Research Topics
Genomes and GenesSpecies | John A MorrisSummaryAffiliation: Vanderbilt University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Reduced heart rate variability: an indicator of cardiac uncoupling and diminished physiologic reserve in 1,425 trauma patientsJohn A Morris
Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 60:1165-73; discussion 1173-4. 2006..We hypothesized: Deteriorating physiologic reserve correlates with reduced HRV and cardiac uncoupling...- Adrenal insufficiency, heart rate variability, and complex biologic systems: a study of 1,871 critically ill trauma patientsJohn A Morris
Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Am Coll Surg 204:885-92; discussion 892-3. 2007..We hypothesize decreased HRVi is associated with AI, and HRVi improves after treatment of AI, suggesting "recomplexification" (resumption of normal stress response to injury)... 
Surgical adverse events, risk management, and malpractice outcome: morbidity and mortality review is not enoughJohn A Morris
Section of Surgical Sciences, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, 243 Medical Center South, 2100 Pierce Avenue, Nashville, TN 37212 3755, USA
Ann Surg 237:844-51; discussion 851-2. 2003..To review all admissions (age > 13) to three surgical patient care centers at a single academic medical center between January 1, 1995, and December 6, 1999, for significant surgical adverse events...- Genetic variation in complement component 2 of the classical complement pathway is associated with increased mortality and infection: a study of 627 patients with traumaJohn A Morris
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Trauma 66:1265-70; discussion 1270-2. 2009..Consequently, genetic variation in C2 may stratify patient risk and illuminate underlying mechanisms for therapeutic intervention... - Volatility: a new vital sign identified using a novel bedside monitoring strategyEric L Grogan
VA Quality Scholars Program, Vanderbilt University Department of Surgery, Nashville, Tennessee, USA
J Trauma 58:7-12; discussion 12-4. 2005..3) Densely sampled aggregated physiologic data may identify sub-groups of patients requiring new treatment strategies... 
Stress insulin resistance is a marker for mortality in traumatic brain injuryNathan T Mowery
Department of Surgery, Wake Forest University, Winston Salem, North Carolina 27157, USA
J Trauma 66:145-51; discussion 151-3. 2009..Both hyper- and hypoglycemia have been associated with poor outcome in traumatic brain injury (TBI). Neither the risks nor benefit of tight glucose control (goal range, 80-110 mg/dL) have been documented in the TBI population...- Increased risk of adrenal insufficiency following etomidate exposure in critically injured patientsBryan A Cotton
Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, 1211 21st Ave S, 404 Medical Arts Bldg, Nashville, TN 37212, USA
Arch Surg 143:62-7; discussion 67. 2008..Timely diagnosis and treatment of adrenal insufficiency (AI) dramatically reduces mortality in trauma patients. We sought to identify risk factors and populations with a high risk of developing AI... - Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patientsGary T Marshall
Department of Surgery, Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 69:275-83. 2010..This is a retrospective cohort study of severe TBI patients receiving PBC at Level I Trauma Center and tertiary university hospital... - Acute care surgery program: mentoring fellows and patient outcomesJose J Diaz
Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Surg Res 160:202-7. 2010..EGS patient outcomes and the mentoring of fellows on EGS service have not been previously studied. We hypothesize that EGS patient outcomes would not differ by provider on a service driven by evidence-based medicine (EBM) protocols... - Personalized medicine: genetic variation and loss of physiologic complexity are associated with mortality in 644 trauma patientsPatrick R Norris
Division of Trauma and Surgical Critical Care, Vanderbilt University, Nashville, Tennessee, USA
Ann Surg 250:524-30. 2009..We hypothesized that variability in ANS receptor proteins (genetics) and loss of complexity (physiology) are independently associated with mortality in critical illness... - Colon anastomosis after damage control laparotomy: recommendations from 174 trauma colectomiesMickey M Ott
From the Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 70:595-602. 2011..We hypothesized that colonic anastomosis for trauma patients requiring an open abdomen (OA) would have a higher anastomotic leak (AL) rate when compared with patients having an immediate abdominal closure following trauma laparotomy... - Insulin resistance heralds positive cultures after severe injuryNathan T Mowery
Department of Surgery, Vanderbilt University, Nashville, Tennessee, USA
Surg Infect (Larchmt) 10:503-9. 2009..We hypothesized that measures of IR during tight glycemic control protocols are associated with infection and may be more predictive than the serum glucose concentration... - Triaging to a regional acute care surgery center: distance is criticalJose J Diaz
