Research Topics
Species | Barbara A MurphySummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Publications
Advances in quality of life and symptom management for head and neck cancer patientsBarbara A Murphy
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Curr Opin Oncol 21:242-7. 2009..This review will encompass the recent studies addressing supportive care issues facing head and neck cancer patients...
A critical component of supportive careBarbara A Murphy
Pain and Symptom Management Program, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232-5536, USA
J Support Oncol 5:228-9. 2007- Systemic and global toxicities of head and neck treatmentBarbara A Murphy
Vanderbilt University Medical Center, Nashville, TN 37232 6307, USA
Expert Rev Anticancer Ther 7:1043-53. 2007..It is important for clinicians to be aware of these late effects in order to provide patients with appropriate support services and referrals. This paper examines the global and systemic effects of therapy... - Symptom control issues and supportive care of patients with head and neck cancersBarbara A Murphy
Vanderbilt University Medical Center, Division of Hematology Oncology, Nashville, TN 37232, USA
Clin Adv Hematol Oncol 5:807-22. 2007..Additionally, the pretreatment and during-treatment evaluation of dental health, as well as posttreatment dental care, are described... - Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapyBarbara A Murphy
Pain and Symptom Management Program, Vanderbilt University, Nashville, Tennessee 37232 5536, USA
J Support Oncol 5:13-21. 2007..Costs generally increase as a function of mucositis severity. Effective treatments to prevent or reduce the incidence and severity of mucositis are needed to decrease function loss, minimize symptom burden, and lower treatment costs... - Reliability and validity of the Vanderbilt Head and Neck Symptom Survey: a tool to assess symptom burden in patients treated with chemoradiationBarbara A Murphy
Department of Medicine, Vanderbilt University Medical Center, USA
Head Neck 32:26-37. 2010.... - Quality of life research in head and neck cancer: a review of the current state of the scienceBarbara A Murphy
Division of Hematology and Oncology, Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, TN 37215, USA
Crit Rev Oncol Hematol 62:251-67. 2007..Whether routine use of QOL measures in the clinical setting is beneficial to patients has yet to be determined. Further studies are warranted as currently available instruments may not be valid for repeated clinical use... - Topoisomerases in the treatment of metastatic or recurrent squamous carcinoma of the head and neckBarbara A Murphy
Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, TN 37232 6307, USA
Expert Opin Pharmacother 6:85-92. 2005..Clarification of the role of irinotecan in the treatment of HNC awaits further studies... - Dysphagia in head and neck cancer patients treated with radiation: assessment, sequelae, and rehabilitationBarbara A Murphy
Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 6307, USA
Semin Radiat Oncol 19:35-42. 2009.... - Longitudinal oncology registry of head and neck carcinoma (LORHAN): initial supportive care findingsBarbara A Murphy
Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
Support Care Cancer 17:1393-401. 2009..We report the first analysis of demographic, socioeconomic, and toxicity data from the Longitudinal Oncology Registry of Head and Neck Carcinoma (LORHAN)... - Vanderbilt Head and Neck Symptom Survey version 2.0: report of the development and initial testing of a subscale for assessment of oral healthEmily Cooperstein
Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Head Neck 34:797-804. 2012..We report development of an oral health outcome subscale for the Vanderbilt Head and Neck Symptom Survey (VHNSS)... - Phase II trial of irinotecan plus cisplatin in patients with recurrent or metastatic squamous carcinoma of the head and neckJill Gilbert
Division of Hematology and Oncology, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 777 PRB, Nashville, TN 37232, USA
Cancer 113:186-92. 2008..Thus, new agents are needed. The authors report the results of a phase II trial of irinotecan and cisplatin in patients with metastatic or recurrent HNC... - Hypothyroidism as a consequence of intensity-modulated radiotherapy with concurrent taxane-based chemotherapy for locally advanced head-and-neck cancerRoberto Diaz
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Int J Radiat Oncol Biol Phys 77:468-76. 2010.... - Factors associated with external and internal lymphedema in patients with head-and-neck cancerJie Deng
School of Nursing, Vanderbilt University, Nashville, TN 37240, USA
Int J Radiat Oncol Biol Phys 84:e319-28. 2012..The purpose of this study was to examine factors associated with the presence of secondary external and internal lymphedema in patients with head-and-neck cancer (HNC)... 
