Research Topics
Genomes and Genes | Dawn C NewcombSummaryAffiliation: Vanderbilt University Country: USA Publications
| Collaborators
|
Detail Information
Publications
IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent mannerDawn C Newcomb
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Immunol 188:1027-35. 2012..These findings are vital to understanding the potential side effects of therapeutics targeting IL-13. Inhibiting IL-13 may decrease IL-10 production and increase IL-17A production, thus potentiating IL-17A-associated diseases...
Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A productionDawn C Newcomb
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Allergy Clin Immunol 127:1006-13.e1-4. 2011..However, little is known about how IL-13 regulates human CD4(+) T-cell lineages because IL-13 receptor (IL-13R) α1, a subunit of IL-13R, has not previously been reported to exist on human T cells...- Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitisWeisong Zhou
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 7:e33518. 2012..Although PGI(2) signaling suppressed Th1 and Th2 immune responses, the role of PGI(2) in Th17 differentiation is not known... - A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine productionDawn C Newcomb
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Immunol 182:5317-21. 2009..Therefore, therapeutic intervention inhibiting IL-13 production could have adverse consequences by up-regulating Th17 inflammation in certain disease states... - A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunctionMartin L Moore
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Virol 83:4185-94. 2009..We identified the F protein of RSV line 19 as a factor that plays a role in pulmonary mucin expression in the setting of RSV infection... - STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infectionMartin L Moore
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN37232, USA
J Immunol 183:2016-26. 2009..Basophils were the primary source of IL-4 in the lung in RSV infection, and STAT1 was a negative regulator of virus-induced basophil IL-4 expression... - Intratracheal bleomycin causes airway remodeling and airflow obstruction in miceVasiliy V Polosukhin
Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
Exp Lung Res 38:135-46. 2012..Thus, this model can be utilized to investigate mechanisms of airway remodeling... - Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout miceRinat Zaynagetdinov
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
Am J Respir Cell Mol Biol 42:564-71. 2010..These findings are in agreement with previous pharmacologic studies suggesting a deleterious role for A(2B) receptor signaling in chronic lung inflammation... - PGI2 as a regulator of CD4+ subset differentiation and functionMadison G Boswell
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Prostaglandins Other Lipid Mediat 96:21-6. 2011..In contrast, PGI(2) seems to enhance Th17-favoring polarization conditions, resulting in Th17 cytokine production. Therefore, PGI(2) may either promote or inhibit individual CD4+ cell subsets and impact adaptive immune responses... - PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expressionWeisong Zhou
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 301:L615-22. 2011..PGI(2) induction of Nqo 1 provides a possible novel mechanism by which this prostanoid protects against bleomycin-induced mortality and identifies a potential therapeutic target for human ALI... 
Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responsesWeisong Zhou
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 181:5360-7. 2008....- Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c miceKate L Stokes
Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
J Virol 85:5782-93. 2011..We found that RSV clinical isolates induce variable pathogenesis in mice, and we established a mouse model of clinical isolate strain-dependent RSV pathogenesis that recapitulates key features of RSV disease... - Endoplasmic reticulum stress enhances fibrotic remodeling in the lungsWilliam E Lawson
Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 108:10562-7. 2011..These data support the concept that ER stress produces a dysfunctional epithelial cell phenotype that facilitates fibrotic remodeling. ER stress pathways may serve as important therapeutic targets in idiopathic pulmonary fibrosis... - Bugs and asthma: a different disease?Dawn C Newcomb
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2650, USA
Proc Am Thorac Soc 6:266-71. 2009....