Barbara A Murphy

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy
    Barbara A Murphy
    Pain and Symptom Management Program, Vanderbilt University, Nashville, Tennessee 37232 5536, USA
    J Support Oncol 5:13-21. 2007
  2. pmc The cost burden of oral, oral pharyngeal, and salivary gland cancers in three groups: commercial insurance, Medicare, and Medicaid
    Jed J Jacobson
    Delta Dental of Michigan, University of Michigan, 4100 Okemos Road, Okemos, MI 48864, USA
    Head Neck Oncol 4:15. 2012
  3. ncbi request reprint A critical component of supportive care
    Barbara A Murphy
    Pain and Symptom Management Program, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232 5536, USA
    J Support Oncol 5:228-9. 2007
  4. ncbi request reprint Quality of life research in head and neck cancer: a review of the current state of the science
    Barbara A Murphy
    Division of Hematology and Oncology, Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, TN 37215, USA
    Crit Rev Oncol Hematol 62:251-67. 2007
  5. ncbi request reprint Symptom control issues and supportive care of patients with head and neck cancers
    Barbara A Murphy
    Vanderbilt University Medical Center, Division of Hematology Oncology, Nashville, TN 37232, USA
    Clin Adv Hematol Oncol 5:807-22. 2007
  6. doi request reprint Reliability and validity of the Vanderbilt Head and Neck Symptom Survey: a tool to assess symptom burden in patients treated with chemoradiation
    Barbara A Murphy
    Department of Medicine, Vanderbilt University Medical Center, USA
    Head Neck 32:26-37. 2010
  7. doi request reprint Advances in quality of life and symptom management for head and neck cancer patients
    Barbara A Murphy
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Curr Opin Oncol 21:242-7. 2009
  8. doi request reprint Dysphagia in head and neck cancer patients treated with radiation: assessment, sequelae, and rehabilitation
    Barbara A Murphy
    Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 6307, USA
    Semin Radiat Oncol 19:35-42. 2009
  9. ncbi request reprint Systemic and global toxicities of head and neck treatment
    Barbara A Murphy
    Vanderbilt University Medical Center, Nashville, TN 37232 6307, USA
    Expert Rev Anticancer Ther 7:1043-53. 2007
  10. ncbi request reprint Topoisomerases in the treatment of metastatic or recurrent squamous carcinoma of the head and neck
    Barbara A Murphy
    Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, TN 37232 6307, USA
    Expert Opin Pharmacother 6:85-92. 2005

Research Grants

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy
    Barbara A Murphy
    Pain and Symptom Management Program, Vanderbilt University, Nashville, Tennessee 37232 5536, USA
    J Support Oncol 5:13-21. 2007
    ..Costs generally increase as a function of mucositis severity. Effective treatments to prevent or reduce the incidence and severity of mucositis are needed to decrease function loss, minimize symptom burden, and lower treatment costs...
  2. pmc The cost burden of oral, oral pharyngeal, and salivary gland cancers in three groups: commercial insurance, Medicare, and Medicaid
    Jed J Jacobson
    Delta Dental of Michigan, University of Michigan, 4100 Okemos Road, Okemos, MI 48864, USA
    Head Neck Oncol 4:15. 2012
    ..Consequently the economic burden of oral cavity, oral pharyngeal, and salivary gland cancer (OC/OP/SG) must be understood. The cost of these cancers in the U.S. has not been investigated...
  3. ncbi request reprint A critical component of supportive care
    Barbara A Murphy
    Pain and Symptom Management Program, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232 5536, USA
    J Support Oncol 5:228-9. 2007
  4. ncbi request reprint Quality of life research in head and neck cancer: a review of the current state of the science
    Barbara A Murphy
    Division of Hematology and Oncology, Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, TN 37215, USA
    Crit Rev Oncol Hematol 62:251-67. 2007
    ..Whether routine use of QOL measures in the clinical setting is beneficial to patients has yet to be determined. Further studies are warranted as currently available instruments may not be valid for repeated clinical use...
  5. ncbi request reprint Symptom control issues and supportive care of patients with head and neck cancers
    Barbara A Murphy
    Vanderbilt University Medical Center, Division of Hematology Oncology, Nashville, TN 37232, USA
    Clin Adv Hematol Oncol 5:807-22. 2007
    ..Additionally, the pretreatment and during-treatment evaluation of dental health, as well as posttreatment dental care, are described...
  6. doi request reprint Reliability and validity of the Vanderbilt Head and Neck Symptom Survey: a tool to assess symptom burden in patients treated with chemoradiation
    Barbara A Murphy
    Department of Medicine, Vanderbilt University Medical Center, USA
    Head Neck 32:26-37. 2010
    ....
