ERIC NEILSON

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint Baumol's curse on medicine
    Eric G Neilson
    Department of Medicine, D 3100 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    J Am Soc Nephrol 19:1049-53. 2008
  2. ncbi request reprint The impact of peer management on test-ordering behavior
    Eric G Neilson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Ann Intern Med 141:196-204. 2004
  3. ncbi request reprint Plasticity, nuclear diapause, and a requiem for the terminal differentiation of epithelia
    Eric G Neilson
    Department of Medicine, D 3100 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    J Am Soc Nephrol 18:1995-8. 2007
  4. ncbi request reprint Mechanisms of disease: Fibroblasts--a new look at an old problem
    Eric G Neilson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    Nat Clin Pract Nephrol 2:101-8. 2006
  5. pmc Epithelial-mesenchymal transitions and the intersecting cell fate of fibroblasts and metastatic cancer cells
    Eric G Neilson
    Departments of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Trans Am Clin Climatol Assoc 114:87-100; discussion 100-1. 2003
  6. pmc The role of medical school admissions committees in the decline of physician-scientists
    Eric G Neilson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 111:765-7. 2003
  7. ncbi request reprint Alport's syndrome, Goodpasture's syndrome, and type IV collagen
    Billy G Hudson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    N Engl J Med 348:2543-56. 2003
  8. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
  9. doi request reprint Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis
    Vadim Pedchenko
    Center for Matrix Biology, Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    N Engl J Med 363:343-54. 2010
  10. ncbi request reprint Human antiglomerular basement membrane autoantibody disease in XenoMouse II
    Kevin E C Meyers
    Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Kidney Int 61:1666-73. 2002

Research Grants

  1. MOLECULAR MECHANISMS OF RENAL FIBROSIS
    ERIC NEILSON; Fiscal Year: 2002
  2. MOLECULAR MECHANISMS OF RENAL FIBROSIS
    ERIC NEILSON; Fiscal Year: 2007

