Jeffry S Nyman

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Non-invasive predictors of human cortical bone mechanical properties: T(2)-discriminated H NMR compared with high resolution X-ray
    R Adam Horch
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16359. 2011
  2. pmc Partial removal of pore and loosely bound water by low-energy drying decreases cortical bone toughness in young and old donors
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 27212, USA
    J Mech Behav Biomed Mater 22:136-45. 2013
  3. doi request reprint The contribution of the extracellular matrix to the fracture resistance of bone
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 27212, USA
    Curr Osteoporos Rep 10:169-77. 2012
  4. pmc Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 27212, USA
    Bone 48:733-40. 2011
  5. pmc Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone
    Jeffry S Nyman
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37215, USA
    Bone 42:193-9. 2008
  6. pmc Age-related factors affecting the postyield energy dissipation of human cortical bone
    Jeffry S Nyman
    Department of Mechanical Engineering and Biomechanics, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Orthop Res 25:646-55. 2007
  7. doi request reprint Measuring differences in compositional properties of bone tissue by confocal Raman spectroscopy
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA
    Calcif Tissue Int 89:111-22. 2011
  8. pmc Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA
    J Bone Miner Res 26:1252-60. 2011
  9. doi request reprint Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography
    Jeffry S Nyman
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Biomech 42:891-7. 2009
  10. pmc Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I
    Weixi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 20:3910-24. 2011