  7. doi request reprint Advances in quality of life and symptom management for head and neck cancer patients
    Barbara A Murphy
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Curr Opin Oncol 21:242-7. 2009
    ..This review will encompass the recent studies addressing supportive care issues facing head and neck cancer patients...
  8. doi request reprint Dysphagia in head and neck cancer patients treated with radiation: assessment, sequelae, and rehabilitation
    Barbara A Murphy
    Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 6307, USA
    Semin Radiat Oncol 19:35-42. 2009
    ....
  9. ncbi request reprint Systemic and global toxicities of head and neck treatment
    Barbara A Murphy
    Vanderbilt University Medical Center, Nashville, TN 37232 6307, USA
    Expert Rev Anticancer Ther 7:1043-53. 2007
    ..It is important for clinicians to be aware of these late effects in order to provide patients with appropriate support services and referrals. This paper examines the global and systemic effects of therapy...
  10. ncbi request reprint Topoisomerases in the treatment of metastatic or recurrent squamous carcinoma of the head and neck
    Barbara A Murphy
    Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, TN 37232 6307, USA
    Expert Opin Pharmacother 6:85-92. 2005
    ..Clarification of the role of irinotecan in the treatment of HNC awaits further studies...
  11. ncbi request reprint Longitudinal oncology registry of head and neck carcinoma (LORHAN): initial supportive care findings
    Barbara A Murphy
    Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Support Care Cancer 17:1393-401. 2009
    ..We report the first analysis of demographic, socioeconomic, and toxicity data from the Longitudinal Oncology Registry of Head and Neck Carcinoma (LORHAN)...
  12. doi request reprint Vanderbilt Head and Neck Symptom Survey version 2.0: report of the development and initial testing of a subscale for assessment of oral health
    Emily Cooperstein
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Head Neck 34:797-804. 2012
    ..We report development of an oral health outcome subscale for the Vanderbilt Head and Neck Symptom Survey (VHNSS)...
  13. ncbi request reprint Impact of secondary lymphedema after head and neck cancer treatment on symptoms, functional status, and quality of life
    Jie Deng
    School of Nursing, Vanderbilt University, Nashville, Tennessee 37240, USA
    Head Neck 35:1026-35. 2013
    ..The purpose of this study was to examine the associations among severity of internal and external lymphedema, symptoms, functional status, and QOL in patients with head and neck cancer...
  14. doi request reprint Phase II trial of irinotecan plus cisplatin in patients with recurrent or metastatic squamous carcinoma of the head and neck
    Jill Gilbert
    Division of Hematology and Oncology, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 777 PRB, Nashville, TN 37232, USA
    Cancer 113:186-92. 2008
    ..Thus, new agents are needed. The authors report the results of a phase II trial of irinotecan and cisplatin in patients with metastatic or recurrent HNC...
  15. doi request reprint Hypothyroidism as a consequence of intensity-modulated radiotherapy with concurrent taxane-based chemotherapy for locally advanced head-and-neck cancer
    Roberto Diaz
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Int J Radiat Oncol Biol Phys 77:468-76. 2010
    ....
  16. doi request reprint Factors associated with external and internal lymphedema in patients with head-and-neck cancer
    Jie Deng
    School of Nursing, Vanderbilt University, Nashville, TN 37240, USA
    Int J Radiat Oncol Biol Phys 84:e319-28. 2012
    ..The purpose of this study was to examine factors associated with the presence of secondary external and internal lymphedema in patients with head-and-neck cancer (HNC)...
  17. pmc Intensity-modulated radiation therapy with concurrent carboplatin and paclitaxel for locally advanced head and neck cancer: toxicities and efficacy
    Gregory Vlacich
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 5671, USA
    Oncologist 17:673-81. 2012
    ..Our experience with concurrent IMRT and taxane-based chemotherapy is presented...
  18. doi request reprint Prevalence of secondary lymphedema in patients with head and neck cancer
    Jie Deng
    School of Nursing, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Pain Symptom Manage 43:244-52. 2012
    ..Yet, no published data are available regarding the prevalence of secondary lymphedema after head and neck cancer treatment...
  19. ncbi request reprint Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas
    Christine H Chung
    Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
    J Clin Oncol 24:4170-6. 2006
    ..A better understanding of the EGFR pathway may improve the use of EGFR inhibitors in HNSCC...
  20. ncbi request reprint Taxane-based chemoirradiation for organ preservation with locally advanced head and neck cancer: results of a phase II multi-institutional trial
    Anthony J Cmelak
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Head Neck 29:315-24. 2007
    ....
