Jason Morrow

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint The isoprostanes - unique products of arachidonate peroxidation: their role as mediators of oxidant stress
    Jason D Morrow
    Department of Medicine, Vanderbilt University, Nashville, TN 37232 6602, USA
    Curr Pharm Des 12:895-902. 2006
  2. ncbi request reprint Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans
    Jason D Morrow
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Arterioscler Thromb Vasc Biol 25:279-86. 2005
  3. doi request reprint Why the United States still needs improved dietary supplement regulation and oversight
    J D Morrow
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Pharmacol Ther 83:391-3. 2008
  4. ncbi request reprint Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress
    Chuan Ming Hao
    Division of Nephrology and Department of Pharmacology, Vanderbilt University and Department of Veterans Affairs Hospital, Nashville, Tennessee 37232, USA
    J Biol Chem 277:21341-5. 2002
  5. ncbi request reprint Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells
    Nipun B Merchant
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 8680, USA
    Surgery 138:415-21. 2005
  6. pmc Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor
    Jian Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 295:F818-25. 2008
  7. ncbi request reprint Energy expenditure, inflammation, and oxidative stress in steady-state adolescents with sickle cell anemia
    Sylvie A Akohoue
    Center for Nutrition and Department of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee 37208, USA
    Pediatr Res 61:233-8. 2007
  8. pmc Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer
    Daniel A Barocas
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    J Urol 185:2102-7. 2011
  9. ncbi request reprint Oxidant stress is increased during treatment of human immunodeficiency virus infection
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Clin Infect Dis 37:1711-7. 2003
  10. pmc Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition
    Cindy L Kanies
    Department of Surgery, Vanderbilt University Medical Center, D 4316 Medical Center North, Nashville, TN 37232 2730, USA
    Mol Cancer Res 6:1124-36. 2008

Detail Information

Publications70

  1. ncbi request reprint The isoprostanes - unique products of arachidonate peroxidation: their role as mediators of oxidant stress
    Jason D Morrow
    Department of Medicine, Vanderbilt University, Nashville, TN 37232 6602, USA
    Curr Pharm Des 12:895-902. 2006
    ..Finally, I will offer avenues for future research related to the development of pharmacological approaches to modulate IsoP formation and action in vivo and thus decrease the pathophysiological sequelae of oxidative injury...
  2. ncbi request reprint Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans
    Jason D Morrow
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Arterioscler Thromb Vasc Biol 25:279-86. 2005
    ..The purpose of this brief review is to discuss the usefulness of quantifying IsoPs as an index of oxidative injury in association with atherosclerosis...
  3. doi request reprint Why the United States still needs improved dietary supplement regulation and oversight
    J D Morrow
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Pharmacol Ther 83:391-3. 2008
    ....
  4. ncbi request reprint Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress
    Chuan Ming Hao
    Division of Nephrology and Department of Pharmacology, Vanderbilt University and Department of Veterans Affairs Hospital, Nashville, Tennessee 37232, USA
    J Biol Chem 277:21341-5. 2002
    ..Inhibition of PPARdelta activity may contribute to the renal papillary necrosis associated with analgesic and/or NSAID use...
  5. ncbi request reprint Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells
    Nipun B Merchant
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 8680, USA
    Surgery 138:415-21. 2005
    ..The purpose of this study was to determine the mechanism by which DCA activates EGFR in human polarizing CRC cell lines HCA-7 and HCT-8...
  6. pmc Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor
    Jian Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 295:F818-25. 2008
    ..Renal medullary PGE(2) promotes renal sodium excretion via the EP2 receptor, thereby maintaining normotension in the setting of high salt intake...
  7. ncbi request reprint Energy expenditure, inflammation, and oxidative stress in steady-state adolescents with sickle cell anemia
    Sylvie A Akohoue
    Center for Nutrition and Department of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee 37208, USA
    Pediatr Res 61:233-8. 2007
    ..778; p < 0.001). Low-grade inflammation and increased oxidative stress are present in adolescents with HbSS in the absence of acute crisis, and their markers are correlated with elevated REE...
  8. pmc Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer
    Daniel A Barocas
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    J Urol 185:2102-7. 2011
    ..We studied the relationship between the level of F2-isoprostanes, a validated biomarker of oxidative stress, and prostate cancer and high grade prostatic intraepithelial neoplasia...
  9. ncbi request reprint Oxidant stress is increased during treatment of human immunodeficiency virus infection
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Clin Infect Dis 37:1711-7. 2003
    ..Oxidant stress associated with therapeutic control of viral replication may have important implications for long-term complications of antiretroviral therapy...
