Research Topics
| Kevin OsteenSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosisKevin G Osteen
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Fertil Steril 83:529-37. 2005..To discuss the role that reduced endometrial responsiveness to progesterone (P) might play in the pathophysiology of endometriosis...- Endometrial biology and the etiology of endometriosisKevin G Osteen
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Fertil Steril 84:33-4; discussion 38-9. 2005..These studies emphasize the complexity of endometriosis and underscore the different roles of clinicians and translational scientists in exploring this disease... - Progesterone action in the human endometrium: induction of a unique tissue environment which limits matrix metalloproteinase (MMP) expressionKevin G Osteen
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Front Biosci 8:d78-86. 2003.... 
Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosisTultul Nayyar
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Avenue S, MCN B 1100, Nashville, TN 37232, USA
Reprod Toxicol 23:326-36. 2007..We find that the uterine phenotype of toxicant-exposed mice is markedly similarly to the endometrial phenotype of women with endometriosis...- Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytesKaylon L Bruner-Tran
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Fertil Steril 93:2519-24. 2010..To develop a chimeric human/mouse model of experimental endometriosis for the examination of the role of human immune cells in this disease... - Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude miceKaylon L Bruner-Tran
Women's Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Endocrinol Metab 87:4782-91. 2002..However, in vitro treatments with retinoic acid and TGF beta restored the ability of progesterone to suppress MMPs in vitro and prevented the establishment of experimental disease... - Progesterone-mediated endometrial maturation limits matrix metalloproteinase (MMP) expression in an inflammatory-like environment: a regulatory system altered in endometriosisKevin G Osteen
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Ann N Y Acad Sci 955:37-47; discussion 86-8, 396-406. 2002.... - Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxinToshio M Igarashi
Women's Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Fertil Steril 84:67-74. 2005.... - Dioxin and endometrial progesterone resistanceKaylon L Bruner-Tran
Department of Obstetrics and Gynecology, Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2519
Semin Reprod Med 28:59-68. 2010..These studies and others underscore the importance of developing a greater understanding of the mechanisms of TCDD action that relate to reproductive disorders such as endometriosis... - Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosisKevin G Osteen
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University of Medicine, Nashville, Tennessee 37232, USA
Ann N Y Acad Sci 955:139-46; discussion 157-8, 396-406. 2002..Targeting pregnancy-associated factors that inhibit endometrial-specific MMP expression and action may enhance the effectiveness of progestin-related treatments for endometriosis... - Dioxin-like PCBs and endometriosisKaylon L Bruner-Tran
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232 2519, USA
Syst Biol Reprod Med 56:132-46. 2010..We will also discuss the potential importance of early life exposures to these toxicants on the subsequent development of endometriosis... - Dioxin may promote inflammation-related development of endometriosisKaylon L Bruner-Tran
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Fertil Steril 89:1287-98. 2008..We discuss evidence that modulation of the endometrial endocrine-immune interface could mechanistically link toxicant exposure to the development of this disease... - Matrix metalloproteinases and endometriosisKevin G Osteen
Women's Reproductive Health Research Center, Department of Obstetrics Gynecology, Vanderbilt University School of Medicine, B-1100 Medical Center North, Nashville, TN 37232, USA
Semin Reprod Med 21:155-64. 2003..Altered regulation of endometrial MMP expression in response to steroids may represent a mechanism linking the invasive potential of refluxed endometrium to the establishment of this disease only in certain women... - Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaprogetKaylon L Bruner-Tran
Women's Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Avenue S, MCN B-1100, Nashville, TN 37232, USA
J Clin Endocrinol Metab 91:1554-60. 2006..CONCLUSION: Given the positive preclinical pharmacological profile of TNPR that has recently been reported, additional development of this compound for the treatment of endometriosis is warranted... - Experimental endometriosis: the nude mouse as a xenographic hostKaylon L Bruner-Tran
Women's Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Ann N Y Acad Sci 955:328-39; discussion 340-2, 396-406. 2002..Developing a better understanding of the impairments in the normal endometrial physiology of women with endometriosis should aid in the development of better treatment or diagnostic strategies... - Regulated expression of osteopontin in the peri-implantation rabbit uterusK B C Apparao
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Fertility, The University of North Carolina at Chapel Hill, 27599-7570, USA
Biol Reprod 68:1484-90. 2003..In The rabbit uterus, as in other mammalian species studied, OPN is expressed in a stage-specific manner by the endometrial glands during the peri-implantation period and is regulated by progesterone... - Simvastatin protects against the development of endometriosis in a nude mouse modelKaylon L Bruner-Tran
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Endocrinol Metab 94:2489-94. 2009..Endometriosis is a common condition associated with infertility and pelvic pain in women. Recent in vitro studies have shown that statins decrease proliferation of endometrial stroma (ES) and inhibit angiogenesis... - Regulation and function of LEFTY-A/EBAF in the human endometrium. mRNA expression during the menstrual cycle, control by progesterone, and effect on matrix metalloprotineasesPatricia B Cornet
Cell Biology Unit, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Avenue Hippocrate, 75, B 1200 Bruxelles, Belgium
J Biol Chem 277:42496-504. 2002..Progesterone appears to exert a dual block, upstream by inhibiting LEFTY-A expression and downstream by suppressing its stimulatory effect on MMPs... - The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycleThomas E Curry
Department of Obstetrics and Gynecology (T.E.C, University of Kentucky, Lexington, Kentucky 40536, USA
Endocr Rev 24:428-65. 2003.... - Antiangiogenic agents are effective inhibitors of endometriosisM Louise Hull
Department of Pathology, Reproductive Molecular Research Group, Cambridge, United Kingdom CB2 1QP
J Clin Endocrinol Metab 88:2889-99. 2003..These findings suggest that antiangiogenic agents may provide a novel therapeutic approach for the treatment of endometriosis... - A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosisHeather A Harris
Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
Hum Reprod 20:936-41. 2005..Because endometriosis is now thought to be, at least in part, an inflammatory disease, we evaluated ERB-041's activity in an experimentally induced model of endometriosis...
Research Grants
- Fetal Dioxin Exposure And The Pathology of EndometriosisKevin Osteen; Fiscal Year: 2005..abstract_text> ..
- Loss of Complement-Protective CD55 Expression in EndometriosisKevin G Osteen; Fiscal Year: 2010....
- Dioxin Exposure and the Invasive Pathogenesis of EndometriosisKevin Osteen; Fiscal Year: 2009....
- Loss of Complement-Protective CD55 Expression in EndometriosisKevin Osteen; Fiscal Year: 2009....
- Dioxin Exposure and the Invasive Pathogenesis of EndometriosisKevin Osteen; Fiscal Year: 2007....
- Loss of Complement-Protective CD55 Expression in EndometriosisKevin Osteen; Fiscal Year: 2007....
- Dioxin Exposure and the Invasive Pathogenesis of EndometriosisKevin G Osteen; Fiscal Year: 2010....