Kevin Osteen

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology
    K L Bruner-Tran
    Department of Obstetrics and Gynecology, Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Minerva Ginecol 65:199-213. 2013
  2. ncbi request reprint Endometrial biology and the etiology of endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 84:33-4; discussion 38-9. 2005
  3. ncbi request reprint Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 83:529-37. 2005
  4. ncbi request reprint Progesterone action in the human endometrium: induction of a unique tissue environment which limits matrix metalloproteinase (MMP) expression
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Front Biosci 8:d78-86. 2003
  5. pmc Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis
    Tultul Nayyar
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Avenue S, MCN B 1100, Nashville, TN 37232, USA
    Reprod Toxicol 23:326-36. 2007
  6. ncbi request reprint Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Endocrinol Metab 87:4782-91. 2002
  7. pmc Dioxin and endometrial progesterone resistance
    Kaylon L Bruner-Tran
    Department of Obstetrics and Gynecology, Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2519
    Semin Reprod Med 28:59-68. 2010
  8. pmc Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 93:2519-24. 2010
  9. ncbi request reprint Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Toshio M Igarashi
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 84:67-74. 2005
  10. ncbi request reprint Progesterone-mediated endometrial maturation limits matrix metalloproteinase (MMP) expression in an inflammatory-like environment: a regulatory system altered in endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Ann N Y Acad Sci 955:37-47; discussion 86-8, 396-406. 2002