Collaborators

Detail Information

Publications42

  1. pmc Non-invasive predictors of human cortical bone mechanical properties: T(2)-discriminated H NMR compared with high resolution X-ray
    R Adam Horch
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16359. 2011
    ..These (1)H NMR signals can, in principle, be extracted from clinical MRI, thus offering the potential for improved clinical assessment of fracture risk...
  2. pmc Partial removal of pore and loosely bound water by low-energy drying decreases cortical bone toughness in young and old donors
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 27212, USA
    J Mech Behav Biomed Mater 22:136-45. 2013
    ..With sensitivity to low-energy bone-water interactions, NMR, which underpins magnetic resonance imaging, has potential to assess fracture resistance of bone as it relates to bone toughness...
  3. doi request reprint The contribution of the extracellular matrix to the fracture resistance of bone
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 27212, USA
    Curr Osteoporos Rep 10:169-77. 2012
    ..Potential regulators and diagnostic tools of the ECM with respect to fracture resistance are also discussed...
  4. pmc Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 27212, USA
    Bone 48:733-40. 2011
    ..Thus, these findings suggest that the elevated fracture risk among diabetics is impacted by complex changes in tissue properties that ultimately reduce the fracture resistance of bone...
  5. pmc Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone
    Jeffry S Nyman
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37215, USA
    Bone 42:193-9. 2008
    ..The results of this study indicate that quantifying mobile and bound water with magnetic resonance techniques could potentially serve as indicators of bone quality...
  6. pmc Age-related factors affecting the postyield energy dissipation of human cortical bone
    Jeffry S Nyman
    Department of Mechanical Engineering and Biomechanics, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Orthop Res 25:646-55. 2007
    ..Among them, pentosidine concentration had the greatest contribution to plastic strain energy and was the best explanatory variable of damage accumulation...
  7. doi request reprint Measuring differences in compositional properties of bone tissue by confocal Raman spectroscopy
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA
    Calcif Tissue Int 89:111-22. 2011
    ....
  8. pmc Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone
    Jeffry S Nyman
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA
    J Bone Miner Res 26:1252-60. 2011
    ..Taken together, this information reveals that MMPs play a complex role in maintaining bone integrity, with the cell type that expresses the MMP likely being a contributing factor to how the enzyme affects bone quality...
  9. doi request reprint Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography
    Jeffry S Nyman
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Biomech 42:891-7. 2009
    ..557, p<0.0001) and stiffness (rxy = 0.468, p = 0.0002). By both reducing structural defects and increasing mineralization, lovastatin appears to increase the callus strength...
  10. pmc Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I
    Weixi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 20:3910-24. 2011
    ....
  11. pmc Raman and mechanical properties correlate at whole bone- and tissue-levels in a genetic mouse model
    Xiaohong Bi
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
    J Biomech 44:297-303. 2011
    ..Causal relationships between Raman and fracture resistance need to be investigated, but Raman has the potential to assess fracture risk...
  12. doi request reprint A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration
    Toshitaka Yoshii
    Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Tissue Eng Part A 16:2369-79. 2010
    ..These results suggest that the sustained LV delivery system from PUR scaffolds is a potentially safe and effective device for bone regeneration...
  13. pmc Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone
    Swati Biswas
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 6:e27090. 2011
    ..This approach of intervention has the potential to reduce skeletal related events (SREs) in breast cancer survivors...
  14. doi request reprint Fracture healing in protease-activated receptor-2 deficient mice
    Kevin R O'Neill
    Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 9565, USA
    J Orthop Res 30:1271-6. 2012
    ..The loss of PAR-2 was found to alter callus morphology as assessed by µCT but was not found to otherwise effect fracture healing in young mice...
  15. pmc The influence of water removal on the strength and toughness of cortical bone
    Jeffry S Nyman
    Department of Mechanical Engineering and Biomechanics, University of Texas at San Antonio, 6900 North Loop 1604 West, TX 78249, USA
    J Biomech 39:931-8. 2006
    ..Therefore, we speculate that loss of water in the collagen phase decreases the toughness of bone, whereas loss of water associated with the mineral phase decreases both bone strength and toughness...
  16. pmc Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone
    R Adam Horch
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA
    Magn Reson Med 68:1774-84. 2012
    ..As such, the strategies for bound and pore water discrimination shown herein should provide diagnostically useful tools for assessing bone fracture risk, once applied to clinical MRI...
  17. pmc Mechanical behavior of human cortical bone in cycles of advancing tensile strain for two age groups
    Jeffry S Nyman
    Vanderbilt Center for Bone Biology and Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee 37215, USA
    J Biomed Mater Res A 89:521-9. 2009
    ....
  18. pmc Age-related effect on the concentration of collagen crosslinks in human osteonal and interstitial bone tissue
    Jeffry S Nyman
    Department of Mechanical Engineering and Biomechanics, The University of Texas at San Antonio, San Antonio, TX 78249, USA
    Bone 39:1210-7. 2006
    ..Such changes could potentially reduce the inherent quality of the bone tissue in the elderly skeleton...
  19. pmc Transdermal lovastatin enhances fracture repair in rats
    Gloria E Gutierrez
    OsteoScreen, San Antonio, Texas, USA
    J Bone Miner Res 23:1722-30. 2008
    ..These studies provide valuable information on the potential of statins and TD delivery as a new and effective therapeutic modality in fracture repair...
  20. pmc Characterization of 1H NMR signal in human cortical bone for magnetic resonance imaging
    R Adam Horch
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA
    Magn Reson Med 64:680-7. 2010
    ..These findings show that modern human cortical bone MRI contrast will be dominated by collagen-bound water, which can also be exploited to study human cortical bone collagen via magnetization transfer...
  21. pmc Polarization control of Raman spectroscopy optimizes the assessment of bone tissue
    Alexander J Makowski
    Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN 27212, USA
    J Biomed Opt 18:55005. 2013
    ..Thus, the polarization bias inherent in commercial RS systems does not preclude the assessment of bone composition when using phase-matched peaks...
  22. doi request reprint Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling
    James R Edwards
    Vanderbilt Center for Bone Biology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Bone Miner Res 28:960-9. 2013
    ..These findings support the notion that SirT1 is a genetic determinant of bone mass, acting in a cell-autonomous manner in both osteoblasts and osteoclasts, through control of NF-κB and bone cell differentiation...
  23. doi request reprint Micro-computed tomography assessment of the progression of fracture healing in mice
