N J Olsen

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Androgen receptors in thymic epithelium modulate thymus size and thymocyte development
    N J Olsen
    Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Endocrinology 142:1278-83. 2001
  2. pmc Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development
    N J Olsen
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 108:1697-704. 2001
  3. ncbi Amyopathic dermatomyositis
    N J Olsen
    Division of Rheumatology, Department of Medicine, Vanderbilt University, T 3219 Medical Center North, Nashville, TN 37232, USA
    Curr Rheumatol Rep 3:346-51. 2001
  4. ncbi Hormones, pregnancy, and rheumatoid arthritis
    Nancy J Olsen
    Department of Medicine, Vanderbilt University, Room T 3219 MCN, 1161 21st Ave, Nashville, TN 37232 2681, USA
    J Gend Specif Med 5:28-37. 2002
  5. ncbi Effects of androgens on T and B lymphocyte development
    N J Olsen
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2681, USA
    Immunol Res 23:281-8. 2001
  6. ncbi Skeletal muscle abnormalities in patients with fibromyalgia
    N J Olsen
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Med Sci 315:351-8. 1998
  7. ncbi Androgens accelerate thymocyte apoptosis
    N J Olsen
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 139:748-52. 1998
  8. ncbi Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes
    S M Viselli
    Division of Endocrinology, Vanderbilt University School of Medicine, Nashville, TN 32732 2250, USA
    Mol Cell Endocrinol 109:19-26. 1995
  9. ncbi Treatment of rheumatoid arthritis with a DR4/1 peptide
    E W St Clair
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Rheumatol 27:1855-63. 2000
  10. ncbi Testosterone induces expression of transforming growth factor-beta 1 in the murine thymus
    N J Olsen
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232
    J Steroid Biochem Mol Biol 45:327-32. 1993

