Harold L Moses

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro
    Kimberly A Brown
    Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Breast Cancer Res 6:R215-31. 2004
  2. pmc Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk
    Lauren A Matise
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 771 Preston Research Building, Nashville, TN 37232, USA
    Breast Cancer Res 14:R98. 2012
  3. pmc Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line
    Lu Xie
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    Breast Cancer Res 5:R187-98. 2003
  4. pmc Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion
    Nikki Cheng
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6838, USA
    Mol Cancer Res 6:1521-33. 2008
  5. doi request reprint Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Cancer Res 68:1809-19. 2008
  6. pmc Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks
    Nikki Cheng
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6838, USA
    Oncogene 24:5053-68. 2005
  7. pmc Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    Hideaki Ijichi
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Genes Dev 20:3147-60. 2006
  8. ncbi request reprint Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis
    Nikki Cheng
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 67:4869-77. 2007
  9. ncbi request reprint Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    Elizabeth Forrester
    Department of Cancer Biology, Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer Res 65:2296-302. 2005
  10. pmc Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 119:1571-82. 2009

Detail Information

Publications67

  1. pmc Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro
    Kimberly A Brown
    Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Breast Cancer Res 6:R215-31. 2004
    ..Although there is growing interest in TGF-beta1-mediated EMT, the phenotype is limited to only a few murine cell lines and mouse models...
  2. pmc Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk
    Lauren A Matise
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 771 Preston Research Building, Nashville, TN 37232, USA
    Breast Cancer Res 14:R98. 2012
    ..Our findings concerning TGF-β signaling in epithelial-stromal interactions are important in identifying migratory mechanisms that can be targeted as recourse for breast cancer treatment...
  3. pmc Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line
    Lu Xie
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    Breast Cancer Res 5:R187-98. 2003
    ..NMuMG is a nontransformed mouse mammary gland epithelial cell line that exhibits both a growth inhibitory response and an EMT response to TGF-beta, rendering NMuMG cells a good model system for studying these TGF-beta effects...
  4. pmc Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion
    Nikki Cheng
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6838, USA
    Mol Cancer Res 6:1521-33. 2008
    ..These studies characterize complex functional roles for HGF and TGF-beta signaling in mediating tumor-stromal interactions during mammary tumor cell scattering and invasion, with important implications in the metastatic process...
  5. doi request reprint Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Cancer Res 68:1809-19. 2008
    ....
  6. pmc Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks
    Nikki Cheng
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6838, USA
    Oncogene 24:5053-68. 2005
    ..These studies characterize a significant role for stromal TGF-beta signaling in mammary tissue homeostasis and mammary tumor progression via regulation of TGF-alpha, MSP, and HGF signaling pathways...
  7. pmc Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    Hideaki Ijichi
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Genes Dev 20:3147-60. 2006
    ..The data show that blockade of TGF-beta signaling and activated Ras signaling cooperate to promote PDAC progression...
  8. ncbi request reprint Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis
    Nikki Cheng
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 67:4869-77. 2007
    ..Furthermore, this co-xenograft model represents a unique context to study stromal TGF-beta and HGF signaling in mammary tumorigenesis...
  9. ncbi request reprint Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    Elizabeth Forrester
    Department of Cancer Biology, Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer Res 65:2296-302. 2005
    ....
  10. pmc Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 119:1571-82. 2009
    ..Together, the results suggest that assessment of TGF-beta signaling pathway status may further stratify the prognosis of ER-positive patients and provide novel therapeutic approaches in the management of breast cancer...
  11. pmc Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas
    Michael W Pickup
    Department of Cancer Biology, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, TN 37212, USA
    Cancer Res 73:5336-46. 2013
    ..Our data indicate that epithelial induction of microenvironmental changes can play a significant role in tumorigenesis and attenuating these changes can inhibit metastasis. Cancer Res; 73(17); 5336-46. ©2013 AACR. ..
  12. pmc Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators
    Philip Owens
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 109:2814-9. 2012
    ..BMP was shown to directly regulate CCL9 expression. We conclude that BMPR2 has tumor-suppressive function in mammary epithelia and microenvironment and that disruption can accelerate mammary carcinoma metastases...
  13. ncbi request reprint TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Science 303:848-51. 2004
    ..Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues...
