Research Topics
Genomes and Genes | Gary OlsonSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cellsGary E Olson
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 283:6854-60. 2008..These results demonstrate that kidney selenium homeostasis is mediated by a megalin-dependent Sepp1 uptake pathway in the proximal tubule...
Zonadhesin assembly into the hamster sperm acrosomal matrix occurs by distinct targeting strategies during spermiogenesis and maturation in the epididymisGary E Olson
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biol Reprod 71:1128-34. 2004....- Sequential development of flagellar defects in spermatids and epididymal spermatozoa of selenium-deficient ratsGary E Olson
Department of Cell and Developmental Biology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
Reproduction 127:335-42. 2004..These data suggest that the known loss of male fertility in selenium deficiency results from the sequential development of sperm defects expressed during both spermiogenesis and maturation in the epididymis... - Selenoprotein P is required for mouse sperm developmentGary E Olson
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
Biol Reprod 73:201-11. 2005..These data demonstrate that SEPP1 is required for development of functional spermatozoa and indicate that it is an essential component of the selenium delivery pathway for developing germ cells... - Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testisGary E Olson
Department of Cell and Developmental Biology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 282:12290-7. 2007..Co-immunoprecipitation analysis demonstrated an interaction of testis ApoER2 with Sepp1. These data demonstrate that Sertoli cell ApoER2 is a Sepp1 receptor and a component of the selenium delivery pathway to spermatogenic cells... - Region-specific expression and secretion of the fibrinogen-related protein, fgl2, by epithelial cells of the hamster epididymis and its role in disposal of defective spermatozoaGary E Olson
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 279:51266-74. 2004.... 
AKAP3 selectively binds PDE4A isoforms in bovine spermatozoaMalini Bajpai
Department of Medicine, Oregon Health and Sciences University and VA Medical Center, Portland, OR 97239, USA
Biol Reprod 74:109-18. 2006..These data suggest that AKAP3 binds both PKA and PDE4A and functions as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions...- Demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expressionMichael H Melner
Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Biol Reprod 75:395-406. 2006..This implantation site-specific expression of UBE2Q2 in luminal epithelial cells could play major roles in orchestrating differentiation events through the modification of specific protein substrates... - Tyrosine phosphorylation generates multiple isoforms of the mitochondrial capsule protein, phospholipid hydroperoxide glutathione peroxidase (PHGPx), during hamster sperm capacitationSubir K Nagdas
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biol Reprod 72:164-71. 2005..These data suggest that the tyrosine-phosphorylation of PHGPx may represent an important event in the signaling pathway(s) associated with capacitation and could potentially affect mitochondrial function... - Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fedRaymond F Burk
Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Neurosci 27:6207-11. 2007.... - Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymesMichael H Melner
Departments of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biol Reprod 70:406-14. 2004..The important roles of ubiquitination in controlling the activities and turnover of key signaling proteins suggest potential roles in controlling critical aspects of implantation... - Identification of ras and its downstream signaling elements and their potential role in hamster sperm motilitySubir K Nagdas
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
Biol Reprod 67:1058-66. 2002..The interaction of Ras with both PI3-kinase and PKCzeta suggests that Ras may regulate several signaling pathways in spermatozoa... - Identification, immunolocalization, regulation, and postnatal development of the lipocalin EP17 (epididymal protein of 17 kilodaltons) in the mouse and rat epididymisSophie Fouchécourt
Department of Obstetrics and Gynecology and Center for Reproductive Biology Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Endocrinology 144:887-900. 2003..This suggests that these two related proteins exhibit distinct functions in the mouse epididymis... - Stage-specific expression of the intermediate filament protein cytokeratin 13 in luminal epithelial cells of secretory phase human endometrium and peri-implantation stage rabbit endometriumGary E Olson
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
Biol Reprod 66:1006-15. 2002.... - Structural modification of the hamster sperm acrosome during posttesticular development in the epididymisGary E Olson
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
Microsc Res Tech 61:46-55. 2003..This cytoskeletal network appears to establish transmembrane structural interactions with the acrosomal matrix and may maintain attachment of the acrosomal cap to the sperm head during the early steps of the acrosome reaction... - Identification of a hamster sperm 26-kilodalton dehydrogenase/reductase that is exclusively localized to the mitochondria of the flagellumSubir K Nagdas
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biol Reprod 75:197-202. 2006..These data indicate that MP26 does not function in zona binding; instead, like GPX4, it may be associated with the mitochondrial capsule and play an important role in sperm mitochondrial function... - The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body seleniumKristina E Hill
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Biol Chem 282:10972-80. 2007..The results of this study demonstrate that the C terminus of Sepp1 is critical for the maintenance of selenium in brain and testis but not for the maintenance of whole body selenium... - A role for the inositol kinase Ipk1 in ciliary beating and length maintenanceBhaskarjyoti Sarmah
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 8240, USA
Proc Natl Acad Sci U S A 104:19843-8. 2007..However, coincident knockdown of Ipk1 and IFT88 or IFT57 had synergistic perturbations. With GFP-Ipk1 enriched in centrosomes and basal bodies, we propose that Ipk1 plays a previously uncharacterized role in ciliary function... - Regulated expression of osteopontin in the peri-implantation rabbit uterusK B C Apparao
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Fertility, The University of North Carolina at Chapel Hill, 27599-7570, USA
Biol Reprod 68:1484-90. 2003..In The rabbit uterus, as in other mammalian species studied, OPN is expressed in a stage-specific manner by the endometrial glands during the peri-implantation period and is regulated by progesterone... - Processing, localization and binding activity of zonadhesin suggest a function in sperm adhesion to the zona pellucida during exocytosis of the acrosomeMing Bi
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, TX 79430, USA
Biochem J 375:477-88. 2003....
Research Grants
- SPERM FUNCTION IN FERTILIZATION EVENTSGary Olson; Fiscal Year: 2001....
- SPERM FUNCTION IN FERTILIZATION EVENTSGary Olson; Fiscal Year: 2006..3: To determine if eFGL binding to specific sperm ligands promotes sperm death and/or death cocoon polymerization.4: To define the function of eFGL by targeted disruption of the fgl2 gene in mice. ..
- SPERM FUNCTION IN FERTILIZATION EVENTSGary Olson; Fiscal Year: 1992..Completion of these specific aims will provide new data on the mechanisms underlying the mosaic construction of the sperm plasma membrane and provide needed data on the molecular basis of specific fertilization events...
- SPERM FUNCTION IN FERTILIZATION EVENTSGary Olson; Fiscal Year: 1993....
- Role of Selenoprotein P in Male FertilityGary Olson; Fiscal Year: 2007..Aim 3: To identify and localize Se-P-binding proteins in the testis and epididymis. Aim 4: To determine the molecular basis for sperm defects in Se-P null mice. ..