Division of Trauma and Surgical Critical Care, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 70:116-9. 2011..We hypothesized that distance to a referral center and severity of illness (SOI) would be predictors of death... - Beta-blocker exposure in patients with severe traumatic brain injury (TBI) and cardiac uncouplingWilliam P Riordan
Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 63:503-10; discussion 510-1. 2007..The purpose of the present study was to evaluate the effect of betaB exposure on the mortality risk of patients with severe TBI and early cardiac uncoupling... - Genetic variation in the autonomic nervous system affects mortality: a study of 1,095 trauma patientsJohn A Morris
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
J Am Coll Surg 208:663-8; discussion 668-70. 2009..We have previously demonstrated an unappreciated link between the autonomic nervous system and mortality, heart rate variability, and physiologic complexity... - Morbid obesity is not a risk factor for mortality in critically ill trauma patientsJose J Diaz
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Trauma 66:226-31. 2009..Our aim was to which risk factors had the highest risk of death in the critically ill trauma patient... - Reduced heart rate multiscale entropy predicts death in critical illness: a study of physiologic complexity in 285 trauma patientsPatrick R Norris
Division of Trauma, Burn, and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Crit Care 23:399-405. 2008..We hypothesized that heart rate multiscale entropy (MSE), a potential measurement of physiologic complexity, would predict death more robustly than HRVi... - Heart rate multiscale entropy at three hours predicts hospital mortality in 3,154 trauma patientsPatrick R Norris
Division of Trauma, Burn, and Surgical Critical Care, Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA
Shock 30:17-22. 2008..2) Multiscale entropy is robust to variation in bedside data duration and density occurring in a working intensive care unit. (3) Complexity may be a new clinical biomarker of outcome... - Cardiac uncoupling and heart rate variability stratify ICU patients by mortality: a study of 2088 trauma patientsPatrick R Norris
Section of Surgical Sciences, Department of Biomedical Engineering, Vanderbilt University Medical Center, 1211 21st Avenue South, Nashville, TN 37212, USA
Ann Surg 243:804-12; discussion 812-4. 2006..CONCLUSIONS: Cardiac uncoupling: 1) is an independent predictor of death throughout the ICU stay, 2) has a predictive window of 2 to 4 days, and 3) appears to increase in response to inflammation, infection, and multiple organ failure... - Acute adrenal insufficiency may affect outcome in the trauma patientOscar D Guillamondegui
Department of Surgery, Division of Trauma, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Am Surg 75:287-90. 2009.... - Cardiac uncoupling and heart rate variability are associated with intracranial hypertension and mortality: a study of 145 trauma patients with continuous monitoringNathan Teague Mowery
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 65:621-7. 2008.... - The open abdomen in trauma: do infectious complications affect primary abdominal closure?Todd R Vogel
Section of Surgical Sciences, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Surg Infect (Larchmt) 7:433-41. 2006.... - Does regionalization of acute care surgery decrease mortality?Jose J Diaz
Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 71:442-6. 2011..We hypothesize that a matured regional EGS service would show decreasing mortality and length of stay (LOS) over time... - Heart rate variability predicts trauma patient outcome as early as 12 h: implications for military and civilian triagePatrick R Norris
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Surg Res 129:122-8. 2005.... - The early work-up for isolated ligamentous injury of the cervical spine: does computed tomography scan have a role?Jose J Diaz
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 59:897-903; discussion 903-4. 2005..Helical computed tomography (HCT) scan is the preferred modality for diagnosing fractures of the cervical spine in blunt trauma. We hypothesize that HCT can be used as a screening tool for isolated ligamentous injury (LI) in blunt trauma... - Are adrenal injuries predictive of adrenal insufficiency in patients sustaining blunt trauma?Eric T Castaldo
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Am Surg 74:262-6. 2008..Adrenal insufficiency should be considered with increasing injury severity and age in the intensive care setting after blunt trauma... - Cervical spine evaluation in urban trauma centers: lowering institutional costs and complications through helical CT scanEric L Grogan
Departments of Surgery, Vanderbilt University, Nashville, TN, USA
J Am Coll Surg 200:160-5. 2005.... - Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe traumaJeffrey A Canter
Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Ann Surg 246:406-11; discussion 411-4. 2007..To determine whether specific genetic variations in the mtDNA that impact energy production and free-radical generation are potential new risk factors for in-hospital mortality after severe trauma... - Bedside laparotomy for trauma: are there risks?Jose J Diaz