  10. pmc Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition
    Cindy L Kanies
    Department of Surgery, Vanderbilt University Medical Center, D 4316 Medical Center North, Nashville, TN 37232 2730, USA
    Mol Cancer Res 6:1124-36. 2008
    ....
  11. ncbi request reprint Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-beta(1) in immortalized mouse colonocytes expressing oncogenic Ras
    Christopher D Roman
    Department of Surgery, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37232 2730, USA
    J Gastrointest Surg 6:304-9. 2002
    ....
  12. ncbi request reprint Targeting cyclooxygenase-2 in recurrent non-small cell lung cancer: a phase II trial of celecoxib and docetaxel
    Ildiko Csiki
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Clin Cancer Res 11:6634-40. 2005
    ..However, in light of the apparent survival prolongation in the subset with a marked decline in urinary PGE-M levels, further investigation of strategies designed to decrease PGE(2) synthesis in NSCLC seems warranted...
  13. ncbi request reprint Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid
    Ling Gao
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 281:14092-9. 2006
    ..Further understanding of the biological consequences of F3-IsoP formation may provide valuable insights into the cardioprotective mechanism of EPA...
  14. ncbi request reprint Recent advances in the biochemistry and clinical relevance of the isoprostane pathway
    Erik S Musiek
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Lipids 40:987-94. 2005
    ..Thus, the complexity of the IsoP pathway has expanded, providing novel insights into mechanisms of lipid peroxidation in vivo and allowing investigators to explore the role of oxidative stress in human disease...
  15. ncbi request reprint Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Circulation 113:108-17. 2006
    ..Here, we examined the impact of COX-1 deficiency in bone marrow-derived cells on early atherogenesis in the mouse...
  16. ncbi request reprint Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 175:8253-9. 2005
    ..These results elucidate the pathways by which COX inhibition exerts a critical effect of the pulmonary allergen-induced inflammatory response and confirm that COX products are important regulators of allergic inflammation...
  17. ncbi request reprint Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages
    Erik S Musiek
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 280:35562-70. 2005
    ..These findings suggest that cyclopentenone IsoPs may serve as negative feedback regulators of inflammation and have important implications for defining the role of oxidative stress in the inflammatory response...
  18. ncbi request reprint F2-isoprostanes as markers of oxidative stress in vivo: an overview
    Ginger L Milne
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Biomarkers 10:S10-23. 2005
    ....
  19. ncbi request reprint Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise
    Steven R McAnulty
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    J Nutr Biochem 16:530-7. 2005
    ..039). This study indicates that prolonged large doses of alpha-tocopherol supplementation did not affect plasma Hcy concentrations and exhibited pro-oxidant characteristics in highly trained athletes during exhaustive exercise...
  20. pmc Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin
    Pascale Gluais
    Institut de Recherches Servier, 92150 Suresnes, France
    Br J Pharmacol 146:834-45. 2005
    ..Thus, in the aorta of SHR and aging WKY, the endothelium-dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2...
  21. pmc Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Virol 78:10303-9. 2004
    ..These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI(2) is a potential therapeutic target in the treatment of RSV...
  22. ncbi request reprint Effect of daily fruit ingestion on angiotensin converting enzyme activity, blood pressure, and oxidative stress in chronic smokers
    Steven R McAnulty
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Free Radic Res 39:1241-8. 2005
    ....
  23. pmc Cimetidine does not prevent lung injury in newborn premature infants
    Robert B Cotton
    Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232, USA
    Pediatr Res 59:795-800. 2006
    ..We conclude that cimetidine does not reduce lung injury in newborn premature infants receiving O2 and mechanical ventilation. It is possible that cimetidine was not an adequate CYP inhibitor in this context...
  24. pmc The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level
    Gladys Block
    School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Free Radic Biol Med 45:377-84. 2008
    ..Further studies are needed to establish whether treatment with vitamins C or E in persons with concentrations above that cut point could slow the development of cardiovascular disease...
  25. pmc Formation of highly reactive cyclopentenone isoprostane compounds (A3/J3-isoprostanes) in vivo from eicosapentaenoic acid
    Joshua D Brooks
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Biol Chem 283:12043-55. 2008
    ..These studies have, for the first time, definitively characterized novel, highly reactive A/J-ring IsoP compounds that form in abundance from the oxidation of EPA in vivo...
  26. ncbi request reprint F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Mol Neurosci 33:114-9. 2007
    ..CSF F(2)-IsoPs may be used to assist in diagnosis and aid in objective assessment of disease progression and response to therapeutics in patients with AD...