Collaborators

Detail Information

Publications24

  1. ncbi Androgen receptors in thymic epithelium modulate thymus size and thymocyte development
    N J Olsen
    Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Endocrinology 142:1278-83. 2001
    ..These data suggest that AR expressed by thymic epithelium are important modulators of thymocyte development...
  2. pmc Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development
    N J Olsen
    Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 108:1697-704. 2001
    ..These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. TGF-beta is a candidate mediator for these hormonal effects...
  3. ncbi Amyopathic dermatomyositis
    N J Olsen
    Division of Rheumatology, Department of Medicine, Vanderbilt University, T 3219 Medical Center North, Nashville, TN 37232, USA
    Curr Rheumatol Rep 3:346-51. 2001
    ..Some early series suggested no association with underlying malignancies, but recent reports indicate that malignancies occur. Determining whether a patient has amyopathic rather than myopathic disease may have prognostic implications...
  4. ncbi Hormones, pregnancy, and rheumatoid arthritis
    Nancy J Olsen
    Department of Medicine, Vanderbilt University, Room T 3219 MCN, 1161 21st Ave, Nashville, TN 37232 2681, USA
    J Gend Specif Med 5:28-37. 2002
    ..Possible mechanisms by which gender-specific factors modulate immune function are also discussed...
  5. ncbi Effects of androgens on T and B lymphocyte development
    N J Olsen
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2681, USA
    Immunol Res 23:281-8. 2001
    ..The long-range goal of these studies is to understand the basis for the disproportionate occurrence of autoimmune diseases in females...
  6. ncbi Skeletal muscle abnormalities in patients with fibromyalgia
    N J Olsen
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Med Sci 315:351-8. 1998
    ..This review will consider both the current state of knowledge and also future studies which might be designed to answer more effectively the outstanding questions regarding the underlying pathogenesis of fibromyalgia...
  7. ncbi Androgens accelerate thymocyte apoptosis
    N J Olsen
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 139:748-52. 1998
    ..Acceleration of thymocyte apoptosis by androgens may mediate processes of thymocyte selection, with the potential to impart gender-specific characteristics on the peripheral T cell repertoire...
  8. ncbi Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes
    S M Viselli
    Division of Endocrinology, Vanderbilt University School of Medicine, Nashville, TN 32732 2250, USA
    Mol Cell Endocrinol 109:19-26. 1995
    ..The data further suggest AR expression in thymocytes may be developmentally regulated in these cells, and that androgen effects early in the process of thymocyte selection may contribute to the sexual dimorphism of immune responsiveness...
  9. ncbi Treatment of rheumatoid arthritis with a DR4/1 peptide
    E W St Clair
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Rheumatol 27:1855-63. 2000
    ..The primary outcomes were the occurrence of adverse effects and changes in measures of immune function. Clinical efficacy was assessed using the American College of Rheumatology 20% criteria for clinical improvement...
  10. ncbi Testosterone induces expression of transforming growth factor-beta 1 in the murine thymus
    N J Olsen
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232
    J Steroid Biochem Mol Biol 45:327-32. 1993
    ..Reverse transcription/polymerase chain reaction amplification of RNA revealed that thymocytes are a source of the androgen-modulated TGF-beta 1. These results suggest that TGF-beta 1 may mediate effects of androgens on the immune system...
  11. ncbi Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies
    J H Park
    Department of Radiology, Vanderbilt University Medical School, MCN CCC 1121, Nashville, TN 37232 2675, USA
    Curr Rheumatol Rep 3:334-45. 2001
    ..Thus, MRI and P-31 MRS are useful in assessing the status of patients with inflammatory myopathies during treatment with prednisone and immunosuppressive drugs...
  12. ncbi Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy
    Z Liu
    Department of Medicine, Division of Rheumatology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Exp Allergy 35:1581-90. 2005
    ..Atopic diseases, resulting from hypersensitivity to a wide variety of allergens, affect 10-20% of the population. Immunotherapy is an effective treatment for atopic diseases, but its mechanisms are not fully understood...
  13. pmc Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus
    Aleksandar K Stanic
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6300, USA
    Proc Natl Acad Sci U S A 103:7018-23. 2006
    ..Collectively, these studies demonstrate that the lupus-susceptible immune system enhances atherogenesis and modulates plaque composition...
  14. ncbi Shared gene expression profiles in individuals with autoimmune disease and unaffected first-degree relatives of individuals with autoimmune disease
    Kevin Maas
    Division of Rheumatology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hum Mol Genet 14:1305-14. 2005
    ..Taken together, these results support the hypothesis that these variations in gene transcript levels are associated with family resemblance rather than clinical manifestations of disease...
  15. ncbi Co-localization of differentially expressed genes and shared susceptibility loci in human autoimmunity
    Thomas M Aune
    Division of Rheumatology, Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Genet Epidemiol 27:162-72. 2004
    ..To our knowledge, this is the first study showing concordance between gene expression and genetic linkage results in common complex multifactorial human diseases...
  16. pmc Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells
    Nancy J Olsen
    Division of Rheumatology, T 3219 Medical Center North, Vanderbilt University, Nashville, Tennessee, USA
    Arthritis Res Ther 6:120-8. 2004
    ..Furthermore, the genes that are identified provide clues to possible pathogenetic mechanisms and are likely to be useful in developing tests to establish diagnostic categories and predict therapeutic responses...
  17. ncbi Profiles of gene expression in human autoimmune disease
    Thomas M Aune
    Division of Rheumatology, Department of Medicine, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Biochem Biophys 40:81-96. 2004
    ..These data argue that that there is a constant pattern of gene expression in autoimmunity that is independent of the specific autoimmune disease and clinical parameters associated with any individual autoimmune disease...
  18. ncbi Gene expression profiles in human autoimmune disease
    Thomas M Aune
    Division of Rheumatology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Pharm Des 9:1905-17. 2003
    ....
  19. ncbi Symbolic discriminant analysis of microarray data in autoimmune disease
    Jason H Moore
    Program in Human Genetics, Vanderbilt University Medical School, Nashville, Tennessee 37232 0700, USA
    Genet Epidemiol 23:57-69. 2002
    ..In the present study, we demonstrate that SDA is capable of identifying combinations of gene expression variables that are able to classify and predict autoimmune diseases...
  20. pmc Identification of molecular biomarkers for multiple sclerosis
    Sallyanne C Fossey
    Department of Pathology, Vanderbilt University School of Medicine, Nashvill, Tennessee, USA
    J Mol Diagn 9:197-204. 2007
    ..This approach may have diagnostic utility not only for multiple sclerosis but also for other clinically complex autoimmune diseases...
  21. ncbi New drugs for rheumatoid arthritis
    Nancy J Olsen
    Division of Rheumatology, Vanderbilt University School of Medicine, Nashville, USA
    N Engl J Med 350:2167-79. 2004
  22. ncbi Drug-induced autoimmunity
    Nancy J Olsen
    Department of Medicine Division of Rheumatology, T 3219 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Best Pract Res Clin Rheumatol 18:677-88. 2004
    ..This chapter will consider these proposed mechanisms, using some of the implicated drugs to illustrate possible pathogenetic pathways...
  23. ncbi Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis
    Kevin Maas
    Vanderbilt University, Nashville, Tennessee, USA
    Arthritis Rheum 52:1047-57. 2005
    ..We aimed to determine whether this gene expression profile confers functional liability on lymphocytes from patients with rheumatoid arthritis (RA)...
  24. pmc Identification of patients with early rheumatoid arthritis: challenges and future directions
    Catalina Orozco
    UT Southwestern Medical Center, Dallas, TX, USA
    Clin Dev Immunol 13:295-7. 2006
    ..It also discusses gene expression analysis, a newer and potentially promising approach to the early diagnosis of RA...