  14. pmc TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms
    Sergey V Novitskiy
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37212, USA
    Cancer Discov 1:430-41. 2011
    ....
  15. ncbi request reprint Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation
    Nina M Munoz
    Department of Cancer Biology, Vanderbilt University Medical School, Nashville, Tennessee, USA
    Cancer Res 66:9837-44. 2006
    ....
  16. pmc TGF-beta signaling is essential for joint morphogenesis
    Anna Spagnoli
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 177:1105-17. 2007
    ..We propose a model for joint development in which TGF-beta signaling represents a means of entry to initiate the process...
  17. pmc TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    J Cell Physiol 219:57-68. 2009
    ..In summary, the results suggest that an epithelial cell response to TGF-beta signaling regulates commitment to cell death and suppression of lactation during the second phase of mammary involution...
  18. pmc GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma
    Ty W Abel
    Department of Pathology, Vanderbilt University Medical Center, MCN C 2318, Nashville, TN 37232 2561, USA
    Mol Cancer Res 7:645-53. 2009
    ..Tumor cells expressed markers associated with neural progenitor cells, including Olig2, Bmi-1, and PDGFR-alpha. These data suggest that infiltrating tumor cells may arise from NSC transformed by activation of oncogenic K-ras in vivo...
  19. pmc Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro
    Lu Xie
    Vanderbilt Ingram Cancer Center, 2220 Pierce Avenue South, Vanderbilt University, Nashville, TN 37232, USA
    Neoplasia 6:603-10. 2004
    ..These data show that TGF-beta1 induces the activation of the Erk signaling pathway, which is required for TGF-beta1-mediated EMT in vitro...
  20. pmc Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts
    Baogang J Xu
    Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA
    Proteomics 10:2458-70. 2010
    ..These results warrant further investigation into the effects of inhibiting the TGF-beta signaling pathway in fibroblasts because systemic inhibition of TGF-beta signaling pathways is being considered as a potential cancer therapy...
  21. pmc Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    Li Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Cell 13:23-35. 2008
    ..Together, these data indicate that Gr-1+CD11b+ cells contribute to TGFbeta-mediated metastasis through enhancing tumor cell invasion and metastasis...
  22. ncbi request reprint Genomic and proteomic analysis of mammary tumors arising in transgenic mice
    Lu Xie
    Department of Cancer Biology, Biostatistics Shared Resource, Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
    J Proteome Res 4:2088-98. 2005
    ..The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer...
  23. pmc Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression
    Swati Biswas
    Department of Cancer Biology, Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, TN 37232, USA
    J Clin Invest 117:1305-13. 2007
    ..These data implicate TGF-beta induced by anticancer therapy as a pro-metastatic signal in tumor cells and provide a rationale for the simultaneous use of these therapies in combination with TGF-beta inhibitors...
  24. pmc ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to bone
    Amanda G Hansen
    Authors Affiliations Departments of Pathology, Microbiology and Immunology, Cancer Biology, and Urologic Surgery, Division of Cancer Biostatistics, Vanderbilt University Department of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Bone Biology and Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee
    Cancer Res 74:1404-15. 2014
    ..Together, these data demonstrate that the ALCAM is both a functional regulator as well as marker of prostate cancer progression...
  25. pmc Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties
    Sergey V Novitskiy
    Department of Cancer Biology, Vanderbilt University School of Medicine and Vanderbilt Ingram Comprehensive Cancer Center, Nashville, TN 37232, USA
    J Leukoc Biol 92:641-51. 2012
    ....
  26. ncbi request reprint Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis
    Sunil K Halder
    Department of Surgery, Vanderbilt Ingram Cancer Center, TN 37232, USA
    Cancer Res 66:6156-66. 2006
    ....
  27. pmc Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation
    Agnieszka E Gorska
    Vanderbilt Ingram Cancer Center and the Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Pathol 163:1539-49. 2003
    ....
  28. pmc Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells
    Alyssa R Bonine-Summers
    Department of Cancer Biology, Vanderbilt lngram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6838, USA
    Cancer Biol Ther 6:561-70. 2007
    ..These results provide a novel mechanism of action for EGFR as a mediator of HGF signaling thereby linking EGFR to the oncogenic potential of c-Met in mammary carcinomas cells...
