John H Newman

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Treatment of primary pulmonary hypertension -- the next generation
    John H Newman
    N Engl J Med 346:933-5. 2002
  2. ncbi Exercise training in pulmonary hypertension: implications for the evaluation of drug trials
    John H Newman
    Circulation 114:1448-9. 2006
  3. ncbi Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension
    Emma K Larkin
    Vanderbilt University Institute for Medicine and Public Health, Vanderbilt Medical Center North, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 186:892-6. 2012
  4. ncbi Pulmonary hypertension
    John H Newman
    T1219 Vanderbilt Medical Center, North Nashville, TN 37232 2650
    Am J Respir Crit Care Med 172:1072-7. 2005
  5. ncbi Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies
    John H Newman
    Division of Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Ann Intern Med 148:278-83. 2008
  6. ncbi Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
    Eric D Austin
    Department of Pediatrics, Vanderbilt University, Medical Center, Nashville, TN, USA
    Respir Res 10:87. 2009
  7. ncbi Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele
    Rizwan Hamid
    Department of Pediatrics, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Hum Mutat 30:649-54. 2009
  8. ncbi Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension
    John A Phillips
    Divisions of Medical Genetics, Vanderbilt University School of Medicine, Nashville, Tennessee 27232 2578, USA
    Genet Med 10:359-65. 2008
  9. ncbi End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment
    Anna R Hemnes
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 Medical Center N, 1161 21st Ave S, Nashville, TN 37232, USA
    Chest 140:1267-73. 2011
  10. ncbi Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension
    Elisabeth D Willers
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Medical Center North T 1218, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 173:798-802. 2006

Detail Information

Publications22

  1. ncbi Treatment of primary pulmonary hypertension -- the next generation
    John H Newman
    N Engl J Med 346:933-5. 2002
  2. ncbi Exercise training in pulmonary hypertension: implications for the evaluation of drug trials
    John H Newman
    Circulation 114:1448-9. 2006
  3. ncbi Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension
    Emma K Larkin
    Vanderbilt University Institute for Medicine and Public Health, Vanderbilt Medical Center North, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 186:892-6. 2012
    ..With accrual of pedigree data over multiple decades, we retested this hypothesis using analyses that eliminate the truncation of data that exists with shorter duration of follow-up...
  4. ncbi Pulmonary hypertension
    John H Newman
    T1219 Vanderbilt Medical Center, North Nashville, TN 37232 2650
    Am J Respir Crit Care Med 172:1072-7. 2005
    ....
  5. ncbi Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies
    John H Newman
    Division of Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Ann Intern Med 148:278-83. 2008
    ..An interaction of these signaling systems with BMPR2 is a focus of research in PAH. Approaches to altering the imbalance of activation of BMPR2 and other TGF-beta receptors may yield future therapies for PAH...
  6. ncbi Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
    Eric D Austin
    Department of Pediatrics, Vanderbilt University, Medical Center, Nashville, TN, USA
    Respir Res 10:87. 2009
    ..We hypothesized that patients with missense BMPR2 mutations have more severe disease than those with truncating mutations...
  7. ncbi Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele
    Rizwan Hamid
    Department of Pediatrics, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Hum Mutat 30:649-54. 2009
    ..Furthermore, our study illustrates a novel application of lymphoblastoid cell lines in the study of PAH, especially important because the affected site, that is, the lung, is not available for unaffected mutation carriers...
  8. ncbi Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension
    John A Phillips
    Divisions of Medical Genetics, Vanderbilt University School of Medicine, Nashville, Tennessee 27232 2578, USA
    Genet Med 10:359-65. 2008
    ....
  9. ncbi End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment
    Anna R Hemnes
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 Medical Center N, 1161 21st Ave S, Nashville, TN 37232, USA
    Chest 140:1267-73. 2011
    ....
  10. ncbi Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension
    Elisabeth D Willers
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Medical Center North T 1218, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 173:798-802. 2006
    ....
  11. ncbi High-altitude pulmonary hypertension in cattle (brisket disease): Candidate genes and gene expression profiling of peripheral blood mononuclear cells
    John H Newman
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pulm Circ 1:462-9. 2011
    ..Further studies are needed to validate and refine these preliminary findings and to determine the role of transcribed genes in the development of HAPH...
  12. ncbi Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop
    John H Newman
    Departments of Medicine, Nashville VA Medical Center (GRECC, and Vanderbilt University, Nashville, Tenn, USA
    Circulation 109:2947-52. 2004
  13. ncbi Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II
    James R Runo
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T 1217 Medical Center North, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 167:889-94. 2003
    ..The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH...
  14. ncbi Association of the metabolic syndrome with pulmonary venous hypertension
    Ivan M Robbins
    Pulmonary Vascular Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Chest 136:31-6. 2009
    ....
  15. ncbi Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression
    Eric D Austin
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Pulm Circ 1:389-98. 2011
    ..HPAH and IPAH share the majority of altered signaling pathways, suggesting that treatments developed to target the molecular etiology of HPAH will also be effective against IPAH...
  16. ncbi Genetic basis of pulmonary arterial hypertension: current understanding and future directions
    John H Newman
    Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom
    J Am Coll Cardiol 43:33S-39S. 2004
    ..Advances in genetic testing, presymptomatic screening, and biomarkers should permit early detection of disease in those at risk of PAH and allow trials of preventive therapy in carriers...
  17. ncbi Unrecognized glucose intolerance is common in pulmonary arterial hypertension
    Meredith E Pugh
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    J Heart Lung Transplant 30:904-11. 2011
    ..We aimed to define the prevalence of elevated HbA(1c) in PAH patients and to correlate HbA(1c) levels with functional assessment...
  18. ncbi Testosterone negatively regulates right ventricular load stress responses in mice
    Anna R Hemnes
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Pulm Circ 2:352-8. 2012
    ..Further study of the role of testosterone in RV dysfunction is warranted to better understand these findings in the context of human disease...
  19. ncbi Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan
    Matthew S King
    Division of Pulmonary and Critical Care Medicine, Meharry Medical College, Nashville, TN, USA
    N Engl J Med 365:222-30. 2011
    ..S. Army's standards for physical fitness...
  20. ncbi Inflammation, growth factors, and pulmonary vascular remodeling
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 54:S10-9. 2009
    ....
  21. ncbi Ambrisentan
    John H Newman
    Nat Rev Drug Discov 6:697-8. 2007
  22. ncbi New risks for pulmonary hypertension: need for a large epidemiologic study
    Elisabeth D Willers
    Chest 130:1633-5. 2006