  27. ncbi request reprint Correlation between two markers of inflammation, serum C-reactive protein and interleukin 6, and indices of oxidative stress in patients with high risk of cardiovascular disease
    Dora Il'yasova
    Duke Comprehensive Cancer Center, 2424 Erwin Rd, Hock Bldg, Ste 602, Box 2949, Durham, NC 27710, USA
    Biomarkers 13:41-51. 2008
    ..Urinary levels of F2-IsoP and serum levels of CRP represent appropriate biomarkers for future studies of inflammation and oxidative status in humans...
  28. ncbi request reprint Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice
    Viswanathan Saraswathi
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Nutr 137:1776-82. 2007
    ..05) and decreased atherosclerotic lesion area (P < 0.05). Taken together, these data highlight the specific role of WAT in regulating dietary fish oil-mediated improvement in systemic lipid homeostasis and atherosclerosis...
  29. ncbi request reprint Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Division of Reproductive and Development Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Cancer Res 67:5285-92. 2007
    ..The ability of aspirin to inhibit EOC growth in vivo is an exciting finding because of its low cost, lack of cardiovascular side effects, and availability...
  30. ncbi request reprint Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans
    Huiyong Yin
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Biol Chem 282:329-36. 2007
    ..The elucidation that urinary PGF(2alpha) in humans is derived from the IsoP pathway has implications regarding PG formation and inhibition in vivo...
  31. pmc Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling
    Dan A Dixon
    Department of Biological Sciences and South Carolina Cancer Center, University of South Carolina, Columbia, South Carolina 29203, USA
    J Clin Invest 116:2727-38. 2006
    ..These checkpoints may be altered in disease and therefore useful as targets for antiinflammatory intervention...
  32. pmc Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors
    Peter B Anning
    Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Blood 108:4059-62. 2006
    ..These data indicate that NO suppresses vascular side effects of NSAIDs, suggesting that risk will be greatest in patients with impaired vascular function associated with decreased NO bioavailability...
  33. ncbi request reprint Isoprostanes and related compounds: update 2006
    Ginger L Milne
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Antioxid Redox Signal 8:1379-84. 2006
    ..The main focus of this discussion is on the role of the IsoPs as biomarkers and mediators of oxidant stress in human disease, their mechanism of formation and metabolism, and their biologic activities...
  34. ncbi request reprint Differentiation of cyclooxygenase 1- and 2-derived prostanoids in mouse kidney and aorta
    Zhonghua Qi
    Division of Nephrology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA
    Hypertension 48:323-8. 2006
    ..These effects may contribute to the specific effect of COX2 inhibitors to increase blood pressure...
  35. ncbi request reprint Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 42:450-4. 2006
    ..Mitochondria play a central role in regulating oxidant stress. We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy...
  36. ncbi request reprint Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model
    Alyssa H Hasty
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Nutr Biochem 18:127-33. 2007
    ..These data provide evidence that vitamin E supplementation is not sufficient to reduce extreme elevations in systemic oxidative stress due to hyperlipidemia and obesity and, thus, may not be cardioprotective in this setting...
  37. ncbi request reprint Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice
    Michael E Burleigh
    Department of Pharmacology, 383 Preston Research Building, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    J Mol Cell Cardiol 39:443-52. 2005
    ..These results are compatible with COX-2 expression by macrophages having a proatherogenic role, and support the potential of anti-inflammatory therapeutic approaches for atherosclerosis...
  38. ncbi request reprint Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Biochem Pharmacol 70:334-42. 2005
    ....
  39. pmc Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Res 65:3735-44. 2005
    ..The growth inhibitory effects of SC-560 result from reduced cell proliferation and/or accelerated apoptosis. Our results imply COX-1 as a target for the prevention and/or treatment of EOC...
  40. ncbi request reprint Acute hyperlipidemia increases oxidative stress more in African Americans than in white Americans
    Heno F Lopes
    Departments of Medicine and Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hypertens 16:331-6. 2003
    ..The findings may have important implications for ethnic differences in the prevalence of hypertension and cardiovascular and renal disease...
  41. ncbi request reprint Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells
    N Shane Cutler
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
    Cancer Res 63:1748-51. 2003
    ..This mechanism may have relevance to maintenance of cells in the normal crypt and to clonal expansion of mutant colonocytes during tumorigenesis...
  42. ncbi request reprint Is oxidant stress a connection between obesity and atherosclerosis?
    Jason D Morrow
    Arterioscler Thromb Vasc Biol 23:368-70. 2003
  43. ncbi request reprint DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity
    Heno F Lopes
    Department of Pharmacology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 826H, Charleston, SC 29425, USA
    Hypertension 41:422-30. 2003
    ..The findings are consistent with evidence that elevated BP in obese subjects may reflect an imbalance between antioxidant capacity and oxidative stress that is improved by the DASH-CD...