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Surg Infect (Larchmt) 5:15-20. 2004..We hypothesized that patients undergoing bedside laparotomy (BSL) and managed with the abdomen left open would have an unacceptably high mortality or intra-abdominal complications... - Early loss of heart rate complexity predicts mortality regardless of mechanism, anatomic location, or severity of injury in 2178 trauma patientsWilliam P Riordan
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Surg Res 156:283-9. 2009..However, this finding has not been validated across the diverse spectrum of traumatic injury, and underlying mechanisms of this relationship are poorly understood... - Reduced heart rate volatility: an early predictor of death in trauma patientsEric L Grogan
VA Quality Scholars Program, Vanderbilt University, Nashville, TN, USA
Ann Surg 240:547-54; discussion 554-6. 2004..CONCLUSIONS: CVRD identifies a subgroup of patients with a high probability of dying. Death is predicted within first 24 hours of stay. We hypothesize CVRD is a surrogate for autonomic nervous system dysfunction... - Role of reduced heart rate volatility in predicting death in trauma patientsJohn A Morris
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Adv Surg 39:77-96. 2005 - Core temperature variation is associated with heart rate variability independent of cardiac index: a study of 278 trauma patientsNathan T Mowery
Department of Surgery, Wake Forest University, Winston Salem, NC 27157, USA
J Crit Care 26:534.e9-534.e17. 2011..The purpose of this study is to determine if temperature extremes are associated with reduced heart rate variability (HRV) and "cardiac uncoupling.".. - Systems initiatives reduce healthcare-associated infections: a study of 22,928 device days in a single trauma unitRichard S Miller
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Trauma 68:23-31. 2010..We hypothesized a system-based initiative to reduce nosocomial infection would lower the incidence of ventilator-associated pneumonia (VAP), urinary tract infection (UTI), and bloodstream infection (BSI)... - Creating an emergency general surgery service enhances the productivity of trauma surgeons, general surgeons and the hospitalMary T Austin
Department of Surgery, the Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
J Trauma 58:906-10. 2005.... - Complications after 344 damage-control open celiotomiesRichard S Miller
Section of Surgical Sciences, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 59:1365-71; discussion 1371-4. 2005..We reviewed our experience with the open abdomen and hypothesized that the known high wound complication rates were related to the timing and method of wound closure... - Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilizationBryan A Cotton
Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Trauma 64:1177-82; discussion 1182-3. 2008.... - Validation of stroke work and ventricular arterial coupling as markers of cardiovascular performance during resuscitationR Shayn Martin
Department of Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Trauma 60:930-4; discussion 934-5. 2006..The purpose of this study was to demonstrate the capabilities of a completely automated data management system by further evaluating SWI-based resuscitation... - Beta-blocker exposure is associated with improved survival after severe traumatic brain injuryBryan A Cotton
Departments of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Trauma 62:26-33; discussion 33-5. 2007..Traumatic brain injury (TBI) is often associated with a hyperadrenergic state. We hypothesized that adrenergic blockade would confer improved survival among TBI patients... - Influence of broad-spectrum antibiotic prophylaxis on intracranial pressure monitor infections and subsequent infectious complications in head-injured patientsAddison K May
Division of Trauma and Surgical Critical Care, Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Surg Infect (Larchmt) 7:409-17. 2006..In April 2002, a protocol change was instituted that substituted cefazolin for ceftriaxone as single-agent prophylaxis for ICP monitors... - Insulin resistance despite tight glucose control is associated with mortality in critically ill surgical patientsNathan T Mowery
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Intensive Care Med 24:242-51. 2009..The hyperglycemic state following trauma and surgery is related partially to insulin resistance (IR). The objective is to determine if critically ill surgical patients vary in their extent of IR and is IR associated with mortality... - Protocol for bedside laparotomy in trauma and emergency general surgery: a low return to the operating roomJose J Diaz
Section of Surgical Sciences, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Am Surg 71:986-91. 2005..3 per cent. Primary fascial closure of the abdomen had a significantly reduced hospital stay. BSL allowed trauma OR charges of dollar 5,300 per cases with 2.12 hours per cases savings... - Repair of giant abdominal hernias: does the type of prosthesis matter?Jose J Diaz