  29. pmc Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia
    Arichika Hoshino
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Int J Biol Sci 3:281-91. 2007
    ..These results demonstrate in vivo roles for BRCA1 in both mammary gland development and in tumor suppression against mutagen-induced mammary gland neoplasia...
  30. pmc TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 6838, USA
    Proc Natl Acad Sci U S A 100:15548-53. 2003
    ..These data provide evidence that signaling through RhoA and p160ROCK is important in TGF-beta inhibition of cell proliferation and links signaling components for epithelial transdifferentiation with regulation of cell-cycle progression...
  31. ncbi request reprint Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy
    Judith Romero-Gallo
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Oncogene 24:3028-41. 2005
    ....
  32. pmc Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion
    Philip Owens
    Department of Cancer Biology and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 8:e67533. 2013
    ..Treatment with BMP in turn elevated pro-tumorigenic secreted factors such as IL-6 and MMP-3. These experiments demonstrate that BMP may stimulate tumor progression within the tumor microenvironment. ..
  33. ncbi request reprint Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development
    Kai Jiao
    Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt Children s Hospital, Nashville, TN 37232, USA
    Development 133:4585-93. 2006
    ..Thus, our study provides a unique mouse genetic model for DILV, further characterization of which suggests a potential cellular mechanism for the defect...
  34. ncbi request reprint Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation
    Jay S Desgrosellier
    Department of Pharmacology, Vanderbilt University Medical Center, Room 476 RRB, 2220 Pierce Avenue, Nashville, TN 37232 6600, USA
    Dev Biol 280:201-10. 2005
    ..These data suggest that ALK2 activation may stimulate EMT in the AV cushion and that Smad6 may act downstream of ALK2 to negatively regulate EMT...
  35. pmc Transforming growth factor beta (TGF-beta) and inflammation in cancer
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA
    Cytokine Growth Factor Rev 21:49-59. 2010
    ....
  36. ncbi request reprint Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer
    Swati Biswas
    Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Cancer Res 64:4687-92. 2004
    ....
  37. ncbi request reprint Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells
    Mete Erdogan
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Res 68:6224-31. 2008
    ..Thus, TAK1 is a novel link between TGF-beta signaling and oncogenic R-Ras in the promotion of tumorigenesis...
  38. ncbi request reprint Signaling pathways regulating TC21-induced tumorigenesis
    Mete Erdogan
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 282:27713-20. 2007
    ..Thus, overexpression of active TC21 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase, p38 MAPK, and mTOR pathways, and these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta...
  39. ncbi request reprint A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling
    Kimberly A Brown
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Cell Biochem 101:9-33. 2007
    ..Determining how Smad2 or Smad3 differentially regulate the TGF-beta response may translate into developing more effective strategies for cancer therapy...
  40. pmc The roles of TGFβ in the tumour microenvironment
    Michael Pickup
    Vanderbilt University Medical Center, Vanderbilt Ingram Comprehensive Cancer Center, Medicine and Pathology, Cancer Biology, 2220 Pierce Avenue, 691 Preston Research Building, Nashville, Tennessee 37232, USA
    Nat Rev Cancer 13:788-99. 2013
    ..In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression. ..
  41. pmc Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1
    Rebecca S Muraoka
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:8691-703. 2003
    ....
  42. ncbi request reprint TGF-beta and cancer
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Cytokine Growth Factor Rev 17:29-40. 2006
    ..According to the current literature and experimental evidence, TGF-beta is a potent ligand that regulates carcinoma initiation, progression and metastasis through a broad and complex spectrum of interdependent interactions...
  43. pmc Stromal fibroblasts in cancer initiation and progression
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nature 432:332-7. 2004
    ..Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications...
  44. ncbi request reprint Under pressure: stromal fibroblasts change their ways
    Brian Bierie
    Department of Cancer Biology and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 691 Preston Building, Nashville, TN 37232, USA
    Cell 123:985-7. 2005
    ..This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression...
  45. pmc Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells
    Brian K Law
    Department of Cancer Biology Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 22:8184-98. 2002
    ..Together, these results indicate that rapamycin and TGF-beta cooperate to inhibit the proliferation of nontransformed cells and cancer cells by acting in concert to inhibit Cdk2 activity...