Collaborators

Detail Information

Publications42

  1. doi request reprint Baumol's curse on medicine
    Eric G Neilson
    Department of Medicine, D 3100 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    J Am Soc Nephrol 19:1049-53. 2008
  2. ncbi request reprint The impact of peer management on test-ordering behavior
    Eric G Neilson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Ann Intern Med 141:196-204. 2004
    ..Laboratory testing of hospitalized patients, although essential, can be expensive and sometimes excessive. Attempts to reduce unnecessary testing have often been difficult to implement or sustain...
  3. ncbi request reprint Plasticity, nuclear diapause, and a requiem for the terminal differentiation of epithelia
    Eric G Neilson
    Department of Medicine, D 3100 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    J Am Soc Nephrol 18:1995-8. 2007
  4. ncbi request reprint Mechanisms of disease: Fibroblasts--a new look at an old problem
    Eric G Neilson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    Nat Clin Pract Nephrol 2:101-8. 2006
    ..This review examines these issues and identifies new targets for the treatment of one of the most difficult problems facing clinical nephrology...
  5. pmc Epithelial-mesenchymal transitions and the intersecting cell fate of fibroblasts and metastatic cancer cells
    Eric G Neilson
    Departments of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Trans Am Clin Climatol Assoc 114:87-100; discussion 100-1. 2003
  6. pmc The role of medical school admissions committees in the decline of physician-scientists
    Eric G Neilson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 111:765-7. 2003
  7. ncbi request reprint Alport's syndrome, Goodpasture's syndrome, and type IV collagen
    Billy G Hudson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    N Engl J Med 348:2543-56. 2003
  8. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    ..As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions...
  9. doi request reprint Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis
    Vadim Pedchenko
    Center for Matrix Biology, Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    N Engl J Med 363:343-54. 2010
    ..We compared the conformations of the antibody epitopes in Goodpasture's disease and Alport's post-transplantation nephritis with the intention of finding clues to the pathogenesis of anti-GBM glomerulonephritis...
  10. ncbi request reprint Human antiglomerular basement membrane autoantibody disease in XenoMouse II
    Kevin E C Meyers
    Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Kidney Int 61:1666-73. 2002
    ..Availability of engineered mice that produce antibodies (that is, XenoMouse II strains) provides an ideal opportunity to examine the human antibody response...
  11. pmc Interventions to regulate ordering of serum magnesium levels: report of an unintended consequence of decision support
    S Trent Rosenbloom
    Eskind Biomedical Library, Room 440, 2209 Garland Avenue, Nashville, TN 37232 8340, USA
    J Am Med Inform Assoc 12:546-53. 2005
    ..Unintended consequences of computerized patient care system interventions may increase resource use, foster clinical errors, and reduce users' confidence...
  12. ncbi request reprint Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy
    Jian Kang Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, S 3223 Medical Center North, Nashville, Tennessee 37232, USA
    J Am Soc Nephrol 16:1384-91. 2005
    ..These studies demonstrate that activation of the mTOR signaling pathway in the remaining kidney after UNX plays an essential role in modulating RNA and protein synthesis during development of compensatory renal hypertrophy...
  13. ncbi request reprint Goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement: novel mechanisms for immune privilege and autoimmune pathogenesis
    Dorin Bogdan Borza
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA
    J Biol Chem 280:27147-54. 2005
    ..These findings provide fundamental new insights into immune privilege and the molecular mechanisms underlying the pathogenesis of human autoimmune Goodpasture disease...
  14. pmc Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis
    Harikrishna Tanjore
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 180:657-65. 2009
    ..Lung fibroblasts are key mediators of fibrosis resulting in accumulation of excessive interstitial collagen and extracellular matrix, but their origins are not well defined...
  15. ncbi request reprint Pathogenesis of Goodpasture syndrome: a molecular perspective
    Dorin Bogdan Borza
    Deparment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Semin Nephrol 23:522-31. 2003
    ..Further insight into the pathogenesis of disease has been obtained from better animal models. These advances provide a foundation for the development of new specific therapies...
  16. pmc Dystroglycan in the diagnosis of FSGS
    Giovanna Giannico
    C 3310 MCN, Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Clin J Am Soc Nephrol 4:1747-53. 2009
    ..Fibrosis has been linked to increased fibroblast-specific protein-1 (FSP1) and epithelial-mesenchymal transition. We studied DG, FSP1, and podocyte differentiation in FSGS variants and cases of suspected FSGS...
  17. ncbi request reprint Effects of performance-based compensation and faculty track on the clinical activity, research portfolio, and teaching mission of a large academic department of medicine
    Gregg T Tarquinio
    Department of Medicine, D 3100 MCN, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Acad Med 78:690-701. 2003
    ..The authors describe the design, implementation, and testing of a performance-based compensation plan in a department of medicine that is closely linked to the faculty appointment track...
  18. pmc The Jeremiah Metzger lecture. The origin of fibroblasts and the terminality of epithelial differentiation
    Eric G Neilson
    Department of Medicine, D 3100 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    Trans Am Clin Climatol Assoc 121:240-50; discussion 250-1. 2010
    ....
  19. ncbi request reprint The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
    Chengsen Xue
    Department of Medicine and the Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 63:3386-94. 2003
    ....
  20. ncbi request reprint Toward a unified theory of renal progression
    Raymond C Harris
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Med 57:365-80. 2006
    ..New knowledge about the cell biology of progression also suggests that other adjunctive therapies may be possible. We describe the progress and highlight those spheres where new-targeted interventions may arise...