Intensity-modulated radiation therapy with concurrent carboplatin and paclitaxel for locally advanced head and neck cancer: toxicities and efficacyGregory Vlacich
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 5671, USA
Oncologist 17:673-81. 2012..Our experience with concurrent IMRT and taxane-based chemotherapy is presented...- Prevalence of secondary lymphedema in patients with head and neck cancerJie Deng
School of Nursing, Vanderbilt University, Nashville, Tennessee 37240, USA
J Pain Symptom Manage 43:244-52. 2012..Yet, no published data are available regarding the prevalence of secondary lymphedema after head and neck cancer treatment... - Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomasChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
J Clin Oncol 24:4170-6. 2006..A better understanding of the EGFR pathway may improve the use of EGFR inhibitors in HNSCC... - Taxane-based chemoirradiation for organ preservation with locally advanced head and neck cancer: results of a phase II multi-institutional trialAnthony J Cmelak
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Head Neck 29:315-24. 2007.... - Preliminary development of a lymphedema symptom assessment scale for patients with head and neck cancerJie Deng
School of Nursing, Vanderbilt University, 461 21st Ave South, 600B Godchaux Hall, Nashville, TN 37240, USA
Support Care Cancer 20:1911-8. 2012..Currently, no instruments are available to assess symptoms secondary to lymphedema in patients with head and neck cancer (HNC). The study aim was to develop and conduct preliminary tests of such an instrument... - Mucositis-related morbidity and resource utilization in head and neck cancer patients receiving radiation therapy with or without chemotherapyBarbara A Murphy
Division of Hematology Oncology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 5536, USA
J Pain Symptom Manage 38:522-32. 2009..Effective treatments to reduce the pain and functional impairment of oral mucositis are needed in this patient population... - Changes in body mass, energy balance, physical function, and inflammatory state in patients with locally advanced head and neck cancer treated with concurrent chemoradiation after low-dose induction chemotherapyHeidi J Silver
Department of Medicine, Vanderbilt Center for Human Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Head Neck 29:893-900. 2007..We aimed to determine changes in body mass and body composition in relation to energy balance, inflammatory state, and physical function before and after concurrent chemoradiation (CCR)... - A Phase II multi-institutional trial of chemoradiation using weekly docetaxel and erythropoietin for high-risk postoperative head and neck cancer patientsChristopher D Willey
Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
Int J Radiat Oncol Biol Phys 67:1323-31. 2007..To determine efficacy and toxicities of postoperative concurrent chemoradiation using docetaxel in high-risk head and neck cancer... - Association of age and symptom burden in patients with head and neck cancerStewart M Bond
Vanderbilt University School of Nursing, Nashville, TN, USA
ORL Head Neck Nurs 29:8-14. 2011..We examined the association of age with symptom burden. Older patients may experience more symptom burden with swallowing, voice/speech, and nutrition. Nurses need to be especially aware of and monitor for these problems... - Delirium in patients with head and neck cancer in the outpatient treatment settingStewart M Bond
Vanderbilt University School of Nursing, 505 Godchaux Hall, 461 21st Avenue South, Nashville, TN 37240, USA
Support Care Cancer 20:1023-30. 2012..We also conducted a retrospective study in a subset of caregivers. In this paper, we report the prevalence and incidence of delirium and subsyndromal delirium (SSD) during outpatient treatment... - Depression in patients with head and neck cancer and a functional genetic polymorphism of the serotonin transporter geneJill Gilbert
Department of Medicine, Hematology Oncology Vanderbilt University School of Medicine Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, Tennessee, USA
Head Neck 34:359-64. 2012..The purpose of this study was to show the evaluated depression in patients with head and neck cancer and a possible association with the 5-HTTLPR... - Outcome of elderly patients with recurrent or metastatic head and neck cancer treated with cisplatin-based chemotherapyAthanassios Argiris
Feinberg School of Medicine, Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
J Clin Oncol 22:262-8. 2004..To evaluate the outcome of elderly patients with head and neck cancer undergoing palliative chemotherapy... - Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinomaChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
Cancer Res 66:8210-8. 2006..The 75-gene list can be used as a prognostic biomarker of recurrence, and our data suggest that the molecular determinants of EMT and NF-kappaB activation can be targeted as the novel therapy in the identified high-risk patients... - Neurocognitive function in head and neck cancer patients prior to treatmentStewart M Bond