  46. pmc Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?
    Li Yang
    Department of Cancer Biology, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tenessee 37232, USA
    Cancer Res 68:9107-11. 2008
    ..Recent advances in multiple disciplines suggest that immune cells from the tumor host may provide the answer...
  47. pmc β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors
    Peter E Clark
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
    Am J Pathol 179:3045-55. 2011
    ..Thus, we developed a novel mouse model in which activated K-RAS synergizes with canonical Wnt/β-catenin signaling to form metastatic primitive renal epithelial tumors that mimic the epithelial component of human WT...
  48. ncbi request reprint Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA
    Cell Cycle 8:3319-27. 2009
    ..Together the current results suggest that, in addition to intrinsic carcinoma cell signaling, TGFbeta dependent host-tumor cell interactions should be considered when designing therapeutic strategies to manage carcinoma progression...
  49. ncbi request reprint A delicate balance: TGF-beta and the tumor microenvironment
    Daniel G Stover
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    J Cell Biochem 101:851-61. 2007
    ..TGF-beta signaling in the tumor microenvironment significantly impacts carcinoma initiation, progression, and metastasis via epithelial cell autonomous and interdependent stromal-epithelial interactions in vivo...
  50. pmc The loss of TGF-beta signaling promotes prostate cancer metastasis
    William H Tu
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neoplasia 5:267-77. 2003
    ..Our study demonstrates for the first time that a disruption of TGF-beta signaling in prostate cancer plays a causal role in promoting tumor metastasis...
  51. ncbi request reprint Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Rev Cancer 6:506-20. 2006
    ..The complex nature of TGFbeta signalling and crosstalk in the tumour microenvironment presents a unique challenge, and an opportunity to develop therapeutic intervention strategies for targeting cancer...
  52. ncbi request reprint Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo
    Anna L Means
    Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2733, USA
    Genesis 42:23-7. 2005
    ....
  53. pmc p120-catenin is essential for terminal end bud function and mammary morphogenesis
    Sarah J Kurley
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Development 139:1754-64. 2012
    ..Our findings reveal an essential role for p120 in mammary morphogenesis...
  54. pmc TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis
    Leslie Gewin
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Am Soc Nephrol 21:1334-43. 2010
    ..These results suggest that inhibiting TGF-beta receptor-mediated function in collecting ducts may exacerbate renal fibrosis by enhancing paracrine TGF-beta signaling between epithelial and interstitial cells...
  55. ncbi request reprint Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling
    Lara Longobardi
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2579, USA
    J Bone Miner Res 21:626-36. 2006
    ..We found that IGF-I had potent chondroinductive actions on MSCs. IGF-I effects were independent from and additive to TGF-beta...
  56. pmc Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians
    Xiangyu Ma
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 21:1176-84. 2012
    ..The TGF-β signaling pathway plays a significant role in the carcinogenic process of breast cancer...
  57. doi request reprint Turn off the IDO: will clinical trials be successful?
    Sergey V Novitskiy
    Vanderbilt University, Nashville, Tennessee, USA
    Cancer Discov 2:673-5. 2012
    ..The study by Smith and colleagues in this issue of Cancer Discovery provides genetic evidence for the importance of IDO in tumorigenesis, which supports the use of IDO inhibitors in clinical trials in humans...
  58. pmc TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis
    Peter E Clark
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
    J Urol 184:1166-74. 2010
    ..We hypothesized that TRAIL and interferon-alpha could synergistically induce apoptosis in renal cell carcinoma cells...
  59. pmc Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences
    Amosy E M'Koma
    Department of Biochemistry and Cancer Biology, Meharry Medical College School of Medicine, 1005 Dr D B Todd Jr Blvd, Nashville, TN 37208 3599, USA
    Int J Colorectal Dis 26:533-52. 2011
    ..We review IBD-associated CRC and pouch-related neoplasia prevalence, adverse events, risk factors, and surveillances...
  60. pmc Tumor-stroma interactions
    Neil A Bhowmick
    Departments of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Genet Dev 15:97-101. 2005
    ..Many of these tumors result from the alteration of paracrine growth factor pathways that act on the epithelia. However, the tissue specificity of the responses to the growth factors is a mystery not yet solved...