  21. ncbi request reprint Antibodies against macrophages that overlap in specificity with fibroblasts
    Tsutomu Inoue
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int 67:2488-93. 2005
    ....
  22. ncbi request reprint Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy
    Jianchun Chen
    Department of Medicine, Vanderbilt University School of Medicine, and Department of Veterans Affairs, Nashville, TN 37232, USA
    J Am Soc Nephrol 17:1615-23. 2006
    ..In summary, this is the first demonstration that HB-EGF shedding-dependent EGFR transactivation, along with activation of TGF-beta signaling pathways, mediates Ang II-induced renal tubular epithelial cell hypertrophy...
  23. ncbi request reprint Characterization of fibroblast-specific protein 1 in pulmonary fibrosis
    William E Lawson
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T 1217 MCN, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 171:899-907. 2005
    ..Therefore, FSP1 is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis...
  24. pmc Stromal fibroblasts in cancer initiation and progression
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nature 432:332-7. 2004
    ..Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications...
  25. pmc A proximal activator of transcription in epithelial-mesenchymal transition
    Christo D Venkov
    Department of Medicine, Vanderbilt University School of Medicine, D 3100 MCN, Nashville, Tennessee 37232, USA
    J Clin Invest 117:482-91. 2007
    ..We believe formation of the CBF-A/KAP-1/FTS-1 complex is sufficient for the induction of FSP1 and a novel proximal activator of EMT...
  26. ncbi request reprint Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 13:952-61. 2007
    ..Our findings show that EndMT contributes to the progression of cardiac fibrosis and that rhBMP-7 can be used to inhibit EndMT and to intervene in the progression of chronic heart disease associated with fibrosis...
  27. ncbi request reprint Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease
    Michele Rossini
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Kidney Int 68:2621-8. 2005
    ....
  28. pmc Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity
    VERONICA R PLACENCIO
    Departments of Cancer Biology, Urologic Surgery, and Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 68:4709-18. 2008
    ..These studies reveal a novel TGF-beta, androgen, and Wnt paracrine signaling axis that enables prostatic regression of the distal ducts after androgen ablation while supporting proximal duct survival...
  29. ncbi request reprint TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Science 303:848-51. 2004
    ..Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues...
  30. ncbi request reprint Chronic kidney disease progression
    Allison A Eddy
    Department of Pediatric, University of Washington, Seattle, WA 98105, USA
    J Am Soc Nephrol 17:2964-6. 2006
  31. ncbi request reprint Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN
    Yoshiharu Nishitani
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Kidney Int 68:1078-85. 2005
    ..In particular, we also prospectively asked if the number of fibroblasts in the renal interstitium correlates with prognosis...
  32. ncbi request reprint Setting a trap for tissue fibrosis
    Eric G Neilson
    Nat Med 11:373-4. 2005
  33. ncbi request reprint Mechanisms of tubulointerstitial fibrosis
    Masayuki Iwano
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Curr Opin Nephrol Hypertens 13:279-84. 2004
    ..The present review focuses on a newly proposed mechanism of tubulointerstitial fibrosis, one that emphasizes the roles of epithelial-mesenchymal transition and cellular activation...
  34. ncbi request reprint Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 61:1714-28. 2002
    ....
  35. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
  36. ncbi request reprint Selective depletion of fibroblasts preserves morphology and the functional integrity of peritoneum in transgenic mice with peritoneal fibrosing syndrome
    Hirokazu Okada
    Department of Nephrology, Saitama Medical College, Saitama, Japan
    Kidney Int 64:1722-32. 2003
    ..The pathogenesis of PFS is unclear and the role of peritoneal fibroblasts has not been evaluated experimentally...
  37. ncbi request reprint Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells
    Michael Zeisberg
    Program in Matrix Biology, Renal and Gastroenterology Divisions, Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Biochem Biophys Res Commun 295:401-7. 2002
    ....
  38. ncbi request reprint New insights into mechanisms of fibrosis in immune renal injury
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Str 40, Gottingen, Germany
    Springer Semin Immunopathol 24:459-76. 2003
    ..Eventually, the collagenous matrix of fibrogenesis destroys blood supply and the perimeter of viability for fibroblasts regresses to the point where scars become acellular...
  39. ncbi request reprint Impaired T cell function in RANTES-deficient mice
    Yasuhiko Makino
    Penn Center for Molecular Studies of Kidney Disease, Renal Electrolyte and Hypertension Division, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Immunol 102:302-9. 2002
    ..Together, these data suggest that RANTES is required for normal T cell functions as well as for recruiting monocytes and T cells to sites of inflammation...
  40. ncbi request reprint The role of fibroblasts in thymocyte-positive selection
    Mirjana Lilic
    Department of Pathology, Michael Heidelberger Division of Immunology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
    J Immunol 169:4945-50. 2002
    ..Contrary to previous suggestions, our results indicate a limited role of fibroblasts in promoting positive selection. In addition, the results suggest that positive selection may occur by a different mechanism in fetal vs adult thymus...
  41. pmc Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice
    Min Peng
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Kidney Int 66:20-8. 2004
    ..By testing for linkage to microsatellite markers, we previously localized the kd gene to a YAC/BAC contig...
  42. ncbi request reprint The downside of a drug-crazed world
    Eric G Neilson
    J Am Soc Nephrol 17:2650-1. 2006

Research Grants10

  1. MOLECULAR MECHANISMS OF RENAL FIBROSIS
    ERIC NEILSON; Fiscal Year: 2002
    ..It may be a key to understanding how to control their behavior during disease. ..
  2. MOLECULAR MECHANISMS OF RENAL FIBROSIS
    ERIC NEILSON; Fiscal Year: 2007
    ..This understanding may be key to learning how we can further manipulate their participation in renal fibrosis. ..