protein (CRP), and duration of acute brain dysfunction in ventilated patients...
  4. pmc Bench-to-bedside review: delirium in ICU patients - importance of sleep deprivation
    Gerald L Weinhouse
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Crit Care 13:234. 2009
    ..Sleep deprivation may prove to be a modifiable risk factor for the development of delirium with important implications for the acute and long-term outcome of critically ill patients...
  5. pmc Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care
    Pratik Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, 1310 24th Ave South, Nashville 37212, USA
    Crit Care 14:157. 2010
    ....
  6. pmc Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
    ....
  7. pmc Narcotic-based sedation regimens for critically ill mechanically ventilated patients
    Pratik Pandharipande
    Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Crit Care 9:247-8. 2005
    ..Modifying sedation paradigms utilizing either narcotic-based regimens with remifentanil or fentanyl, or by using alpha2 agonists such as dexmedetomidine may help in improving these outcomes in critically ill patients...
  8. pmc Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients
    P P Pandharipande
    Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt Medical Center, 526 MAB, Nashville, TN, 37212, USA
    Intensive Care Med 35:1886-92. 2009
    ..This pilot study investigated whether alterations of tryptophan (Trp), phenylalanine (Phe), and tyrosine (Tyr) plasma levels were associated with a higher risk of transitioning to delirium in critically ill patients...
  9. pmc Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score
    Pratik P Pandharipande
    Department of Anesthesiology, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:1317-21. 2009
    ....
  10. ncbi request reprint Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill
    Pratik Pandharipande
    Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, 324 MAB, 1313 21st Avenue South, Nashville, TN 37232, USA
    Crit Care Clin 22:313-27, vii. 2006
    ....
  11. ncbi request reprint Delirium: acute cognitive dysfunction in the critically ill
    Pratik Pandharipande
    Department of Anesthesiology Division of Critical Care, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Crit Care 11:360-8. 2005
    ..Hence, critical care physicians and nurses should routinely assess their patients for delirium and develop strategies for its prevention and treatment...
  12. ncbi request reprint Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Anesthesiology 104:21-6. 2006
    ..Sedative and analgesic medications relieve anxiety and pain but may contribute to patients' transitioning into delirium...
  13. ncbi request reprint Alpha-2 agonists: can they modify the outcomes in the Postanesthesia Care Unit?
    P Pandharipande
    Department of Anesthesiology, Division of Critical Care Medicine, Vanderbilt University School of Medicine, 324 MAB, 21st Ave South, Nashville, TN 37232, USA
    Curr Drug Targets 6:749-54. 2005
    ....
  14. ncbi request reprint Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
  15. pmc The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*
    Alessandro Morandi
    Center for Quality of Aging, Vanderbilt University Medical Center, Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 40:2182-9. 2012
    ..Relationships between 1) delirium duration and brain white matter integrity, and 2) white matter integrity and long-term cognitive impairment are poorly understood and could be explored using magnetic resonance imaging...
  16. pmc The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*
    Max L Gunther
    Department of Psychiatry, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232 8300, USA
    Crit Care Med 40:2022-32. 2012
    ....
  17. pmc Prevalence and risk factors for development of delirium in burn intensive care unit patients
    Vivek Agarwal
    Vanderbilt School of Medicine, Nashville, Tennessee, USA
    J Burn Care Res 31:706-15. 2010
    ..Exposure to benzodiazepines was an independent risk factor for delirium, whereas opiates and methadone reduced the risk of developing delirium, possibly through reduction of pain in these patients...
  18. pmc CYP2A6 genetic variation and dexmedetomidine disposition
    Utkarsh Kohli
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Eur J Clin Pharmacol 68:937-42. 2012
    ..We examined whether CYP2A6 genotypes affect dexmedetomidine disposition...
  19. ncbi request reprint Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients
    E Wesley Ely
    Department of Medicine, Saint Thomas Hospital, and Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Crit Care Med 35:112-7. 2007
    ..To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium...
  20. pmc Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Trauma 65:34-41. 2008
    ..The purpose of this study was to analyze the prevalence of and risk factors for delirium in surgical and trauma ICU patients...
  21. doi request reprint Feasibility of implementing a reduced fasting protocol for critically ill trauma patients undergoing operative and nonoperative procedures
    Robert M Pousman
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, West Los Angeles VA, Los Angeles, California, USA
    JPEN J Parenter Enteral Nutr 33:176-80. 2009
    ..This prospective, observational cohort study was designed to determine the feasibility of implementing a reduced enteral fasting protocol in mechanically ventilated trauma patients undergoing selected operative and nonoperative procedures...