Vanderbilt University School of Nursing, 505 Godchaux Hall, 461 21st Avenue South, Nashville, TN 37240, USA
Support Care Cancer 20:149-57. 2012.... - Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactoseChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
N Engl J Med 358:1109-17. 2008..A high prevalence of hypersensitivity reactions to cetuximab has been reported in some areas of the United States... - Lymphedema in patients with head and neck cancerJie Deng
School of Nursing, Vanderbilt University, Nashville, TN, USA
Oncol Nurs Forum 38:E1-E10. 2011..to describe the current state of the science on secondary lymphedema in patients with head and neck cancer... - Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicitiesMario E Lacouture
Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Rockefeller Outpatient Pavilion Suite 228, 160 East 53rd Street, New York, NY 10022, USA
Support Care Cancer 19:1079-95. 2011..The purpose of this panel was to develop evidence-based recommendations for EGFRI-associated dermatologic toxicities... - Improving cancer pain management through patient and family educationNancy Wells
Vanderbilt University Medical Center, TT-0102 Medical Center North, Nashville, TN 37232-2424, USA
J Pain Symptom Manage 25:344-56. 2003..Continued access to pain related information using either a patient- or provider-initiated format did not affect long-term pain outcomes... - Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinomaDavid M Brizel
Department of Radiation Oncology, Duke University, Durham, NC, USA
J Clin Oncol 26:2489-96. 2008..This study assessed the efficacy and safety of palifermin in patients receiving concurrent chemoradiotherapy for advanced head and neck squamous cell carcinoma... - Cisplatin and fluorouracil alone or with docetaxel in head and neck cancerMarshall R Posner
Dana Farber Cancer Institute, Boston, MA 02115, USA
N Engl J Med 357:1705-15. 2007.... - Phase II Trial of docetaxel and cisplatin combination chemotherapy in patients with squamous cell carcinoma of the head and neckBonnie S Glisson
University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 20:1593-9. 2002..To assess the antitumor activity and toxicity of docetaxel plus cisplatin chemotherapy in patients with recurrent or incurable squamous cell carcinoma of the head and neck (SCCHN)... - Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinomaRobert J Motzer
Genitourinary Oncology Service, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
J Clin Oncol 20:289-96. 2002..The data can be applied to design and interpretation of clinical trials of new agents and treatment programs against this refractory malignancy... - Analysis of the epidermal growth factor receptor promoter: the effect of nuclear factor-kappaBHirotaka Nishi
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA
Int J Mol Med 11:49-55. 2003..Also, TNF-alpha did not induce EGFR expression at the protein level. These results indicate that even though purified NF-kappaB can bind to the putative sites, there is no evidence that NF-kappaB transactivates the EGFR promoter region... - Stratification by risk factors predicts survival on the active treatment arm in a randomized phase II study of interferon-gamma plus/minus interferon-alpha in advanced renal cell carcinoma (E6890)Janice P Dutcher
Our Lady of Mercy Cancer Center, NY Med College Bronx, New York 10466, USA
Med Oncol 20:271-81. 2003.... - Evidence of an oscillating peripheral clock in an equine fibroblast cell line and adipose tissue but not in peripheral bloodBarbara A Murphy
Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546 0099, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:743-51. 2006.... - GCF2: expression and molecular analysis of repressionToshiki Rikiyama
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 5002, Building 37, 37 Convent Drive MSC 4264, Bethesda, MD 20892 4264, USA
Biochim Biophys Acta 1629:15-25. 2003..Thus, GCF2 is a transcriptional repressor overexpressed in cancer cell lines with a role in regulating expression of the EGFR... - Acute systemic inflammation transiently synchronizes clock gene expression in equine peripheral bloodBarbara A Murphy
Maxwell H Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546 0099, USA
Brain Behav Immun 21:467-76. 2007.... - Effects of systemic inflammation on insulin sensitivity in horses and inflammatory cytokine expression in adipose tissueMandi M Vick
Gluck Equine Research Center, Department of Veterinary Science, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
Am J Vet Res 69:130-9. 2008..To determine whether an inflammatory challenge induces insulin resistance in horses and examine possible contributions of adipose tissue to inflammatory cytokine production...
Research Grants
- Hospice Pain Control: Developing an Opioid Order SheetBarbara Murphy; Fiscal Year: 2006..Once the modifications lave been made, we will conduct a pilot study to assess feasibility, utility and efficacy of the order sheet in the outpatient hospice setting. ..