  44. ncbi request reprint The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease
    Jason D Morrow
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Am J Respir Crit Care Med 166:S25-30. 2002
    ....
  45. ncbi request reprint Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent
    Thomas J Montine
    Department of Pathology, Vanderbilt University, Nashville, Tennessee, USA
    J Neurochem 83:463-70. 2002
    ..These results suggest the EP2 receptor as a therapeutic target to limit oxidative damage from activation of innate immunity in cerebrum...
  46. ncbi request reprint Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:44877-85. 2002
    ..These results define the in vitro diversity of endocannabinoid-derived prostanoids and will permit focused investigations into their production and potential biological actions in vivo...
  47. ncbi request reprint Factors associated with oxidative stress in human populations
    Gladys Block
    Division of Health Policy and Management, School of Public Health, University of California, Berkeley, CA 94720, USA
    Am J Epidemiol 156:274-85. 2002
    ..These data would permit a better understanding of the role that oxidants and antioxidants play in the health of human populations...
  48. pmc Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
    Zhonghua Qi
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    J Clin Invest 110:61-9. 2002
    ..In contrast, the pressor effect of Ang II is blunted by COX1 inhibition. These results suggest that, rather than having similar cardiovascular effects, the activities of COX1 and COX2 are functionally antagonistic...
  49. ncbi request reprint Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro
    Layton Harris Smith
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn 37232, USA
    Arterioscler Thromb Vasc Biol 22:983-8. 2002
    ....
  50. ncbi request reprint Increasing plasma fatty acids elevates F2-isoprostanes in humans: implications for the cardiovascular risk factor cluster
    Milos P Stojiljkovic
    Department of Pharmacology and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Hypertens 20:1215-21. 2002
    ..To determine whether raised concentrations of non-esterified fatty acids (NEFAs) may contribute to the cardiovascular risk factor cluster by increasing oxidative stress in vivo...
  51. ncbi request reprint Characterization of LPS-induced lung inflammation in cftr-/- mice and the effect of docosahexaenoic acid
    Steven D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Appl Physiol (1985) 92:2169-76. 2002
    ..In contrast, neutrophils and eicosanoids were decreased in cftr-/- but not in WT mice treated with DHA, indicating that the effects of DHA on these inflammatory parameters may be related to correction of the membrane lipid defect...
  52. ncbi request reprint Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 105:1816-23. 2002
    ....
  53. ncbi request reprint Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 165:1154-60. 2002
    ..We conclude that in the BALB/c mouse, COX inhibition with either a COX-1 or COX-2 inhibitor during allergen sensitization augments production of IL-13 and increases airway hyperresponsiveness...
  54. ncbi request reprint Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase
    Ling Gao
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 278:28479-89. 2003
    ..These findings strongly support the contention that a second pathway exists for the formation of bioactive PGs in vivo that is independent of COX...
  55. ncbi request reprint Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:310-5. 2003
    ....
  56. pmc Fatty acid oxidation in the pathogenesis of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 166:1283-9. 2005
    ..If successful, these interventions are unlikely to cure AD, but may check its explosive growth and hopefully reduce its incidence and prevalence in the elderly...
  57. ncbi request reprint RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretion
    Carol A Rouzer
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    J Lipid Res 46:1027-37. 2005
    ....
  58. ncbi request reprint Oxidant stress but not thromboxane decreases with epoprostenol therapy
    Ivan M Robbins
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue S, T 1217 MCN, Nashville, TN 37232 2650, USA
    Free Radic Biol Med 38:568-74. 2005
    ..The failure of Tx-M to decrease with therapy suggests that epoprostenol does not exert a beneficial effect through inhibition of TxA2 production in patients with PPH...
  59. ncbi request reprint F2-isoprostanes in Alzheimer and other neurodegenerative diseases
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Antioxid Redox Signal 7:269-75. 2005
    ..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD, and that CSF F2-IsoPs may aid in the assessment of antioxidant experimental therapeutics and laboratory diagnosis of AD...
  60. ncbi request reprint Introduction for special forum issue on isoprostanes and related compounds
    Jason D Morrow
    Antioxid Redox Signal 7:153-6. 2005
  61. ncbi request reprint Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 174:525-32. 2005
    ..These results illustrate the central role played by products derived from the COX pathway in the regulation of allergic immune responses...
  62. ncbi request reprint Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer
    Laine J Murphey
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Anal Biochem 334:266-75. 2004
    ..In summary, quantification of PGE-M using LC/MS/MS provides a facile and accurate method to assess PGE2 formation in human physiological and pathophysiological processes...