  21. doi request reprint Preliminary development of a lymphedema symptom assessment scale for patients with head and neck cancer
    Jie Deng
    School of Nursing, Vanderbilt University, 461 21st Ave South, 600B Godchaux Hall, Nashville, TN 37240, USA
    Support Care Cancer 20:1911-8. 2012
    ..Currently, no instruments are available to assess symptoms secondary to lymphedema in patients with head and neck cancer (HNC). The study aim was to develop and conduct preliminary tests of such an instrument...
  22. ncbi request reprint Changes in body mass, energy balance, physical function, and inflammatory state in patients with locally advanced head and neck cancer treated with concurrent chemoradiation after low-dose induction chemotherapy
    Heidi J Silver
    Department of Medicine, Vanderbilt Center for Human Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Head Neck 29:893-900. 2007
    ..We aimed to determine changes in body mass and body composition in relation to energy balance, inflammatory state, and physical function before and after concurrent chemoradiation (CCR)...
  23. ncbi request reprint Mucositis-related morbidity and resource utilization in head and neck cancer patients receiving radiation therapy with or without chemotherapy
    Barbara A Murphy
    Division of Hematology Oncology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 5536, USA
    J Pain Symptom Manage 38:522-32. 2009
    ..Effective treatments to reduce the pain and functional impairment of oral mucositis are needed in this patient population...
  24. ncbi request reprint A Phase II multi-institutional trial of chemoradiation using weekly docetaxel and erythropoietin for high-risk postoperative head and neck cancer patients
    Christopher D Willey
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Int J Radiat Oncol Biol Phys 67:1323-31. 2007
    ..To determine efficacy and toxicities of postoperative concurrent chemoradiation using docetaxel in high-risk head and neck cancer...
  25. ncbi request reprint Association of age and symptom burden in patients with head and neck cancer
    Stewart M Bond
    Vanderbilt University School of Nursing, Nashville, TN, USA
    ORL Head Neck Nurs 29:8-14. 2011
    ..We examined the association of age with symptom burden. Older patients may experience more symptom burden with swallowing, voice/speech, and nutrition. Nurses need to be especially aware of and monitor for these problems...
  26. doi request reprint Delirium in patients with head and neck cancer in the outpatient treatment setting
    Stewart M Bond
    Vanderbilt University School of Nursing, 505 Godchaux Hall, 461 21st Avenue South, Nashville, TN 37240, USA
    Support Care Cancer 20:1023-30. 2012
    ..We also conducted a retrospective study in a subset of caregivers. In this paper, we report the prevalence and incidence of delirium and subsyndromal delirium (SSD) during outpatient treatment...
  27. doi request reprint Depression in patients with head and neck cancer and a functional genetic polymorphism of the serotonin transporter gene
    Jill Gilbert
    Department of Medicine, Hematology Oncology Vanderbilt University School of Medicine Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, Tennessee, USA
    Head Neck 34:359-64. 2012
    ..The purpose of this study was to show the evaluated depression in patients with head and neck cancer and a possible association with the 5-HTTLPR...
  28. ncbi request reprint Outcome of elderly patients with recurrent or metastatic head and neck cancer treated with cisplatin-based chemotherapy
    Athanassios Argiris
    Feinberg School of Medicine, Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    J Clin Oncol 22:262-8. 2004
    ..To evaluate the outcome of elderly patients with head and neck cancer undergoing palliative chemotherapy...
  29. ncbi request reprint Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma
    Christine H Chung
    Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
    Cancer Res 66:8210-8. 2006
    ..The 75-gene list can be used as a prognostic biomarker of recurrence, and our data suggest that the molecular determinants of EMT and NF-kappaB activation can be targeted as the novel therapy in the identified high-risk patients...
  30. doi request reprint Neurocognitive function in head and neck cancer patients prior to treatment
    Stewart M Bond
    Vanderbilt University School of Nursing, 505 Godchaux Hall, 461 21st Avenue South, Nashville, TN 37240, USA
    Support Care Cancer 20:149-57. 2012
    ....
  31. pmc Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose
    Christine H Chung
    Division of Hematology Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
    N Engl J Med 358:1109-17. 2008
    ..A high prevalence of hypersensitivity reactions to cetuximab has been reported in some areas of the United States...
  32. doi request reprint Lymphedema in patients with head and neck cancer
    Jie Deng
    School of Nursing, Vanderbilt University, Nashville, TN, USA
    Oncol Nurs Forum 38:E1-E10. 2011
    ..to describe the current state of the science on secondary lymphedema in patients with head and neck cancer...
  33. pmc Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities
    Mario E Lacouture
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Rockefeller Outpatient Pavilion Suite 228, 160 East 53rd Street, New York, NY 10022, USA
    Support Care Cancer 19:1079-95. 2011
    ..The purpose of this panel was to develop evidence-based recommendations for EGFRI-associated dermatologic toxicities...
