Dawn C Newcomb

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Th17-mediated inflammation in asthma
    Dawn C Newcomb
    Vanderbilt University Medical Center, Department of Medicine, Nashville, TN 37232, United States Electronic address
    Curr Opin Immunol 25:755-60. 2013
  2. pmc IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation
    Dawn Catherine Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Thorax 68:717-23. 2013
  3. pmc IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Respir Cell Mol Biol 48:711-6. 2013
  4. pmc IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 188:1027-35. 2012
  5. pmc Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Allergy Clin Immunol 127:1006-13.e1-4. 2011
  6. pmc Deficiency of gp91phox inhibits allergic airway inflammation
    Carla M Sevin
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Am J Respir Cell Mol Biol 49:396-402. 2013
  7. pmc PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells
    Shinji Toki
    Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, 1161 21st Ave, T 1218 MCN, Nashville, TN 37232 2650, USA
    J Leukoc Biol 94:77-88. 2013
  8. pmc A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction
    Martin L Moore
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Virol 83:4185-94. 2009
  9. pmc Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis
    Weisong Zhou
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33518. 2012
  10. pmc Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice
    Rinat Zaynagetdinov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
    Am J Respir Cell Mol Biol 42:564-71. 2010

Collaborators

Detail Information

Publications22

  1. pmc Th17-mediated inflammation in asthma
    Dawn C Newcomb
    Vanderbilt University Medical Center, Department of Medicine, Nashville, TN 37232, United States Electronic address
    Curr Opin Immunol 25:755-60. 2013
    ..However, the role of Th17 cells in asthma will be answered in ongoing clinical trials with therapeutics targeting IL-17A and IL-17 receptor signaling. ..
  2. pmc IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation
    Dawn Catherine Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Thorax 68:717-23. 2013
    ..Furthermore, interleukin 17A (IL-17A) was only increased in OVA/RSV mice...
  3. pmc IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Respir Cell Mol Biol 48:711-6. 2013
    ..STAT6 KO mTECs showed increased periodic acid-Schiff staining with IL-17A but not with IL-13. Thus, asthma therapies targeting STAT6 may increase IL-17A protein expression, without preventing IL-17A-induced mucus production...
  4. pmc IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 188:1027-35. 2012
    ..These findings are vital to understanding the potential side effects of therapeutics targeting IL-13. Inhibiting IL-13 may decrease IL-10 production and increase IL-17A production, thus potentiating IL-17A-associated diseases...
  5. pmc Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Allergy Clin Immunol 127:1006-13.e1-4. 2011
    ..However, little is known about how IL-13 regulates human CD4(+) T-cell lineages because IL-13 receptor (IL-13R) α1, a subunit of IL-13R, has not previously been reported to exist on human T cells...
  6. pmc Deficiency of gp91phox inhibits allergic airway inflammation
    Carla M Sevin
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Am J Respir Cell Mol Biol 49:396-402. 2013
    ..This study demonstrates the importance of NADPH oxidase activity and ROS production in a murine model of asthma. ..
  7. pmc PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells
    Shinji Toki
    Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, 1161 21st Ave, T 1218 MCN, Nashville, TN 37232 2650, USA
    J Leukoc Biol 94:77-88. 2013
    ..Our results suggest PGI2-IP signaling increases immature DC migration to the draining LNs and may represent a novel mechanism by which this eicosanoid inhibits immune responses...
  8. pmc A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction
    Martin L Moore
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Virol 83:4185-94. 2009
    ..We identified the F protein of RSV line 19 as a factor that plays a role in pulmonary mucin expression in the setting of RSV infection...
  9. pmc Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis
    Weisong Zhou
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33518. 2012
    ..Although PGI(2) signaling suppressed Th1 and Th2 immune responses, the role of PGI(2) in Th17 differentiation is not known...
  10. pmc Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice
    Rinat Zaynagetdinov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