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Am Surg 70:396-401; discussion 401-2. 2004..2) There was a trend toward a higher wound infection in the GT (44.4%) versus NG (24.3%), but it did not reach statistical significance... - The impact of aviation-based teamwork training on the attitudes of health-care professionalsEric L Grogan
Department of Surgery, Vanderbilt University, Nashville, TN 37232-9485, USA
J Am Coll Surg 199:843-8. 2004..Participants agreed that CRM training will reduce errors and improve patient safety... - Acute care surgery: a functioning program and fellowship trainingJose J Diaz
Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Surgery 141:310-6. 2007 - A simple non-physiological artifact filter for invasive arterial blood pressure monitoring: a study of 1852 trauma ICU patientsHanqing Cao
Medical Centre, Vanderbilt University, Nashville, TN, USA
Conf Proc IEEE Eng Med Biol Soc 1:1417-20. 2006..Therefore, we concluded that our strategy of removing non-physiological artifact was simple, fast and useful for an accurate assessment of BP measures in trauma patients... - Occipital condyle fractures: clinical presentation and imaging findings in 76 patientsJoseph M Aulino
Department of Radiology and Radiological Sciences, Neuroradiology and Musculoskeletal Imaging Sections, Vanderbilt University Medical Center, MCN, 21st Avenue South, Nashville, TN, 37232 2675, USA
Emerg Radiol 11:342-7. 2005..Neurosurgery 41: 368-376, 1997) is useful, but suffers from the lack of a defined distinction between undisplaced (Type I, stable) and displaced (Type 2A, unstable) fracture fragments... - The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategiesBryan A Cotton
Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Shock 26:115-21. 2006..Future resuscitation research is likely to focus on improvements in fluid composition and adjuncts to administration of large volume of fluid... - Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patientsPratik Pandharipande
Department of Anesthesia Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Trauma 65:34-41. 2008..The purpose of this study was to analyze the prevalence of and risk factors for delirium in surgical and trauma ICU patients... - Are five-view plain films of the cervical spine unreliable? A prospective evaluation in blunt trauma patients with altered mental statusJose J Diaz
Department of Surgery, Trauma Paatient Care Center, Banderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 55:658-63; discussion 663-4. 2003.... - Early one-stage closure in patients with abdominal compartment syndrome: fascial replacement with human acellular dermis and bipedicle flapsJeffrey S Guy
Division of Trauma, Section of Surgical Sciences, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232-3755, USA
Am Surg 69:1025-8; discussion 1028-9. 2003..Once closed, patients were able to be discharged from the hospital early and without need for specialized wound care. Further investigation on the usefulness of this technique is required... - Post hoc mortality analysis of the efficacy trial of diaspirin cross-linked hemoglobin in the treatment of severe traumatic hemorrhagic shockEdward P Sloan
Department of Emergency Medicine, University of Illinois at Chicago, 60612, USA
J Trauma 52:887-95. 2002..The efficacy trial of diaspirin cross-linked hemoglobin (DCLHb) in traumatic hemorrhagic shock demonstrated an unexpected mortality imbalance, prompting a three-step review to better understand the cause of this finding... - Androgen-sensitivity of somata and dendrites of spinal nucleus of the bulbocavernosus (SNB) motoneurons in male C57BL6J miceDamian G Zuloaga
Department of Psychology and Program in Neuroscience, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824 1101, USA
Horm Behav 51:207-12. 2007..This pattern of AR labeling is consistent with the possibility that androgens also act directly on SNB motoneurons in mice to regulate soma size in mice... - Practice guidelines in mental health and addiction services: contributions from the American College of Mental Health AdministrationGail W Stuart
College of Nursing, Medical University of South Carolina, Charleston 29425, USA
Adm Policy Ment Health 30:21-33. 2002.... - A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injuryGreg S Martin
Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Crit Care Med 33:1681-7. 2005..Additional randomized clinical trials are necessary to examine mechanisms and determine the effect on important clinical outcomes, such as the duration of mechanical ventilation... - Sexual dimorphism in neuronal number of the posterodorsal medial amygdala is independent of circulating androgens and regional volume in adult ratsJohn A Morris
Neuroscience Program, Michigan State University, East Lansing, Michigan 48824 1101, USA
J Comp Neurol 506:851-9. 2008.... - Androgen receptors are required for full masculinization of the ventromedial hypothalamus (VMH) in ratsBrittany N Dugger
Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
Horm Behav 51:195-201. 2007..ARs may regulate aromatase expression or activity to affect estrogen receptor activation, or may act independently of estrogen receptors to influence VMH morphology...