  34. ncbi request reprint Caregiver-reported neuropsychiatric symptoms in patients undergoing treatment for head and neck cancer: a pilot study
    Stewart M Bond
    Author Affiliations Boston College William F Connell School of Nursing, Chestnut Hill, Massachusetts Dr Bond Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee Ms Hawkins and Dr Murphy and School of Medicine, Vanderbilt University, Nashville, Tennessee Dr Murphy
    Cancer Nurs 37:227-35. 2014
    ..Patients with cancer experience multiple neuropsychiatric symptoms. Whereas individual symptoms have been studied in patients with head and neck cancer, the broader context of neuropsychiatric symptoms needs to be explored...
  35. ncbi request reprint Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel
    Douglas B Johnson
    Department of Medicine, Department of Cancer Biology, and Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Oncologist 19:616-22. 2014
    ..To determine the clinical impact of extensive genetic analysis, we reviewed our experience using a targeted NGS platform (FoundationOne) in advanced cancer patients...
  36. ncbi request reprint Improving cancer pain management through patient and family education
    Nancy Wells
    Vanderbilt University Medical Center, TT 0102 Medical Center North, Nashville, TN 37232 2424, USA
    J Pain Symptom Manage 25:344-56. 2003
    ..Continued access to pain related information using either a patient- or provider-initiated format did not affect long-term pain outcomes...
  37. doi request reprint Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma
    David M Brizel
    Department of Radiation Oncology, Duke University, Durham, NC, USA
    J Clin Oncol 26:2489-96. 2008
    ..This study assessed the efficacy and safety of palifermin in patients receiving concurrent chemoradiotherapy for advanced head and neck squamous cell carcinoma...
  38. ncbi request reprint Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer
    Marshall R Posner
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 357:1705-15. 2007
    ....
  39. ncbi request reprint Phase II Trial of docetaxel and cisplatin combination chemotherapy in patients with squamous cell carcinoma of the head and neck
    Bonnie S Glisson
    University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 20:1593-9. 2002
    ..To assess the antitumor activity and toxicity of docetaxel plus cisplatin chemotherapy in patients with recurrent or incurable squamous cell carcinoma of the head and neck (SCCHN)...
  40. ncbi request reprint Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    Robert J Motzer
    Genitourinary Oncology Service, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 20:289-96. 2002
    ..The data can be applied to design and interpretation of clinical trials of new agents and treatment programs against this refractory malignancy...
  41. ncbi request reprint Stratification by risk factors predicts survival on the active treatment arm in a randomized phase II study of interferon-gamma plus/minus interferon-alpha in advanced renal cell carcinoma (E6890)
    Janice P Dutcher
    Our Lady of Mercy Cancer Center, NY Med College Bronx, New York 10466, USA
    Med Oncol 20:271-81. 2003
    ....
  42. doi request reprint Effects of systemic inflammation on insulin sensitivity in horses and inflammatory cytokine expression in adipose tissue
    Mandi M Vick
    Gluck Equine Research Center, Department of Veterinary Science, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Am J Vet Res 69:130-9. 2008
    ..To determine whether an inflammatory challenge induces insulin resistance in horses and examine possible contributions of adipose tissue to inflammatory cytokine production...
  43. ncbi request reprint Analysis of the epidermal growth factor receptor promoter: the effect of nuclear factor-kappaB
    Hirotaka Nishi
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Int J Mol Med 11:49-55. 2003
    ..Also, TNF-alpha did not induce EGFR expression at the protein level. These results indicate that even though purified NF-kappaB can bind to the putative sites, there is no evidence that NF-kappaB transactivates the EGFR promoter region...
  44. ncbi request reprint Evidence of an oscillating peripheral clock in an equine fibroblast cell line and adipose tissue but not in peripheral blood
    Barbara A Murphy
    Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546 0099, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:743-51. 2006
    ....
  45. ncbi request reprint Acute systemic inflammation transiently synchronizes clock gene expression in equine peripheral blood
    Barbara A Murphy
    Maxwell H Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546 0099, USA
    Brain Behav Immun 21:467-76. 2007
    ....
  46. ncbi request reprint GCF2: expression and molecular analysis of repression
    Toshiki Rikiyama
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 5002, Building 37, 37 Convent Drive MSC 4264, Bethesda, MD 20892 4264, USA
    Biochim Biophys Acta 1629:15-25. 2003
    ..Thus, GCF2 is a transcriptional repressor overexpressed in cancer cell lines with a role in regulating expression of the EGFR...

Research Grants1

  1. Hospice Pain Control: Developing an Opioid Order Sheet
    Barbara Murphy; Fiscal Year: 2006
    ..Once the modifications lave been made, we will conduct a pilot study to assess feasibility, utility and efficacy of the order sheet in the outpatient hospice setting. ..