Research Topics
| ERIC NEILSONSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Baumol's curse on medicineEric G Neilson
Department of Medicine, D-3100 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232-2358, USA
J Am Soc Nephrol 19:1049-53. 2008- The impact of peer management on test-ordering behaviorEric G Neilson
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Ann Intern Med 141:196-204. 2004..Laboratory testing of hospitalized patients, although essential, can be expensive and sometimes excessive. Attempts to reduce unnecessary testing have often been difficult to implement or sustain... - Plasticity, nuclear diapause, and a requiem for the terminal differentiation of epitheliaEric G Neilson
Department of Medicine, D-3100 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232-2358, USA
J Am Soc Nephrol 18:1995-8. 2007 - Mechanisms of disease: Fibroblasts--a new look at an old problemEric G Neilson
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
Nat Clin Pract Nephrol 2:101-8. 2006..This review examines these issues and identifies new targets for the treatment of one of the most difficult problems facing clinical nephrology... 
Epithelial-mesenchymal transitions and the intersecting cell fate of fibroblasts and metastatic cancer cellsEric G Neilson
Departments of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Trans Am Clin Climatol Assoc 114:87-100; discussion 100-1. 2003- The role of medical school admissions committees in the decline of physician-scientistsEric G Neilson
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Invest 111:765-7. 2003 - Alport's syndrome, Goodpasture's syndrome, and type IV collagenBilly G Hudson
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2358, USA
N Engl J Med 348:2543-56. 2003 - Evidence that fibroblasts derive from epithelium during tissue fibrosisMasayuki Iwano
Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Clin Invest 110:341-50. 2002..As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions... 
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritisVadim Pedchenko
Center for Matrix Biology, Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
N Engl J Med 363:343-54. 2010..We compared the conformations of the antibody epitopes in Goodpasture's disease and Alport's post-transplantation nephritis with the intention of finding clues to the pathogenesis of anti-GBM glomerulonephritis...- Human antiglomerular basement membrane autoantibody disease in XenoMouse IIKevin E C Meyers
Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Kidney Int 61:1666-73. 2002.... - Interventions to regulate ordering of serum magnesium levels: report of an unintended consequence of decision supportS Trent Rosenbloom
Eskind Biomedical Library, Room 440, 2209 Garland Avenue, Nashville, TN 37232 8340, USA
J Am Med Inform Assoc 12:546-53. 2005..Unintended consequences of computerized patient care system interventions may increase resource use, foster clinical errors, and reduce users' confidence... - Role of mammalian target of rapamycin signaling in compensatory renal hypertrophyJian Kang Chen
Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, S 3223 Medical Center North, Nashville, Tennessee 37232, USA
J Am Soc Nephrol 16:1384-91. 2005..These studies demonstrate that activation of the mTOR signaling pathway in the remaining kidney after UNX plays an essential role in modulating RNA and protein synthesis during development of compensatory renal hypertrophy... - Goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement: novel mechanisms for immune privilege and autoimmune pathogenesisDorin Bogdan Borza
Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA
J Biol Chem 280:27147-54. 2005..These findings provide fundamental new insights into immune privilege and the molecular mechanisms underlying the pathogenesis of human autoimmune Goodpasture disease... - Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosisHarikrishna Tanjore
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Am J Respir Crit Care Med 180:657-65. 2009..Lung fibroblasts are key mediators of fibrosis resulting in accumulation of excessive interstitial collagen and extracellular matrix, but their origins are not well defined... - Pathogenesis of Goodpasture syndrome: a molecular perspectiveDorin Bogdan Borza
Deparment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
Semin Nephrol 23:522-31. 2003..Further insight into the pathogenesis of disease has been obtained from better animal models. These advances provide a foundation for the development of new specific therapies... - Dystroglycan in the diagnosis of FSGSGiovanna Giannico
C 3310 MCN, Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
Clin J Am Soc Nephrol 4:1747-53. 2009..Fibrosis has been linked to increased fibroblast-specific protein-1 (FSP1) and epithelial-mesenchymal transition. We studied DG, FSP1, and podocyte differentiation in FSGS variants and cases of suspected FSGS... - Effects of performance-based compensation and faculty track on the clinical activity, research portfolio, and teaching mission of a large academic department of medicineGregg T Tarquinio
Department of Medicine, D 3100 MCN, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Acad Med 78:690-701. 2003..The authors describe the design, implementation, and testing of a performance-based compensation plan in a department of medicine that is closely linked to the faculty appointment track... - The Jeremiah Metzger lecture. The origin of fibroblasts and the terminality of epithelial differentiationEric G Neilson
Department of Medicine, D 3100 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
Trans Am Clin Climatol Assoc 121:240-50; discussion 250-1. 2010.... - The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasisChengsen Xue
Department of Medicine and the Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Cancer Res 63:3386-94. 2003.... - Toward a unified theory of renal progressionRaymond C Harris
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Annu Rev Med 57:365-80. 2006..New knowledge about the cell biology of progression also suggests that other adjunctive therapies may be possible. We describe the progress and highlight those spheres where new-targeted interventions may arise... - Antibodies against macrophages that overlap in specificity with fibroblastsTsutomu Inoue
Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Kidney Int 67:2488-93. 2005..CONCLUSION: Antibodies directed against F4/80 clearly distinguish macrophages from FSP1(+) fibroblasts in fibrotic tissues and is the preferred antibody in mice... - Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophyJianchun Chen
Department of Medicine, Vanderbilt University School of Medicine, and Department of Veterans Affairs, Nashville, TN 37232, USA
J Am Soc Nephrol 17:1615-23. 2006..In summary, this is the first demonstration that HB-EGF shedding-dependent EGFR transactivation, along with activation of TGF-beta signaling pathways, mediates Ang II-induced renal tubular epithelial cell hypertrophy... - Characterization of fibroblast-specific protein 1 in pulmonary fibrosisWilliam E Lawson
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T-1217 MCN, Nashville, TN 37232-2650, USA
Am J Respir Crit Care Med 171:899-907. 2005..Therefore, FSP1 is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis... - Stromal fibroblasts in cancer initiation and progressionNeil A Bhowmick
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Nature 432:332-7. 2004..Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications... - A proximal activator of transcription in epithelial-mesenchymal transitionChristo D Venkov
Department of Medicine, Vanderbilt University School of Medicine, D 3100 MCN, Nashville, Tennessee 37232, USA
J Clin Invest 117:482-91. 2007..We believe formation of the CBF-A/KAP-1/FTS-1 complex is sufficient for the induction of FSP1 and a novel proximal activator of EMT... - Endothelial-to-mesenchymal transition contributes to cardiac fibrosisElisabeth M Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Med 13:952-61. 2007..Our findings show that EndMT contributes to the progression of cardiac fibrosis and that rhBMP-7 can be used to inhibit EndMT and to intervene in the progression of chronic heart disease associated with fibrosis... - Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal diseaseMichele Rossini
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Kidney Int 68:2621-8. 2005.... - Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activityVERONICA R PLACENCIO
Departments of Cancer Biology, Urologic Surgery, and Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
Cancer Res 68:4709-18. 2008..These studies reveal a novel TGF-beta, androgen, and Wnt paracrine signaling axis that enables prostatic regression of the distal ducts after androgen ablation while supporting proximal duct survival... - TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epitheliaNeil A Bhowmick
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Science 303:848-51. 2004..Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues... - Chronic kidney disease progressionAllison A Eddy
Department of Pediatric, University of Washington, Seattle, WA 98105, USA
J Am Soc Nephrol 17:2964-6. 2006 - Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgANYoshiharu Nishitani
First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
Kidney Int 68:1078-85. 2005..FSP1+ fibroblasts are critically related to the progression of IgAN; consequently, staining FSP1 in renal biopsy specimens provides a valuable histologic index of progression... - Setting a trap for tissue fibrosisEric G Neilson
Nat Med 11:373-4. 2005 - Mechanisms of tubulointerstitial fibrosisMasayuki Iwano
First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
Curr Opin Nephrol Hypertens 13:279-84. 2004..SUMMARY: In combination with traditional angiotensin converting enzyme inhibitors, newly identified cytokines may eventually form the basis for new therapeutic strategies aimed at inhibiting the progression of renal disease... - Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformationFrank Strutz
Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
Kidney Int 61:1714-28. 2002.... - Epithelial-mesenchymal transition and its implications for fibrosisRaghu Kalluri
Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
J Clin Invest 112:1776-84. 2003..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors... - Selective depletion of fibroblasts preserves morphology and the functional integrity of peritoneum in transgenic mice with peritoneal fibrosing syndromeHirokazu Okada
Department of Nephrology, Saitama Medical College, Saitama, Japan
Kidney Int 64:1722-32. 2003..The pathogenesis of PFS is unclear and the role of peritoneal fibroblasts has not been evaluated experimentally... - Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cellsMichael Zeisberg
Program in Matrix Biology, Renal and Gastroenterology Divisions, Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Biochem Biophys Res Commun 295:401-7. 2002.... - New insights into mechanisms of fibrosis in immune renal injuryFrank Strutz
Department of Nephrology and Rheumatology, , Robert-Koch-Str. 40, , Germany
Springer Semin Immunopathol 24:459-76. 2003..Eventually, the collagenous matrix of fibrogenesis destroys blood supply and the perimeter of viability for fibroblasts regresses to the point where scars become acellular... - Impaired T cell function in RANTES-deficient miceYasuhiko Makino
Penn Center for Molecular Studies of Kidney Disease, Renal Electrolyte and Hypertension Division, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Immunol 102:302-9. 2002..Together, these data suggest that RANTES is required for normal T cell functions as well as for recruiting monocytes and T cells to sites of inflammation... - The role of fibroblasts in thymocyte-positive selectionMirjana Lilic
Department of Pathology, Michael Heidelberger Division of Immunology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
J Immunol 169:4945-50. 2002..Contrary to previous suggestions, our results indicate a limited role of fibroblasts in promoting positive selection. In addition, the results suggest that positive selection may occur by a different mechanism in fetal vs adult thymus... - Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd miceMin Peng
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Kidney Int 66:20-8. 2004..By testing for linkage to microsatellite markers, we previously localized the kd gene to a YAC/BAC contig... - The downside of a drug-crazed worldEric G Neilson
J Am Soc Nephrol 17:2650-1. 2006
Research Grants
- MOLECULAR MECHANISMS OF RENAL FIBROSISERIC NEILSON; Fiscal Year: 2002..It may be a key to understanding how to control their behavior during disease. ..
- MOLECULAR MECHANISMS OF RENAL FIBROSISERIC NEILSON; Fiscal Year: 2007..This understanding may be key to learning how we can further manipulate their participation in renal fibrosis. ..