  61. ncbi request reprint Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    Berna C Ozdemir
    Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 25:719-34. 2014
    ..This study underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC. ..
  62. ncbi request reprint Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
    Yoshihiro Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 130:5269-80. 2003
    ..This study demonstrates that TGFbeta IIR plays an essential role in the development of the CNC and provides a model for the study of abnormal CNC development...
  63. ncbi request reprint Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones
    Michael O Baffi
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA
    Dev Biol 276:124-42. 2004
    ..The data provide information regarding mechanisms of skeletal development and suggest that TGF-beta signaling is a critical component...
  64. ncbi request reprint Transforming growth factor beta mimetics: discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamic acid, a biaryl hydroxamate inhibitor of histone deacetylase
    Keith B Glaser
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6121, USA
    Mol Cancer Ther 1:759-68. 2002
    ..These results and those of others demonstrate the importance of HDACs in regulation of the TGF-beta signaling pathway(s)...
  65. ncbi request reprint Conditional inactivation of the TGF-beta type II receptor using Cre:Lox
    Anna Chytil
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    Genesis 32:73-5. 2002
  66. pmc Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice
    Kenneth B R Ewan
    Life Sciences Division, Bldg 74 355, 1 Cyclotron Rd, Lawrence Berkeley National Laboratory, Berkeley CA 94720, USA
    Am J Pathol 167:409-17. 2005
    ..Accordingly, we propose that TGF-beta1 dysregulation may promote proliferation of ER-alpha-positive cells associated with breast cancer risk in humans...
  67. ncbi request reprint Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis
    Etienne Labbé
    Departments of Medical Biophysics and Biochemistry, University of Toronto, 160 College Street, Toronto, Ontario, Canada
    Cancer Res 67:75-84. 2007
    ..Our results indicate that the TGF-beta and Wnt/beta-catenin pathways are firmly intertwined and generate a unique gene expression pattern that can contribute to tumor progression...

Research Grants26

  1. TGF-beta in Mammary Development and Tumorigenesis
    Harold Moses; Fiscal Year: 2006
    ..3. Characterization of Tgfbr2 null stromal cells and determination of their effect on invasion and metastasis of carcinoma cells. ..
  2. Mentored Patient-Oriented Research Career Development Aw
    Harold Moses; Fiscal Year: 2004
    ..These studies will determine both the optimal antibiotic treatment of CNS C. pneumoniae infection in MS patients and if antibiotic therapy favorable alters the natural history of MS. ..
  3. TGF-Beta Suppression and Promotion of Mammary Carcinomas
    Harold Moses; Fiscal Year: 2009
    ..Specific Aim 3. Determine mechanisms for enhanced metastatic capability with loss of tumor cell TGF-li signaling by examining both tumor cells and their microenvironment. ..
  4. TGF-beta in Mammary Development and Tumorigenesis
    Harold Moses; Fiscal Year: 2003
    ..3. Characterization of Tgfbr2 null stromal cells and determination of their effect on invasion and metastasis of carcinoma cells. ..
  5. Mentored Patient-Oriented Research Career Development Aw
    Harold Moses; Fiscal Year: 2003
    ..These studies will determine both the optimal antibiotic treatment of CNS C. pneumoniae infection in MS patients and if antibiotic therapy favorable alters the natural history of MS. ..
  6. Mentored Patient-Oriented Research Career Development Aw
    Harold Moses; Fiscal Year: 2002
    ..These studies will determine both the optimal antibiotic treatment of CNS C. pneumoniae infection in MS patients and if antibiotic therapy favorable alters the natural history of MS. ..
  7. TGF-beta in Mammary Development and Tumorigenesis
    Harold Moses; Fiscal Year: 2007
    ..3. Characterization of Tgfbr2 null stromal cells and determination of their effect on invasion and metastasis of carcinoma cells. ..
  8. Mentored Patient-Oriented Research Career Development Aw
    Harold Moses; Fiscal Year: 2001
    ..These studies will determine both the optimal antibiotic treatment of CNS C. pneumoniae infection in MS patients and if antibiotic therapy favorable alters the natural history of MS. ..