Collaborators

Detail Information

Publications22

  1. pmc Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology
    K L Bruner-Tran
    Department of Obstetrics and Gynecology, Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Minerva Ginecol 65:199-213. 2013
    ....
  2. ncbi request reprint Endometrial biology and the etiology of endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 84:33-4; discussion 38-9. 2005
    ..These studies emphasize the complexity of endometriosis and underscore the different roles of clinicians and translational scientists in exploring this disease...
  3. ncbi request reprint Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 83:529-37. 2005
    ..To discuss the role that reduced endometrial responsiveness to progesterone (P) might play in the pathophysiology of endometriosis...
  4. ncbi request reprint Progesterone action in the human endometrium: induction of a unique tissue environment which limits matrix metalloproteinase (MMP) expression
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Front Biosci 8:d78-86. 2003
    ....
  5. pmc Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis
    Tultul Nayyar
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Avenue S, MCN B 1100, Nashville, TN 37232, USA
    Reprod Toxicol 23:326-36. 2007
    ..We find that the uterine phenotype of toxicant-exposed mice is markedly similarly to the endometrial phenotype of women with endometriosis...
  6. ncbi request reprint Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Endocrinol Metab 87:4782-91. 2002
    ..However, in vitro treatments with retinoic acid and TGF beta restored the ability of progesterone to suppress MMPs in vitro and prevented the establishment of experimental disease...
  7. pmc Dioxin and endometrial progesterone resistance
    Kaylon L Bruner-Tran
    Department of Obstetrics and Gynecology, Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2519
    Semin Reprod Med 28:59-68. 2010
    ..These studies and others underscore the importance of developing a greater understanding of the mechanisms of TCDD action that relate to reproductive disorders such as endometriosis...
  8. pmc Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 93:2519-24. 2010
    ..To develop a chimeric human/mouse model of experimental endometriosis for the examination of the role of human immune cells in this disease...
  9. ncbi request reprint Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Toshio M Igarashi
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 84:67-74. 2005
    ..To analyze endometrial progesterone receptor (PR) expression in women with endometriosis compared with disease-free women and to assess the impact of in vitro 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on PR isotype expression...
  10. ncbi request reprint Progesterone-mediated endometrial maturation limits matrix metalloproteinase (MMP) expression in an inflammatory-like environment: a regulatory system altered in endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Ann N Y Acad Sci 955:37-47; discussion 86-8, 396-406. 2002
    ....
  11. ncbi request reprint Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University of Medicine, Nashville, Tennessee 37232, USA
    Ann N Y Acad Sci 955:139-46; discussion 157-8, 396-406. 2002
    ..Targeting pregnancy-associated factors that inhibit endometrial-specific MMP expression and action may enhance the effectiveness of progestin-related treatments for endometriosis...
  12. pmc Dioxin-like PCBs and endometriosis
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232 2519, USA
    Syst Biol Reprod Med 56:132-46. 2010
    ..We will also discuss the potential importance of early life exposures to these toxicants on the subsequent development of endometriosis...
  13. pmc Dioxin may promote inflammation-related development of endometriosis
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 89:1287-98. 2008
    ..We discuss evidence that modulation of the endometrial endocrine-immune interface could mechanistically link toxicant exposure to the development of this disease...
  14. ncbi request reprint Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Avenue S, MCN B 1100, Nashville, TN 37232, USA
    J Clin Endocrinol Metab 91:1554-60. 2006
    ..However, recent research suggests that the presence of endometriosis impairs the capacity of the eutopic endometrium to respond to endogenous progesterone...
  15. ncbi request reprint Matrix metalloproteinases and endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics Gynecology, Vanderbilt University School of Medicine, B 1100 Medical Center North, Nashville, TN 37232, USA
    Semin Reprod Med 21:155-64. 2003
    ..Altered regulation of endometrial MMP expression in response to steroids may represent a mechanism linking the invasive potential of refluxed endometrium to the establishment of this disease only in certain women...
  16. ncbi request reprint Experimental endometriosis: the nude mouse as a xenographic host
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Ann N Y Acad Sci 955:328-39; discussion 340-2, 396-406. 2002
    ..Developing a better understanding of the impairments in the normal endometrial physiology of women with endometriosis should aid in the development of better treatment or diagnostic strategies...
  17. pmc Simvastatin protects against the development of endometriosis in a nude mouse model
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Endocrinol Metab 94:2489-94. 2009
    ..Endometriosis is a common condition associated with infertility and pelvic pain in women. Recent in vitro studies have shown that statins decrease proliferation of endometrial stroma (ES) and inhibit angiogenesis...
  18. ncbi request reprint Regulated expression of osteopontin in the peri-implantation rabbit uterus
    K B C Apparao
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Fertility, The University of North Carolina at Chapel Hill, 27599 7570, USA
    Biol Reprod 68:1484-90. 2003
    ..In The rabbit uterus, as in other mammalian species studied, OPN is expressed in a stage-specific manner by the endometrial glands during the peri-implantation period and is regulated by progesterone...
  19. ncbi request reprint Regulation and function of LEFTY-A/EBAF in the human endometrium. mRNA expression during the menstrual cycle, control by progesterone, and effect on matrix metalloprotineases
    Patricia B Cornet
    Cell Biology Unit, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Avenue Hippocrate, 75, B 1200 Bruxelles, Belgium
    J Biol Chem 277:42496-504. 2002
    ..Progesterone appears to exert a dual block, upstream by inhibiting LEFTY-A expression and downstream by suppressing its stimulatory effect on MMPs...
  20. ncbi request reprint Antiangiogenic agents are effective inhibitors of endometriosis
    M Louise Hull
    Department of Pathology, Reproductive Molecular Research Group, Cambridge, United Kingdom CB2 1QP
    J Clin Endocrinol Metab 88:2889-99. 2003
    ..These findings suggest that antiangiogenic agents may provide a novel therapeutic approach for the treatment of endometriosis...
  21. ncbi request reprint The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle
    Thomas E Curry
    Department of Obstetrics and Gynecology T E C, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocr Rev 24:428-65. 2003
    ....
  22. ncbi request reprint A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis
    Heather A Harris
    Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Hum Reprod 20:936-41. 2005
    ..Because endometriosis is now thought to be, at least in part, an inflammatory disease, we evaluated ERB-041's activity in an experimentally induced model of endometriosis...