  22. pmc The complex interplay between delirium, sedation, and early mobility during critical illness: applications in the trauma unit
    Arna Banerjee
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Curr Opin Anaesthesiol 24:195-201. 2011
    ..This review will focus on the epidemiology of these two disease processes and discuss strategies aimed at reducing these devastating complications of critical illness...
  23. pmc Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals
    Rina P Patel
    School of Medicine RPP, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:825-32. 2009
    ..Our objective was to assess beliefs and practices regarding ICU delirium and sedation management...
  24. doi request reprint Atypical sleep in ventilated patients: empirical electroencephalography findings and the path toward revised ICU sleep scoring criteria
    Paula L Watson
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 41:1958-67. 2013
    ....
  25. ncbi request reprint Acute dermal capillary rupture associated with noninvasive blood pressure monitoring
    Michael W Chester
    Department of Anesthesiology, Vanderbilt Medical Center, Nashville, TN 37212 1204, USA
    J Clin Anesth 19:473-5. 2007
    ..Anesthesiologists need to be aware that acute dermal capillary rupture, although rare, can occur in patients with thrombocytopenia and/or long-standing diabetes...
  26. pmc Delirium in the intensive care unit
    Timothy D Girard
    Department of Medicine Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University School of Medicine 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Crit Care 12:S3. 2008
    ..Strategies for the prevention and treatment of ICU delirium are the subjects of multiple ongoing investigations...
  27. pmc Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality
    Paula L Watson
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 36:3171-7. 2008
    ..Burst suppression has never been studied as a potential risk factor for death in patients without a known neurologic disorder or injury...
  28. pmc Delirium: an emerging frontier in the management of critically ill children
    Heidi A B Smith
    Pediatrics and Anesthesiology Division of Critical Care, Department of Pediatrics, 5121 Doctor s Office Tower, 2200 Children s Way, Nashville, TN 37232 9075, USA
    Crit Care Clin 25:593-614, x. 2009
    ....
  29. pmc Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
    Crit Care Med 38:1513-20. 2010
    ..To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation...
  30. pmc Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:428-37. 2010
    ..To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma...
  31. pmc Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit
    Heidi A B Smith
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 39:150-7. 2011
    ..To validate a diagnostic instrument for pediatric delirium in critically ill children, both ventilated and nonventilated, that uses standardized, developmentally appropriate measurements...
  32. pmc A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study
    Leena Choi
    Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN, USA
    J Pharmacokinet Pharmacodyn 38:613-36. 2011
    ..We also conducted simulation studies with a varying proportion of the outliers. These simulation results showed that the proposed model can accommodate the outliers well so that the estimated PK parameters are less biased...
  33. pmc Neuroimaging in delirious intensive care unit patients: a preliminary case series report
    Alessandro Morandi
    Center for Health Services Research Center, Vanderbilt Center for Quality of Aging, Nashville, Tennesee, USA
    Psychiatry (Edgmont) 7:28-33. 2010
    ..e. white matter hyperintensities) and short- and long-term neurological outcomes...
  34. doi request reprint Anesthesia for liver transplantation in US academic centers: institutional structure and perioperative care
    Ann Walia
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA
    Liver Transpl 18:737-43. 2012
    ..However, similarities in specific duties across all teams suggest some degree of self-initiated specialization...
  35. doi request reprint Intraoperative risk factors for acute respiratory distress syndrome in critically ill patients
    Christopher G Hughes
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
    Anesth Analg 111:464-7. 2010
    ..However, research examining intraoperative factors such as fluid resuscitation, mechanical ventilation strategies, and blood administration on the postoperative development of ARDS is lacking...
  36. ncbi request reprint Dolasetron-induced torsades de pointes
    Sarah Turner
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Clin Anesth 19:622-5. 2007
    ..On transport to the neurological intensive care unit, the patient developed torsades de pointes, requiring cardiopulmonary resuscitation, before a return to normal sinus rhythm...
  37. pmc Implementation, reliability testing, and compliance monitoring of the Confusion Assessment Method for the Intensive Care Unit in trauma patients
    Stacie L Soja
    Department of Pharmacy, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Intensive Care Med 34:1263-8. 2008
    ..To implement delirium monitoring, test reliability, and monitor compliance of performing the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) in trauma patients...