  9. TGF-Beta Suppression and Promotion of Mammary Carcinomas
    Harold Moses; Fiscal Year: 2007
    ..Specific Aim 3. Determine mechanisms for enhanced metastatic capability with loss of tumor cell TGF-beta signaling by examining both tumor cells and their microenvironment. ..
  10. TGF-beta in Mammary Development and Tumorigenesis
    Harold Moses; Fiscal Year: 2009
    ..This work will identify new targets for cancer therapy. ..
  11. TGF-Beta Suppression and Promotion of Mammary Carcinomas
    Harold L Moses; Fiscal Year: 2010
    ..Specific Aim 3. Determine mechanisms for enhanced metastatic capability with loss of tumor cell TGF-li signaling by examining both tumor cells and their microenvironment. ..
  12. TGF-beta in Mammary Development and Tumorigenesis
    Harold L Moses; Fiscal Year: 2010
    ..This work will identify new targets for cancer therapy. ..
  13. Mentored Patient-Oriented Research Career Development Aw
    Harold Moses; Fiscal Year: 2000
    ..These studies will determine both the optimal antibiotic treatment of CNS C. pneumoniae infection in MS patients and if antibiotic therapy favorable alters the natural history of MS. ..
  14. TGF BETA SUPPRESSION AND PROMOTION OF MAMMARY CARCINOMAS
    Harold Moses; Fiscal Year: 2005
    ..3) Determine the effect of decreased functional TbRII levels and different TGF-b signaling pathways on growth inhibition and conversion to a fibroblastoid morphology in NMUMG cells and cultures of carcinoma cells from aims 1 and 2. ..
  15. TGF BETA SUPPRESSION AND PROMOTION OF MAMMARY CARCINOMAS
    Harold Moses; Fiscal Year: 2001
    ..3) Determine the effect of decreased functional TbRII levels and different TGF-b signaling pathways on growth inhibition and conversion to a fibroblastoid morphology in NMUMG cells and cultures of carcinoma cells from aims 1 and 2. ..
  16. TGF BETA SUPPRESSION AND PROMOTION OF MAMMARY CARCINOMAS
    Harold Moses; Fiscal Year: 2002
    ..3) Determine the effect of decreased functional TbRII levels and different TGF-b signaling pathways on growth inhibition and conversion to a fibroblastoid morphology in NMUMG cells and cultures of carcinoma cells from aims 1 and 2. ..
  17. TGF BETA SUPPRESSION AND PROMOTION OF MAMMARY CARCINOMAS
    Harold Moses; Fiscal Year: 2003
    ..3) Determine the effect of decreased functional TbRII levels and different TGF-b signaling pathways on growth inhibition and conversion to a fibroblastoid morphology in NMUMG cells and cultures of carcinoma cells from aims 1 and 2. ..
  18. TGF BETA SUPPRESSION AND PROMOTION OF MAMMARY CARCINOMAS
    Harold Moses; Fiscal Year: 2004
    ..3) Determine the effect of decreased functional TbRII levels and different TGF-b signaling pathways on growth inhibition and conversion to a fibroblastoid morphology in NMUMG cells and cultures of carcinoma cells from aims 1 and 2. ..
  19. TGF-beta in Mammary Development and Tumorigenesis
    Harold Moses; Fiscal Year: 2004
    ..3. Characterization of Tgfbr2 null stromal cells and determination of their effect on invasion and metastasis of carcinoma cells. ..
  20. TGF-beta in Mammary Development and Tumorigenesis
    Harold Moses; Fiscal Year: 2005
    ..3. Characterization of Tgfbr2 null stromal cells and determination of their effect on invasion and metastasis of carcinoma cells. ..
  21. Overcoming Colorectal Cancer Disparities
    Harold Moses; Fiscal Year: 2005
    ..A specific number of travel awards will be provided to aid in this effort. ..
  22. TGF-Beta Suppression and Promotion of Mammary Carcinomas
    Harold Moses; Fiscal Year: 2006
    ..Specific Aim 3. Determine mechanisms for enhanced metastatic capability with loss of tumor cell TGF-beta signaling by examining both tumor cells and their microenvironment. ..
  23. TGF-beta in Mammary Development and Tumorigenesis
    Harold L Moses; Fiscal Year: 2011
    ..This work will identify new targets for cancer therapy. ..