  63. ncbi request reprint Cell proliferation and apoptotic indices predict adenoma regression in a placebo-controlled trial of celecoxib in familial adenomatous polyposis patients
    Frank A Sinicrope
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston, USA
    Cancer Epidemiol Biomarkers Prev 13:920-7. 2004
    ....
  64. ncbi request reprint Angiotensin receptor blockade improves arterial distensibility and reduces exercise-induced pressor responses in obese hypertensive patients with the metabolic syndrome
    Khaled Nashar
    Departments of Medicine and Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hypertens 17:477-82. 2004
    ..In addition to lowering basal BP, angiotensin receptor blockade in patients with metabolic syndrome improves arterial compliance and reduces pressor reactivity to exercise...
  65. ncbi request reprint Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners
    Angela Mastaloudis
    Departments of Exercise and Sport Science, Oregon State University, Corvallis, OR 97731, USA
    Free Radic Biol Med 36:1329-41. 2004
    ..03). Markers of inflammation were increased dramatically in response to the run regardless of treatment group. Thus, AO supplementation prevented endurance exercise-induced lipid peroxidation but had no effect on inflammatory markers...
  66. ncbi request reprint Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease
    Joseph F Quinn
    Department Neurology, Oregon Health and Sciences University, Portland, OR, USA
    J Alzheimers Dis 6:93-7. 2004
    ....
  67. ncbi request reprint Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup
    Haibin Wang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:10649-58. 2004
    ..In light of this finding, the therapeutic use and efficacy of COX-2-specific inhibitors among human populations without regard for genetic and ethnic diversities should be revisited...
  68. ncbi request reprint Lipid oxidative markers are significantly increased in lipoatrophy but not in sustained asymptomatic hyperlactatemia
    Grace A McComsey
    Rainbow Babies and Children s Hospital, and Center for AIDS Research of Case Western Reserve University, and University Hospitals of Cleveland, Ohio, USA
    J Acquir Immune Defic Syndr 34:45-9. 2003
    ..082 +/- 0.021 vs. 0.053 +/- 0.021, respectively; P < 0.05)...
  69. ncbi request reprint Vitamin C supplementation decreases oxidative stress biomarker f2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smoke
    Marion Dietrich
    School of Public Health, University of California Berkeley, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Nutr Cancer 45:176-84. 2003
    ..Daily AO supplementation (especially with vitamin C) decreases this oxidative stress biomarker in passive smokers. This finding might be of importance for the prevention of ETS-associated adverse health effects in nonsmokers...
  70. ncbi request reprint Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokers
    Marion Dietrich
    Department of Nutritional Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 11:7-13. 2002
    ..The intake of antioxidants may help prevent smoking-related diseases. Smoking cessation should still be considered the most effective way to prevent smoking-related diseases...

Research Grants16

  1. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 2007
    ..Studies will examine mechanisms related to the formation, metabolism and biological actions of glyceryMsoPs in vivo. ..
  2. CLINICAL PHARMACOLOGY TRAINING PROGRAM
    Huiyong Yin; Fiscal Year: 2007
    ..Clinical Pharmacology at Vanderbilt is a vibrant and dynamic enterprise poised for significant growth. As a consequence, support for ten training positions per year is requested in this renewal. ..
  3. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 2006
    ..Studies will examine mechanisms related to the formation, metabolism and biological actions of glyceryMsoPs in vivo. ..
  4. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 2005
    ..Studies will examine mechanisms related to the formation, metabolism and biological actions of glyceryMsoPs in vivo. ..
  5. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 2004
    ..Studies will examine mechanisms related to the formation, metabolism and biological actions of glyceryMsoPs in vivo. ..
  6. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 2003
    ..Thus, as a basis for the development of a means to assess the formation of A2/J2- IsoPs in vivo, the nature of this conjugate will be structurally elucidated. ..
  7. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 2002
    ..Thus, as a basis for the development of a means to assess the formation of A2/J2- IsoPs in vivo, the nature of this conjugate will be structurally elucidated. ..
  8. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 2001
    ..Thus, as a basis for the development of a means to assess the formation of A2/J2- IsoPs in vivo, the nature of this conjugate will be structurally elucidated. ..
  9. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 2000
    ..Thus, as a basis for the development of a means to assess the formation of A2/J2- IsoPs in vivo, the nature of this conjugate will be structurally elucidated. ..
  10. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Jason Morrow; Fiscal Year: 1999
    ..Thus, as a basis for the development of a means to assess the formation of A2/J2- IsoPs in vivo, the nature of this conjugate will be structurally elucidated. ..