    Kevin R O'Neill
    Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA
    Bone 50:1357-67. 2012
    ..Sample size estimates based on these results indicate that utilization of μCT requires fewer animals than biomechanics and thus is more practical for evaluating the healing femur in the mouse fracture model...
  24. pmc Differences in the mechanical behavior of cortical bone between compression and tension when subjected to progressive loading
    Jeffry S Nyman
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37215, United States
    J Mech Behav Biomed Mater 2:613-9. 2009
    ..Such detailed information about failure mechanisms of bone at the tissue-level would help explain the underlying causes of bone fractures...
  25. ncbi request reprint Effect of ultrastructural changes on the toughness of bone
    Jeffry S Nyman
    Mechanical Engineering and Biomechanics, University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, TX 78249, USA
    Micron 36:566-82. 2005
    ..Finally, we describe how changes in the ultrastructure-caused by osteogenesis imperfecta, gamma irradiation, fluoride treatment, and aging affect the toughness and competence of bone...
  26. doi request reprint Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit
    Jerald E Dumas
    Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA
    Acta Biomater 6:2394-406. 2010
    ....
  27. pmc Prostate cancer metastases alter bone mineral and matrix composition independent of effects on bone architecture in mice--a quantitative study using microCT and Raman spectroscopy
    Xiaohong Bi
    Department of Biomedical Engineering, Vanderbilt University, VU Station B 351631, 2301 Vanderbilt Place, Nashville, TN 37235, USA
    Bone 56:454-60. 2013
    ..Raman spectroscopy may provide a new avenue of investigation into interactions between tumor and bone microenvironment. ..
  28. doi request reprint Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo
    James R Edwards
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Bone Miner Res 25:2419-26. 2010
    ....
  29. pmc β2-Adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone
    Yun Ma
    Department of Medicine, Vanderbilt University, 2215 Garland Avenue, MRB IV, Room 1225E, Nashville, Tennessee 37232 0575, USA
    Endocrinology 152:1412-22. 2011
    ..This study emphasizes the importance of sympathetic nerves in the regulation of bone homeostasis and indicates that this neuroskeletal signaling axis can be modulated by hormones or drugs and contribute to enhance pathological bone loss...
  30. pmc Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts
    Weixi Wang
    Vanderbilt University Medical Center, Department of Medicine, Nashville, TN 37232 0575, USA
    J Bone Miner Res 25:1658-67. 2010
    ....
  31. doi request reprint The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness
    Alexander J Makowski
    Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 27212, USA Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37232, USA
    Bone 62:1-9. 2014
    ..Target genes of ATF4 activity are not only important to osteoblast differentiation but also in maintaining bone toughness and fracture toughness. ..
  32. doi request reprint Biomechanical evaluation of physeal-sparing fixation methods in tibial eminence fractures
    Christian N Anderson
    Tennessee Orthopaedic Alliance The Lipscomb Clinic, St Thomas Medical Plaza, Suite 1000, 4230 Harding Road, Nashville, TN 37205, USA
    Am J Sports Med 41:1586-94. 2013
    ..Tibial eminence fractures occur most commonly in skeletally immature children. Several techniques using physeal-sparing fracture fixation have been described, but their structural properties have not been evaluated...
  33. pmc Transforming growth factor β suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis
    Na Lian
    Vanderbilt Center for Bone Biology, Nashville, Tennessee 37232, USA
    J Biol Chem 287:35975-84. 2012
    ..Thus, our study identifies that TGFβ stimulates vimentin production via PI3K-Akt-mTOR signaling, which leads to suppression of ATF4-dependent Ocn transcription and osteoblast differentiation...
  34. pmc A novel approach to assess post-yield energy dissipation of bone in tension
    Xiaodu Wang
    Department of Mechanical Engineering, University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, TX 78249, USA
    J Biomech 40:674-7. 2007
    ..These results implicate that this novel approach could detect the age-related differences in energy dissipation of bone and may aid in understanding the underlying mechanisms of such changes...
  35. ncbi request reprint The effects of rhBMP-2 released from biodegradable polyurethane/microsphere composite scaffolds on new bone formation in rat femora
    Bing Li
    Department of Chemical and Biomolecular Engineering, Vanderbilt University, 2301 Vanderbilt Place, VU Station B 351604, Nashville, TN 37235, USA
    Biomaterials 30:6768-79. 2009
    ..Thus our observations suggest that an initial burst release followed by sustained release is better for promoting new bone formation...
  36. pmc Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells
    Wuchen Yang
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Cell Sci 126:4085-98. 2013
    ..Critical roles of Bmp2 in osteoblasts and MSCs are a vital link between bone formation, vascularization and mesenchymal stem cells. ..
  37. ncbi request reprint Micro-computed tomography derived anisotropy detects tumor provoked deviations in bone in an orthotopic osteosarcoma murine model
    Heather A Cole
    Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 9:e97381. 2014
    ..These findings suggest that monitoring tumor-induced changes in the structural property isotropy of the invaded bone may represent a novel means of diagnosing primary and metastatic bone tumors. ..
  38. ncbi request reprint Validation of quantitative bound- and pore-water imaging in cortical bone
    Mary Kate Manhard
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA
    Magn Reson Med 71:2166-71. 2014
    ..To implement and validate a previously proposed ultra-short echo time method for measuring collagen-bound- and pore-water concentrations in bone based on their T2 differences...
  39. doi request reprint Differential development of the distal and proximal femoral epiphysis and physis in mice
    Heather A Cole
    Vanderbilt University Medical Center, Department of Orthopaedics, 2200 Children s Way, Nashville, TN 37232 9565, USA
    Bone 52:337-46. 2013
    ....
  40. pmc Integrated system for combined Raman spectroscopy-spectral domain optical coherence tomography
    Chetan A Patil
    Vanderbilt University, Department of Biomedical Engineering, Station B, Box 351631, Nashville, Tennessee 37235, USA
    J Biomed Opt 16:011007. 2011
    ..The capabilities of the instrument are demonstrated ex vivo in the calvaria and retina of rodents, as well as in vivo in human skin...
  41. ncbi request reprint Long stemmed total knee arthroplasty with interlocking screws: a computational bone adaptation study
    Jeffry S Nyman
    Biomedical Engineering Graduate Group, College of Engineering, University of California at Davis, Davis, CA 95616, USA
    J Orthop Res 22:51-7. 2004
    ..An interlocking stem with a smooth, matted finish did not reduce the bone loss associated with interlocking fixation...
  42. ncbi request reprint Predictions on preserving bone mass in knee arthroplasty with bisphosphonates
    Jeffry S Nyman
    Orthopaedic Research Laboratory, Davis, Research Facility, University of California, Sacramento, California, USA
    J Arthroplasty 21:106-13. 2006
    ..Late bisphosphonate treatment did not reverse the bone loss that occurred 3.5 years after TKA, although it preserved 3% of bone normally lost without treatment...