    Am J Respir Cell Mol Biol 42:564-71. 2010
    ..These findings are in agreement with previous pharmacologic studies suggesting a deleterious role for A(2B) receptor signaling in chronic lung inflammation...
  11. pmc A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
    Dawn C Newcomb
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 182:5317-21. 2009
    ..Therefore, therapeutic intervention inhibiting IL-13 production could have adverse consequences by up-regulating Th17 inflammation in certain disease states...
  12. pmc PGI2 as a regulator of CD4+ subset differentiation and function
    Madison G Boswell
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Prostaglandins Other Lipid Mediat 96:21-6. 2011
    ..In contrast, PGI(2) seems to enhance Th17-favoring polarization conditions, resulting in Th17 cytokine production. Therefore, PGI(2) may either promote or inhibit individual CD4+ cell subsets and impact adaptive immune responses...
  13. pmc β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin
    Harikrishna Tanjore
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 187:630-9. 2013
    ..Objectives: We aimed to determine the role of β-catenin in alveolar epithelium during bleomycin-induced lung fibrosis...
  14. pmc STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection
    Martin L Moore
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN37232, USA
    J Immunol 183:2016-26. 2009
    ..Basophils were the primary source of IL-4 in the lung in RSV infection, and STAT1 was a negative regulator of virus-induced basophil IL-4 expression...
  15. pmc Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice
    Vasiliy V Polosukhin
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Exp Lung Res 38:135-46. 2012
    ..Thus, this model can be utilized to investigate mechanisms of airway remodeling...
  16. pmc Allergic Airway Inflammation Decreases Lung Bacterial Burden following Acute Klebsiella pneumoniae Infection in a Neutrophil- and CCL8-Dependent Manner
    Daniel E Dulek
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Infect Immun 82:3723-39. 2014
    ..These findings suggest a novel role for CCL8 in lung antibacterial immunity against K. pneumoniae and suggest new mechanisms of orchestrating lung antibacterial immunity. ..
  17. pmc STAT4 Deficiency Fails To Induce Lung Th2 or Th17 Immunity following Primary or Secondary Respiratory Syncytial Virus (RSV) Challenge but Enhances the Lung RSV-Specific CD8+ T Cell Immune Response to Secondary Challenge
    Daniel E Dulek
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Virol 88:9655-72. 2014
    ..These data demonstrate that STAT4 regulates the RSV-specific CD8(+) T cell response to secondary infection but does not independently regulate lung Th2 or Th17 immune responses to RSV challenge...
  18. pmc PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression
    Weisong Zhou
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 301:L615-22. 2011
    ..PGI(2) induction of Nqo 1 provides a possible novel mechanism by which this prostanoid protects against bleomycin-induced mortality and identifies a potential therapeutic target for human ALI...
  19. ncbi request reprint Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses
    Weisong Zhou
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 181:5360-7. 2008
    ....
  20. pmc Bugs and asthma: a different disease?
    Dawn C Newcomb
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2650, USA
    Proc Am Thorac Soc 6:266-71. 2009
    ....
  21. pmc Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice
    Kate L Stokes
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    J Virol 85:5782-93. 2011
    ..We found that RSV clinical isolates induce variable pathogenesis in mice, and we established a mouse model of clinical isolate strain-dependent RSV pathogenesis that recapitulates key features of RSV disease...
  22. pmc Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs
    William E Lawson
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 108:10562-7. 2011
    ..These data support the concept that ER stress produces a dysfunctional epithelial cell phenotype that facilitates fibrotic remodeling. ER stress pathways may serve as important therapeutic targets in idiopathic pulmonary fibrosis...

Research Grants1

  1. Regulation of Il-17A Expression with RSV Infection During Allergic Inflammation
    DAWN NEWCOMB; Fiscal Year: 2008
    ..Defining the mechanisms by which RSV-infection on an allergic background induces lung IL-17A production may provide potential therapeutic targets for reducing RSV-induced asthma exacerbations. ..